UniProtKB - P12956 (XRCC6_HUMAN)
X-ray repair cross-complementing protein 6
XRCC6
Functioni
Miscellaneous
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 31 | Schiff-base intermediate with DNA; for 5'-deoxyribose-5-phosphate lyase activityCurated | 1 |
GO - Molecular functioni
- 5'-deoxyribose-5-phosphate lyase activity Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- cyclin binding Source: UniProtKB
- damaged DNA binding Source: InterPro
- DNA binding Source: UniProtKB
- DNA-dependent ATPase activity Source: FlyBase
- DNA helicase activity Source: FlyBase
- double-stranded DNA binding Source: ProtInc
- protein-containing complex binding Source: BHF-UCL
- protein C-terminus binding Source: UniProtKB
- RNA binding Source: UniProtKB
- telomeric DNA binding Source: GO_Central
- transcription regulatory region sequence-specific DNA binding Source: BHF-UCL
GO - Biological processi
- activation of innate immune response Source: UniProtKB
- brain development Source: Ensembl
- cellular hyperosmotic salinity response Source: Ensembl
- cellular response to gamma radiation Source: UniProtKB
- cellular response to X-ray Source: GO_Central
- DNA ligation Source: ProtInc
- DNA recombination Source: UniProtKB-KW
- double-strand break repair via classical nonhomologous end joining Source: BHF-UCL
- double-strand break repair via nonhomologous end joining Source: UniProtKB
- establishment of integrated proviral latency Source: Reactome
- innate immune response Source: UniProtKB-KW
- negative regulation of transcription, DNA-templated Source: UniProtKB
- neutrophil degranulation Source: Reactome
- positive regulation of lymphocyte differentiation Source: UniProtKB
- positive regulation of protein kinase activity Source: CAFA
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of type I interferon production Source: Reactome
- regulation of smooth muscle cell proliferation Source: UniProtKB
- telomere maintenance Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding, Helicase, Hydrolase, Lyase, Multifunctional enzyme |
Biological process | DNA damage, DNA recombination, DNA repair, Host-virus interaction, Immunity, Innate immunity, Transcription, Transcription regulation |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P12956 |
Reactomei | R-HSA-164843, 2-LTR circle formation R-HSA-1834949, Cytosolic sensors of pathogen-associated DNA R-HSA-3270619, IRF3-mediated induction of type I IFN R-HSA-5693571, Nonhomologous End-Joining (NHEJ) R-HSA-6798695, Neutrophil degranulation |
SIGNORi | P12956 |
Protein family/group databases
MoonDBi | P12956, Curated |
Names & Taxonomyi
Protein namesi | Recommended name: X-ray repair cross-complementing protein 6 (EC:3.6.4.-, EC:4.2.99.-)Alternative name(s): 5'-deoxyribose-5-phosphate lyase Ku70 Short name: 5'-dRP lyase Ku70 70 kDa subunit of Ku antigen ATP-dependent DNA helicase 2 subunit 1 ATP-dependent DNA helicase II 70 kDa subunit CTC box-binding factor 75 kDa subunit Short name: CTC75 Short name: CTCBF DNA repair protein XRCC6 Lupus Ku autoantigen protein p70 Short name: Ku70 Thyroid-lupus autoantigen Short name: TLAA X-ray repair complementing defective repair in Chinese hamster cells 6 |
Gene namesi | Name:XRCC6 Synonyms:G22P1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4055, XRCC6 |
MIMi | 152690, gene |
neXtProti | NX_P12956 |
VEuPathDBi | HostDB:ENSG00000196419.12 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Other locations
- Chromosome 1 Publication
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular region Source: Reactome
Nucleus
- Ku70:Ku80 complex Source: UniProtKB
- nuclear telomere cap complex Source: BHF-UCL
- nucleolus Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: ProtInc
Other locations
- chromosome, telomeric region Source: BHF-UCL
- ficolin-1-rich granule lumen Source: Reactome
- membrane Source: UniProtKB
- nonhomologous end joining complex Source: UniProtKB
- protein-containing complex Source: CAFA
- protein-DNA complex Source: CAFA
- secretory granule lumen Source: Reactome
- transcription regulator complex Source: UniProtKB
Keywords - Cellular componenti
Chromosome, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 31 | K → A: Diminishes the ability to form a Schiff base. Abolishes adduct formation; when associated with A-160 and A-164. 1 Publication | 1 | |
