UniProtKB - P12843 (IBP2_RAT)
Protein
Insulin-like growth factor-binding protein 2
Gene
Igfbp2
Organism
Rattus norvegicus (Rat)
Status
Functioni
Inhibits IGF-mediated growth and developmental rates (By similarity). IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.By similarity
GO - Molecular functioni
- insulin-like growth factor binding Source: RGD
- insulin-like growth factor I binding Source: UniProtKB
- insulin-like growth factor II binding Source: RGD
GO - Biological processi
- aging Source: RGD
- cellular response to hormone stimulus Source: RGD
- female pregnancy Source: RGD
- multicellular organism development Source: UniProtKB-KW
- positive regulation of activated T cell proliferation Source: UniProtKB
- regulation of growth Source: UniProtKB-KW
- regulation of insulin-like growth factor receptor signaling pathway Source: UniProtKB
- response to drug Source: RGD
- response to estradiol Source: RGD
- response to estrogen Source: RGD
- response to glucocorticoid Source: RGD
- response to lithium ion Source: RGD
- response to mechanical stimulus Source: RGD
- response to nutrient Source: RGD
- response to retinoic acid Source: RGD
- response to steroid hormone Source: RGD
- signal transduction Source: RGD
Keywordsi
Molecular function | Developmental protein, Growth factor binding |
Biological process | Growth regulation |
Enzyme and pathway databases
Reactomei | R-RNO-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
Protein family/group databases
MEROPSi | I31.953 |
Names & Taxonomyi
Protein namesi | Recommended name: Insulin-like growth factor-binding protein 2Short name: IBP-2 Short name: IGF-binding protein 2 Short name: IGFBP-2 Alternative name(s): BRL-BP |
Gene namesi | Name:Igfbp2 Synonyms:Igfbp-2 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2873, Igfbp2 |
Subcellular locationi
Extracellular region or secreted
- Secreted 3 Publications
Extracellular region or secreted
- extracellular region Source: UniProtKB
- extracellular space Source: RGD
Plasma Membrane
- apical plasma membrane Source: RGD
Other locations
- cytoplasmic vesicle Source: RGD
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 34 | 1 PublicationAdd BLAST | 34 | |
ChainiPRO_0000014373 | 35 – 304 | Insulin-like growth factor-binding protein 2Add BLAST | 270 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 206 ↔ 240 | PROSITE-ProRule annotation | ||
Disulfide bondi | 251 ↔ 262 | PROSITE-ProRule annotation | ||
Disulfide bondi | 264 ↔ 285 | PROSITE-ProRule annotation |
Post-translational modificationi
O-glycosylated.By similarity
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P12843 |
PRIDEi | P12843 |
PTM databases
iPTMneti | P12843 |
PhosphoSitePlusi | P12843 |
Expressioni
Tissue specificityi
In adults, expressed in brain, testes, ovaries, and kidney. Expression in the adult liver is barely detectable.1 Publication
Developmental stagei
Predominantly expressed at fetal stages with highest expression in fetal liver. Also expressed in fetal kidney, intestine and lung, as well as muscle, heart and stomach.2 Publications
Gene expression databases
Bgeei | ENSRNOG00000016957, Expressed in stomach and 22 other tissues |
Genevisiblei | P12843, RN |
Interactioni
Subunit structurei
Binds IGF2 more than IGF1.
GO - Molecular functioni
- insulin-like growth factor binding Source: RGD
- insulin-like growth factor I binding Source: UniProtKB
- insulin-like growth factor II binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000023068 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 36 – 118 | IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST | 83 | |
Domaini | 203 – 285 | Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST | 83 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 280 – 282 | Cell attachment site | 3 |
Domaini
The C-terminus is required for IGF-binding and growth inhibition.1 Publication
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QRWQ, Eukaryota |
GeneTreei | ENSGT00940000158542 |
HOGENOMi | CLU_070833_3_0_1 |
InParanoidi | P12843 |
OMAi | PKQCKMS |
OrthoDBi | 979270at2759 |
PhylomeDBi | P12843 |
TreeFami | TF331211 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR012210, IGFBP-2 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01978, IGFBPFAMILY2 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P12843-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLPRLGGPAL PLLLPSLLLL LLLGAGGCGP GVRAEVLFRC PPCTPERLAA
60 70 80 90 100
CGPPPDAPCA ELVREPGCGC CSVCARQEGE ACGVYIPRCA QTLRCYPNPG
110 120 130 140 150
SELPLKALVT GAGTCEKRRV GATPQQVADS EDDHSEGGLV ENHVDGTMNM
160 170 180 190 200
LGGSSAGRKP PKSGMKELAV FREKVNEQHR QMGKGAKHLS LEEPKKLRPP
210 220 230 240 250
PARTPCQQEL DQVLERISTM RLPDDRGPLE HLYSLHIPNC DKHGLYNLKQ
260 270 280 290 300
CKMSLNGQRG ECWCVNPNTG KPIQGAPTIR GDPECHLFYN EQQENDGAHA
QRVQ
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 298 | A → V in AAA40829 (PubMed:2538475).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04486 mRNA Translation: AAA40829.1 M31672 mRNA Translation: AAA41381.1 BC092570 mRNA Translation: AAH92570.1 |
PIRi | A33274 |
RefSeqi | NP_037254.2, NM_013122.2 |
Genome annotation databases
Ensembli | ENSRNOT00000023068; ENSRNOP00000023068; ENSRNOG00000016957 |
GeneIDi | 25662 |
KEGGi | rno:25662 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04486 mRNA Translation: AAA40829.1 M31672 mRNA Translation: AAA41381.1 BC092570 mRNA Translation: AAH92570.1 |
PIRi | A33274 |
RefSeqi | NP_037254.2, NM_013122.2 |
3D structure databases
SMRi | P12843 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000023068 |
Protein family/group databases
MEROPSi | I31.953 |
PTM databases
iPTMneti | P12843 |
PhosphoSitePlusi | P12843 |
Proteomic databases
PaxDbi | P12843 |
PRIDEi | P12843 |
Genome annotation databases
Ensembli | ENSRNOT00000023068; ENSRNOP00000023068; ENSRNOG00000016957 |
GeneIDi | 25662 |
KEGGi | rno:25662 |
Organism-specific databases
CTDi | 3485 |
RGDi | 2873, Igfbp2 |
Phylogenomic databases
eggNOGi | ENOG502QRWQ, Eukaryota |
GeneTreei | ENSGT00940000158542 |
HOGENOMi | CLU_070833_3_0_1 |
InParanoidi | P12843 |
OMAi | PKQCKMS |
OrthoDBi | 979270at2759 |
PhylomeDBi | P12843 |
TreeFami | TF331211 |
Enzyme and pathway databases
Reactomei | R-RNO-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
Miscellaneous databases
PROi | PR:P12843 |
Gene expression databases
Bgeei | ENSRNOG00000016957, Expressed in stomach and 22 other tissues |
Genevisiblei | P12843, RN |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR012210, IGFBP-2 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01978, IGFBPFAMILY2 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IBP2_RAT | |
Accessioni | P12843Primary (citable) accession number: P12843 Secondary accession number(s): Q569C7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | May 1, 2007 | |
Last modified: | December 2, 2020 | |
This is version 159 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |