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UniProtKB - P12956 (XRCC6_HUMAN)

Protein

X-ray repair cross-complementing protein 6

Gene

XRCC6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.8 Publications

Miscellaneous

Individuals with systemic lupus erythematosus (SLE) and related disorders produce extremely large amounts of autoantibodies to XRCC5 and XRCC6. Existence of a major autoantigenic epitope or epitopes on the C-terminal 190 amino acids of XRCC6 containing the leucine repeat. The majority of autoantibodies to XRCC6 in most sera from patients with SLE seem to be reactive with this region.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei31Schiff-base intermediate with DNA; for 5'-deoxyribose-5-phosphate lyase activityCurated1

GO - Molecular functioni

  • 5'-deoxyribose-5-phosphate lyase activity Source: UniProtKB
  • ATP binding Source: UniProtKB-KW
  • ATP-dependent DNA helicase activity Source: ProtInc
  • cyclin binding Source: UniProtKB
  • damaged DNA binding Source: InterPro
  • DNA binding Source: UniProtKB
  • double-stranded DNA binding Source: ProtInc
  • protein-containing complex binding Source: BHF-UCL
  • protein C-terminus binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • telomeric DNA binding Source: GO_Central
  • transcription regulatory region DNA binding Source: BHF-UCL
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActivator, DNA-binding, Helicase, Hydrolase, Lyase, Multifunctional enzyme
Biological processDNA damage, DNA recombination, DNA repair, Immunity, Innate immunity, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-164843 2-LTR circle formation
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA
R-HSA-3270619 IRF3-mediated induction of type I IFN
R-HSA-5693571 Nonhomologous End-Joining (NHEJ)
R-HSA-6798695 Neutrophil degranulation
SIGNORiP12956

Protein family/group databases

MoonDBiP12956 Curated

Names & Taxonomyi

Protein namesi
Recommended name:
X-ray repair cross-complementing protein 6 (EC:3.6.4.-, EC:4.2.99.-)
Alternative name(s):
5'-deoxyribose-5-phosphate lyase Ku70
Short name:
5'-dRP lyase Ku70
70 kDa subunit of Ku antigen
ATP-dependent DNA helicase 2 subunit 1
ATP-dependent DNA helicase II 70 kDa subunit
CTC box-binding factor 75 kDa subunit
Short name:
CTC75
Short name:
CTCBF
DNA repair protein XRCC6
Lupus Ku autoantigen protein p70
Short name:
Ku70
Thyroid-lupus autoantigen
Short name:
TLAA
X-ray repair complementing defective repair in Chinese hamster cells 6
Gene namesi
Name:XRCC6
Synonyms:G22P1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000196419.12
HGNCiHGNC:4055 XRCC6
MIMi152690 gene
neXtProtiNX_P12956

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi31K → A: Diminishes the ability to form a Schiff base. Abolishes adduct formation; when associated with A-160 and A-164. 1 Publication1
Mutagenesisi160K → A: Abolishes adduct formation; when associated with A-31 and A-160. 1 Publication1
Mutagenesisi164K → A: Abolishes adduct formation; when associated with A-31 and A-164. 1 Publication1

Keywords - Diseasei

Systemic lupus erythematosus

Organism-specific databases

DisGeNETi2547
OpenTargetsiENSG00000196419
PharmGKBiPA28467

Polymorphism and mutation databases

DMDMi125729

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002101792 – 609X-ray repair cross-complementing protein 6Add BLAST608

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1
Modified residuei6Phosphoserine; by PRKDC1 Publication1
Modified residuei27PhosphoserineCombined sources1
Modified residuei31N6-acetyllysineCombined sources1
Modified residuei51Phosphoserine; by PRKDC1 Publication1
Cross-linki287Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei306PhosphoserineCombined sources1
Cross-linki317Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei331N6-acetyllysineCombined sources1
Modified residuei338N6-acetyllysineCombined sources1
Modified residuei455PhosphothreonineCombined sources1
Modified residuei461N6-acetyllysineCombined sources1
Modified residuei477PhosphoserineCombined sources1
Modified residuei520PhosphoserineCombined sources1
Modified residuei550PhosphoserineCombined sources1
Cross-linki556Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei560PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation by PRKDC may enhance helicase activity. Phosphorylation of Ser-51 does not affect DNA repair.3 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP12956
MaxQBiP12956
PaxDbiP12956
PeptideAtlasiP12956
PRIDEiP12956
ProteomicsDBi52888

