UniProtKB - P12830 (CADH1_HUMAN)
Cadherin-1
CDH1
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 257 | Calcium 1 | 1 | |
Metal bindingi | 257 | Calcium 2 | 1 | |
Metal bindingi | 288 | Calcium 3 | 1 |
GO - Molecular functioni
- ankyrin binding Source: BHF-UCL
- beta-catenin binding Source: BHF-UCL
- cadherin binding Source: BHF-UCL
- calcium ion binding Source: GO_Central
- cell adhesion molecule binding Source: UniProtKB
- gamma-catenin binding Source: BHF-UCL
- GTPase activating protein binding Source: UniProtKB
- identical protein binding Source: IntAct
GO - Biological processi
- adherens junction organization Source: UniProtKB
- cell-cell adhesion Source: BHF-UCL
- cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
- cellular response to indole-3-methanol Source: UniProtKB
- cellular response to lithium ion Source: UniProtKB
- entry of bacterium into host cell Source: Reactome
- extracellular matrix organization Source: Reactome
- homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
- negative regulation of cell-cell adhesion Source: UniProtKB
- negative regulation of cell migration Source: ARUK-UCL
- neuron projection development Source: Ensembl
- pituitary gland development Source: Ensembl
- positive regulation of protein import into nucleus Source: BHF-UCL
- positive regulation of transcription, DNA-templated Source: BHF-UCL
- protein localization to plasma membrane Source: BHF-UCL
- regulation of gene expression Source: UniProtKB
- regulation of protein catabolic process at postsynapse, modulating synaptic transmission Source: Ensembl
- response to drug Source: Ensembl
- response to toxic substance Source: Ensembl
- synapse assembly Source: GO_Central
Keywordsi
Biological process | Cell adhesion |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | P12830 |
Reactomei | R-HSA-1474228, Degradation of the extracellular matrix R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-216083, Integrin cell surface interactions R-HSA-351906, Apoptotic cleavage of cell adhesion proteins R-HSA-418990, Adherens junctions interactions R-HSA-5626467, RHO GTPases activate IQGAPs R-HSA-8876493, InlA-mediated entry of Listeria monocytogenes into host cells |
SIGNORi | P12830 |
Names & Taxonomyi
Protein namesi | Recommended name: Cadherin-1Alternative name(s): CAM 120/80 Epithelial cadherin Short name: E-cadherin Uvomorulin CD_antigen: CD324 Cleaved into the following 3 chains: |
Gene namesi | Name:CDH1 Synonyms:CDHE, UVO |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1748, CDH1 |
MIMi | 192090, gene |
neXtProti | NX_P12830 |
VEuPathDBi | HostDB:ENSG00000039068.18 |
Subcellular locationi
Endosome
Golgi apparatus
Plasma membrane
- Cell membrane 2 Publications; Single-pass type I membrane protein
Other locations
- adherens junction 1 Publication
Note: Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane.
Cytoskeleton
- actin cytoskeleton Source: BHF-UCL
Endosome
- endosome Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
Golgi apparatus
- trans-Golgi network Source: BHF-UCL
Plasma Membrane
- catenin complex Source: BHF-UCL
- cytoplasmic side of plasma membrane Source: UniProtKB
- flotillin complex Source: UniProtKB
- lateral plasma membrane Source: BHF-UCL
- plasma membrane Source: UniProtKB
Other locations
- adherens junction Source: UniProtKB
- apical junction complex Source: UniProtKB
- cell junction Source: UniProtKB
- cytoplasm Source: GO_Central
- glutamatergic synapse Source: Ensembl
- integral component of membrane Source: BHF-UCL
