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Protein

Xaa-Pro dipeptidase

Gene

PEPD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolysis of Xaa-|-Pro dipeptides. Also acts on aminoacyl-hydroxyproline analogs. No action on Pro-|-Pro. EC:3.4.13.9

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+1 PublicationNote: Binds 2 manganese ions per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi276Manganese 11
Metal bindingi287Manganese 11
Metal bindingi287Manganese 21
Metal bindingi370Manganese 21
Metal bindingi412Manganese 21
Metal bindingi452Manganese 11
Metal bindingi452Manganese 21

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDipeptidase, Hydrolase, Metalloprotease, Protease
Biological processCollagen degradation
LigandManganese, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.13.9 2681

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M24.007

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Xaa-Pro dipeptidase (EC:3.4.13.9)
Short name:
X-Pro dipeptidase
Alternative name(s):
Imidodipeptidase
Peptidase D
Proline dipeptidase
Short name:
Prolidase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PEPD
Synonyms:PRD
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000124299.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8840 PEPD

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613230 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P12955

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Prolidase deficiency (PD)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA multisystem disorder associated with massive iminodipeptiduria and lack of or reduced prolidase activity in erythrocytes, leukocytes, or cultured fibroblasts. Clinical features include skin ulcers, developmental delay, recurrent infections, and a characteristic facies.
See also OMIM:170100
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_011614184R → Q in PD. 1 PublicationCorresponds to variant dbSNP:rs121917722EnsemblClinVar.1
Natural variantiVAR_004404276D → N in PD. 1 PublicationCorresponds to variant dbSNP:rs121917721EnsemblClinVar.1
Natural variantiVAR_011615278G → D in PD. 1 PublicationCorresponds to variant dbSNP:rs121917723EnsemblClinVar.1
Natural variantiVAR_004405448G → R in PD. 3 PublicationsCorresponds to variant dbSNP:rs121917724EnsemblClinVar.1
Natural variantiVAR_004406452Missing in PD. 2 Publications1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
5184

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
PEPD

MalaCards human disease database

More...
MalaCardsi
PEPD
MIMi170100 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000124299

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
742 Prolidase deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33181

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL4185

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PEPD

Domain mapping of disease mutations (DMDM)

More...
DMDMi
50403718

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001850872 – 493Xaa-Pro dipeptidaseAdd BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei167PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P12955

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P12955

MaxQB - The MaxQuant DataBase

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MaxQBi
P12955

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P12955

PeptideAtlas

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PeptideAtlasi
P12955

PRoteomics IDEntifications database

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PRIDEi
P12955

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52886
52887 [P12955-2]

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00257882

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P12955

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P12955

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P12955

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000124299 Expressed in 219 organ(s), highest expression level in nephron tubule

CleanEx database of gene expression profiles

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CleanExi
HS_PEPD

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P12955 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P12955 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA015599
HPA072045

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TERF1P542742EBI-948765,EBI-710997

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111208, 43 interactors

Database of interacting proteins

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DIPi
DIP-50038N

Protein interaction database and analysis system

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IntActi
P12955, 14 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000244137

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P12955

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1493
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IW2X-ray1.82A/B2-493[»]
2OKNX-ray2.45A/B2-493[»]
5M4GX-ray1.48A/B6-488[»]
5M4JX-ray1.55A/B6-489[»]
5M4LX-ray1.49A/B6-489[»]
5M4QX-ray1.73A/B6-489[»]
5MBYX-ray1.55A/B6-490[»]
5MBZX-ray1.50A/B6-489[»]
5MC0X-ray1.56A/B6-486[»]
5MC1X-ray1.43A/B6-490[»]
5MC2X-ray1.70A/B6-488[»]
5MC3X-ray1.52A/B6-489[»]
5MC4X-ray1.80A/B6-487[»]
5MC5X-ray1.90A/B6-484[»]
6H2PX-ray1.48A/B1-493[»]
6H2QX-ray1.78A/B1-493[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P12955

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P12955

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P12955

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2737 Eukaryota
COG0006 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153657

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000008763

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG053562

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P12955

KEGG Orthology (KO)

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KOi
K14213

Identification of Orthologs from Complete Genome Data

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OMAi
HALFFPH

Database of Orthologous Groups

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OrthoDBi
352329at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P12955

TreeFam database of animal gene trees

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TreeFami
TF313396

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.350.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007865 Aminopep_P_N
IPR029149 Creatin/AminoP/Spt16_NTD
IPR036005 Creatinase/aminopeptidase-like
IPR000994 Pept_M24
IPR001131 Peptidase_M24B_aminopep-P_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05195 AMP_N, 1 hit
PF00557 Peptidase_M24, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01011 AMP_N, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF53092 SSF53092, 1 hit
SSF55920 SSF55920, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00491 PROLINE_PEPTIDASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P12955-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAATGPSFW LGNETLKVPL ALFALNRQRL CERLRKNPAV QAGSIVVLQG
60 70 80 90 100
GEETQRYCTD TGVLFRQESF FHWAFGVTEP GCYGVIDVDT GKSTLFVPRL
110 120 130 140 150
PASHATWMGK IHSKEHFKEK YAVDDVQYVD EIASVLTSQK PSVLLTLRGV
160 170 180 190 200
NTDSGSVCRE ASFDGISKFE VNNTILHPEI VECRVFKTDM ELEVLRYTNK
210 220 230 240 250
ISSEAHREVM KAVKVGMKEY ELESLFEHYC YSRGGMRHSS YTCICGSGEN
260 270 280 290 300
SAVLHYGHAG APNDRTIQNG DMCLFDMGGE YYCFASDITC SFPANGKFTA
310 320 330 340 350
DQKAVYEAVL RSSRAVMGAM KPGVWWPDMH RLADRIHLEE LAHMGILSGS
360 370 380 390 400
VDAMVQAHLG AVFMPHGLGH FLGIDVHDVG GYPEGVERID EPGLRSLRTA
410 420 430 440 450
RHLQPGMVLT VEPGIYFIDH LLDEALADPA RASFLNREVL QRFRGFGGVR
460 470 480 490
IEEDVVVTDS GIELLTCVPR TVEEIEACMA GCDKAFTPFS GPK
Length:493
Mass (Da):54,548
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE8C4A2497E44BA22
GO
Isoform 2 (identifier: P12955-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     184-224: Missing.

Note: No experimental confirmation available.
Show »
Length:452
Mass (Da):49,691
Checksum:iEA1B0DFBE694A180
GO
Isoform 3 (identifier: P12955-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-131: Missing.

Note: No experimental confirmation available.
Show »
Length:429
Mass (Da):47,261
Checksum:i2D094B4069E39CF5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GYL0V9GYL0_HUMAN
Xaa-Pro dipeptidase
PEPD
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GY89V9GY89_HUMAN
Xaa-Pro dipeptidase
PEPD
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYE4V9GYE4_HUMAN
Xaa-Pro dipeptidase
PEPD
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ES25K7ES25_HUMAN
Xaa-Pro dipeptidase
PEPD
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti48L → R in BAF84250 (PubMed:14702039).Curated1
Sequence conflicti66R → L in AAA60064 (PubMed:2925654).Curated1
Sequence conflicti107W → R in BAF83470 (PubMed:14702039).Curated1
Sequence conflicti108M → I in BAF83445 (PubMed:14702039).Curated1
Sequence conflicti183C → S in AAA60064 (PubMed:2925654).Curated1
Sequence conflicti221E → G in AAA60064 (PubMed:2925654).Curated1
Sequence conflicti283 – 284CF → SV in AAA60064 (PubMed:2925654).Curated2
Sequence conflicti294A → R in AAA60064 (PubMed:2925654).Curated1
Sequence conflicti311R → L in AAA60064 (PubMed:2925654).Curated1
Sequence conflicti324V → D in AAA60064 (PubMed:2925654).Curated1
Sequence conflicti329 – 330MH → ID in AAA60064 (PubMed:2925654).Curated2
Sequence conflicti408V → A in BAG56678 (PubMed:14702039).Curated1
Sequence conflicti458T → I in AAA60064 (PubMed:2925654).Curated1
Sequence conflicti478C → R in BAF83470 (PubMed:14702039).Curated1