2D gel databases

SWISS-2DPAGEiP12956

PTM databases

iPTMnetiP12956
PhosphoSitePlusiP12956
SwissPalmiP12956

Miscellaneous databases

PMAP-CutDBiP12956

Expressioni

Developmental stagei

Expression does not increase during promyelocyte differentiation.1 Publication

Inductioni

In osteoblasts, by FGF2.

Gene expression databases

BgeeiENSG00000196419 Expressed in 232 organ(s), highest expression level in testis
CleanExiHS_XRCC6
ExpressionAtlasiP12956 baseline and differential
GenevisibleiP12956 HS

Organism-specific databases

HPAiCAB004254
HPA047549
HPA062226

Interactioni

Subunit structurei

Heterodimer composed of XRCC5/Ku80 and XRCC6/Ku70. The dimer associates in a DNA-dependent manner with PRKDC to form the DNA-dependent protein kinase complex DNA-PK, and with the LIG4-XRCC4 complex to form the core of the non-homologous end joining (NHEJ) complex. Additional components of the NHEJ complex include NHEJ1/XLF and PAXX (PubMed:25574025, PubMed:25941166, PubMed:25670504). The dimer also associates with NAA15, and this complex binds to the osteocalcin promoter and activates osteocalcin expression. In addition, XRCC6 interacts with the osteoblast-specific transcription factors MSX2, RUNX2 and DLX5. Interacts with ELF3. Interacts with ATP23. The XRCC5/6 dimer associates in a DNA-dependent manner with APEX1. Binds to CDK9 isoform 2. Identified in a complex with DEAF1 and XRCC5. Interacts with DEAF1 (via the SAND domain); the interaction is direct and may be inhibited by DNA-binding (PubMed:10219089, PubMed:11493912, PubMed:12145306, PubMed:12509254, PubMed:12547193, PubMed:15075319, PubMed:20493174, PubMed:22442688, PubMed:8621488, PubMed:9742108). Interacts with CLU (By similarity). Interacts with NR4A3; the DNA-dependent protein kinase complex DNA-PK phosphorylates and activates NR4A3 and prevents NR4A3 ubiquitinylation and degradation (PubMed:25852083). Interacts with CYREN isoform 1 (CYREN-1) and isoform 4 (CYREN-2) (PubMed:24610814, PubMed:28959974). Interacts (via N-terminus) with HSF1 (via N-terminus); this interaction is direct and prevents XRCC5/XRCC6 heterodimeric binding and non-homologous end joining (NHEJ) repair activities induced by ionizing radiation (IR) (PubMed:26359349). Part of the HDP-RNP complex composed of at least HEXIM1, PRKDC, XRCC5, XRCC6, paraspeckle proteins (SFPQ, NONO, PSPC1, RBM14, and MATR3) and NEAT1 RNA (PubMed:28712728). Interacts with HMBOX1 (PubMed:23685356).By similarity16 Publications
(Microbial infection) Interacts with human T-cell leukemia virus 1/HTLV-1 protein HBZ.1 Publication

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi108822, 296 interactors
ComplexPortaliCPX-1993 Ku70:Ku80 complex
CORUMiP12956
DIPiDIP-24188N
ELMiP12956
IntActiP12956, 167 interactors
MINTiP12956
STRINGi9606.ENSP00000352257

Structurei

Secondary structure

1609
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP12956
SMRiP12956
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12956