Mutagenesisi | 160 | K → A: Abolishes adduct formation; when associated with A-31 and A-160. 1 Publication | 1 | |
Mutagenesisi | 164 | K → A: Abolishes adduct formation; when associated with A-31 and A-164. 1 Publication | 1 |
Keywords - Diseasei
Systemic lupus erythematosusOrganism-specific databases
DisGeNETi | 2547 |
OpenTargetsi | ENSG00000196419 |
PharmGKBi | PA28467 |
Miscellaneous databases
Pharosi | P12956, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4106136 |
Genetic variation databases
BioMutai | XRCC6 |
DMDMi | 125729 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000210179 | 2 – 609 | X-ray repair cross-complementing protein 6Add BLAST | 608 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 2 | PhosphoserineCombined sources | 1 | |
Modified residuei | 6 | Phosphoserine; by PRKDC1 Publication | 1 | |
Modified residuei | 27 | PhosphoserineCombined sources | 1 | |
Modified residuei | 31 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 51 | Phosphoserine; by PRKDC1 Publication | 1 | |
Cross-linki | 287 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 306 | PhosphoserineCombined sources | 1 | |
Cross-linki | 317 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 331 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 338 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 455 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 461 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 477 | PhosphoserineCombined sources | 1 | |
Modified residuei | 520 | PhosphoserineCombined sources | 1 | |
Modified residuei | 550 | PhosphoserineCombined sources | 1 | |
Cross-linki | 556 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 560 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, ADP-ribosylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P12956 |
jPOSTi | P12956 |
MassIVEi | P12956 |
MaxQBi | P12956 |
PaxDbi | P12956 |
PeptideAtlasi | P12956 |
PRIDEi | P12956 |
ProteomicsDBi | 2929 52888 [P12956-1] |
2D gel databases
SWISS-2DPAGEi | P12956 |
PTM databases
iPTMneti | P12956 |
MetOSitei | P12956 |
PhosphoSitePlusi | P12956 |
SwissPalmi | P12956 |
Expressioni
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSG00000196419, Expressed in testis and 245 other tissues |
ExpressionAtlasi | P12956, baseline and differential |
Genevisiblei | P12956, HS |
Organism-specific databases
HPAi | ENSG00000196419, Low tissue specificity |
Interactioni
Subunit structurei
Heterodimer composed of XRCC5/Ku80 and XRCC6/Ku70. The dimer associates in a DNA-dependent manner with PRKDC to form the DNA-dependent protein kinase complex DNA-PK, and with the LIG4-XRCC4 complex to form the core of the non-homologous end joining (NHEJ) complex. Additional components of the NHEJ complex include NHEJ1/XLF and PAXX (PubMed:25574025, PubMed:25941166, PubMed:25670504). The dimer also associates with NAA15, and this complex binds to the osteocalcin promoter and activates osteocalcin expression. In addition, XRCC6 interacts with the osteoblast-specific transcription factors MSX2, RUNX2 and DLX5.
Interacts with ELF3.
Interacts with ATP23. The XRCC5/6 dimer associates in a DNA-dependent manner with APEX1. Binds to CDK9 isoform 2.
Identified in a complex with DEAF1 and XRCC5.
Interacts with DEAF1 (via the SAND domain); the interaction is direct and may be inhibited by DNA-binding (PubMed:10219089, PubMed:11493912, PubMed:12145306, PubMed:12509254, PubMed:12547193, PubMed:15075319, PubMed:20493174, PubMed:22442688, PubMed:8621488, PubMed:9742108).
Interacts with CLU (By similarity).
Interacts with NR4A3; the DNA-dependent protein kinase complex DNA-PK phosphorylates and activates NR4A3 and prevents NR4A3 ubiquitinylation and degradation (PubMed:25852083).
Interacts with CYREN isoform 1 (CYREN-1) and isoform 4 (CYREN-2) (PubMed:24610814, PubMed:28959974).
Interacts (via N-terminus) with HSF1 (via N-terminus); this interaction is direct and prevents XRCC5/XRCC6 heterodimeric binding and non-homologous end joining (NHEJ) repair activities induced by ionizing radiation (IR) (PubMed:26359349). Part of the HDP-RNP complex composed of at least HEXIM1, PRKDC, XRCC5, XRCC6, paraspeckle proteins (SFPQ, NONO, PSPC1, RBM14, and MATR3) and NEAT1 RNA (PubMed:28712728).
Interacts with HMBOX1 (PubMed:23685356).
Interacts with ATF7 (PubMed:29490055).
By similarity17 Publications(Microbial infection) Interacts with human T-cell leukemia virus 1/HTLV-1 protein HBZ.
