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UniProtKB - P12940 (IBB_HORVU)
Protein
Bowman-Birk type trypsin inhibitor
Gene
BBBI
Organism
Hordeum vulgare (Barley)
Status
Functioni
This inhibitor interacts with two molecules of trypsin.
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 17 – 18 | Reactive bond | 2 | |
Sitei | 75 – 76 | Reactive bond | 2 |
GO - Molecular functioni
- serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Keywordsi
Molecular function | Protease inhibitor, Serine protease inhibitor |
Ligand | Calcium |
Protein family/group databases
MEROPSi | I12.009 |
Names & Taxonomyi
Protein namesi | Recommended name: Bowman-Birk type trypsin inhibitor |
Gene namesi | Name:BBBI |
Organismi | Hordeum vulgare (Barley) |
Taxonomic identifieri | 4513 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Liliopsida › Poales › Poaceae › BOP clade › Pooideae › Triticodae › Triticeae › Hordeinae › Hordeum |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000105857 | 1 – 124 | Bowman-Birk type trypsin inhibitorAdd BLAST | 124 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 9 ↔ 62 | 2 Publications | ||
Disulfide bondi | 10 ↔ 25 | 2 Publications | ||
Disulfide bondi | 15 ↔ 23 | 2 Publications | ||
Disulfide bondi | 32 ↔ 39 | 2 Publications | ||
Disulfide bondi | 36 ↔ 50 | 2 Publications | ||
Disulfide bondi | 67 ↔ 121 | 2 Publications | ||
Disulfide bondi | 68 ↔ 83 | 2 Publications | ||
Disulfide bondi | 73 ↔ 81 | 2 Publications | ||
Disulfide bondi | 90 ↔ 97 | 2 Publications | ||
Disulfide bondi | 94 ↔ 109 | 2 Publications |
Keywords - PTMi
Disulfide bondStructurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P12940 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P12940 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 1 – 62 | Add BLAST | 62 | |
Repeati | 63 – 124 | Add BLAST | 62 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 70 – 80 | Calcium bindingAdd BLAST | 11 |
Sequence similaritiesi
Belongs to the Bowman-Birk serine protease inhibitor family.Curated
Keywords - Domaini
RepeatFamily and domain databases
CDDi | cd00023, BBI, 2 hits |
Gene3Di | 2.10.69.10, 2 hits |
InterProi | View protein in InterPro IPR035995, Bowman-Birk_prot_inh IPR000877, Prot_inh_BBI |
Pfami | View protein in Pfam PF00228, Bowman-Birk_leg, 3 hits |
SMARTi | View protein in SMART SM00269, BowB, 2 hits |
SUPFAMi | SSF57247, SSF57247, 2 hits |
PROSITEi | View protein in PROSITE PS00281, BOWMAN_BIRK, 2 hits |
i Sequence
Sequence statusi: Complete.
P12940-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
AGKKRPWKCC DEAVCTRSIP PICTCMDEVF ECPKTCKSCG PMGDPSRRIC
60 70 80 90 100
QDQYVGDPGP ICRPWECCDK AICTRSNPPT CRCVDEVKKC APTCKTCLPS
110 120
RSRPSRRVCI DSYFGPVPPR CTPR
Sequence databases
PIRi | JT0235, TIBHB |
Cross-referencesi
Sequence databases
PIRi | JT0235, TIBHB |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1C2A | X-ray | 1.90 | A | 4-122 | [»] | |
1TX6 | X-ray | 2.20 | I/J | 1-124 | [»] | |
2FJ8 | X-ray | 1.19 | A | 1-124 | [»] | |
SMRi | P12940 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein family/group databases
MEROPSi | I12.009 |
Miscellaneous databases
EvolutionaryTracei | P12940 |
Gene expression databases
ExpressionAtlasi | P12940, baseline and differential |
Family and domain databases
CDDi | cd00023, BBI, 2 hits |
Gene3Di | 2.10.69.10, 2 hits |
InterProi | View protein in InterPro IPR035995, Bowman-Birk_prot_inh IPR000877, Prot_inh_BBI |
Pfami | View protein in Pfam PF00228, Bowman-Birk_leg, 3 hits |
SMARTi | View protein in SMART SM00269, BowB, 2 hits |
SUPFAMi | SSF57247, SSF57247, 2 hits |
PROSITEi | View protein in PROSITE PS00281, BOWMAN_BIRK, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | IBB_HORVU | |
Accessioni | P12940Primary (citable) accession number: P12940 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | October 1, 1989 | |
Last modified: | June 2, 2021 | |
This is version 100 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families