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Protein

Myosin light chain 4

Gene

MYL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory light chain of myosin. Does not bind calcium.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin filament binding Source: BHF-UCL
  • actin monomer binding Source: BHF-UCL
  • calcium ion binding Source: InterPro
  • myosin II heavy chain binding Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein, Muscle protein, Myosin

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-390522 Striated Muscle Contraction

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P12829

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myosin light chain 4
Alternative name(s):
Myosin light chain 1, embryonic muscle/atrial isoform
Myosin light chain alkali GT-1 isoform
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYL4
Synonyms:MLC1
ORF Names:PRO1957
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000198336.9

Human Gene Nomenclature Database

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HGNCi
HGNC:7585 MYL4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
160770 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P12829

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Atrial fibrillation, familial, 18 (ATFB18)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.
See also OMIM:617280
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07795911E → K in ATFB18. 1 PublicationCorresponds to variant dbSNP:rs886037778EnsemblClinVar.1

Keywords - Diseasei

Atrial fibrillation, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
4635

MalaCards human disease database

More...
MalaCardsi
MYL4
MIMi617280 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000198336

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
334 Familial atrial fibrillation

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31382

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3831286

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MYL4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
127138

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001986992 – 197Myosin light chain 4Add BLAST196

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N,N,N-trimethylalanineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P12829

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P12829

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P12829

PeptideAtlas

More...
PeptideAtlasi
P12829

PRoteomics IDEntifications database

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PRIDEi
P12829

ProteomicsDB human proteome resource

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ProteomicsDBi
52878

2D gel databases

University College Dublin 2-DE Proteome Database

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UCD-2DPAGEi
P12829

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P12829

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P12829

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000198336 Expressed in 139 organ(s), highest expression level in right atrium auricular region

CleanEx database of gene expression profiles

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CleanExi
HS_MLC1
HS_MYL4

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P12829 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P12829 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA046859
HPA051884
HPA063034

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110719, 5 interactors

Protein interaction database and analysis system

More...
IntActi
P12829, 4 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000347055

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P12829

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P12829

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 88EF-hand 1PROSITE-ProRule annotationAdd BLAST38
Domaini130 – 165EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0030 Eukaryota
COG5126 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153812

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000233018

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG012180

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P12829

KEGG Orthology (KO)

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KOi
K12750

Identification of Orthologs from Complete Genome Data

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OMAi
GHINYTE

Database of Orthologous Groups

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OrthoDBi
EOG091G0TQL

Database for complete collections of gene phylogenies

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PhylomeDBi
P12829

TreeFam database of animal gene trees

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TreeFami
TF351553

Family and domain databases

Conserved Domains Database

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CDDi
cd00051 EFh, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47473 SSF47473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222 EF_HAND_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P12829-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPKKPEPKK EAAKPAPAPA PAPAPAPAPA PEAPKEPAFD PKSVKIDFTA
60 70 80 90 100
DQIEEFKEAF SLFDRTPTGE MKITYGQCGD VLRALGQNPT NAEVLRVLGK
110 120 130 140 150
PKPEEMNVKM LDFETFLPIL QHISRNKEQG TYEDFVEGLR VFDKESNGTV
160 170 180 190
MGAELRHVLA TLGEKMTEAE VEQLLAGQED ANGCINYEAF VKHIMSG
Length:197
Mass (Da):21,565
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFB147B49E8506E6C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L4B1I3L4B1_HUMAN
Myosin light chain 4
MYL4
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1K6I3L1K6_HUMAN
Myosin light chain 4
MYL4
172Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1C7CYY4A0A1C7CYY4_HUMAN
Myosin light chain 4
MYL4
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3U1I3L3U1_HUMAN
Myosin light chain 4
MYL4
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L532I3L532_HUMAN
Myosin light chain 4
MYL4
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1R3I3L1R3_HUMAN
Myosin light chain 4
MYL4
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti51D → E in AAA59891 (PubMed:3417683).Curated1
Sequence conflicti56F → L in AAA59891 (PubMed:3417683).Curated1
Sequence conflicti119I → V in AAA59856 (PubMed:2458299).Curated1
Sequence conflicti143D → E in AAA59891 (PubMed:3417683).Curated1
Sequence conflicti150V → D in AAA59891 (PubMed:3417683).Curated1
Sequence conflicti181A → V in AAA59856 (PubMed:2458299).Curated1
Sequence conflicti185I → V in AAA59856 (PubMed:2458299).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07795911E → K in ATFB18. 1 PublicationCorresponds to variant dbSNP:rs886037778EnsemblClinVar.1
Natural variantiVAR_050458186N → Y. Corresponds to variant dbSNP:rs16941677EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M36172 mRNA Translation: AAA36319.1
X13955 mRNA Translation: CAA32137.1
M24121 mRNA Translation: AAA59891.1
M37074
, M37069, M37070, M37071, M37072, M37073 Genomic DNA Translation: AAA59858.1
X58851
, X58852, X58853, X58854 Genomic DNA Translation: CAA41655.1
AF116676 mRNA Translation: AAF71096.1
CH471231 Genomic DNA Translation: EAW57684.1
CH471231 Genomic DNA Translation: EAW57685.1
BC030228 mRNA Translation: AAH30228.1
M20641 mRNA Translation: AAA59856.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11510.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A32730 MOHU4E

