UniProtKB - P12821 (ACE_HUMAN)
Angiotensin-converting enzyme
ACE
Functioni
Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.
Miscellaneous
Catalytic activityi
- Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II. EC:3.4.15.1
Cofactori
Protein has several cofactor binding sites:Activity regulationi
Kineticsi
- KM=2.51 mM for Hip-His-Leu2 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 231 | Chloride 1 | 1 | |
Metal bindingi | 390 | Zinc 1; catalytic1 Publication | 1 | |
Active sitei | 391 | 1 | 1 | |
Metal bindingi | 394 | Zinc 1; catalytic1 Publication | 1 | |
Metal bindingi | 418 | Zinc 1; catalytic1 Publication | 1 | |
Binding sitei | 529 | Chloride 1 | 1 | |
Binding sitei | 791 | Chloride 2 | 1 | |
Binding sitei | 829 | Chloride 3 | 1 | |
Metal bindingi | 988 | Zinc 2; catalytic1 Publication | 1 | |
Active sitei | 989 | 2 | 1 | |
Metal bindingi | 992 | Zinc 2; catalytic1 Publication | 1 | |
Metal bindingi | 1016 | Zinc 2; catalytic1 Publication | 1 | |
Binding sitei | 1090 | Chloride 2 | 1 | |
Binding sitei | 1094 | Chloride 2 | 1 | |
Binding sitei | 1127 | Chloride 3 | 1 |
GO - Molecular functioni
- actin binding Source: UniProtKB
- bradykinin receptor binding Source: BHF-UCL
- carboxypeptidase activity Source: UniProtKB-KW
- chloride ion binding Source: BHF-UCL
- endopeptidase activity Source: UniProtKB
- exopeptidase activity Source: BHF-UCL
- heterocyclic compound binding Source: Ensembl
- metallodipeptidase activity Source: Reactome
- metallopeptidase activity Source: UniProtKB
- mitogen-activated protein kinase binding Source: BHF-UCL
- mitogen-activated protein kinase kinase binding Source: BHF-UCL
- peptidyl-dipeptidase activity Source: UniProtKB
- tripeptidyl-peptidase activity Source: BHF-UCL
- zinc ion binding Source: BHF-UCL
GO - Biological processi
- aging Source: Ensembl
- amyloid-beta metabolic process Source: BHF-UCL
- angiogenesis involved in coronary vascular morphogenesis Source: Ensembl
- angiotensin maturation Source: Reactome
- animal organ regeneration Source: Ensembl
- antigen processing and presentation of peptide antigen via MHC class I Source: BHF-UCL
- arachidonic acid secretion Source: BHF-UCL
- blood vessel diameter maintenance Source: BHF-UCL
- blood vessel remodeling Source: BHF-UCL
- bradykinin catabolic process Source: Ensembl
- brain development Source: Ensembl
- cell proliferation in bone marrow Source: BHF-UCL
- cellular response to aldosterone Source: Ensembl
- cellular response to glucose stimulus Source: Ensembl
- eating behavior Source: Ensembl
- embryo development ending in birth or egg hatching Source: Ensembl
- female pregnancy Source: Ensembl
- heart contraction Source: BHF-UCL
- hematopoietic stem cell differentiation Source: BHF-UCL
- hormone catabolic process Source: BHF-UCL
- kidney development Source: BHF-UCL
- lung alveolus development Source: Ensembl
- male gonad development Source: Ensembl
- mononuclear cell proliferation Source: BHF-UCL
- negative regulation of calcium ion import Source: Ensembl
- negative regulation of gap junction assembly Source: BHF-UCL
- negative regulation of gene expression Source: Ensembl
- negative regulation of glucose import Source: Ensembl
- negative regulation of protein binding Source: Ensembl
- negative regulation of renal sodium excretion Source: Ensembl
- neutrophil mediated immunity Source: BHF-UCL
- peptide catabolic process Source: BHF-UCL
- positive regulation of apoptotic process Source: Ensembl
