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Entry version 251 (25 May 2022)
Sequence version 1 (01 Oct 1989)
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Protein

Angiotensin-converting enzyme

Gene

ACE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.

Miscellaneous

Inhibitors of ACE are commonly used to treat hypertension and some types of renal and cardiac dysfunction.
The glycosidase activity probably uses different active site residues than the metalloprotease activity.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II. EC:3.4.15.1

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:
Isoform Testis-specific:
Zn2+Note: Isoform Testis-specific only binds 1 Zn2+ ion per subunit.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Strongly activated by chloride. Specifically inhibited by lisinopril, captopril and enalaprilat.

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=2.51 mM for Hip-His-Leu2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei231Chloride 11
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi390Zinc 1; catalytic1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei39111
Metal bindingi394Zinc 1; catalytic1 Publication1
Metal bindingi418Zinc 1; catalytic1 Publication1
Binding sitei529Chloride 11
Binding sitei791Chloride 21
Binding sitei829Chloride 31
Metal bindingi988Zinc 2; catalytic1 Publication1
Active sitei98921
Metal bindingi992Zinc 2; catalytic1 Publication1
Metal bindingi1016Zinc 2; catalytic1 Publication1
Binding sitei1090Chloride 21
Binding sitei1094Chloride 21
Binding sitei1127Chloride 31

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.15.1, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P12821

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2022377, Metabolism of Angiotensinogen to Angiotensins

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P12821

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P12821

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P12821

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M02.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Angiotensin-converting enzyme (EC:3.2.1.-, EC:3.4.15.1)
Short name:
ACE
Alternative name(s):
Dipeptidyl carboxypeptidase I
Kininase II
CD_antigen: CD143
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACE
Synonyms:DCP, DCP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2707, ACE

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
106180, gene+phenotype

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P12821

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000159640

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini30 – 1256ExtracellularSequence analysisAdd BLAST1227
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1257 – 1277HelicalSequence analysisAdd BLAST21
Topological domaini1278 – 1306CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ischemic stroke (ISCHSTR)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionA stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
Related information in OMIM
Renal tubular dysgenesis (RTD)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAutosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
Related information in OMIM
Microvascular complications of diabetes 3 (MVCD3)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionPathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
Related information in OMIM
Intracerebral hemorrhage (ICH)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionA pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1299S → A: Abolishes phosphorylation and decreases membrane retention. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
1636

MalaCards human disease database

More...
MalaCardsi
ACE
MIMi106180, gene+phenotype
267430, phenotype
601367, phenotype
612624, phenotype
614519, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000159640

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
34145, NON RARE IN EUROPE: Berger disease
97369, Renal tubular dysgenesis of genetic origin

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA139

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P12821, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1808

Drug and drug target database

More...
DrugBanki
DB00542, Benazepril
DB00616, Candoxatril
DB01197, Captopril
DB01340, Cilazapril
DB15565, Cilazaprilat
DB00584, Enalapril
DB09477, Enalaprilat
DB02032, Epicaptopril
DB00492, Fosinopril
DB00722, Lisinopril
DB00691, Moexipril
DB03740, N-acetyl-alpha-D-glucosamine
DB00886, Omapatrilat
DB00790, Perindopril
DB00881, Quinapril
DB00178, Ramipril
DB01180, Rescinnamine
DB01348, Spirapril
DB08836, Temocapril
DB00519, Trandolapril
DB13166, Zofenopril

DrugCentral

More...
DrugCentrali
P12821

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1613

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ACE

Domain mapping of disease mutations (DMDM)

More...
DMDMi
113045

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 291 PublicationAdd BLAST29
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002853030 – 1306Angiotensin-converting enzymeAdd BLAST1277
ChainiPRO_000002853130 – 1232Angiotensin-converting enzyme, soluble formAdd BLAST1203
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000285321233 – 1306Removed in soluble formAdd BLAST74

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi38N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi54N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi74N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi111N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi146N-linked (GlcNAc...) asparagine2 Publications1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi157 ↔ 1651 Publication
Glycosylationi160N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi318N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi445N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi509N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi677N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi695N-linked (GlcNAc...) (complex) asparagine2 Publications1
Glycosylationi714N-linked (GlcNAc...) (complex) asparagine3 Publications1
Disulfide bondi757 ↔ 7631 Publication
Glycosylationi760N-linked (GlcNAc...) asparagine; partial1 Publication1
Glycosylationi942N-linked (GlcNAc...) asparagine; partial1 Publication1
Disulfide bondi957 ↔ 9751 Publication
Disulfide bondi1143 ↔ 11551 Publication
Glycosylationi1191N-linked (GlcNAc...) asparagine; partial1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1299Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by CK2 on Ser-1299; which allows membrane retention.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1225Not glycosylated1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-2597

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P12821

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P12821

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P12821

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P12821

PeptideAtlas

More...
PeptideAtlasi
P12821

PRoteomics IDEntifications database

More...
PRIDEi
P12821

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
52874 [P12821-1]
52875 [P12821-2]
52876 [P12821-3]
52877 [P12821-4]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1011, 24 N-Linked glycans (7 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P12821, 18 sites, 25 N-linked glycans (7 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P12821

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P12821

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. Isoform Testis-specific is expressed in spermatocytes and adult testis.4 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in failing heart.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000159640, Expressed in small intestine and 138 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P12821, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P12821, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000159640, Tissue enhanced (intestine, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
108004, 15 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P12821

Protein interaction database and analysis system

More...
IntActi
P12821, 5 interactors

Molecular INTeraction database

More...
MINTi
P12821

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000290866

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P12821

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P12821, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11306
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
P12821

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P12821

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P12821

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni30 – 630Peptidase M2 1Add BLAST601
Regioni631 – 1232Peptidase M2 2Add BLAST602

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M2 family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3690, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162051

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014364_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P12821

Identification of Orthologs from Complete Genome Data

More...
OMAi
WEGWHNV

Database of Orthologous Groups

More...
OrthoDBi
238880at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P12821

TreeFam database of animal gene trees

More...
TreeFami
TF312861

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06461, M2_ACE, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001548, Peptidase_M2

The PANTHER Classification System

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PANTHERi
PTHR10514, PTHR10514, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01401, Peptidase_M2, 2 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00791, PEPDIPTASEA

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00142, ZINC_PROTEASE, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform Somatic-1 (identifier: P12821-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGAASGRRGP GLLLPLPLLL LLPPQPALAL DPGLQPGNFS ADEAGAQLFA
60 70 80 90 100
QSYNSSAEQV LFQSVAASWA HDTNITAENA RRQEEAALLS QEFAEAWGQK
110 120 130 140 150
AKELYEPIWQ NFTDPQLRRI IGAVRTLGSA NLPLAKRQQY NALLSNMSRI
160 170 180 190 200
YSTAKVCLPN KTATCWSLDP DLTNILASSR SYAMLLFAWE GWHNAAGIPL
210 220 230 240 250
KPLYEDFTAL SNEAYKQDGF TDTGAYWRSW YNSPTFEDDL EHLYQQLEPL
260 270 280 290 300
YLNLHAFVRR ALHRRYGDRY INLRGPIPAH LLGDMWAQSW ENIYDMVVPF
310 320 330 340 350
PDKPNLDVTS TMLQQGWNAT HMFRVAEEFF TSLELSPMPP EFWEGSMLEK
360 370 380 390 400
PADGREVVCH ASAWDFYNRK DFRIKQCTRV TMDQLSTVHH EMGHIQYYLQ
410 420 430 440 450
YKDLPVSLRR GANPGFHEAI GDVLALSVST PEHLHKIGLL DRVTNDTESD
460 470 480 490 500
INYLLKMALE KIAFLPFGYL VDQWRWGVFS GRTPPSRYNF DWWYLRTKYQ
510 520 530 540 550
GICPPVTRNE THFDAGAKFH VPNVTPYIRY FVSFVLQFQF HEALCKEAGY
560 570 580 590 600
EGPLHQCDIY RSTKAGAKLR KVLQAGSSRP WQEVLKDMVG LDALDAQPLL
610 620 630 640 650
KYFQPVTQWL QEQNQQNGEV LGWPEYQWHP PLPDNYPEGI DLVTDEAEAS
660 670 680 690 700
KFVEEYDRTS QVVWNEYAEA NWNYNTNITT ETSKILLQKN MQIANHTLKY
710 720 730 740 750
GTQARKFDVN QLQNTTIKRI IKKVQDLERA ALPAQELEEY NKILLDMETT
760 770 780 790 800
YSVATVCHPN GSCLQLEPDL TNVMATSRKY EDLLWAWEGW RDKAGRAILQ
810 820 830 840 850
FYPKYVELIN QAARLNGYVD AGDSWRSMYE TPSLEQDLER LFQELQPLYL
860 870 880 890 900
NLHAYVRRAL HRHYGAQHIN LEGPIPAHLL GNMWAQTWSN IYDLVVPFPS
910 920 930 940 950
APSMDTTEAM LKQGWTPRRM FKEADDFFTS LGLLPVPPEF WNKSMLEKPT
960 970 980 990 1000
DGREVVCHAS AWDFYNGKDF RIKQCTTVNL EDLVVAHHEM GHIQYFMQYK
1010 1020 1030 1040 1050
DLPVALREGA NPGFHEAIGD VLALSVSTPK HLHSLNLLSS EGGSDEHDIN
1060 1070 1080 1090 1100
FLMKMALDKI AFIPFSYLVD QWRWRVFDGS ITKENYNQEW WSLRLKYQGL
1110 1120 1130 1140 1150
CPPVPRTQGD FDPGAKFHIP SSVPYIRYFV SFIIQFQFHE ALCQAAGHTG
1160 1170 1180 1190 1200
PLHKCDIYQS KEAGQRLATA MKLGFSRPWP EAMQLITGQP NMSASAMLSY
1210 1220 1230 1240 1250
FKPLLDWLRT ENELHGEKLG WPQYNWTPNS ARSEGPLPDS GRVSFLGLDL
1260 1270 1280 1290 1300
DAQQARVGQW LLLFLGIALL VATLGLSQRL FSIRHRSLHR HSHGPQFGSE