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini261 – 468KuAdd BLAST208
Domaini573 – 607SAPPROSITE-ProRule annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni550 – 609Interaction with DEAF11 PublicationAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 61Ser-rich (potentially targets for phosphorylation)Add BLAST60
Compositional biasi11 – 29Asp/Glu-rich (acidic)Add BLAST19
Compositional biasi330 – 342Asp/Glu-rich (acidic)Add BLAST13

Sequence similaritiesi

Belongs to the ku70 family.Curated

Phylogenomic databases

eggNOGiKOG2327 Eukaryota
ENOG410XNXU LUCA
GeneTreeiENSGT00390000001422
HOGENOMiHOG000006588
HOVERGENiHBG006236
InParanoidiP12956
KOiK10884
OMAiDVFTSCN
OrthoDBiEOG091G04AI
PhylomeDBiP12956
TreeFamiTF315101

Family and domain databases

Gene3Di1.10.720.30, 1 hit
2.40.290.10, 1 hit
3.40.50.410, 1 hit
4.10.970.10, 1 hit
InterProiView protein in InterPro
IPR006165 Ku70
IPR006164 Ku70/Ku80_beta-barrel_dom
IPR027388 Ku70_bridge/pillars_dom_sf
IPR005160 Ku_C
IPR005161 Ku_N
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
IPR016194 SPOC-like_C_dom_sf
IPR036465 vWFA_dom_sf
PANTHERiPTHR12604:SF2 PTHR12604:SF2, 1 hit
PfamiView protein in Pfam
PF02735 Ku, 1 hit
PF03730 Ku_C, 1 hit
PF03731 Ku_N, 1 hit
PF02037 SAP, 1 hit
PIRSFiPIRSF003033 Ku70, 1 hit
SMARTiView protein in SMART
SM00559 Ku78, 1 hit
SM00513 SAP, 1 hit
SUPFAMiSSF100939 SSF100939, 1 hit
SSF53300 SSF53300, 1 hit
SSF68906 SSF68906, 1 hit
TIGRFAMsiTIGR00578 ku70, 1 hit
PROSITEiView protein in PROSITE
PS50800 SAP, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P12956-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGWESYYKT EGDEEAEEEQ EENLEASGDY KYSGRDSLIF LVDASKAMFE 
        60         70         80         90        100
SQSEDELTPF DMSIQCIQSV YISKIISSDR DLLAVVFYGT EKDKNSVNFK 
       110        120        130        140        150
NIYVLQELDN PGAKRILELD QFKGQQGQKR FQDMMGHGSD YSLSEVLWVC 
       160        170        180        190        200
ANLFSDVQFK MSHKRIMLFT NEDNPHGNDS AKASRARTKA GDLRDTGIFL 
       210        220        230        240        250
DLMHLKKPGG FDISLFYRDI ISIAEDEDLR VHFEESSKLE DLLRKVRAKE 
       260        270        280        290        300
TRKRALSRLK LKLNKDIVIS VGIYNLVQKA LKPPPIKLYR ETNEPVKTKT 
       310        320        330        340        350
RTFNTSTGGL LLPSDTKRSQ IYGSRQIILE KEETEELKRF DDPGLMLMGF 
       360        370        380        390        400
KPLVLLKKHH YLRPSLFVYP EESLVIGSST LFSALLIKCL EKEVAALCRY 
       410        420        430        440        450
TPRRNIPPYF VALVPQEEEL DDQKIQVTPP GFQLVFLPFA DDKRKMPFTE 
       460        470        480        490        500
KIMATPEQVG KMKAIVEKLR FTYRSDSFEN PVLQQHFRNL EALALDLMEP 
       510        520        530        540        550
EQAVDLTLPK VEAMNKRLGS LVDEFKELVY PPDYNPEGKV TKRKHDNEGS 
       560        570        580        590        600
GSKRPKVEYS EEELKTHISK GTLGKFTVPM LKEACRAYGL KSGLKKQELL 

EALTKHFQD
Length:609
Mass (Da):69,843
Last modified:January 23, 2007 - v2
Checksum:iBBD3CD434526DFCB
GO
Isoform 2 (identifier: P12956-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     65-105: Missing.