- positive regulation of inflammatory response Source: Ensembl
- positive regulation of neurogenesis Source: Ensembl
- positive regulation of peptidyl-cysteine S-nitrosylation Source: BHF-UCL
- positive regulation of peptidyl-tyrosine autophosphorylation Source: BHF-UCL
- positive regulation of protein binding Source: Ensembl
- positive regulation of protein tyrosine kinase activity Source: BHF-UCL
- positive regulation of systemic arterial blood pressure Source: GO_Central
- positive regulation of vasoconstriction Source: Ensembl
- posttranscriptional regulation of gene expression Source: Ensembl
- proteolysis Source: UniProtKB
- regulation of angiotensin metabolic process Source: BHF-UCL
- regulation of blood pressure Source: BHF-UCL
- regulation of hematopoietic stem cell proliferation Source: BHF-UCL
- regulation of renal output by angiotensin Source: BHF-UCL
- regulation of smooth muscle cell migration Source: BHF-UCL
- regulation of systemic arterial blood pressure by renin-angiotensin Source: BHF-UCL
- regulation of vasoconstriction Source: UniProtKB
- response to dexamethasone Source: Ensembl
- response to hypoxia Source: Ensembl
- response to laminar fluid shear stress Source: Ensembl
- response to lipopolysaccharide Source: Ensembl
- response to nutrient levels Source: Ensembl
- response to thyroid hormone Source: Ensembl
- response to xenobiotic stimulus Source: Ensembl
- sensory perception of pain Source: Ensembl
- spermatogenesis Source: BHF-UCL
- vasoconstriction Source: Ensembl
Keywordsi
Molecular function | Carboxypeptidase, Hydrolase, Metalloprotease, Protease |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
BRENDAi | 3.4.15.1, 2681 |
PathwayCommonsi | P12821 |
Reactomei | R-HSA-2022377, Metabolism of Angiotensinogen to Angiotensins |
SABIO-RKi | P12821 |
SignaLinki | P12821 |
SIGNORi | P12821 |
Protein family/group databases
MEROPSi | M02.001 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ACE Synonyms:DCP, DCP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2707, ACE |
MIMi | 106180, gene+phenotype |
neXtProti | NX_P12821 |
VEuPathDBi | HostDB:ENSG00000159640 |
Subcellular locationi
Extracellular region or secreted
Plasma membrane
Cytoplasm and Cytosol
- Cytoplasm By similarity
Note: Detected in both cell membrane and cytoplasm in neurons.By similarity
Endosome
- endosome Source: BHF-UCL
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
Lysosome
- lysosome Source: BHF-UCL
Plasma Membrane
- basal plasma membrane Source: Ensembl
- brush border membrane Source: Ensembl
- external side of plasma membrane Source: BHF-UCL
- plasma membrane Source: BHF-UCL
Other locations
- integral component of membrane Source: UniProtKB-KW
- sperm midpiece Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 30 – 1256 | ExtracellularSequence analysisAdd BLAST | 1227 | |
Transmembranei | 1257 – 1277 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1278 – 1306 | CytoplasmicSequence analysisAdd BLAST | 29 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, SecretedPathology & Biotechi
Involvement in diseasei
Ischemic stroke (ISCHSTR)1 Publication
Renal tubular dysgenesis (RTD)1 Publication
Microvascular complications of diabetes 3 (MVCD3)1 Publication
Intracerebral hemorrhage (ICH)1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1299 | S → A: Abolishes phosphorylation and decreases membrane retention. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 1636 |
MalaCardsi | ACE |
