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Protein

Myosin-1

Gene

MYH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Muscle contraction.

Caution

Represents a conventional myosin. This protein should not be confused with the unconventional myosin-1 (MYO1).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi179 – 186ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Muscle protein, Myosin
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P12882

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myosin-1
Alternative name(s):
Myosin heavy chain 1
Myosin heavy chain 2x
Short name:
MyHC-2x
Myosin heavy chain IIx/d
Short name:
MyHC-IIx/d
Myosin heavy chain, skeletal muscle, adult 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYH1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000109061.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7567 MYH1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
160730 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P12882

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Thick filament

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4619

Open Targets

More...
OpenTargetsi
ENSG00000109061

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31365

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MYH1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
226694176

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001233911 – 1939Myosin-1Add BLAST1939

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei64PhosphothreonineBy similarity1
Modified residuei69PhosphothreonineBy similarity1
Modified residuei130N6,N6,N6-trimethyllysineSequence analysis1
Modified residuei389PhosphotyrosineBy similarity1
Modified residuei419PhosphothreonineBy similarity1
Modified residuei424PhosphotyrosineBy similarity1
Modified residuei757Pros-methylhistidineBy similarity1
Modified residuei1092PhosphoserineBy similarity1
Modified residuei1096PhosphoserineBy similarity1
Modified residuei1162PhosphoserineBy similarity1
Modified residuei1237PhosphoserineBy similarity1
Modified residuei1241PhosphothreonineBy similarity1
Modified residuei1243PhosphoserineBy similarity1
Modified residuei1261PhosphoserineBy similarity1
Modified residuei1265PhosphothreonineBy similarity1
Modified residuei1286PhosphothreonineBy similarity1
Modified residuei1288PhosphoserineBy similarity1
Modified residuei1292PhosphoserineBy similarity1
Modified residuei1303PhosphoserineBy similarity1
Modified residuei1306PhosphoserineBy similarity1
Modified residuei1467PhosphothreonineBy similarity1
Modified residuei1474PhosphoserineBy similarity1
Modified residuei1492PhosphotyrosineBy similarity1
Modified residuei1495PhosphoserineBy similarity1
Modified residuei1501PhosphothreonineBy similarity1
Modified residuei1514PhosphoserineBy similarity1
Modified residuei1517PhosphothreonineBy similarity1
Modified residuei1542PhosphoserineBy similarity1
Modified residuei1554PhosphoserineBy similarity1
Modified residuei1574PhosphoserineBy similarity1
Modified residuei1600PhosphoserineBy similarity1
Modified residuei1603PhosphoserineBy similarity1
Modified residuei1714PhosphoserineBy similarity1
Modified residuei1726PhosphoserineBy similarity1
Modified residuei1730PhosphothreonineBy similarity1
Modified residuei1736PhosphothreonineBy similarity1
Modified residuei1739PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P12882

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P12882

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P12882

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P12882

PeptideAtlas

More...
PeptideAtlasi
P12882

PRoteomics IDEntifications database

More...
PRIDEi
P12882

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52882

2D gel databases

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P12882

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P12882

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P12882

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P12882

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000109061 Expressed in 100 organ(s), highest expression level in vastus lateralis

CleanEx database of gene expression profiles

More...
CleanExi
HS_MYH1

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P12882 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB010759
HPA001349

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
KRT13A1A4E93EBI-366238,EBI-10171552

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110704, 27 interactors

Protein interaction database and analysis system

More...
IntActi
P12882, 15 interactors

Molecular INTeraction database

More...
MINTi
P12882

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000226207

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P12882

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P12882

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 82Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST50
Domaini86 – 782Myosin motorPROSITE-ProRule annotationAdd BLAST697
Domaini785 – 814IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni659 – 681Actin-bindingBy similarityAdd BLAST23
Regioni761 – 775Actin-bindingBy similarityAdd BLAST15

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili843 – 1939Sequence analysisAdd BLAST1097