Note: No experimental confirmation available.
Show »
Length:568
Mass (Da):65,149
Checksum:iB6DBBED4C80118C1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AHC9B1AHC9_HUMAN
X-ray repair cross-complementing pr...
XRCC6
559Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20Q → D AA sequence (PubMed:1537839).Curated1
Sequence conflicti101N → K AA sequence (PubMed:8605992).Curated1
Sequence conflicti103Y → L AA sequence (PubMed:8605992).Curated1
Sequence conflicti116I → S AA sequence (PubMed:8605992).Curated1
Sequence conflicti125Q → S AA sequence (PubMed:8605992).Curated1
Sequence conflicti181A → T in CAG47015 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05603065 – 105Missing in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04607 mRNA Translation: AAA61177.1
J04611 mRNA Translation: AAA51733.1
M32865 mRNA Translation: AAA36155.1
S38729 mRNA Translation: AAB22381.1
AK055786 mRNA Translation: BAG51575.1
CR542219 mRNA Translation: CAG47015.1
AY870329 Genomic DNA Translation: AAW34364.1
Z83840 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60448.1
BC008343 mRNA Translation: AAH08343.1
BC010034 mRNA Translation: AAH10034.1
BC012154 mRNA Translation: AAH12154.1
BC018259 mRNA Translation: AAH18259.1
BC072449 mRNA Translation: AAH72449.1
CCDSiCCDS14021.1 [P12956-1]
CCDS74870.1 [P12956-2]
PIRiA30299 A30894
RefSeqiNP_001275905.1, NM_001288976.1 [P12956-1]
NP_001275906.1, NM_001288977.1 [P12956-2]
NP_001460.1, NM_001469.4 [P12956-1]
UniGeneiHs.292493
Hs.730702

Genome annotation databases

EnsembliENST00000359308; ENSP00000352257; ENSG00000196419 [P12956-1]
ENST00000360079; ENSP00000353192; ENSG00000196419 [P12956-1]
ENST00000402580; ENSP00000384941; ENSG00000196419 [P12956-2]
ENST00000405878; ENSP00000384257; ENSG00000196419 [P12956-1]
GeneIDi2547
KEGGihsa:2547
UCSCiuc003bao.3 human [P12956-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04607 mRNA Translation: AAA61177.1
J04611 mRNA Translation: AAA51733.1
M32865 mRNA Translation: AAA36155.1
S38729 mRNA Translation: AAB22381.1
AK055786 mRNA Translation: BAG51575.1
CR542219 mRNA Translation: CAG47015.1
AY870329 Genomic DNA Translation: AAW34364.1
Z83840 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60448.1
BC008343 mRNA Translation: AAH08343.1
BC010034 mRNA Translation: AAH10034.1
BC012154 mRNA Translation: AAH12154.1
BC018259 mRNA Translation: AAH18259.1
BC072449 mRNA Translation: AAH72449.1
CCDSiCCDS14021.1 [P12956-1]
CCDS74870.1 [P12956-2]
PIRiA30299 A30894
RefSeqiNP_001275905.1, NM_001288976.1 [P12956-1]
NP_001275906.1, NM_001288977.1 [P12956-2]
NP_001460.1, NM_001469.4 [P12956-1]
UniGeneiHs.292493
Hs.730702

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JEQX-ray2.70A1-609[»]
1JEYX-ray2.50A1-609[»]
1JJRNMR-A556-609[»]
3RZXX-ray2.61B537-558[»]
5Y3Relectron microscopy6.60A34-534[»]
ProteinModelPortaliP12956
SMRiP12956
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108822, 296 interactors
ComplexPortaliCPX-1993 Ku70:Ku80 complex
CORUMiP12956
DIPiDIP-24188N
ELMiP12956
IntActiP12956, 167 interactors
MINTiP12956
STRINGi9606.ENSP00000352257