- lamellipodium Source: UniProtKB
- perinuclear region of cytoplasm Source: BHF-UCL
- postsynapse Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 155 – 709 | ExtracellularSequence analysisAdd BLAST | 555 | |
Transmembranei | 710 – 730 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 731 – 882 | CytoplasmicSequence analysisAdd BLAST | 152 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Endosome, Golgi apparatus, MembranePathology & Biotechi
Involvement in diseasei
Hereditary diffuse gastric cancer (HDGC)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_008712 | 244 | D → G in HDGC. 1 PublicationCorresponds to variant dbSNP:rs1064794231EnsemblClinVar. | 1 | |
Natural variantiVAR_008713 | 487 | V → A in HDGC. 1 Publication | 1 | |
Natural variantiVAR_023358 | 832 | V → M in HDGC. 2 PublicationsCorresponds to variant dbSNP:rs35572355EnsemblClinVar. | 1 |
Endometrial cancer (ENDMC)
Ovarian cancer (OC)1 Publication
Breast cancer, lobular (LBC)1 Publication
Blepharocheilodontic syndrome 1 (BCDS1)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_079392 | 254 | D → Y in BCDS1; abolishes protein abundance; loss of cell membrane localization. 1 PublicationCorresponds to variant dbSNP:rs1555515445EnsemblClinVar. | 1 | |
Natural variantiVAR_079393 | 257 | D → V in BCDS1; slightly decreases protein abundance; loss of cell membrane localization. 1 Publication | 1 | |
Natural variantiVAR_079394 | 454 | Missing in BCDS1; decreases protein abundance; loss of cell membrane localization. 1 Publication | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 156 | W → A or S: No longer binds L.monocytogenes InlA. 1 Publication | 1 | |
Mutagenesisi | 156 | W → D: Protein is partially unfolded, no longer binds L.monocytogenes InlA. 1 Publication | 1 | |
Mutagenesisi | 170 | P → A, E or V: No longer binds L.monocytogenes InlA. 1 Publication | 1 | |
Mutagenesisi | 170 | P → E: No longer adheres to L.monocytogenes InlA coated beads, nor do cells take up InlA coated beads. 1 Publication | 1 | |
Mutagenesisi | 637 | N → Q: CDH1 becomes a substrate for ERAD and is retro-translocated from ER to cytoplasm. 1 Publication | 1 | |
Mutagenesisi | 754 | Y → F: Abolishes binding to CBLL1. 1 Publication | 1 | |
Mutagenesisi | 759 – 761 | GGG → AAA: Binds to CTNNB1 but abolishes interaction of CTNNB1 with PSEN1. Abolishes gamma-secretase cleavage. 2 Publications | 3 |
Keywords - Diseasei
Disease variant, Ectodermal dysplasiaOrganism-specific databases
DisGeNETi | 999 |
GeneReviewsi | CDH1 |
MalaCardsi | CDH1 |
MIMi | 119580, phenotype 137215, phenotype 167000, phenotype 608089, phenotype |
OpenTargetsi | ENSG00000039068 |
Orphaneti | 1997, Blepharo-cheilo-odontic syndrome 199306, Cleft lip/palate 227535, Hereditary breast cancer 26106, Hereditary diffuse gastric cancer |
PharmGKBi | PA26282 |
Miscellaneous databases
Pharosi | P12830, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2321609 |
Genetic variation databases
BioMutai | CDH1 |
DMDMi | 399166 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
PropeptideiPRO_0000003715 | 23 – 154 | Sequence analysisAdd BLAST | 132 | |
ChainiPRO_0000003716 | 155 – 882 | Cadherin-1Add BLAST | 728 | |
ChainiPRO_0000236067 | 701 – 882 | E-Cad/CTF1Add BLAST | 182 | |
ChainiPRO_0000236068 | 732 – 882 | E-Cad/CTF2Add BLAST | 151 | |
ChainiPRO_0000236069 | 751 – 882 | E-Cad/CTF3Add BLAST | 132 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 163 | Interchain | ||
Glycosylationi | 280 | O-linked (Man...) serineBy similarity | 1 | |