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).Curated

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0161 Eukaryota
COG5022 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154760

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000173959

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004704

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P12882

KEGG Orthology (KO)

More...
KOi
K10352

Identification of Orthologs from Complete Genome Data

More...
OMAi
IMDVEND

Database of Orthologous Groups

More...
OrthoDBi
47111at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P12882

TreeFam database of animal gene trees

More...
TreeFami
TF314375

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00015 IQ, 1 hit
SM00242 MYSc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P12882-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSDSEMAIF GEAAPFLRKS ERERIEAQNK PFDAKTSVFV VDPKESFVKA
60 70 80 90 100
TVQSREGGKV TAKTEAGATV TVKDDQVFPM NPPKYDKIED MAMMTHLHEP
110 120 130 140 150
AVLYNLKERY AAWMIYTYSG LFCVTVNPYK WLPVYNAEVV TAYRGKKRQE
160 170 180 190 200
APPHIFSISD NAYQFMLTDR ENQSILITGE SGAGKTVNTK RVIQYFATIA
210 220 230 240 250
VTGEKKKEEV TSGKMQGTLE DQIISANPLL EAFGNAKTVR NDNSSRFGKF
260 270 280 290 300
IRIHFGTTGK LASADIETYL LEKSRVTFQL KAERSYHIFY QIMSNKKPDL
310 320 330 340 350
IEMLLITTNP YDYAFVSQGE ITVPSIDDQE ELMATDSAIE ILGFTSDERV
360 370 380 390 400
SIYKLTGAVM HYGNMKFKQK QREEQAEPDG TEVADKAAYL QNLNSADLLK
410 420 430 440 450
ALCYPRVKVG NEYVTKGQTV QQVYNAVGAL AKAVYDKMFL WMVTRINQQL
460 470 480 490 500
DTKQPRQYFI GVLDIAGFEI FDFNSLEQLC INFTNEKLQQ FFNHHMFVLE
510 520 530 540 550
QEEYKKEGIE WTFIDFGMDL AACIELIEKP MGIFSILEEE CMFPKATDTS
560 570 580 590 600
FKNKLYEQHL GKSNNFQKPK PAKGKPEAHF SLIHYAGTVD YNIAGWLDKN
610 620 630 640 650
KDPLNETVVG LYQKSAMKTL ALLFVGATGA EAEAGGGKKG GKKKGSSFQT
660 670 680 690 700
VSALFRENLN KLMTNLRSTH PHFVRCIIPN ETKTPGAMEH ELVLHQLRCN
710 720 730 740 750
GVLEGIRICR KGFPSRILYA DFKQRYKVLN ASAIPEGQFI DSKKASEKLL
760 770 780 790 800
GSIDIDHTQY KFGHTKVFFK AGLLGLLEEM RDEKLAQLIT RTQAMCRGFL
810 820 830 840 850
ARVEYQKMVE RRESIFCIQY NVRAFMNVKH WPWMKLYFKI KPLLKSAETE
860 870 880 890 900
KEMANMKEEF EKTKEELAKT EAKRKELEEK MVTLMQEKND LQLQVQAEAD
910 920 930 940 950
SLADAEERCD QLIKTKIQLE AKIKEVTERA EDEEEINAEL TAKKRKLEDE
960 970 980 990 1000
CSELKKDIDD LELTLAKVEK EKHATENKVK NLTEEMAGLD ETIAKLTKEK
1010 1020 1030 1040 1050
KALQEAHQQT LDDLQAEEDK VNTLTKAKIK LEQQVDDLEG SLEQEKKIRM
1060 1070 1080 1090 1100
DLERAKRKLE GDLKLAQEST MDIENDKQQL DEKLKKKEFE MSGLQSKIED
1110 1120 1130 1140 1150
EQALGMQLQK KIKELQARIE ELEEEIEAER ASRAKAEKQR SDLSRELEEI
1160 1170 1180 1190 1200
SERLEEAGGA TSAQIEMNKK REAEFQKMRR DLEEATLQHE ATAATLRKKH
1210 1220 1230 1240 1250
ADSVAELGEQ IDNLQRVKQK LEKEKSEMKM EIDDLASNME TVSKAKGNLE
1260 1270 1280 1290 1300
KMCRALEDQL SEIKTKEEEQ QRLINDLTAQ RARLQTESGE YSRQLDEKDT
1310 1320 1330 1340 1350
LVSQLSRGKQ AFTQQIEELK RQLEEEIKAK SALAHALQSS RHDCDLLREQ
1360 1370 1380 1390 1400
YEEEQEAKAE LQRAMSKANS EVAQWRTKYE TDAIQRTEEL EEAKKKLAQR
1410 1420 1430 1440 1450
LQDAEEHVEA VNAKCASLEK TKQRLQNEVE DLMIDVERTN AACAALDKKQ
1460 1470 1480 1490 1500
RNFDKILAEW KQKCEETHAE LEASQKESRS LSTELFKIKN AYEESLDQLE
1510 1520 1530 1540 1550
TLKRENKNLQ QEISDLTEQI AEGGKRIHEL EKIKKQVEQE KSELQAALEE
