Insulin-like growth factor-binding protein 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• insulin-like growth factor binding Source: RGDInferred from sequence orthologyⁱ
  • "Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4."
    Donahue L.R., Beamer W.G.
    J. Endocrinol. 136:91-104(1993) [PubMed] [Europe PMC] [Abstract]
• insulin-like growth factor I binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.1

    "Nucleotide sequence and expression of a cDNA clone encoding a fetal rat binding protein for insulin-like growth factors."
    Brown A.L., Chiariotti L., Orlowski C.C., Mehlman T., Burgers W.H., Ackerman E.J., Bruni C.B., Rechler M.M.
    J. Biol. Chem. 264:5148-5154(1989) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, INTERACTION WITH IGF1 AND IGF2, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
• insulin-like growth factor II binding Source: RGDInferred from direct assayⁱ
  • "Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human."
    Shimasaki S., Shimonaka M., Zhang H.-P., Ling N.
    J. Biol. Chem. 266:10646-10653(1991) [PubMed] [Europe PMC] [Abstract]
  • Ref.1

    "Nucleotide sequence and expression of a cDNA clone encoding a fetal rat binding protein for insulin-like growth factors."
    Brown A.L., Chiariotti L., Orlowski C.C., Mehlman T., Burgers W.H., Ackerman E.J., Bruni C.B., Rechler M.M.
    J. Biol. Chem. 264:5148-5154(1989) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, INTERACTION WITH IGF1 AND IGF2, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.

GO - Biological processⁱ

• aging Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Altered IGF-I and IGFBPs in senescent male and female rats."
    Severgnini S., Lowenthal D.T., Millard W.J., Simmen F.A., Pollock B.H., Borst S.E.
    J. Gerontol. A Biol. Sci. Med. Sci. 54:B111-5(1999) [PubMed] [Europe PMC] [Abstract]
• cellular response to hormone stimulus Source: RGDInferred from expression patternⁱ
  • "The regulation of IGFs and IGFBPs by prolactin in primary culture of fetal rat hepatocytes is influenced by maternal malnutrition."
    El Khattabi I., Remacle C., Reusens B.
    Am. J. Physiol. Endocrinol. Metab. 291:E835-42(2006) [PubMed] [Europe PMC] [Abstract]
• female pregnancy Source: RGDInferred from expression patternⁱ
  • "Insulin-like growth factors and their binding proteins define specific phases of myometrial differentiation during pregnancy in the rat."
    Shynlova O., Tsui P., Dorogin A., Langille B.L., Lye S.J.
    Biol. Reprod. 76:571-578(2007) [PubMed] [Europe PMC] [Abstract]
• multicellular organism development Source: UniProtKB-KW
• positive regulation of activated T cell proliferation Source: UniProtKB
• regulation of growth Source: UniProtKB-KW
• regulation of insulin-like growth factor receptor signaling pathway Source: UniProtKB
• response to drug Source: RGDInferred from expression patternⁱ
  • "Growth factors and proliferation of cultured rat gingival cells in response to cyclosporin A."
    Yoshida T., Nagata J., Yamane A.
    J. Periodont. Res. 40:11-19(2005) [PubMed] [Europe PMC] [Abstract]
• response to estradiol Source: RGDInferred from expression patternⁱ
  • "Estradiol and progesterone regulate the expression of insulin-like growth factor-I receptor and insulin-like growth factor binding protein-2 in the hypothalamus of adult female rats."
    Cardona-Gomez G.P., Chowen J.A., Garcia-Segura L.M.
    J. Neurobiol. 43:269-281(2000) [PubMed] [Europe PMC] [Abstract]
• response to estrogen Source: RGDInferred from expression patternⁱ
  • "Gene expression profiling of the effects of castration and estrogen treatment in the rat uterus."
    Wu X., Pang S.T., Sahlin L., Blanck A., Norstedt G., Flores-Morales A.
    Biol. Reprod. 69:1308-1317(2003) [PubMed] [Europe PMC] [Abstract]
• response to glucocorticoid Source: RGDInferred from expression patternⁱ
  • "A 14-kDa cathepsin L-derived carboxyl IGFBP-2 fragment is sequestered by cultured rat ileal crypt cells."
    Gordon P.V., Paxton J.B., Kuemmerle J.F., Fox N.S.
    Am. J. Physiol. Gastrointest. Liver Physiol. 289:G79-87(2005) [PubMed] [Europe PMC] [Abstract]
• response to lithium ion Source: RGDInferred from expression patternⁱ
  • "Insulin-like growth factor binding protein-2 expression is decreased by lithium."
    Bezchlibnyk Y.B., Wang J.F., Shao L., Young L.T.
    Neuroreport 17:897-901(2006) [PubMed] [Europe PMC] [Abstract]
• response to mechanical stimulus Source: RGDInferred from expression patternⁱ
  • "In vivo mechanical loading modulates insulin-like growth factor binding protein-2 gene expression in rat osteocytes."
    Reijnders C.M., Bravenboer N., Holzmann P.J., Bhoelan F., Blankenstein M.A., Lips P.
    Calcif. Tissue Int. 80:137-143(2007) [PubMed] [Europe PMC] [Abstract]
• response to nutrient Source: RGDInferred from expression patternⁱ
  • "Protein-caloric food restriction affects insulin-like growth factor system in fetal Wistar rat."
    Martin M.A., Serradas P., Ramos S., Fernandez E., Goya L., Gangnerau M.N., Lacorne M., Pascual-Leone A.M., Escriva F., Portha B., Alvarez C.
    Endocrinology 146:1364-1371(2005) [PubMed] [Europe PMC] [Abstract]
• response to retinoic acid Source: RGDInferred from expression patternⁱ
  • "Protective role of retinoic acid from antiproliferative action of TNF-alpha on lung epithelial cells."
    Besnard V., Nabeyrat E., Henrion-Caude A., Chadelat K., Perin L., Le Bouc Y., Clement A.
    Am. J. Physiol. Lung Cell Mol. Physiol. 282:L863-71(2002) [PubMed] [Europe PMC] [Abstract]
• response to steroid hormone Source: RGDInferred from expression patternⁱ
  • "Estradiol and progesterone regulate the expression of insulin-like growth factor-I receptor and insulin-like growth factor binding protein-2 in the hypothalamus of adult female rats."
    Cardona-Gomez G.P., Chowen J.A., Garcia-Segura L.M.
    J. Neurobiol. 43:269-281(2000) [PubMed] [Europe PMC] [Abstract]
• signal transduction Source: RGDInferred from expression patternⁱ
  • "Depolarization induces insulin-like growth factor binding protein-2 expression in vivo via NMDA receptor stimulation."
    Holmin S., Mathiesen T., Langmoen I.A., Sandberg Nordqvist A.C.
    Growth Horm. IGF Res. 11:399-406(2001) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• insulin-like growth factor binding Source: RGDInferred from sequence orthologyⁱ
  • "Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4."
    Donahue L.R., Beamer W.G.
    J. Endocrinol. 136:91-104(1993) [PubMed] [Europe PMC] [Abstract]
• insulin-like growth factor I binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.1