Glycosylationi | 285 | O-linked (Man...) threonineBy similarity | 1 | |
Glycosylationi | 358 | O-linked (Man...) threonineBy similarity | 1 | |
Glycosylationi | 470 | O-linked (Man...) threonineBy similarity | 1 | |
Glycosylationi | 472 | O-linked (Man...) threonineBy similarity | 1 | |
Glycosylationi | 509 | O-linked (Man...) threonineBy similarity | 1 | |
Glycosylationi | 558 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 570 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 576 | O-linked (Man...) threonineBy similarity | 1 | |
Glycosylationi | 578 | O-linked (Man...) threonineBy similarity | 1 | |
Glycosylationi | 580 | O-linked (Man...) threonineBy similarity | 1 | |
Glycosylationi | 622 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 637 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Modified residuei | 753 | Phosphotyrosine; by SRC1 Publication | 1 | |
Modified residuei | 754 | Phosphotyrosine; by SRC1 Publication | 1 | |
Modified residuei | 755 | Phosphotyrosine; by SRC1 Publication | 1 | |
Modified residuei | 770 | PhosphoserineCombined sources | 1 | |
Modified residuei | 793 | PhosphoserineCombined sources | 1 | |
Modified residuei | 838 | PhosphoserineBy similarity | 1 | |
Modified residuei | 840 | PhosphoserineBy similarity | 1 | |
Modified residuei | 846 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 700 – 701 | Cleavage; by a metalloproteinase | 2 | |
Sitei | 731 – 732 | Cleavage; by gamma-secretase/PS1 | 2 | |
Sitei | 750 – 751 | Cleavage; by caspase-3 | 2 |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-1599 |
EPDi | P12830 |
jPOSTi | P12830 |
MassIVEi | P12830 |
MaxQBi | P12830 |
PaxDbi | P12830 |
PeptideAtlasi | P12830 |
PRIDEi | P12830 |
ProteomicsDBi | 52879 [P12830-1] 84533 |
TopDownProteomicsi | P12830-2 [P12830-2] |
PTM databases
GlyGeni | P12830, 13 sites |
iPTMneti | P12830 |
PhosphoSitePlusi | P12830 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000039068, Expressed in jejunal mucosa and 195 other tissues |
ExpressionAtlasi | P12830, baseline and differential |
Genevisiblei | P12830, HS |
Organism-specific databases
HPAi | ENSG00000039068, Tissue enhanced (intestine) |
Interactioni
Subunit structurei
Homodimer; disulfide-linked (PubMed:11856755).
Component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1, beta-catenin/CTNNB1 or gamma-catenin/JUP, and potentially alpha-catenin/CTNNA1; the complex is located to adherens junctions (PubMed:16126725, PubMed:7982500).
Interacts with the TRPV4 and CTNNB1 complex (By similarity).
Interacts with CTNND1 (PubMed:15240885). The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex (By similarity). Alternatively, the CTNNA1-containing complex may be linked to F-actin by other proteins such as LIMA1 (By similarity). Interaction with PSEN1, cleaves CDH1 resulting in the disassociation of cadherin-based adherens junctions (CAJs) (PubMed:11226248, PubMed:16126725).
Interacts with AJAP1 and DLGAP5 (PubMed:14699157, PubMed:14595118).
Interacts with TBC1D2 (PubMed:20116244).
Interacts with LIMA1 (PubMed:18093941).
Interacts with CAV1.
Interacts with PIP5K1C (PubMed:17261850).
Interacts with RAB8B (By similarity).
Interacts with RAPGEF2 (By similarity).
Interacts with DDR1; this stabilizes CDH1 at the cell surface and inhibits its internalization (PubMed:20432435).
Interacts with KLRG1 (PubMed:19604491).
Forms a ternary complex composed of ADAM10, CADH1 and EPHA4; within the complex, CADH1 is cleaved by ADAM10 which disrupts adherens junctions (By similarity).
Interacts with SPEF1 (PubMed:31473225).