MIMi | 106180, gene+phenotype 267430, phenotype 601367, phenotype 612624, phenotype 614519, phenotype |
OpenTargetsi | ENSG00000159640 |
Orphaneti | 34145, NON RARE IN EUROPE: Berger disease 97369, Renal tubular dysgenesis of genetic origin |
PharmGKBi | PA139 |
Miscellaneous databases
Pharosi | P12821, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1808 |
DrugBanki | DB00542, Benazepril DB00616, Candoxatril DB01197, Captopril DB01340, Cilazapril DB15565, Cilazaprilat DB00584, Enalapril DB09477, Enalaprilat DB02032, Epicaptopril DB00492, Fosinopril DB00722, Lisinopril DB00691, Moexipril DB03740, N-acetyl-alpha-D-glucosamine DB00886, Omapatrilat DB00790, Perindopril DB00881, Quinapril DB00178, Ramipril DB01180, Rescinnamine DB01348, Spirapril DB08836, Temocapril DB00519, Trandolapril DB13166, Zofenopril |
DrugCentrali | P12821 |
GuidetoPHARMACOLOGYi | 1613 |
Genetic variation databases
BioMutai | ACE |
DMDMi | 113045 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | 1 PublicationAdd BLAST | 29 | |
ChainiPRO_0000028530 | 30 – 1306 | Angiotensin-converting enzymeAdd BLAST | 1277 | |
ChainiPRO_0000028531 | 30 – 1232 | Angiotensin-converting enzyme, soluble formAdd BLAST | 1203 | |
PropeptideiPRO_0000028532 | 1233 – 1306 | Removed in soluble formAdd BLAST | 74 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 38 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 54 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 74 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 111 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 146 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Disulfide bondi | 157 ↔ 165 | 1 Publication | ||
Glycosylationi | 160 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 318 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 445 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 509 | N-linked (GlcNAc...) asparagine3 Publications | 1 | |
Glycosylationi | 677 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 695 | N-linked (GlcNAc...) (complex) asparagine2 Publications | 1 | |
Glycosylationi | 714 | N-linked (GlcNAc...) (complex) asparagine3 Publications | 1 | |
Disulfide bondi | 757 ↔ 763 | 1 Publication | ||
Glycosylationi | 760 | N-linked (GlcNAc...) asparagine; partial1 Publication | 1 | |
Glycosylationi | 942 | N-linked (GlcNAc...) asparagine; partial1 Publication | 1 | |
Disulfide bondi | 957 ↔ 975 | 1 Publication | ||
Disulfide bondi | 1143 ↔ 1155 | 1 Publication | ||
Glycosylationi | 1191 | N-linked (GlcNAc...) asparagine; partial1 Publication | 1 | |
Modified residuei | 1299 | Phosphoserine1 Publication | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 1225 | Not glycosylated1 Publication | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
CPTACi | CPTAC-2597 |
jPOSTi | P12821 |
MassIVEi | P12821 |
MaxQBi | P12821 |
PaxDbi | P12821 |
PeptideAtlasi | P12821 |
PRIDEi | P12821 |
ProteomicsDBi | 52874 [P12821-1] 52875 [P12821-2] 52876 [P12821-3] 52877 [P12821-4] |
PTM databases
GlyConnecti | 1011, 24 N-Linked glycans (7 sites) |
GlyGeni | P12821, 18 sites, 25 N-linked glycans (7 sites) |
iPTMneti | P12821 |
PhosphoSitePlusi | P12821 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000159640, Expressed in small intestine and 138 other tissues |
ExpressionAtlasi | P12821, baseline and differential |
Genevisiblei | P12821, HS |
Organism-specific databases
HPAi | ENSG00000159640, Tissue enhanced (intestine, testis) |
Interactioni
Binary interactionsi
GO - Molecular functioni