1 PublicationBinary interactionsi
Hide detailsP12956
GO - Molecular functioni
- cyclin binding Source: UniProtKB
- protein C-terminus binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 108822, 660 interactors |
ComplexPortali | CPX-1993, Ku70:Ku80 complex |
CORUMi | P12956 |
DIPi | DIP-24188N |
ELMi | P12956 |
IntActi | P12956, 205 interactors |
MINTi | P12956 |
STRINGi | 9606.ENSP00000352257 |
Miscellaneous databases
RNActi | P12956, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P12956 |
SASBDBi | P12956 |
SMRi | P12956 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P12956 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 261 – 468 | KuAdd BLAST | 208 | |
Domaini | 573 – 607 | SAPPROSITE-ProRule annotationAdd BLAST | 35 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 550 – 609 | Interaction with DEAF11 PublicationAdd BLAST | 60 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 2 – 61 | Ser-rich (potentially targets for phosphorylation)Add BLAST | 60 | |
Compositional biasi | 11 – 29 | Asp/Glu-rich (acidic)Add BLAST | 19 | |
Compositional biasi | 330 – 342 | Asp/Glu-rich (acidic)Add BLAST | 13 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2327, Eukaryota |
GeneTreei | ENSGT00940000153239 |
HOGENOMi | CLU_014815_2_0_1 |
InParanoidi | P12956 |
OMAi | PNDMMGI |
PhylomeDBi | P12956 |
TreeFami | TF315101 |
Family and domain databases
DisProti | DP01254 |
Gene3Di | 1.10.720.30, 1 hit 2.40.290.10, 1 hit 3.40.50.410, 1 hit 4.10.970.10, 1 hit |
IDEALi | IID00023 |
InterProi | View protein in InterPro IPR006165, Ku70 IPR006164, Ku70/Ku80_beta-barrel_dom IPR027388, Ku70_bridge/pillars_dom_sf IPR005160, Ku_C IPR005161, Ku_N IPR003034, SAP_dom IPR036361, SAP_dom_sf IPR016194, SPOC-like_C_dom_sf IPR036465, vWFA_dom_sf |
Pfami | View protein in Pfam PF02735, Ku, 1 hit PF03730, Ku_C, 1 hit PF03731, Ku_N, 1 hit PF02037, SAP, 1 hit |
PIRSFi | PIRSF003033, Ku70, 1 hit |
SMARTi | View protein in SMART SM00559, Ku78, 1 hit SM00513, SAP, 1 hit |
SUPFAMi | SSF100939, SSF100939, 1 hit SSF53300, SSF53300, 1 hit SSF68906, SSF68906, 1 hit |
TIGRFAMsi | TIGR00578, ku70, 1 hit |
PROSITEi | View protein in PROSITE PS50800, SAP, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSGWESYYKT EGDEEAEEEQ EENLEASGDY KYSGRDSLIF LVDASKAMFE
60 70 80 90 100
SQSEDELTPF DMSIQCIQSV YISKIISSDR DLLAVVFYGT EKDKNSVNFK
110 120 130 140 150
NIYVLQELDN PGAKRILELD QFKGQQGQKR FQDMMGHGSD YSLSEVLWVC
160 170 180 190 200
ANLFSDVQFK MSHKRIMLFT NEDNPHGNDS AKASRARTKA GDLRDTGIFL
210 220 230 240 250
DLMHLKKPGG FDISLFYRDI ISIAEDEDLR VHFEESSKLE DLLRKVRAKE
260 270 280 290 300
TRKRALSRLK LKLNKDIVIS VGIYNLVQKA LKPPPIKLYR ETNEPVKTKT
310 320 330 340 350
RTFNTSTGGL LLPSDTKRSQ IYGSRQIILE KEETEELKRF DDPGLMLMGF
360 370 380 390 400
KPLVLLKKHH YLRPSLFVYP EESLVIGSST LFSALLIKCL EKEVAALCRY
410 420 430 440 450
TPRRNIPPYF VALVPQEEEL DDQKIQVTPP GFQLVFLPFA DDKRKMPFTE
460 470 480 490 500
KIMATPEQVG KMKAIVEKLR FTYRSDSFEN PVLQQHFRNL EALALDLMEP
510 520 530 540 550
EQAVDLTLPK VEAMNKRLGS LVDEFKELVY PPDYNPEGKV TKRKHDNEGS
560 570 580 590 600
GSKRPKVEYS EEELKTHISK GTLGKFTVPM LKEACRAYGL KSGLKKQELL
EALTKHFQD
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB1AHC9 | B1AHC9_HUMAN | ATP-dependent DNA helicase 2 subuni... | XRCC6 | 559 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 20 | Q → D AA sequence (PubMed:1537839).Curated | 1 | |