By similarity14 PublicationsBinary interactionsi
Hide detailsP12830
GO - Molecular functioni
- ankyrin binding Source: BHF-UCL
- beta-catenin binding Source: BHF-UCL
- cadherin binding Source: BHF-UCL
- cell adhesion molecule binding Source: UniProtKB
- gamma-catenin binding Source: BHF-UCL
- GTPase activating protein binding Source: UniProtKB
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 107434, 660 interactors |
CORUMi | P12830 |
DIPi | DIP-477N |
ELMi | P12830 |
IntActi | P12830, 109 interactors |
MINTi | P12830 |
STRINGi | 9606.ENSP00000261769 |
Miscellaneous databases
RNActi | P12830, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P12830 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P12830 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 155 – 262 | Cadherin 1PROSITE-ProRule annotationAdd BLAST | 108 | |
Domaini | 263 – 375 | Cadherin 2PROSITE-ProRule annotationAdd BLAST | 113 | |
Domaini | 376 – 486 | Cadherin 3PROSITE-ProRule annotationAdd BLAST | 111 | |
Domaini | 487 – 593 | Cadherin 4PROSITE-ProRule annotationAdd BLAST | 107 | |
Domaini | 594 – 697 | Cadherin 5PROSITE-ProRule annotationAdd BLAST | 104 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 758 – 769 | Required for binding CTNND1 and PSEN1Add BLAST | 12 | |
Regioni | 811 – 882 | Required for binding alpha, beta and gamma cateninsAdd BLAST | 72 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 838 – 851 | Ser-richAdd BLAST | 14 |
Domaini
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000157175 |
HOGENOMi | CLU_005284_2_1_1 |
InParanoidi | P12830 |
OrthoDBi | 182239at2759 |
PhylomeDBi | P12830 |
TreeFami | TF316817 |
Family and domain databases
Gene3Di | 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR000233, Cadherin_cytoplasmic-dom IPR014868, Cadherin_pro_dom IPR027397, Catenin-bd_sf IPR030049, CDH1 |
PANTHERi | PTHR24027, PTHR24027, 1 hit PTHR24027:SF319, PTHR24027:SF319, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF01049, Cadherin_C, 1 hit PF08758, Cadherin_pro, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 4 hits SM01055, Cadherin_pro, 1 hit |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 3 hits PS50268, CADHERIN_2, 5 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGPWSRSLSA LLLLLQVSSW LCQEPEPCHP GFDAESYTFT VPRRHLERGR
60 70 80 90 100
VLGRVNFEDC TGRQRTAYFS LDTRFKVGTD GVITVKRPLR FHNPQIHFLV
110 120 130 140 150
YAWDSTYRKF STKVTLNTVG HHHRPPPHQA SVSGIQAELL TFPNSSPGLR
160 170 180 190 200
RQKRDWVIPP ISCPENEKGP FPKNLVQIKS NKDKEGKVFY SITGQGADTP
210 220 230 240 250
PVGVFIIERE TGWLKVTEPL DRERIATYTL FSHAVSSNGN AVEDPMEILI
260 270 280 290 300
TVTDQNDNKP EFTQEVFKGS VMEGALPGTS VMEVTATDAD DDVNTYNAAI
310 320 330 340 350
AYTILSQDPE LPDKNMFTIN RNTGVISVVT TGLDRESFPT YTLVVQAADL
360 370 380 390 400
QGEGLSTTAT AVITVTDTND NPPIFNPTTY KGQVPENEAN VVITTLKVTD
410 420 430 440 450
ADAPNTPAWE AVYTILNDDG GQFVVTTNPV NNDGILKTAK GLDFEAKQQY
460 470 480 490 500
ILHVAVTNVV PFEVSLTTST ATVTVDVLDV NEAPIFVPPE KRVEVSEDFG
510 520 530 540 550
VGQEITSYTA QEPDTFMEQK ITYRIWRDTA NWLEINPDTG AISTRAELDR
560 570 580 590 600
EDFEHVKNST YTALIIATDN GSPVATGTGT LLLILSDVND NAPIPEPRTI
610 620 630 640 650
FFCERNPKPQ VINIIDADLP PNTSPFTAEL THGASANWTI QYNDPTQESI
660 670 680 690 700
ILKPKMALEV GDYKINLKLM DNQNKDQVTT LEVSVCDCEG AAGVCRKAQP
710 720 730 740 750
VEAGLQIPAI LGILGGILAL LILILLLLLF LRRRAVVKEP LLPPEDDTRD
760 770 780 790 800
NVYYYDEEGG GEEDQDFDLS QLHRGLDARP EVTRNDVAPT LMSVPRYLPR