NCBI Reference Sequences

More...
RefSeqi
NP_001002841.1, NM_001002841.1
NP_002467.1, NM_002476.2
XP_005257448.1, XM_005257391.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.463300

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000354968; ENSP00000347055; ENSG00000198336
ENST00000393450; ENSP00000377096; ENSG00000198336
ENST00000572316; ENSP00000461570; ENSG00000198336

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4635

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4635

UCSC genome browser

More...
UCSCi
uc002ilg.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36172 mRNA Translation: AAA36319.1
X13955 mRNA Translation: CAA32137.1
M24121 mRNA Translation: AAA59891.1
M37074
, M37069, M37070, M37071, M37072, M37073 Genomic DNA Translation: AAA59858.1
X58851
, X58852, X58853, X58854 Genomic DNA Translation: CAA41655.1
AF116676 mRNA Translation: AAF71096.1
CH471231 Genomic DNA Translation: EAW57684.1
CH471231 Genomic DNA Translation: EAW57685.1
BC030228 mRNA Translation: AAH30228.1
M20641 mRNA Translation: AAA59856.1
CCDSiCCDS11510.1
PIRiA32730 MOHU4E
RefSeqiNP_001002841.1, NM_001002841.1
NP_002467.1, NM_002476.2
XP_005257448.1, XM_005257391.4
UniGeneiHs.463300

3D structure databases

ProteinModelPortaliP12829
SMRiP12829
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110719, 5 interactors
IntActiP12829, 4 interactors
STRINGi9606.ENSP00000347055

Chemistry databases

ChEMBLiCHEMBL3831286

PTM databases

iPTMnetiP12829
PhosphoSitePlusiP12829

Polymorphism and mutation databases

BioMutaiMYL4
DMDMi127138

2D gel databases

UCD-2DPAGEiP12829

Proteomic databases

EPDiP12829
MaxQBiP12829
PaxDbiP12829
PeptideAtlasiP12829
PRIDEiP12829
ProteomicsDBi52878

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4635
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354968; ENSP00000347055; ENSG00000198336
ENST00000393450; ENSP00000377096; ENSG00000198336
ENST00000572316; ENSP00000461570; ENSG00000198336
GeneIDi4635
KEGGihsa:4635
UCSCiuc002ilg.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4635
DisGeNETi4635
EuPathDBiHostDB:ENSG00000198336.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MYL4
HGNCiHGNC:7585 MYL4
HPAiHPA046859
HPA051884
HPA063034
MalaCardsiMYL4
MIMi160770 gene
617280 phenotype
neXtProtiNX_P12829
OpenTargetsiENSG00000198336
Orphaneti334 Familial atrial fibrillation
PharmGKBiPA31382

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0030 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00940000153812
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiP12829
KOiK12750
OMAiGHINYTE
OrthoDBiEOG091G0TQL
PhylomeDBiP12829
TreeFamiTF351553

Enzyme and pathway databases

ReactomeiR-HSA-390522 Striated Muscle Contraction
SIGNORiP12829

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MYL4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4635

Protein Ontology

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PROi
PR:P12829

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000198336 Expressed in 139 organ(s), highest expression level in right atrium auricular region
CleanExiHS_MLC1
HS_MYL4
ExpressionAtlasiP12829 baseline and differential
GenevisibleiP12829 HS

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYL4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P12829
Secondary accession number(s): D3DXJ7, P11783
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 174 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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