    "Nucleotide sequence and expression of a cDNA clone encoding a fetal rat binding protein for insulin-like growth factors."
    Brown A.L., Chiariotti L., Orlowski C.C., Mehlman T., Burgers W.H., Ackerman E.J., Bruni C.B., Rechler M.M.
    J. Biol. Chem. 264:5148-5154(1989) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, INTERACTION WITH IGF1 AND IGF2, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
• insulin-like growth factor II binding Source: RGDInferred from direct assayⁱ
  • "Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human."
    Shimasaki S., Shimonaka M., Zhang H.-P., Ling N.
    J. Biol. Chem. 266:10646-10653(1991) [PubMed] [Europe PMC] [Abstract]
  • Ref.1

    "Nucleotide sequence and expression of a cDNA clone encoding a fetal rat binding protein for insulin-like growth factors."
    Brown A.L., Chiariotti L., Orlowski C.C., Mehlman T., Burgers W.H., Ackerman E.J., Bruni C.B., Rechler M.M.
    J. Biol. Chem. 264:5148-5154(1989) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, INTERACTION WITH IGF1 AND IGF2, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Motif

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MLPRLGGPAL PLLLPSLLLL LLLGAGGCGP GVRAEVLFRC PPCTPERLAA 
        60         70         80         90        100
CGPPPDAPCA ELVREPGCGC CSVCARQEGE ACGVYIPRCA QTLRCYPNPG 
       110        120        130        140        150
SELPLKALVT GAGTCEKRRV GATPQQVADS EDDHSEGGLV ENHVDGTMNM 
       160        170        180        190        200
LGGSSAGRKP PKSGMKELAV FREKVNEQHR QMGKGAKHLS LEEPKKLRPP 
       210        220        230        240        250
PARTPCQQEL DQVLERISTM RLPDDRGPLE HLYSLHIPNC DKHGLYNLKQ 
       260        270        280        290        300
CKMSLNGQRG ECWCVNPNTG KPIQGAPTIR GDPECHLFYN EQQENDGAHA 

QRVQ                                                   

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