- actin binding Source: UniProtKB
- bradykinin receptor binding Source: BHF-UCL
- mitogen-activated protein kinase binding Source: BHF-UCL
- mitogen-activated protein kinase kinase binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 108004, 14 interactors |
CORUMi | P12821 |
IntActi | P12821, 5 interactors |
MINTi | P12821 |
STRINGi | 9606.ENSP00000290866 |
Chemistry databases
BindingDBi | P12821 |
Miscellaneous databases
RNActi | P12821, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P12821 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P12821 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 30 – 630 | Peptidase M2 1Add BLAST | 601 | |
Regioni | 631 – 1232 | Peptidase M2 2Add BLAST | 602 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3690, Eukaryota |
GeneTreei | ENSGT00940000162051 |
HOGENOMi | CLU_014364_3_0_1 |
InParanoidi | P12821 |
OMAi | PKHLHTI |
OrthoDBi | 238880at2759 |
PhylomeDBi | P12821 |
TreeFami | TF312861 |
Family and domain databases
CDDi | cd06461, M2_ACE, 2 hits |
InterProi | View protein in InterPro IPR001548, Peptidase_M2 |
PANTHERi | PTHR10514, PTHR10514, 2 hits |
Pfami | View protein in Pfam PF01401, Peptidase_M2, 2 hits |
PRINTSi | PR00791, PEPDIPTASEA |
PROSITEi | View protein in PROSITE PS00142, ZINC_PROTEASE, 2 hits |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGAASGRRGP GLLLPLPLLL LLPPQPALAL DPGLQPGNFS ADEAGAQLFA
60 70 80 90 100
QSYNSSAEQV LFQSVAASWA HDTNITAENA RRQEEAALLS QEFAEAWGQK
110 120 130 140 150
AKELYEPIWQ NFTDPQLRRI IGAVRTLGSA NLPLAKRQQY NALLSNMSRI
160 170 180 190 200
YSTAKVCLPN KTATCWSLDP DLTNILASSR SYAMLLFAWE GWHNAAGIPL
210 220 230 240 250
KPLYEDFTAL SNEAYKQDGF TDTGAYWRSW YNSPTFEDDL EHLYQQLEPL
260 270 280 290 300
YLNLHAFVRR ALHRRYGDRY INLRGPIPAH LLGDMWAQSW ENIYDMVVPF
310 320 330 340 350
PDKPNLDVTS TMLQQGWNAT HMFRVAEEFF TSLELSPMPP EFWEGSMLEK
360 370 380 390 400
PADGREVVCH ASAWDFYNRK DFRIKQCTRV TMDQLSTVHH EMGHIQYYLQ
410 420 430 440 450
YKDLPVSLRR GANPGFHEAI GDVLALSVST PEHLHKIGLL DRVTNDTESD
460 470 480 490 500
INYLLKMALE KIAFLPFGYL VDQWRWGVFS GRTPPSRYNF DWWYLRTKYQ
510 520 530 540 550
GICPPVTRNE THFDAGAKFH VPNVTPYIRY FVSFVLQFQF HEALCKEAGY
560 570 580 590 600
EGPLHQCDIY RSTKAGAKLR KVLQAGSSRP WQEVLKDMVG LDALDAQPLL
610 620 630 640 650
KYFQPVTQWL QEQNQQNGEV LGWPEYQWHP PLPDNYPEGI DLVTDEAEAS
660 670 680 690 700
KFVEEYDRTS QVVWNEYAEA NWNYNTNITT ETSKILLQKN MQIANHTLKY
710 720 730 740 750
GTQARKFDVN QLQNTTIKRI IKKVQDLERA ALPAQELEEY NKILLDMETT
760 770 780 790 800
YSVATVCHPN GSCLQLEPDL TNVMATSRKY EDLLWAWEGW RDKAGRAILQ
810 820 830 840 850
FYPKYVELIN QAARLNGYVD AGDSWRSMYE TPSLEQDLER LFQELQPLYL
860 870 880 890 900
NLHAYVRRAL HRHYGAQHIN LEGPIPAHLL GNMWAQTWSN IYDLVVPFPS
910 920 930 940 950
APSMDTTEAM LKQGWTPRRM FKEADDFFTS LGLLPVPPEF WNKSMLEKPT
960 970 980 990 1000
DGREVVCHAS AWDFYNGKDF RIKQCTTVNL EDLVVAHHEM GHIQYFMQYK
1010 1020 1030 1040 1050
DLPVALREGA NPGFHEAIGD VLALSVSTPK HLHSLNLLSS EGGSDEHDIN
1060 1070 1080 1090 1100
FLMKMALDKI AFIPFSYLVD QWRWRVFDGS ITKENYNQEW WSLRLKYQGL
1110 1120 1130 1140 1150
CPPVPRTQGD FDPGAKFHIP SSVPYIRYFV SFIIQFQFHE ALCQAAGHTG
1160 1170 1180 1190 1200
PLHKCDIYQS KEAGQRLATA MKLGFSRPWP EAMQLITGQP NMSASAMLSY
1210 1220 1230 1240 1250
FKPLLDWLRT ENELHGEKLG WPQYNWTPNS ARSEGPLPDS GRVSFLGLDL
1260 1270 1280 1290 1300
DAQQARVGQW LLLFLGIALL VATLGLSQRL FSIRHRSLHR HSHGPQFGSE
VELRHS
The sequence of this isoform differs from the canonical sequence as follows:
1137-1145: QFHEALCQA → HPFSQHTAA
1146-1306: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-574: Missing.