810 820 830 840 850
PANPDEIGNF IDENLKAADT DPTAPPYDSL LVFDYEGSGS EAASLSSLNS
860 870 880
SESDKDQDYD YLNEWGNRFK KLADMYGGGE DD
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WXI5 | A0A087WXI5_HUMAN | Cadherin-1 | CDH1 | 903 | Annotation score: | ||
H3BNC6 | H3BNC6_HUMAN | Cadherin-1 | CDH1 | 537 | Annotation score: | ||
H3BVI7 | H3BVI7_HUMAN | Cadherin-1 | CDH1 | 414 | Annotation score: | ||
A0A087WU43 | A0A087WU43_HUMAN | Cadherin-1 | CDH1 | 647 | Annotation score: | ||
A0A087WX17 | A0A087WX17_HUMAN | Cadherin-1 | CDH1 | 647 | Annotation score: | ||
J3QKP1 | J3QKP1_HUMAN | Cadherin-1 | CDH1 | 155 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 10 | A → G in AAA61259 (PubMed:8185635).Curated | 1 | |
Sequence conflicti | 29 | H → L in AAA61259 (PubMed:8185635).Curated | 1 | |
Sequence conflicti | 47 | E → R in AAA61259 (PubMed:8185635).Curated | 1 | |
Sequence conflicti | 70 – 71 | SL → P in AAA61259 (PubMed:8185635).Curated | 2 | |
Sequence conflicti | 483 | A → G in AAA61259 (PubMed:8185635).Curated | 1 | |
Sequence conflicti | 530 | A → R in AAA61259 (PubMed:8185635).Curated | 1 | |
Sequence conflicti | 543 | S → F in CAA79356 (PubMed:8127895).Curated | 1 | |
Sequence conflicti | 615 | I → H in AAA61259 (PubMed:8185635).Curated | 1 | |
Sequence conflicti | 634 – 636 | ASA → RVP in AAA61259 (PubMed:8185635).Curated | 3 | |
Sequence conflicti | 868 | R → P in AAA61259 (PubMed:8185635).Curated | 1 | |
Sequence conflicti | 882 | D → H in AAA61259 (PubMed:8185635).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048500 | 72 | D → N. Corresponds to variant dbSNP:rs35606263EnsemblClinVar. | 1 | |
Natural variantiVAR_001306 | 123 | H → Y in a gastric cancer sample. | 1 | |
Natural variantiVAR_001307 | 193 | T → P in a diffuse gastric cancer sample. 1 Publication | 1 | |
Natural variantiVAR_008712 | 244 | D → G in HDGC. 1 PublicationCorresponds to variant dbSNP:rs1064794231EnsemblClinVar. | 1 | |
Natural variantiVAR_079392 | 254 | D → Y in BCDS1; abolishes protein abundance; loss of cell membrane localization. 1 PublicationCorresponds to variant dbSNP:rs1555515445EnsemblClinVar. | 1 | |
Natural variantiVAR_079393 | 257 | D → V in BCDS1; slightly decreases protein abundance; loss of cell membrane localization. 1 Publication | 1 | |
Natural variantiVAR_013970 | 270 | S → A May contribute to prostate cancer. 1 PublicationCorresponds to variant dbSNP:rs587776399EnsemblClinVar. | 1 | |
Natural variantiVAR_001308 | 274 – 277 | Missing Found in gastric carcinoma cell lines. 1 Publication | 4 | |
Natural variantiVAR_033026 | 282 | M → I in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs200932258EnsemblClinVar. | 1 | |
Natural variantiVAR_001309 | 315 | N → S in lobular breast carcinoma. 1 Publication | 1 | |
Natural variantiVAR_001310 | 336 | E → D1 PublicationCorresponds to variant dbSNP:rs267606712EnsemblClinVar. | 1 | |
Natural variantiVAR_013971 | 340 | T → A Found in gastric and colorectal cancer samples; cells exhibited decreased aggregation increased invasiveness and non-uniform migration in vitro compared to cells transfected with wild-type sequence. 3 PublicationsCorresponds to variant dbSNP:rs116093741EnsemblClinVar. | 1 | |
Natural variantiVAR_001311 | 370 | D → A in a diffuse gastric cancer sample. 1 Publication | 1 | |
Natural variantiVAR_048501 | 393 | I → N. Corresponds to variant dbSNP:rs34466743EnsemblClinVar. | 1 | |