1560 1570 1580 1590 1600
AEASLEHEEG KILRIQLELN QVKSEVDRKI AEKDEEIDQM KRNHIRIVES
1610 1620 1630 1640 1650
MQSTLDAEIR SRNDAIRLKK KMEGDLNEME IQLNHANRMA AEALRNYRNT
1660 1670 1680 1690 1700
QAILKDTQLH LDDALRSQED LKEQLAMVER RANLLQAEIE ELRATLEQTE
1710 1720 1730 1740 1750
RSRKIAEQEL LDASERVQLL HTQNTSLINT KKKLETDISQ IQGEMEDIIQ
1760 1770 1780 1790 1800
EARNAEEKAK KAITDAAMMA EELKKEQDTS AHLERMKKNL EQTVKDLQHR
1810 1820 1830 1840 1850
LDEAEQLALK GGKKQIQKLE ARVRELEGEV ESEQKRNVEA VKGLRKHERK
1860 1870 1880 1890 1900
VKELTYQTEE DRKNILRLQD LVDKLQAKVK SYKRQAEEAE EQSNVNLSKF
1910 1920 1930
RRIQHELEEA EERADIAESQ VNKLRVKSRE VHTKIISEE
Length:1,939
Mass (Da):223,145
Last modified:April 14, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD2B6F28C2C63CBDF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1070T → A in AAD29951 (PubMed:10388558).Curated1
Sequence conflicti1070T → A in CAA27380 (PubMed:2421254).Curated1
Sequence conflicti1131A → T in CAA27380 (PubMed:2421254).Curated1
Sequence conflicti1139Q → L in CAA27380 (PubMed:2421254).Curated1
Sequence conflicti1158G → V in CAA27380 (PubMed:2421254).Curated1
Sequence conflicti1163A → T in CAA27380 (PubMed:2421254).Curated1
Sequence conflicti1286 – 1289TESG → QNQV in CAA27380 (PubMed:2421254).Curated4
Sequence conflicti1302 – 1303VS → ET in CAA27380 (PubMed:2421254).Curated2
Sequence conflicti1451R → T in CAA27380 (PubMed:2421254).Curated1
Sequence conflicti1470E → V in CAA27380 (PubMed:2421254).Curated1
Sequence conflicti1473 – 1474AS → SF in CAA27380 (PubMed:2421254).Curated2
Sequence conflicti1531E → K in AAI14546 (PubMed:15489334).Curated1
Sequence conflicti1569L → V in CAA27380 (PubMed:2421254).Curated1
Sequence conflicti1598V → E in CAA27380 (PubMed:2421254).Curated1
Sequence conflicti1606D → N in CAA27380 (PubMed:2421254).Curated1
Sequence conflicti1643A → D in CAA27380 (PubMed:2421254).Curated1
Sequence conflicti1648R → Q in CAA27380 (PubMed:2421254).Curated1
Sequence conflicti1750Q → K in CAA27380 (PubMed:2421254).Curated1
Sequence conflicti1822R → K in CAA27380 (PubMed:2421254).Curated1
Sequence conflicti1845R → H in CAA27380 (PubMed:2421254).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054159640G → S1 PublicationCorresponds to variant dbSNP:rs150346984Ensembl.1
Natural variantiVAR_0360031306S → L in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs752643679Ensembl.1
Natural variantiVAR_0301931341R → C. Corresponds to variant dbSNP:rs3744564Ensembl.1
Natural variantiVAR_0360041445A → T in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs139860229Ensembl.1
Natural variantiVAR_0301941539Q → H. Corresponds to variant dbSNP:rs3764850Ensembl.1
Natural variantiVAR_0647351566Q → K Found in a renal cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0360051598V → M in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs150456818Ensembl.1
Natural variantiVAR_0301951716R → C. Corresponds to variant dbSNP:rs1077841Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF111785 mRNA Translation: AAD29951.1
AC005323 Genomic DNA No translation available.
BC114545 mRNA Translation: AAI14546.1
X03740 mRNA Translation: CAA27380.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11155.1