VELRHS
Length:1,306
Mass (Da):149,715
Last modified:October 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1B33BCA7301A26AA
GO
Isoform Somatic-2 (identifier: P12821-2) [UniParc]FASTAAdd to basket
Also known as: Soluble

The sequence of this isoform differs from the canonical sequence as follows:
     1137-1145: QFHEALCQA → HPFSQHTAA
     1146-1306: Missing.

Note: Incomplete sequence.Curated
Show »
Length:1,145
Mass (Da):131,659
Checksum:iB7EED12CAB675583
GO
Isoform Testis-specific (identifier: P12821-3) [UniParc] [UniParc]FASTAAdd to basket
Also known as: ACE-T

The sequence of this isoform differs from the canonical sequence as follows:
     1-574: Missing.
     575-641: AGSSRPWQEV...LPDNYPEGID → MGQGWATAGL...AHQTSAQSPN

Show »
Length:732
Mass (Da):83,330
Checksum:i80E0D19CFA642313
GO
Isoform 4 (identifier: P12821-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-641: MGAASGRRGP...LPDNYPEGID → MGQGWATAGL...AHQTSAQSPN
     1128-1168: Missing.

Show »
Length:691
Mass (Da):78,694
Checksum:iF31FE078F52FF0B2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSN4A0A0A0MSN4_HUMAN
Angiotensin-converting enzyme
ACE
1,242Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KS28J3KS28_HUMAN
Angiotensin-converting enzyme
ACE
314Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KTB8J3KTB8_HUMAN
Angiotensin-converting enzyme
ACE
282Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSQ5J3KSQ5_HUMAN
Angiotensin-converting enzyme
ACE
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRH5J3KRH5_HUMAN
Angiotensin-converting enzyme
ACE
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KTH9J3KTH9_HUMAN
Angiotensin-converting enzyme
ACE
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLR4J3QLR4_HUMAN
Angiotensin-converting enzyme
ACE
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QSC7J3QSC7_HUMAN
Angiotensin-converting enzyme
ACE
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92208 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti35Q → E AA sequence (PubMed:2558109).Curated1
Sequence conflicti42D → R AA sequence (PubMed:2558109).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_029139154A → T. Corresponds to variant dbSNP:rs13306087EnsemblClinVar.1
Natural variantiVAR_029140183A → T. Corresponds to variant dbSNP:rs12720754EnsemblClinVar.1
Natural variantiVAR_023430244Y → C. Corresponds to variant dbSNP:rs3730025EnsemblClinVar.1
Natural variantiVAR_054000260R → C. Corresponds to variant dbSNP:rs4302Ensembl.1
Natural variantiVAR_054001260R → L. Corresponds to variant dbSNP:rs4303EnsemblClinVar.1
Natural variantiVAR_011707261A → S1 PublicationCorresponds to variant dbSNP:rs4303EnsemblClinVar.1
Natural variantiVAR_074173295D → N1 PublicationCorresponds to variant dbSNP:rs989500910Ensembl.1
Natural variantiVAR_023431351P → L. Corresponds to variant dbSNP:rs2229839EnsemblClinVar.1
Natural variantiVAR_035434354G → R1 PublicationCorresponds to variant dbSNP:rs56394458EnsemblClinVar.1
Natural variantiVAR_029141379R → Q. Corresponds to variant dbSNP:rs13306085Ensembl.1
Natural variantiVAR_029142524V → A. Corresponds to variant dbSNP:rs12720746Ensembl.1
Natural variantiVAR_011708561R → W1 PublicationCorresponds to variant dbSNP:rs4314EnsemblClinVar.1
Natural variantiVAR_020053592D → G. Corresponds to variant dbSNP:rs12709426EnsemblClinVar.1
Natural variantiVAR_034602828M → T. Corresponds to variant dbSNP:rs13306091EnsemblClinVar.1
Natural variantiVAR_023432916T → M. Corresponds to variant dbSNP:rs3730043EnsemblClinVar.1
Natural variantiVAR_0141891018I → T1 PublicationCorresponds to variant dbSNP:rs4976EnsemblClinVar.1
Natural variantiVAR_0141901051F → V1 PublicationCorresponds to variant dbSNP:rs4977Ensembl.1
Natural variantiVAR_0234331187T → M. Corresponds to variant dbSNP:rs12709442EnsemblClinVar.1
Natural variantiVAR_0234341228P → L No effect on activity; increases secretion; rate of solubilization is 2.5-fold higher than wild-type. 3 PublicationsCorresponds to variant dbSNP:rs121912703EnsemblClinVar.1
Natural variantiVAR_0141911279R → Q1 PublicationCorresponds to variant dbSNP:rs4980EnsemblClinVar.1
Natural variantiVAR_0117091286R → S2 PublicationsCorresponds to variant dbSNP:rs4364EnsemblClinVar.1
Natural variantiVAR_0141921296Q → P1 PublicationCorresponds to variant dbSNP:rs4981Ensembl.1
Isoform Testis-specific (identifier: P12821-3)
Natural variantiVAR_08289832S → PCuratedCorresponds to variant dbSNP:rs4317Ensembl.1
Natural variantiVAR_08289949S → GCuratedCorresponds to variant dbSNP:rs4318Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0548361 – 641MGAAS…PEGID → MGQGWATAGLPSLLFLLLCY GHPLLVPSQEASQQVTVTHG TSSQATTSSQTTTHQATAHQ TSAQSPN in isoform 4. 1 PublicationAdd BLAST641
Alternative sequenceiVSP_0351201 – 574Missing in isoform Testis-specific. 2 PublicationsAdd BLAST574
Alternative sequenceiVSP_035121575 – 641AGSSR…PEGID → MGQGWATAGLPSLLFLLLCY GHPLLVPSQEASQQVTVTHG TSSQATTSSQTTTHQATAHQ TSAQSPN in isoform Testis-specific. 2 PublicationsAdd BLAST67
Alternative sequenceiVSP_0548371128 – 1168Missing in isoform 4. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_0299321137 – 1145QFHEALCQA → HPFSQHTAA in isoform Somatic-2. 1 Publication9
Alternative sequenceiVSP_0299331146 – 1306Missing in isoform Somatic-2. 1 PublicationAdd BLAST161

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J04144 mRNA Translation: AAA51684.1
M26657 mRNA Translation: AAA60611.1
X16295 mRNA Translation: CAA34362.1
AF118569 Genomic DNA Translation: AAD28560.1
AY436326 Genomic DNA Translation: AAR03504.1
AK301988 mRNA Translation: BAG63395.1
EU332840 Genomic DNA Translation: ABY87529.1
AB208971 mRNA Translation: BAD92208.1 Different initiation.
AC113554 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11637.1 [P12821-1]
CCDS45755.1 [P12821-3]
CCDS54155.1 [P12821-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
A31759
PW0053
S05238

NCBI Reference Sequences

More...
RefSeqi
NP_000780.1, NM_000789.3 [P12821-1]
NP_001171528.1, NM_001178057.1 [P12821-4]
NP_690043.1, NM_152830.2 [P12821-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000290863.10; ENSP00000290863.6; ENSG00000159640.17 [P12821-3]
ENST00000290866.10; ENSP00000290866.4; ENSG00000159640.17
ENST00000413513.7; ENSP00000392247.3; ENSG00000159640.17 [P12821-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1636