Natural variantiVAR_001312 | 400 | Missing in a gastric carcinoma sample; loss of heterozygosity. 1 Publication | 1 | |
Natural variantiVAR_001313 | 418 – 423 | Missing in a gastric carcinoma sample. 1 Publication | 6 | |
Natural variantiVAR_079394 | 454 | Missing in BCDS1; decreases protein abundance; loss of cell membrane localization. 1 Publication | 1 | |
Natural variantiVAR_001314 | 463 | E → Q in a gastric carcinoma sample. | 1 | |
Natural variantiVAR_001315 | 470 | T → I1 PublicationCorresponds to variant dbSNP:rs370864592EnsemblClinVar. | 1 | |
Natural variantiVAR_001317 | 473 | V → D in a diffuse gastric cancer sample. 1 Publication | 1 | |
Natural variantiVAR_048502 | 473 | V → I. Corresponds to variant dbSNP:rs36087757EnsemblClinVar. | 1 | |
Natural variantiVAR_023357 | 478 | L → P1 PublicationCorresponds to variant dbSNP:rs35520415EnsemblClinVar. | 1 | |
Natural variantiVAR_008713 | 487 | V → A in HDGC. 1 Publication | 1 | |
Natural variantiVAR_001318 | 592 | A → T in a thyroid cancer sample; may play a role in colorectal carcinogenesis. 2 PublicationsCorresponds to variant dbSNP:rs35187787EnsemblClinVar. | 1 | |
Natural variantiVAR_001319 | 598 | R → Q in a gastric cancer sample. Corresponds to variant dbSNP:rs780759537EnsemblClinVar. | 1 | |
Natural variantiVAR_001320 | 617 | A → T Detected in an endometrial cancer sample; loss of heterozygosity; cells exhibited an intermediate phenotype concerning aggregation invasiveness and migration in vitro compared to cells transfected with wild-type sequence. 3 PublicationsCorresponds to variant dbSNP:rs33935154EnsemblClinVar. | 1 | |
Natural variantiVAR_021868 | 630 | L → V. Corresponds to variant dbSNP:rs2276331EnsemblClinVar. | 1 | |
Natural variantiVAR_055431 | 634 | A → V Found in a gastric cancer sample; cells exhibited decreased aggregation increased invasiveness and non-uniform migration in vitro compared to cells transfected with wild-type sequence. 1 PublicationCorresponds to variant dbSNP:rs121964878EnsemblClinVar. | 1 | |
Natural variantiVAR_021869 | 695 | C → R. Corresponds to variant dbSNP:rs9282655Ensembl. | 1 | |
Natural variantiVAR_001321 | 711 | L → V Detected in an endometrial cancer sample. 1 PublicationCorresponds to variant dbSNP:rs121964871EnsemblClinVar. | 1 | |
Natural variantiVAR_033027 | 777 | D → N in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs372989292EnsemblClinVar. | 1 | |
Natural variantiVAR_023358 | 832 | V → M in HDGC. 2 PublicationsCorresponds to variant dbSNP:rs35572355EnsemblClinVar. | 1 | |
Natural variantiVAR_001322 | 838 | S → G in an ovarian carcinoma sample; somatic mutation; loss of heterozygosity. 1 PublicationCorresponds to variant dbSNP:rs121964872EnsemblClinVar. | 1 | |
Natural variantiVAR_023359 | 880 | E → K1 PublicationCorresponds to variant dbSNP:rs34507583EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055586 | 380 – 440 | Missing in isoform 2. 1 PublicationAdd BLAST | 61 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z13009 mRNA Translation: CAA78353.1 Z18923 mRNA Translation: CAA79356.1 L08599 mRNA Translation: AAA61259.1 Frameshift. AB025105 mRNA Translation: BAA88956.1 AK290012 mRNA Translation: BAF82701.1 AK312551 mRNA Translation: BAG35448.1 DQ090940 Genomic DNA Translation: AAY68225.1 AC099314 Genomic DNA No translation available. CH471092 Genomic DNA Translation: EAW83243.1 CH471092 Genomic DNA Translation: EAW83244.1 L34545 Genomic DNA Translation: AAA21764.1 D49685 Genomic DNA Translation: BAA08537.1 Z35402 , Z35403, Z35404, Z35405, Z35406, Z35407, Z35408, Z35409, Z35410, Z35411, Z35412, Z35413, Z35414, Z35415 Genomic DNA Translation: CAA84586.1 X12790 mRNA Translation: CAA31279.1 X52279 mRNA Translation: CAA36522.1 S72492, S72397, S72491 Genomic DNA Translation: AAD14108.1 |
