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Protein

Alcohol dehydrogenase 1

Gene
N/A
Organism
Pisum sativum (Garden pea)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.1 Publication
A secondary alcohol + NAD+ = a ketone + NADH.1 Publication

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi48Zinc 1; catalyticBy similarity1
Metal bindingi50Zinc 1By similarity1
Binding sitei50NADBy similarity1
Binding sitei50SubstrateBy similarity1
Metal bindingi70Zinc 1; catalyticBy similarity1
Binding sitei70SubstrateBy similarity1
Metal bindingi100Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi106Zinc 2By similarity1
Metal bindingi114Zinc 2By similarity1
Metal bindingi178Zinc 1; catalyticBy similarity1
Binding sitei227NADBy similarity1
Binding sitei232NADBy similarity1
Binding sitei273NAD; via carbonyl oxygenBy similarity1
Binding sitei296NAD; via carbonyl oxygenBy similarity1
Binding sitei373NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi203 – 208NADBy similarity6
Nucleotide bindingi296 – 298NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15105

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 11 Publication (EC:1.1.1.11 Publication)
OrganismiPisum sativum (Garden pea)
Taxonomic identifieri3888 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideae50 kb inversion cladeNPAAA cladeHologaleginaIRL cladeFabeaePisum

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607091 – 380Alcohol dehydrogenase 1Add BLAST380

Proteomic databases

PRIDEiP12886

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP12886
SMRiP12886
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P12886-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNTVGQIIK CRAAVAWEAG KPLVIEEVEV APPQAGEVRL KILFTSLCHT
60 70 80 90 100
DVYFWEAKGQ TPLFPRIFGH EAGGIVESVG EGVTHLKPGD HALPVFTGEC
110 120 130 140 150
GECPHCKSEE SNMCDLLRIN TDRGVMLNDN KSRFSIKGQP VHHFVGTSTF
160 170 180 190 200
SEYTVVHAGC VAKINPDAPL DKVCILSCGI CTGLGATINV AKPKPGSSVA
210 220 230 240 250
IFGLGAVGLA AAEGARISGA SRIIGVDLVS SRFELAKKFG VNEFVNPKEH
260 270 280 290 300
DKPVQQVIAE MTNGGVDRAV ECTGSIQAMI SAFECVHDGW GVAVLVGVPS
310 320 330 340 350
KDDAFKTHPM NFLNERTLKG TFYGNYKPRT DLPNVVEKYM KGELELEKFI
360 370 380
THTVPFSEIN KAFDYMLKGE SIRCIIKMEE
Length:380
Mass (Da):41,155
Last modified:October 1, 1989 - v1
Checksum:i09CECCBB889BF475
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06281 Genomic DNA Translation: CAA29609.1
PIRiS00912

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06281 Genomic DNA Translation: CAA29609.1
PIRiS00912

3D structure databases

ProteinModelPortaliP12886
SMRiP12886
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP12886

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15105

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH1_PEA
AccessioniPrimary (citable) accession number: P12886
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: September 12, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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