Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Promotilin

Gene

MLN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.

GO - Molecular functioni

  • hormone activity Source: UniProtKB-KW
  • motilin receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
SIGNORiP12872

Names & Taxonomyi

Protein namesi
Recommended name:
Promotilin
Cleaved into the following 2 chains:
Gene namesi
Name:MLN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000096395.10
HGNCiHGNC:7141 MLN
MIMi158270 gene
neXtProtiNX_P12872

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4295
OpenTargetsiENSG00000096395
PharmGKBiPA30856

Polymorphism and mutation databases

BioMutaiMLN
DMDMi127253

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000034217126 – 115PromotilinAdd BLAST90
PeptideiPRO_000001918426 – 47MotilinAdd BLAST22
PeptideiPRO_000001918550 – 115Motilin-associated peptideAdd BLAST66

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiP12872
PeptideAtlasiP12872
PRIDEiP12872
ProteomicsDBi52881

PTM databases

iPTMnetiP12872
PhosphoSitePlusiP12872

Expressioni

Gene expression databases

BgeeiENSG00000096395 Expressed in 70 organ(s), highest expression level in intestine
CleanExiHS_MLN
GenevisibleiP12872 HS

Organism-specific databases

HPAiHPA069392

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP12872, 2 interactors
STRINGi9606.ENSP00000388825

Chemistry databases

BindingDBiP12872

Structurei

Secondary structure

1115
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP12872
SMRiP12872
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12872

Family & Domainsi

Sequence similaritiesi

Belongs to the motilin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J17F Eukaryota
ENOG411197B LUCA
GeneTreeiENSGT00390000000489
HOGENOMiHOG000108883
HOVERGENiHBG003618
InParanoidiP12872
KOiK05265
OMAiIFTYGEL
OrthoDBiEOG091G0X9Z
PhylomeDBiP12872
TreeFamiTF336217

Family and domain databases

InterProiView protein in InterPro
IPR006737 Motilin_assoc
IPR006738 Motilin_ghrelin
IPR015662 Promotilin
PANTHERiPTHR14156 PTHR14156, 1 hit
PfamiView protein in Pfam
PF04643 Motilin_assoc, 1 hit
PF04644 Motilin_ghrelin, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P12872-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVSRKAVAAL LVVHVAAMLA SQTEAFVPIF TYGELQRMQE KERNKGQKKS
60 70 80 90 100
LSVWQRSGEE GPVDPAEPIR EEENEMIKLT APLEIGMRMN SRQLEKYPAT
110
LEGLLSEMLP QHAAK
Length:115
Mass (Da):12,920
Last modified:October 1, 1989 - v1
Checksum:i30D4BB59B2F42783
GO
Isoform 2 (identifier: P12872-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-113: SEMLPQHA → T

Note: No experimental confirmation available.
Show »
Length:108
Mass (Da):12,127
Checksum:i66C99EF7F1B1E1B6
GO
Isoform 3 (identifier: P12872-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-115: AK → K

Note: No experimental confirmation available.
Show »
Length:114
Mass (Da):12,849
Checksum:i1A5B59B2F427836F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02037215V → A1 PublicationCorresponds to variant dbSNP:rs2281820Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045484106 – 113SEMLPQHA → T in isoform 2. 1 Publication8
Alternative sequenceiVSP_047653114 – 115AK → K in isoform 3. Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00695 mRNA Translation: CAA68690.1
X15393
, X15396, X15395, X15394 Genomic DNA Translation: CAA33448.1
M30281
, M30278, M30279, M30280 Genomic DNA Translation: AAA59860.1
AL138889 Genomic DNA No translation available.
AL158049 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03752.1
CH471081 Genomic DNA Translation: EAX03753.1
BC069675 mRNA Translation: AAH69675.1
BC112314 mRNA Translation: AAI12315.1
BC143981 mRNA Translation: AAI43982.1
CCDSiCCDS47412.1 [P12872-3]
CCDS4786.1 [P12872-1]
CCDS54993.1 [P12872-2]
PIRiA33323
RefSeqiNP_001035198.1, NM_001040109.1 [P12872-3]
NP_001171627.1, NM_001184698.1 [P12872-2]
NP_002409.1, NM_002418.2 [P12872-1]
UniGeneiHs.2813