575-641: AGSSRPWQEV...LPDNYPEGID → MGQGWATAGL...AHQTSAQSPN
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MSN4 | A0A0A0MSN4_HUMAN | Angiotensin-converting enzyme | ACE | 1,242 | Annotation score: | ||
J3KS28 | J3KS28_HUMAN | Angiotensin-converting enzyme | ACE | 314 | Annotation score: | ||
J3KTB8 | J3KTB8_HUMAN | Angiotensin-converting enzyme | ACE | 282 | Annotation score: | ||
J3KSQ5 | J3KSQ5_HUMAN | Angiotensin-converting enzyme | ACE | 208 | Annotation score: | ||
J3KRH5 | J3KRH5_HUMAN | Angiotensin-converting enzyme | ACE | 145 | Annotation score: | ||
J3KTH9 | J3KTH9_HUMAN | Angiotensin-converting enzyme | ACE | 168 | Annotation score: | ||
J3QLR4 | J3QLR4_HUMAN | Angiotensin-converting enzyme | ACE | 119 | Annotation score: | ||
J3QSC7 | J3QSC7_HUMAN | Angiotensin-converting enzyme | ACE | 36 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 35 | Q → E AA sequence (PubMed:2558109).Curated | 1 | |
Sequence conflicti | 42 | D → R AA sequence (PubMed:2558109).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Natural variantiVAR_029139 | 154 | A → T. Corresponds to variant dbSNP:rs13306087EnsemblClinVar. | 1 | ||
Natural variantiVAR_029140 | 183 | A → T. Corresponds to variant dbSNP:rs12720754EnsemblClinVar. | 1 | ||
Natural variantiVAR_023430 | 244 | Y → C. Corresponds to variant dbSNP:rs3730025EnsemblClinVar. | 1 | ||
Natural variantiVAR_054000 | 260 | R → C. Corresponds to variant dbSNP:rs4302Ensembl. | 1 | ||
Natural variantiVAR_054001 | 260 | R → L. Corresponds to variant dbSNP:rs4303EnsemblClinVar. | 1 | ||
Natural variantiVAR_011707 | 261 | A → S1 PublicationCorresponds to variant dbSNP:rs4303EnsemblClinVar. | 1 | ||
Natural variantiVAR_074173 | 295 | D → N1 PublicationCorresponds to variant dbSNP:rs989500910Ensembl. | 1 | ||
Natural variantiVAR_023431 | 351 | P → L. Corresponds to variant dbSNP:rs2229839EnsemblClinVar. | 1 | ||
Natural variantiVAR_035434 | 354 | G → R1 PublicationCorresponds to variant dbSNP:rs56394458EnsemblClinVar. | 1 | ||
Natural variantiVAR_029141 | 379 | R → Q. Corresponds to variant dbSNP:rs13306085Ensembl. | 1 | ||
Natural variantiVAR_029142 | 524 | V → A. Corresponds to variant dbSNP:rs12720746Ensembl. | 1 | ||
Natural variantiVAR_011708 | 561 | R → W1 PublicationCorresponds to variant dbSNP:rs4314EnsemblClinVar. | 1 | ||
Natural variantiVAR_020053 | 592 | D → G. Corresponds to variant dbSNP:rs12709426EnsemblClinVar. | 1 | ||
Natural variantiVAR_034602 | 828 | M → T. Corresponds to variant dbSNP:rs13306091EnsemblClinVar. | 1 | ||
Natural variantiVAR_023432 | 916 | T → M. Corresponds to variant dbSNP:rs3730043EnsemblClinVar. | 1 | ||
Natural variantiVAR_014189 | 1018 | I → T1 PublicationCorresponds to variant dbSNP:rs4976EnsemblClinVar. | 1 | ||
Natural variantiVAR_014190 | 1051 | F → V1 PublicationCorresponds to variant dbSNP:rs4977Ensembl. | 1 | ||
Natural variantiVAR_023433 | 1187 | T → M. Corresponds to variant dbSNP:rs12709442EnsemblClinVar. | 1 | ||
Natural variantiVAR_023434 | 1228 | P → L No effect on activity; increases secretion; rate of solubilization is 2.5-fold higher than wild-type. 3 PublicationsCorresponds to variant dbSNP:rs121912703EnsemblClinVar. | 1 | ||