CCDSi | CCDS10869.1 [P12830-1] CCDS82005.1 [P12830-2] |
PIRi | S37654, IJHUCE |
RefSeqi | NP_001304113.1, NM_001317184.1 [P12830-2] NP_001304114.1, NM_001317185.1 NP_001304115.1, NM_001317186.1 NP_004351.1, NM_004360.4 [P12830-1] |
Genome annotation databases
Ensembli | ENST00000261769; ENSP00000261769; ENSG00000039068 [P12830-1] ENST00000422392; ENSP00000414946; ENSG00000039068 [P12830-2] |
GeneIDi | 999 |
KEGGi | hsa:999 |
UCSCi | uc002ewg.2, human [P12830-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
NIEHS-SNPs |
Wikipedia E-cadherin entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z13009 mRNA Translation: CAA78353.1 Z18923 mRNA Translation: CAA79356.1 L08599 mRNA Translation: AAA61259.1 Frameshift. AB025105 mRNA Translation: BAA88956.1 AK290012 mRNA Translation: BAF82701.1 AK312551 mRNA Translation: BAG35448.1 DQ090940 Genomic DNA Translation: AAY68225.1 AC099314 Genomic DNA No translation available. CH471092 Genomic DNA Translation: EAW83243.1 CH471092 Genomic DNA Translation: EAW83244.1 L34545 Genomic DNA Translation: AAA21764.1 D49685 Genomic DNA Translation: BAA08537.1 Z35402 , Z35403, Z35404, Z35405, Z35406, Z35407, Z35408, Z35409, Z35410, Z35411, Z35412, Z35413, Z35414, Z35415 Genomic DNA Translation: CAA84586.1 X12790 mRNA Translation: CAA31279.1 X52279 mRNA Translation: CAA36522.1 S72492, S72397, S72491 Genomic DNA Translation: AAD14108.1 |
CCDSi | CCDS10869.1 [P12830-1] CCDS82005.1 [P12830-2] |
PIRi | S37654, IJHUCE |
RefSeqi | NP_001304113.1, NM_001317184.1 [P12830-2] NP_001304114.1, NM_001317185.1 NP_001304115.1, NM_001317186.1 NP_004351.1, NM_004360.4 [P12830-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1O6S | X-ray | 1.80 | B | 156-255 | [»] | |
2O72 | X-ray | 2.00 | A | 155-367 | [»] | |
2OMT | X-ray | 2.00 | B | 156-255 | [»] | |
2OMU | X-ray | 1.80 | B | 156-255 | [»] | |
2OMV | X-ray | 1.90 | B | 156-255 | [»] | |
2OMX | X-ray | 1.70 | B | 156-258 | [»] | |
2OMY | X-ray | 1.70 | B | 156-254 | [»] | |
2OMZ | X-ray | 1.60 | B | 156-254 | [»] | |
3FF7 | X-ray | 1.80 | A/B | 155-253 | [»] | |
3FF8 | X-ray | 2.00 | A/B | 155-254 | [»] | |
3L6X | X-ray | 2.40 | B | 756-773 | [»] | |
3L6Y | X-ray | 3.00 | B/D/F | 756-773 | [»] | |
4ZT1 | X-ray | 1.92 | A/B | 157-367 | [»] | |
4ZTE | X-ray | 2.13 | A/B | 157-367 | [»] | |
6CXY | X-ray | 2.20 | C | 155-371 | [»] | |
6OLE | electron microscopy | 3.10 | y | 693-730 | [»] | |
6OLF | electron microscopy | 3.90 | y | 693-730 | [»] | |
6OLG | electron microscopy | 3.40 | A | 693-730 | [»] | |
6VEL | X-ray | 2.65 | C | 155-371 | [»] | |
SMRi | P12830 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107434, 660 interactors |
CORUMi | P12830 |
DIPi | DIP-477N |
ELMi | P12830 |
IntActi | P12830, 109 interactors |
MINTi | P12830 |
STRINGi | 9606.ENSP00000261769 |
Chemistry databases
ChEMBLi | CHEMBL2321609 |
PTM databases
GlyGeni | P12830, 13 sites |
iPTMneti | P12830 |
PhosphoSitePlusi | P12830 |
Genetic variation databases
BioMutai | CDH1 |
DMDMi | 399166 |