Sequence conflicti | 101 | N → K AA sequence (PubMed:8605992).Curated | 1 | |
Sequence conflicti | 103 | Y → L AA sequence (PubMed:8605992).Curated | 1 | |
Sequence conflicti | 116 | I → S AA sequence (PubMed:8605992).Curated | 1 | |
Sequence conflicti | 125 | Q → S AA sequence (PubMed:8605992).Curated | 1 | |
Sequence conflicti | 181 | A → T in CAG47015 (Ref. 5) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056030 | 65 – 105 | Missing in isoform 2. 1 PublicationAdd BLAST | 41 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04607 mRNA Translation: AAA61177.1 J04611 mRNA Translation: AAA51733.1 M32865 mRNA Translation: AAA36155.1 S38729 mRNA Translation: AAB22381.1 AK055786 mRNA Translation: BAG51575.1 CR542219 mRNA Translation: CAG47015.1 AY870329 Genomic DNA Translation: AAW34364.1 Z83840 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW60448.1 BC008343 mRNA Translation: AAH08343.1 BC010034 mRNA Translation: AAH10034.1 BC012154 mRNA Translation: AAH12154.1 BC018259 mRNA Translation: AAH18259.1 BC072449 mRNA Translation: AAH72449.1 |
CCDSi | CCDS14021.1 [P12956-1] CCDS74870.1 [P12956-2] |
PIRi | A30299, A30894 |
RefSeqi | NP_001275905.1, NM_001288976.1 [P12956-1] NP_001275906.1, NM_001288977.1 [P12956-2] NP_001460.1, NM_001469.4 [P12956-1] |
Genome annotation databases
Ensembli | ENST00000359308; ENSP00000352257; ENSG00000196419 [P12956-1] ENST00000360079; ENSP00000353192; ENSG00000196419 [P12956-1] ENST00000402580; ENSP00000384941; ENSG00000196419 [P12956-2] ENST00000405878; ENSP00000384257; ENSG00000196419 [P12956-1] |
GeneIDi | 2547 |
KEGGi | hsa:2547 |
UCSCi | uc003bao.3, human [P12956-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04607 mRNA Translation: AAA61177.1 J04611 mRNA Translation: AAA51733.1 M32865 mRNA Translation: AAA36155.1 S38729 mRNA Translation: AAB22381.1 AK055786 mRNA Translation: BAG51575.1 CR542219 mRNA Translation: CAG47015.1 AY870329 Genomic DNA Translation: AAW34364.1 Z83840 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW60448.1 BC008343 mRNA Translation: AAH08343.1 BC010034 mRNA Translation: AAH10034.1 BC012154 mRNA Translation: AAH12154.1 BC018259 mRNA Translation: AAH18259.1 BC072449 mRNA Translation: AAH72449.1 |
CCDSi | CCDS14021.1 [P12956-1] CCDS74870.1 [P12956-2] |
PIRi | A30299, A30894 |
RefSeqi | NP_001275905.1, NM_001288976.1 [P12956-1] NP_001275906.1, NM_001288977.1 [P12956-2] NP_001460.1, NM_001469.4 [P12956-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1JEQ | X-ray | 2.70 | A | 1-609 | [»] | |
1JEY | X-ray | 2.50 | A | 1-609 | [»] | |
1JJR | NMR | - | A | 556-609 | [»] | |
3RZX | X-ray | 2.61 | B | 537-558 | [»] | |
5Y3R | electron microscopy | 6.60 | A | 34-534 | [»] | |
6ERF | X-ray | 3.01 | A/C/E/G | 1-544 | [»] | |
6ERG | X-ray | 2.90 | A/D | 1-544 | [»] | |
6ERH | X-ray | 2.80 | A/C | 1-544 | [»] | |
6ZHA | electron microscopy | 3.91 | B | 1-609 | [»] | |
6ZHE | electron microscopy | 7.24 | B/G | 1-609 | [»] | |
7K1J | electron microscopy | 3.90 | B | 1-609 | [»] | |
7K1K | electron microscopy | 4.10 | B | 1-609 | [»] | |
7K1N | electron microscopy | 3.90 | B | 1-609 | [»] | |
BMRBi | P12956 | |||||
SASBDBi | P12956 | |||||
SMRi | P12956 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108822, 660 interactors |
ComplexPortali | CPX-1993, Ku70:Ku80 complex |
CORUMi | P12956 |
DIPi | DIP-24188N |
ELMi | P12956 |
IntActi | P12956, 205 interactors |