Natural variantiVAR_014191 | 1279 | R → Q1 PublicationCorresponds to variant dbSNP:rs4980EnsemblClinVar. | 1 | ||
Natural variantiVAR_011709 | 1286 | R → S2 PublicationsCorresponds to variant dbSNP:rs4364EnsemblClinVar. | 1 | ||
Natural variantiVAR_014192 | 1296 | Q → P1 PublicationCorresponds to variant dbSNP:rs4981Ensembl. | 1 | ||
Isoform Testis-specific (identifier: P12821-3) | |||||
Natural variantiVAR_082898 | 32 | S → PCuratedCorresponds to variant dbSNP:rs4317Ensembl. | 1 | ||
Natural variantiVAR_082899 | 49 | S → GCuratedCorresponds to variant dbSNP:rs4318Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054836 | 1 – 641 | MGAAS…PEGID → MGQGWATAGLPSLLFLLLCY GHPLLVPSQEASQQVTVTHG TSSQATTSSQTTTHQATAHQ TSAQSPN in isoform 4. 1 PublicationAdd BLAST | 641 | |
Alternative sequenceiVSP_035120 | 1 – 574 | Missing in isoform Testis-specific. 2 PublicationsAdd BLAST | 574 | |
Alternative sequenceiVSP_035121 | 575 – 641 | AGSSR…PEGID → MGQGWATAGLPSLLFLLLCY GHPLLVPSQEASQQVTVTHG TSSQATTSSQTTTHQATAHQ TSAQSPN in isoform Testis-specific. 2 PublicationsAdd BLAST | 67 | |
Alternative sequenceiVSP_054837 | 1128 – 1168 | Missing in isoform 4. 1 PublicationAdd BLAST | 41 | |
Alternative sequenceiVSP_029932 | 1137 – 1145 | QFHEALCQA → HPFSQHTAA in isoform Somatic-2. 1 Publication | 9 | |
Alternative sequenceiVSP_029933 | 1146 – 1306 | Missing in isoform Somatic-2. 1 PublicationAdd BLAST | 161 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04144 mRNA Translation: AAA51684.1 M26657 mRNA Translation: AAA60611.1 X16295 mRNA Translation: CAA34362.1 AF118569 Genomic DNA Translation: AAD28560.1 AY436326 Genomic DNA Translation: AAR03504.1 AK301988 mRNA Translation: BAG63395.1 EU332840 Genomic DNA Translation: ABY87529.1 AB208971 mRNA Translation: BAD92208.1 Different initiation. AC113554 Genomic DNA No translation available. |
CCDSi | CCDS11637.1 [P12821-1] CCDS45755.1 [P12821-3] CCDS54155.1 [P12821-4] |
PIRi | A31759 PW0053 S05238 |
RefSeqi | NP_000780.1, NM_000789.3 [P12821-1] NP_001171528.1, NM_001178057.1 [P12821-4] NP_690043.1, NM_152830.2 [P12821-3] |
Genome annotation databases
Ensembli | ENST00000290863; ENSP00000290863; ENSG00000159640 [P12821-3] ENST00000290866; ENSP00000290866; ENSG00000159640 ENST00000413513; ENSP00000392247; ENSG00000159640 [P12821-4] |
GeneIDi | 1636 |
KEGGi | hsa:1636 |
MANE-Selecti | ENST00000290866.10; ENSP00000290866.4; NM_000789.4; NP_000780.1 |
UCSCi | uc002jau.3, human [P12821-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
SHMPD The Singapore human mutation and polymorphism database |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04144 mRNA Translation: AAA51684.1 M26657 mRNA Translation: AAA60611.1 X16295 mRNA Translation: CAA34362.1 AF118569 Genomic DNA Translation: AAD28560.1 AY436326 Genomic DNA Translation: AAR03504.1 AK301988 mRNA Translation: BAG63395.1 EU332840 Genomic DNA Translation: ABY87529.1 AB208971 mRNA Translation: BAD92208.1 Different initiation. AC113554 Genomic DNA No translation available. |
CCDSi | CCDS11637.1 [P12821-1] CCDS45755.1 [P12821-3] CCDS54155.1 [P12821-4] |
PIRi | A31759 PW0053 S05238 |
RefSeqi | NP_000780.1, NM_000789.3 [P12821-1] NP_001171528.1, NM_001178057.1 [P12821-4] NP_690043.1, NM_152830.2 [P12821-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1O86 | X-ray | 2.00 | A | 642-1230 | [»] | |