Protein family/group databases

MoonDBiP12956 Curated

PTM databases

iPTMnetiP12956
PhosphoSitePlusiP12956
SwissPalmiP12956

Polymorphism and mutation databases

DMDMi125729

2D gel databases

SWISS-2DPAGEiP12956

Proteomic databases

EPDiP12956
MaxQBiP12956
PaxDbiP12956
PeptideAtlasiP12956
PRIDEiP12956
ProteomicsDBi52888

Protocols and materials databases

DNASUi2547
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359308; ENSP00000352257; ENSG00000196419 [P12956-1]
ENST00000360079; ENSP00000353192; ENSG00000196419 [P12956-1]
ENST00000402580; ENSP00000384941; ENSG00000196419 [P12956-2]
ENST00000405878; ENSP00000384257; ENSG00000196419 [P12956-1]
GeneIDi2547
KEGGihsa:2547
UCSCiuc003bao.3 human [P12956-1]

Organism-specific databases

CTDi2547
DisGeNETi2547
EuPathDBiHostDB:ENSG00000196419.12
GeneCardsiXRCC6
HGNCiHGNC:4055 XRCC6
HPAiCAB004254
HPA047549
HPA062226
MIMi152690 gene
neXtProtiNX_P12956
OpenTargetsiENSG00000196419
PharmGKBiPA28467
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2327 Eukaryota
ENOG410XNXU LUCA
GeneTreeiENSGT00390000001422
HOGENOMiHOG000006588
HOVERGENiHBG006236
InParanoidiP12956
KOiK10884
OMAiDVFTSCN
OrthoDBiEOG091G04AI
PhylomeDBiP12956
TreeFamiTF315101

Enzyme and pathway databases

ReactomeiR-HSA-164843 2-LTR circle formation
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA
R-HSA-3270619 IRF3-mediated induction of type I IFN
R-HSA-5693571 Nonhomologous End-Joining (NHEJ)
R-HSA-6798695 Neutrophil degranulation
SIGNORiP12956

Miscellaneous databases

ChiTaRSiXRCC6 human
EvolutionaryTraceiP12956
GeneWikiiKu70
GenomeRNAii2547
PMAP-CutDBiP12956
PROiPR:P12956
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196419 Expressed in 232 organ(s), highest expression level in testis
CleanExiHS_XRCC6
ExpressionAtlasiP12956 baseline and differential
GenevisibleiP12956 HS

Family and domain databases

Gene3Di1.10.720.30, 1 hit
2.40.290.10, 1 hit
3.40.50.410, 1 hit
4.10.970.10, 1 hit
InterProiView protein in InterPro
IPR006165 Ku70
IPR006164 Ku70/Ku80_beta-barrel_dom
IPR027388 Ku70_bridge/pillars_dom_sf
IPR005160 Ku_C
IPR005161 Ku_N
IPR003034 SAP_dom
IPR036361 SAP_dom_sf
IPR016194 SPOC-like_C_dom_sf
IPR036465 vWFA_dom_sf
PANTHERiPTHR12604:SF2 PTHR12604:SF2, 1 hit
PfamiView protein in Pfam
PF02735 Ku, 1 hit
PF03730 Ku_C, 1 hit
PF03731 Ku_N, 1 hit
PF02037 SAP, 1 hit
PIRSFiPIRSF003033 Ku70, 1 hit
SMARTiView protein in SMART
SM00559 Ku78, 1 hit
SM00513 SAP, 1 hit
SUPFAMiSSF100939 SSF100939, 1 hit
SSF53300 SSF53300, 1 hit
SSF68906 SSF68906, 1 hit
TIGRFAMsiTIGR00578 ku70, 1 hit
PROSITEiView protein in PROSITE
PS50800 SAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiXRCC6_HUMAN
AccessioniPrimary (citable) accession number: P12956
Secondary accession number(s): B1AHC8
, Q6FG89, Q9UCQ2, Q9UCQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 223 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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