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 54251.73 Da from positions 2 - 493. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011614184R → Q in PD. 1 PublicationCorresponds to variant dbSNP:rs121917722EnsemblClinVar.1
Natural variantiVAR_004404276D → N in PD. 1 PublicationCorresponds to variant dbSNP:rs121917721EnsemblClinVar.1
Natural variantiVAR_011615278G → D in PD. 1 PublicationCorresponds to variant dbSNP:rs121917723EnsemblClinVar.1
Natural variantiVAR_051574388R → H. Corresponds to variant dbSNP:rs2230062EnsemblClinVar.1
Natural variantiVAR_014723435L → F2 PublicationsCorresponds to variant dbSNP:rs17570EnsemblClinVar.1
Natural variantiVAR_004405448G → R in PD. 3 PublicationsCorresponds to variant dbSNP:rs121917724EnsemblClinVar.1
Natural variantiVAR_004406452Missing in PD. 2 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04537068 – 131Missing in isoform 3. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_042629184 – 224Missing in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J04605 mRNA Translation: AAA60064.1
BT006692 mRNA Translation: AAP35338.1
AK290756 mRNA Translation: BAF83445.1
AK290781 mRNA Translation: BAF83470.1
AK291561 mRNA Translation: BAF84250.1
AK293126 mRNA Translation: BAG56678.1
AK294619 mRNA Translation: BAG57802.1
AC008744 Genomic DNA No translation available.
AC010485 Genomic DNA No translation available.
BC004305 mRNA Translation: AAH04305.1
BC015027 mRNA Translation: AAH15027.1
BC028295 mRNA Translation: AAH28295.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42544.1 [P12955-1]
CCDS54244.1 [P12955-3]
CCDS54245.1 [P12955-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A32454

NCBI Reference Sequences

More...
RefSeqi
NP_000276.2, NM_000285.3 [P12955-1]
NP_001159528.1, NM_001166056.1 [P12955-2]
NP_001159529.1, NM_001166057.1 [P12955-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.36473

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000244137; ENSP00000244137; ENSG00000124299 [P12955-1]
ENST00000397032; ENSP00000380226; ENSG00000124299 [P12955-2]
ENST00000436370; ENSP00000391890; ENSG00000124299 [P12955-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5184

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5184

UCSC genome browser

More...
UCSCi
uc002nur.5 human [P12955-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04605 mRNA Translation: AAA60064.1
BT006692 mRNA Translation: AAP35338.1
AK290756 mRNA Translation: BAF83445.1
AK290781 mRNA Translation: BAF83470.1
AK291561 mRNA Translation: BAF84250.1
AK293126 mRNA Translation: BAG56678.1
AK294619 mRNA Translation: BAG57802.1
AC008744 Genomic DNA No translation available.
AC010485 Genomic DNA No translation available.
BC004305 mRNA Translation: AAH04305.1
BC015027 mRNA Translation: AAH15027.1
BC028295 mRNA Translation: AAH28295.1
CCDSiCCDS42544.1 [P12955-1]
CCDS54244.1 [P12955-3]
CCDS54245.1 [P12955-2]
PIRiA32454
RefSeqiNP_000276.2, NM_000285.3 [P12955-1]
NP_001159528.1, NM_001166056.1 [P12955-2]
NP_001159529.1, NM_001166057.1 [P12955-3]
UniGeneiHs.36473