1O8A | X-ray | 2.00 | A | 642-1230 | [»] | |
1UZE | X-ray | 1.82 | A | 642-1230 | [»] | |
1UZF | X-ray | 2.00 | A | 642-1230 | [»] | |
2C6F | X-ray | 3.01 | A/B | 30-641 | [»] | |
2C6N | X-ray | 3.00 | A/B | 30-641 | [»] | |
2IUL | X-ray | 2.01 | A | 642-1232 | [»] | |
2IUX | X-ray | 2.80 | A | 642-1232 | [»] | |
2OC2 | X-ray | 2.25 | A | 642-1232 | [»] | |
2XY9 | X-ray | 1.97 | A | 645-1228 | [»] | |
2XYD | X-ray | 2.15 | A/B | 30-639 | [»] | |
2YDM | X-ray | 2.44 | A | 642-1230 | [»] | |
3BKK | X-ray | 2.17 | A | 642-1232 | [»] | |
3BKL | X-ray | 2.18 | A | 642-1232 | [»] | |
3L3N | X-ray | 2.30 | A | 642-1232 | [»] | |
3NXQ | X-ray | 1.99 | A/B | 30-658 | [»] | |
4APH | X-ray | 1.99 | A | 642-1230 | [»] | |
4APJ | X-ray | 2.60 | A | 642-1230 | [»] | |
4BXK | X-ray | 2.20 | A/B | 30-657 | [»] | |
4BZR | X-ray | 1.84 | A | 642-1230 | [»] | |
4BZS | X-ray | 2.10 | A/B | 30-657 | [»] | |
4C2N | X-ray | 2.59 | A | 642-1230 | [»] | |
4C2O | X-ray | 1.80 | A | 642-1230 | [»] | |
4C2P | X-ray | 1.99 | A | 642-1230 | [»] | |
4C2Q | X-ray | 2.40 | A | 642-1230 | [»] | |
4C2R | X-ray | 2.30 | A | 642-1230 | [»] | |
4CA5 | X-ray | 1.85 | A | 642-1230 | [»] | |
4CA6 | X-ray | 1.91 | A/B | 30-639 | [»] | |
4UFA | X-ray | 1.80 | A/B | 30-657 | [»] | |
4UFB | X-ray | 1.80 | A/B/C/D | 30-657 | [»] | |
5AM8 | X-ray | 1.90 | A/B/C/D | 30-658 | [»] | |
5AM9 | X-ray | 1.80 | A/B/C/D | 30-658 | [»] | |
5AMA | X-ray | 1.80 | A/B/C/D | 30-658 | [»] | |
5AMB | X-ray | 1.55 | A/B | 30-658 | [»] | |
5AMC | X-ray | 1.65 | A/B | 30-658 | [»] | |
6EN5 | X-ray | 1.75 | A/B/C/D | 30-657 | [»] | |
6EN6 | X-ray | 1.80 | A/B/C/D | 30-657 | [»] | |
6F9R | X-ray | 1.85 | A/B | 30-657 | [»] | |
6F9T | X-ray | 1.60 | A | 642-1232 | [»] | |
6F9U | X-ray | 1.90 | A | 642-1232 | [»] | |
6F9V | X-ray | 1.69 | A/B | 30-657 | [»] | |
6H5W | X-ray | 1.37 | A | 642-1232 | [»] | |
6H5X | X-ray | 1.80 | A/B | 30-657 | [»] | |
6QS1 | X-ray | 1.80 | A/B | 30-657 | [»] | |
6TT1 | X-ray | 1.80 | A/B | 30-657 | [»] | |
6TT3 | X-ray | 1.70 | A/B | 30-657 | [»] | |
6TT4 | X-ray | 1.80 | A/B | 30-657 | [»] | |
6ZPQ | X-ray | 1.85 | A/B/C/D | 30-657 | [»] | |
6ZPT | X-ray | 2.80 | A/B/C/D | 30-657 | [»] | |
6ZPU | X-ray | 2.00 | A | 642-1238 | [»] | |
SMRi | P12821 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108004, 14 interactors |
CORUMi | P12821 |
IntActi | P12821, 5 interactors |
MINTi | P12821 |
STRINGi | 9606.ENSP00000290866 |
Chemistry databases
BindingDBi | P12821 |
ChEMBLi | CHEMBL1808 |
DrugBanki | DB00542, Benazepril DB00616, Candoxatril DB01197, Captopril DB01340, Cilazapril DB15565, Cilazaprilat DB00584, Enalapril DB09477, Enalaprilat DB02032, Epicaptopril DB00492, Fosinopril DB00722, Lisinopril DB00691, Moexipril DB03740, N-acetyl-alpha-D-glucosamine DB00886, Omapatrilat DB00790, Perindopril DB00881, Quinapril DB00178, Ramipril DB01180, Rescinnamine DB01348, Spirapril DB08836, Temocapril DB00519, Trandolapril DB13166, Zofenopril |
DrugCentrali | P12821 |
GuidetoPHARMACOLOGYi | 1613 |
Protein family/group databases
MEROPSi | M02.001 |
PTM databases
GlyConnecti | 1011, 24 N-Linked glycans (7 sites) |