Proteomic databases
CPTACi | CPTAC-1599 |
EPDi | P12830 |
jPOSTi | P12830 |
MassIVEi | P12830 |
MaxQBi | P12830 |
PaxDbi | P12830 |
PeptideAtlasi | P12830 |
PRIDEi | P12830 |
ProteomicsDBi | 52879 [P12830-1] 84533 |
TopDownProteomicsi | P12830-2 [P12830-2] |
Protocols and materials databases
Antibodypediai | 1347, 2964 antibodies |
CPTCi | P12830, 5 antibodies |
Genome annotation databases
Ensembli | ENST00000261769; ENSP00000261769; ENSG00000039068 [P12830-1] ENST00000422392; ENSP00000414946; ENSG00000039068 [P12830-2] |
GeneIDi | 999 |
KEGGi | hsa:999 |
UCSCi | uc002ewg.2, human [P12830-1] |
Organism-specific databases
CTDi | 999 |
DisGeNETi | 999 |
GeneCardsi | CDH1 |
GeneReviewsi | CDH1 |
HGNCi | HGNC:1748, CDH1 |
HPAi | ENSG00000039068, Tissue enhanced (intestine) |
MalaCardsi | CDH1 |
MIMi | 119580, phenotype 137215, phenotype 167000, phenotype 192090, gene 608089, phenotype |
neXtProti | NX_P12830 |
OpenTargetsi | ENSG00000039068 |
Orphaneti | 1997, Blepharo-cheilo-odontic syndrome 199306, Cleft lip/palate 227535, Hereditary breast cancer 26106, Hereditary diffuse gastric cancer |
PharmGKBi | PA26282 |
VEuPathDBi | HostDB:ENSG00000039068.18 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3594, Eukaryota |
GeneTreei | ENSGT00940000157175 |
HOGENOMi | CLU_005284_2_1_1 |
InParanoidi | P12830 |
OrthoDBi | 182239at2759 |
PhylomeDBi | P12830 |
TreeFami | TF316817 |
Enzyme and pathway databases
PathwayCommonsi | P12830 |
Reactomei | R-HSA-1474228, Degradation of the extracellular matrix R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-216083, Integrin cell surface interactions R-HSA-351906, Apoptotic cleavage of cell adhesion proteins R-HSA-418990, Adherens junctions interactions R-HSA-5626467, RHO GTPases activate IQGAPs R-HSA-8876493, InlA-mediated entry of Listeria monocytogenes into host cells |
SIGNORi | P12830 |
Miscellaneous databases
BioGRID-ORCSi | 999, 38 hits in 993 CRISPR screens |
ChiTaRSi | CDH1, human |
EvolutionaryTracei | P12830 |
GeneWikii | CDH1_(gene) |
GenomeRNAii | 999 |
Pharosi | P12830, Tbio |
PROi | PR:P12830 |
RNActi | P12830, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000039068, Expressed in jejunal mucosa and 195 other tissues |
ExpressionAtlasi | P12830, baseline and differential |
Genevisiblei | P12830, HS |
Family and domain databases
Gene3Di | 4.10.900.10, 1 hit |
InterProi | View protein in InterPro IPR039808, Cadherin IPR002126, Cadherin-like_dom IPR015919, Cadherin-like_sf IPR020894, Cadherin_CS IPR000233, Cadherin_cytoplasmic-dom IPR014868, Cadherin_pro_dom IPR027397, Catenin-bd_sf IPR030049, CDH1 |
PANTHERi | PTHR24027, PTHR24027, 1 hit PTHR24027:SF319, PTHR24027:SF319, 1 hit |
Pfami | View protein in Pfam PF00028, Cadherin, 5 hits PF01049, Cadherin_C, 1 hit PF08758, Cadherin_pro, 1 hit |
PRINTSi | PR00205, CADHERIN |
SMARTi | View protein in SMART SM00112, CA, 4 hits SM01055, Cadherin_pro, 1 hit |
SUPFAMi | SSF49313, SSF49313, 6 hits |
PROSITEi | View protein in PROSITE PS00232, CADHERIN_1, 3 hits PS50268, CADHERIN_2, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CADH1_HUMAN | |
Accessioni | P12830Primary (citable) accession number: P12830 Secondary accession number(s): A8K1U7 Q9UII8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | July 1, 1993 | |
Last modified: | April 7, 2021 | |
This is version 249 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references