Genome annotation databases

EnsembliENST00000266003; ENSP00000266003; ENSG00000096395 [P12872-3]
ENST00000430124; ENSP00000388825; ENSG00000096395 [P12872-1]
ENST00000507738; ENSP00000425467; ENSG00000096395 [P12872-2]
GeneIDi4295
KEGGihsa:4295
UCSCiuc003off.2 human [P12872-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Motilin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00695 mRNA Translation: CAA68690.1
X15393
, X15396, X15395, X15394 Genomic DNA Translation: CAA33448.1
M30281
, M30278, M30279, M30280 Genomic DNA Translation: AAA59860.1
AL138889 Genomic DNA No translation available.
AL158049 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03752.1
CH471081 Genomic DNA Translation: EAX03753.1
BC069675 mRNA Translation: AAH69675.1
BC112314 mRNA Translation: AAI12315.1
BC143981 mRNA Translation: AAI43982.1
CCDSiCCDS47412.1 [P12872-3]
CCDS4786.1 [P12872-1]
CCDS54993.1 [P12872-2]
PIRiA33323
RefSeqiNP_001035198.1, NM_001040109.1 [P12872-3]
NP_001171627.1, NM_001184698.1 [P12872-2]
NP_002409.1, NM_002418.2 [P12872-1]
UniGeneiHs.2813

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LBJNMR-A26-47[»]
ProteinModelPortaliP12872
SMRiP12872
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP12872, 2 interactors
STRINGi9606.ENSP00000388825

Chemistry databases

BindingDBiP12872

PTM databases

iPTMnetiP12872
PhosphoSitePlusiP12872

Polymorphism and mutation databases

BioMutaiMLN
DMDMi127253

Proteomic databases

PaxDbiP12872
PeptideAtlasiP12872
PRIDEiP12872
ProteomicsDBi52881

Protocols and materials databases

DNASUi4295
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266003; ENSP00000266003; ENSG00000096395 [P12872-3]
ENST00000430124; ENSP00000388825; ENSG00000096395 [P12872-1]
ENST00000507738; ENSP00000425467; ENSG00000096395 [P12872-2]
GeneIDi4295
KEGGihsa:4295
UCSCiuc003off.2 human [P12872-1]

Organism-specific databases

CTDi4295
DisGeNETi4295
EuPathDBiHostDB:ENSG00000096395.10
GeneCardsiMLN
HGNCiHGNC:7141 MLN
HPAiHPA069392
MIMi158270 gene
neXtProtiNX_P12872
OpenTargetsiENSG00000096395
PharmGKBiPA30856
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J17F Eukaryota
ENOG411197B LUCA
GeneTreeiENSGT00390000000489
HOGENOMiHOG000108883
HOVERGENiHBG003618
InParanoidiP12872
KOiK05265
OMAiIFTYGEL
OrthoDBiEOG091G0X9Z
PhylomeDBiP12872
TreeFamiTF336217

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
SIGNORiP12872

Miscellaneous databases

EvolutionaryTraceiP12872
GenomeRNAii4295
PROiPR:P12872
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000096395 Expressed in 70 organ(s), highest expression level in intestine
CleanExiHS_MLN
GenevisibleiP12872 HS

Family and domain databases

InterProiView protein in InterPro
IPR006737 Motilin_assoc
IPR006738 Motilin_ghrelin
IPR015662 Promotilin
PANTHERiPTHR14156 PTHR14156, 1 hit
PfamiView protein in Pfam
PF04643 Motilin_assoc, 1 hit
PF04644 Motilin_ghrelin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMOTI_HUMAN
AccessioniPrimary (citable) accession number: P12872
Secondary accession number(s): B7ZLR7
, E9PDN2, J3KN51, Q2M1L2, Q5T975, Q6NSY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: September 12, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again