GlyGeni | P12821, 18 sites, 25 N-linked glycans (7 sites) |
iPTMneti | P12821 |
PhosphoSitePlusi | P12821 |
Genetic variation databases
BioMutai | ACE |
DMDMi | 113045 |
Proteomic databases
CPTACi | CPTAC-2597 |
jPOSTi | P12821 |
MassIVEi | P12821 |
MaxQBi | P12821 |
PaxDbi | P12821 |
PeptideAtlasi | P12821 |
PRIDEi | P12821 |
ProteomicsDBi | 52874 [P12821-1] 52875 [P12821-2] 52876 [P12821-3] 52877 [P12821-4] |
Protocols and materials databases
ABCDi | P12821, 1 sequenced antibody |
Antibodypediai | 31288, 867 antibodies from 42 providers |
DNASUi | 1636 |
Genome annotation databases
Ensembli | ENST00000290863; ENSP00000290863; ENSG00000159640 [P12821-3] ENST00000290866; ENSP00000290866; ENSG00000159640 ENST00000413513; ENSP00000392247; ENSG00000159640 [P12821-4] |
GeneIDi | 1636 |
KEGGi | hsa:1636 |
MANE-Selecti | ENST00000290866.10; ENSP00000290866.4; NM_000789.4; NP_000780.1 |
UCSCi | uc002jau.3, human [P12821-1] |
Organism-specific databases
CTDi | 1636 |
DisGeNETi | 1636 |
GeneCardsi | ACE |
HGNCi | HGNC:2707, ACE |
HPAi | ENSG00000159640, Tissue enhanced (intestine, testis) |
MalaCardsi | ACE |
MIMi | 106180, gene+phenotype 267430, phenotype 601367, phenotype 612624, phenotype 614519, phenotype |
neXtProti | NX_P12821 |
OpenTargetsi | ENSG00000159640 |
Orphaneti | 34145, NON RARE IN EUROPE: Berger disease 97369, Renal tubular dysgenesis of genetic origin |
PharmGKBi | PA139 |
VEuPathDBi | HostDB:ENSG00000159640 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3690, Eukaryota |
GeneTreei | ENSGT00940000162051 |
HOGENOMi | CLU_014364_3_0_1 |
InParanoidi | P12821 |
OMAi | PKHLHTI |
OrthoDBi | 238880at2759 |
PhylomeDBi | P12821 |
TreeFami | TF312861 |
Enzyme and pathway databases
BRENDAi | 3.4.15.1, 2681 |
PathwayCommonsi | P12821 |
Reactomei | R-HSA-2022377, Metabolism of Angiotensinogen to Angiotensins |
SABIO-RKi | P12821 |
SignaLinki | P12821 |
SIGNORi | P12821 |
Miscellaneous databases
BioGRID-ORCSi | 1636, 7 hits in 1036 CRISPR screens |
ChiTaRSi | ACE, human |
EvolutionaryTracei | P12821 |
GeneWikii | Angiotensin-converting_enzyme |
GenomeRNAii | 1636 |
Pharosi | P12821, Tclin |
PROi | PR:P12821 |
RNActi | P12821, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000159640, Expressed in small intestine and 138 other tissues |
ExpressionAtlasi | P12821, baseline and differential |
Genevisiblei | P12821, HS |
Family and domain databases
CDDi | cd06461, M2_ACE, 2 hits |
InterProi | View protein in InterPro IPR001548, Peptidase_M2 |
PANTHERi | PTHR10514, PTHR10514, 2 hits |
Pfami | View protein in Pfam PF01401, Peptidase_M2, 2 hits |
PRINTSi | PR00791, PEPDIPTASEA |
PROSITEi | View protein in PROSITE PS00142, ZINC_PROTEASE, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ACE_HUMAN | |
Accessioni | P12821Primary (citable) accession number: P12821 Secondary accession number(s): B0LPF0 Q7M4L4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | October 1, 1989 | |
Last modified: | February 23, 2022 | |
This is version 250 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Peptidase families
Classification of peptidase families and list of entries - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families