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1636

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...
MANE-Selecti
ENST00000290866.10; ENSP00000290866.4; NM_000789.4; NP_000780.1

UCSC genome browser

More...
UCSCi
uc002jau.3, human [P12821-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04144 mRNA Translation: AAA51684.1
M26657 mRNA Translation: AAA60611.1
X16295 mRNA Translation: CAA34362.1
AF118569 Genomic DNA Translation: AAD28560.1
AY436326 Genomic DNA Translation: AAR03504.1
AK301988 mRNA Translation: BAG63395.1
EU332840 Genomic DNA Translation: ABY87529.1
AB208971 mRNA Translation: BAD92208.1 Different initiation.
AC113554 Genomic DNA No translation available.
CCDSiCCDS11637.1 [P12821-1]
CCDS45755.1 [P12821-3]
CCDS54155.1 [P12821-4]
PIRiA31759
PW0053
S05238
RefSeqiNP_000780.1, NM_000789.3 [P12821-1]
NP_001171528.1, NM_001178057.1 [P12821-4]
NP_690043.1, NM_152830.2 [P12821-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1O86X-ray2.00A642-1230[»]
1O8AX-ray2.00A642-1230[»]
1UZEX-ray1.82A642-1230[»]
1UZFX-ray2.00A642-1230[»]
2C6FX-ray3.01A/B30-641[»]
2C6NX-ray3.00A/B30-641[»]
2IULX-ray2.01A642-1232[»]
2IUXX-ray2.80A642-1232[»]
2OC2X-ray2.25A642-1232[»]
2XY9X-ray1.97A645-1228[»]
2XYDX-ray2.15A/B30-639[»]
2YDMX-ray2.44A642-1230[»]
3BKKX-ray2.17A642-1232[»]
3BKLX-ray2.18A642-1232[»]
3L3NX-ray2.30A642-1232[»]
3NXQX-ray1.99A/B30-658[»]
4APHX-ray1.99A642-1230[»]
4APJX-ray2.60A642-1230[»]
4BXKX-ray2.20A/B30-657[»]
4BZRX-ray1.84A642-1230[»]
4BZSX-ray2.10A/B30-657[»]
4C2NX-ray2.59A642-1230[»]
4C2OX-ray1.80A642-1230[»]
4C2PX-ray1.99A642-1230[»]
4C2QX-ray2.40A642-1230[»]
4C2RX-ray2.30A642-1230[»]
4CA5X-ray1.85A642-1230[»]
4CA6X-ray1.91A/B30-639[»]
4UFAX-ray1.80A/B30-657[»]
4UFBX-ray1.80A/B/C/D30-657[»]
5AM8X-ray1.90A/B/C/D30-658[»]
5AM9X-ray1.80A/B/C/D30-658[»]
5AMAX-ray1.80A/B/C/D30-658[»]
5AMBX-ray1.55A/B30-658[»]
5AMCX-ray1.65A/B30-658[»]
6EN5X-ray1.75A/B/C/D30-657[»]
6EN6X-ray1.80A/B/C/D30-657[»]
6F9RX-ray1.85A/B30-657[»]
6F9TX-ray1.60A642-1232[»]
6F9UX-ray1.90A642-1232[»]
6F9VX-ray1.69A/B30-657[»]
6H5WX-ray1.37A642-1232[»]
6H5XX-ray1.80A/B30-657[»]
6QS1X-ray1.80A/B30-657[»]
6TT1X-ray1.80A/B30-657[»]
6TT3X-ray1.70A/B30-657[»]
6TT4X-ray1.80A/B30-657[»]
6ZPQX-ray1.85A/B/C/D30-657[»]
6ZPTX-ray2.80A/B/C/D30-657[»]
6ZPUX-ray2.00A642-1238[»]
AlphaFoldDBiP12821
SMRiP12821
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108004, 15 interactors
CORUMiP12821
IntActiP12821, 5 interactors
MINTiP12821
STRINGi9606.ENSP00000290866