Protein sequence database of the Protein Information Resource

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PIRi
A23767

NCBI Reference Sequences

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RefSeqi
NP_005954.3, NM_005963.3
XP_016880164.1, XM_017024675.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.689619

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000226207; ENSP00000226207; ENSG00000109061

Database of genes from NCBI RefSeq genomes

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GeneIDi
4619

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4619

UCSC genome browser

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UCSCi
uc002gmo.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111785 mRNA Translation: AAD29951.1
AC005323 Genomic DNA No translation available.
BC114545 mRNA Translation: AAI14546.1
X03740 mRNA Translation: CAA27380.1
CCDSiCCDS11155.1
PIRiA23767
RefSeqiNP_005954.3, NM_005963.3
XP_016880164.1, XM_017024675.1
UniGeneiHs.689619

3D structure databases

ProteinModelPortaliP12882
SMRiP12882
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110704, 27 interactors
IntActiP12882, 15 interactors
MINTiP12882
STRINGi9606.ENSP00000226207

PTM databases

CarbonylDBiP12882
iPTMnetiP12882
PhosphoSitePlusiP12882

Polymorphism and mutation databases

BioMutaiMYH1
DMDMi226694176

2D gel databases

UCD-2DPAGEiP12882

Proteomic databases

EPDiP12882
jPOSTiP12882
MaxQBiP12882
PaxDbiP12882
PeptideAtlasiP12882
PRIDEiP12882
ProteomicsDBi52882

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000226207; ENSP00000226207; ENSG00000109061
GeneIDi4619
KEGGihsa:4619
UCSCiuc002gmo.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4619
DisGeNETi4619
EuPathDBiHostDB:ENSG00000109061.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MYH1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0027129
HGNCiHGNC:7567 MYH1
HPAiCAB010759
HPA001349
MIMi160730 gene
neXtProtiNX_P12882
OpenTargetsiENSG00000109061
PharmGKBiPA31365

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00940000154760
HOGENOMiHOG000173959
HOVERGENiHBG004704
InParanoidiP12882
KOiK10352
OMAiIMDVEND
OrthoDBi47111at2759
PhylomeDBiP12882
TreeFamiTF314375

Enzyme and pathway databases

SIGNORiP12882

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MYH1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4619

Protein Ontology

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PROi
PR:P12882

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000109061 Expressed in 100 organ(s), highest expression level in vastus lateralis
CleanExiHS_MYH1
GenevisibleiP12882 HS

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 1 hit
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYH1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P12882
Secondary accession number(s): Q14CA4, Q9Y622
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: April 14, 2009
Last modified: January 16, 2019
This is version 189 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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