MINTi | P12956 |
STRINGi | 9606.ENSP00000352257 |
Chemistry databases
ChEMBLi | CHEMBL4106136 |
Protein family/group databases
MoonDBi | P12956, Curated |
PTM databases
iPTMneti | P12956 |
MetOSitei | P12956 |
PhosphoSitePlusi | P12956 |
SwissPalmi | P12956 |
Genetic variation databases
BioMutai | XRCC6 |
DMDMi | 125729 |
2D gel databases
SWISS-2DPAGEi | P12956 |
Proteomic databases
EPDi | P12956 |
jPOSTi | P12956 |
MassIVEi | P12956 |
MaxQBi | P12956 |
PaxDbi | P12956 |
PeptideAtlasi | P12956 |
PRIDEi | P12956 |
ProteomicsDBi | 2929 52888 [P12956-1] |
Protocols and materials databases
Antibodypediai | 3790, 1298 antibodies |
DNASUi | 2547 |
Genome annotation databases
Ensembli | ENST00000359308; ENSP00000352257; ENSG00000196419 [P12956-1] ENST00000360079; ENSP00000353192; ENSG00000196419 [P12956-1] ENST00000402580; ENSP00000384941; ENSG00000196419 [P12956-2] ENST00000405878; ENSP00000384257; ENSG00000196419 [P12956-1] |
GeneIDi | 2547 |
KEGGi | hsa:2547 |
UCSCi | uc003bao.3, human [P12956-1] |
Organism-specific databases
CTDi | 2547 |
DisGeNETi | 2547 |
GeneCardsi | XRCC6 |
HGNCi | HGNC:4055, XRCC6 |
HPAi | ENSG00000196419, Low tissue specificity |
MIMi | 152690, gene |
neXtProti | NX_P12956 |
OpenTargetsi | ENSG00000196419 |
PharmGKBi | PA28467 |
VEuPathDBi | HostDB:ENSG00000196419.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2327, Eukaryota |
GeneTreei | ENSGT00940000153239 |
HOGENOMi | CLU_014815_2_0_1 |
InParanoidi | P12956 |
OMAi | PNDMMGI |
PhylomeDBi | P12956 |
TreeFami | TF315101 |
Enzyme and pathway databases
PathwayCommonsi | P12956 |
Reactomei | R-HSA-164843, 2-LTR circle formation R-HSA-1834949, Cytosolic sensors of pathogen-associated DNA R-HSA-3270619, IRF3-mediated induction of type I IFN R-HSA-5693571, Nonhomologous End-Joining (NHEJ) R-HSA-6798695, Neutrophil degranulation |
SIGNORi | P12956 |
Miscellaneous databases
BioGRID-ORCSi | 2547, 785 hits in 977 CRISPR screens |
ChiTaRSi | XRCC6, human |
EvolutionaryTracei | P12956 |
GeneWikii | Ku70 |
GenomeRNAii | 2547 |
Pharosi | P12956, Tbio |
PROi | PR:P12956 |
RNActi | P12956, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000196419, Expressed in testis and 245 other tissues |
ExpressionAtlasi | P12956, baseline and differential |
Genevisiblei | P12956, HS |
Family and domain databases
DisProti | DP01254 |
Gene3Di | 1.10.720.30, 1 hit 2.40.290.10, 1 hit 3.40.50.410, 1 hit 4.10.970.10, 1 hit |
IDEALi | IID00023 |
InterProi | View protein in InterPro IPR006165, Ku70 IPR006164, Ku70/Ku80_beta-barrel_dom IPR027388, Ku70_bridge/pillars_dom_sf IPR005160, Ku_C IPR005161, Ku_N IPR003034, SAP_dom IPR036361, SAP_dom_sf IPR016194, SPOC-like_C_dom_sf IPR036465, vWFA_dom_sf |
Pfami | View protein in Pfam PF02735, Ku, 1 hit PF03730, Ku_C, 1 hit PF03731, Ku_N, 1 hit PF02037, SAP, 1 hit |
PIRSFi | PIRSF003033, Ku70, 1 hit |
SMARTi | View protein in SMART SM00559, Ku78, 1 hit SM00513, SAP, 1 hit |
SUPFAMi | SSF100939, SSF100939, 1 hit SSF53300, SSF53300, 1 hit SSF68906, SSF68906, 1 hit |
TIGRFAMsi | TIGR00578, ku70, 1 hit |
PROSITEi | View protein in PROSITE PS50800, SAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | XRCC6_HUMAN | |
Accessioni | P12956Primary (citable) accession number: P12956 Secondary accession number(s): B1AHC8 Q9UCQ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 242 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families