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IW2X-ray1.82A/B2-493[»]
2OKNX-ray2.45A/B2-493[»]
5M4GX-ray1.48A/B6-488[»]
5M4JX-ray1.55A/B6-489[»]
5M4LX-ray1.49A/B6-489[»]
5M4QX-ray1.73A/B6-489[»]
5MBYX-ray1.55A/B6-490[»]
5MBZX-ray1.50A/B6-489[»]
5MC0X-ray1.56A/B6-486[»]
5MC1X-ray1.43A/B6-490[»]
5MC2X-ray1.70A/B6-488[»]
5MC3X-ray1.52A/B6-489[»]
5MC4X-ray1.80A/B6-487[»]
5MC5X-ray1.90A/B6-484[»]
6H2PX-ray1.48A/B1-493[»]
6H2QX-ray1.78A/B1-493[»]
ProteinModelPortaliP12955
SMRiP12955
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111208, 43 interactors
DIPiDIP-50038N
IntActiP12955, 14 interactors
STRINGi9606.ENSP00000244137

Chemistry databases

BindingDBiP12955
ChEMBLiCHEMBL4185

Protein family/group databases

MEROPSiM24.007

PTM databases

iPTMnetiP12955
PhosphoSitePlusiP12955
SwissPalmiP12955

Polymorphism and mutation databases

BioMutaiPEPD
DMDMi50403718

2D gel databases

REPRODUCTION-2DPAGEiIPI00257882

Proteomic databases

EPDiP12955
jPOSTiP12955
MaxQBiP12955
PaxDbiP12955
PeptideAtlasiP12955
PRIDEiP12955
ProteomicsDBi52886
52887 [P12955-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5184
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244137; ENSP00000244137; ENSG00000124299 [P12955-1]
ENST00000397032; ENSP00000380226; ENSG00000124299 [P12955-2]
ENST00000436370; ENSP00000391890; ENSG00000124299 [P12955-3]
GeneIDi5184
KEGGihsa:5184
UCSCiuc002nur.5 human [P12955-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5184
DisGeNETi5184
EuPathDBiHostDB:ENSG00000124299.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PEPD
GeneReviewsiPEPD
HGNCiHGNC:8840 PEPD
HPAiHPA015599
HPA072045
MalaCardsiPEPD
MIMi170100 phenotype
613230 gene
neXtProtiNX_P12955
OpenTargetsiENSG00000124299
Orphaneti742 Prolidase deficiency
PharmGKBiPA33181

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2737 Eukaryota
COG0006 LUCA
GeneTreeiENSGT00940000153657
HOGENOMiHOG000008763
HOVERGENiHBG053562
InParanoidiP12955
KOiK14213
OMAiHALFFPH
OrthoDBi352329at2759
PhylomeDBiP12955
TreeFamiTF313396

Enzyme and pathway databases

BRENDAi3.4.13.9 2681

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PEPD human
EvolutionaryTraceiP12955

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PEPD

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5184

Protein Ontology

More...
PROi
PR:P12955

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000124299 Expressed in 219 organ(s), highest expression level in nephron tubule
CleanExiHS_PEPD
ExpressionAtlasiP12955 baseline and differential
GenevisibleiP12955 HS

Family and domain databases

Gene3Di3.40.350.10, 1 hit
InterProiView protein in InterPro
IPR007865 Aminopep_P_N
IPR029149 Creatin/AminoP/Spt16_NTD
IPR036005 Creatinase/aminopeptidase-like
IPR000994 Pept_M24
IPR001131 Peptidase_M24B_aminopep-P_CS
PfamiView protein in Pfam
PF05195 AMP_N, 1 hit
PF00557 Peptidase_M24, 1 hit
SMARTiView protein in SMART
SM01011 AMP_N, 1 hit
SUPFAMiSSF53092 SSF53092, 1 hit
SSF55920 SSF55920, 1 hit
PROSITEiView protein in PROSITE
PS00491 PROLINE_PEPTIDASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPEPD_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P12955
Secondary accession number(s): A8K3Z1
, A8K416, A8K696, A8MX47, B4DDB7, B4DGJ1, E9PCE8, Q8TBN9, Q9BT75
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: January 16, 2019
This is version 212 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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