Chemistry databases

BindingDBiP12821
ChEMBLiCHEMBL1808
DrugBankiDB00542, Benazepril
DB00616, Candoxatril
DB01197, Captopril
DB01340, Cilazapril
DB15565, Cilazaprilat
DB00584, Enalapril
DB09477, Enalaprilat
DB02032, Epicaptopril
DB00492, Fosinopril
DB00722, Lisinopril
DB00691, Moexipril
DB03740, N-acetyl-alpha-D-glucosamine
DB00886, Omapatrilat
DB00790, Perindopril
DB00881, Quinapril
DB00178, Ramipril
DB01180, Rescinnamine
DB01348, Spirapril
DB08836, Temocapril
DB00519, Trandolapril
DB13166, Zofenopril
DrugCentraliP12821
GuidetoPHARMACOLOGYi1613

Protein family/group databases

MEROPSiM02.001

PTM databases

GlyConnecti1011, 24 N-Linked glycans (7 sites)
GlyGeniP12821, 18 sites, 25 N-linked glycans (7 sites)
iPTMnetiP12821
PhosphoSitePlusiP12821

Genetic variation databases

BioMutaiACE
DMDMi113045

Proteomic databases

CPTACiCPTAC-2597
jPOSTiP12821
MassIVEiP12821
MaxQBiP12821
PaxDbiP12821
PeptideAtlasiP12821
PRIDEiP12821
ProteomicsDBi52874 [P12821-1]
52875 [P12821-2]
52876 [P12821-3]
52877 [P12821-4]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P12821, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

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Antibodypediai
31288, 867 antibodies from 42 providers

The DNASU plasmid repository

More...
DNASUi
1636

Genome annotation databases

EnsembliENST00000290863.10; ENSP00000290863.6; ENSG00000159640.17 [P12821-3]
ENST00000290866.10; ENSP00000290866.4; ENSG00000159640.17
ENST00000413513.7; ENSP00000392247.3; ENSG00000159640.17 [P12821-4]
GeneIDi1636
KEGGihsa:1636
MANE-SelectiENST00000290866.10; ENSP00000290866.4; NM_000789.4; NP_000780.1
UCSCiuc002jau.3, human [P12821-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1636
DisGeNETi1636

GeneCards: human genes, protein and diseases

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GeneCardsi
ACE
HGNCiHGNC:2707, ACE
HPAiENSG00000159640, Tissue enhanced (intestine, testis)
MalaCardsiACE
MIMi106180, gene+phenotype
267430, phenotype
601367, phenotype
612624, phenotype
614519, phenotype
neXtProtiNX_P12821
OpenTargetsiENSG00000159640
Orphaneti34145, NON RARE IN EUROPE: Berger disease
97369, Renal tubular dysgenesis of genetic origin
PharmGKBiPA139
VEuPathDBiHostDB:ENSG00000159640

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3690, Eukaryota
GeneTreeiENSGT00940000162051
HOGENOMiCLU_014364_3_0_1
InParanoidiP12821
OMAiWEGWHNV
OrthoDBi238880at2759
PhylomeDBiP12821
TreeFamiTF312861

Enzyme and pathway databases

BRENDAi3.4.15.1, 2681
PathwayCommonsiP12821
ReactomeiR-HSA-2022377, Metabolism of Angiotensinogen to Angiotensins
SABIO-RKiP12821
SignaLinkiP12821
SIGNORiP12821

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
1636, 12 hits in 1072 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ACE, human
EvolutionaryTraceiP12821

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Angiotensin-converting_enzyme

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1636
PharosiP12821, Tclin

Protein Ontology

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PROi
PR:P12821
RNActiP12821, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000159640, Expressed in small intestine and 138 other tissues
ExpressionAtlasiP12821, baseline and differential
GenevisibleiP12821, HS

Family and domain databases

CDDicd06461, M2_ACE, 2 hits
InterProiView protein in InterPro
IPR001548, Peptidase_M2
PANTHERiPTHR10514, PTHR10514, 2 hits
PfamiView protein in Pfam
PF01401, Peptidase_M2, 2 hits
PRINTSiPR00791, PEPDIPTASEA
PROSITEiView protein in PROSITE
PS00142, ZINC_PROTEASE, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACE_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P12821
Secondary accession number(s): B0LPF0
, B4DXI3, E7EU16, P22966, Q53YX9, Q59GY8, Q7M4L4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: May 25, 2022
This is version 251 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  5. Human entries with genetic variants
    List of human entries with genetic variants
  6. Human variants curated from literature reports
    Index of human variants curated from literature reports
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  8. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  9. SIMILARITY comments
    Index of protein domains and families
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