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Protein

Nuclear receptor subfamily 4 group A member 1

Gene

Nr4a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). Plays a role in the vascular response to injury (PubMed:22427340).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi267 – 342Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri270 – 290NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri306 – 330NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-198693 AKT phosphorylates targets in the nucleus
R-MMU-383280 Nuclear Receptor transcription pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 4 group A member 1
Alternative name(s):
Nuclear hormone receptor NUR/77
Nuclear protein N10
Orphan nuclear receptor HMR
Gene namesi
Name:Nr4a1
Synonyms:Gfrp, Hmr, N10, Nur77
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1352454 Nr4a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Homozygous knockout mice display restenosis, the narrowing of blood vessels upon vascular injury.1 Publication

Chemistry databases

ChEMBLiCHEMBL3308901

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000537161 – 601Nuclear receptor subfamily 4 group A member 1Add BLAST601

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei344Phosphoserine; by PKABy similarity1
Modified residuei354Phosphoserine; by PKA, RPS6KA1 and RPS6KA3By similarity1

Post-translational modificationi

Phosphorylated at Ser-354 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli.By similarity
Acetylated by p300/CBP, acetylation increases stability. Deacetylated by HDAC1 (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP12813
PRIDEiP12813

PTM databases

iPTMnetiP12813
PhosphoSitePlusiP12813

Expressioni

Tissue specificityi

Highest levels occur in the testis followed by brain and muscle tissue.

Developmental stagei

Highest levels are found in the adult with barely detectable levels in pre- and early postnatal tissue.

Inductioni

By serum growth factors and during liver regeneration.

Gene expression databases

BgeeiENSMUSG00000023034 Expressed in 271 organ(s), highest expression level in adrenal gland
CleanExiMM_NR4A1
ExpressionAtlasiP12813 baseline and differential
GenevisibleiP12813 MM

Interactioni

Subunit structurei

Binds DNA as a monomer (By similarity). Interacts with GADD45GIP1. Interacts with STK11 (By similarity). Interacts with IFI27 (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200346, 4 interactors
CORUMiP12813
DIPiDIP-61643N
ELMiP12813
IntActiP12813, 16 interactors
STRINGi10090.ENSMUSP00000023779

Structurei

3D structure databases

ProteinModelPortaliP12813
SMRiP12813
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini363 – 598NR LBDPROSITE-ProRule annotationAdd BLAST236

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi83 – 94Poly-SerAdd BLAST12
Compositional biasi186 – 190Poly-Pro5
Compositional biasi586 – 589Poly-Pro4

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri270 – 290NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri306 – 330NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4217 Eukaryota
ENOG410YWNC LUCA
GeneTreeiENSGT00760000118887
HOGENOMiHOG000230925
HOVERGENiHBG052663
InParanoidiP12813
KOiK04465
OMAiELSKPTM
OrthoDBiEOG091G0GUM
PhylomeDBiP12813
TreeFamiTF315430

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR003071 Nuc_orp_HMR_rcpt
IPR003070 Nuc_orph_rcpt
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01285 HMRNUCRECPTR
PR01284 NUCLEARECPTR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P12813-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPCIQAQYGT PATSPGPRDH LTGDPLALEF GKPTMDLASP ETAPAAPATL
60 70 80 90 100
PSFSTFMDGY TGEFDTFLYQ LPGTTQPCSS ACSSASSTSS SSSSATSPAS
110 120 130 140 150
ASFKFEDFQV YGCYPGTLSG PLDETLSSSG SEYYGSPCSA PSPSTPNFQP
160 170 180 190 200
SQLSPWDGSF GHFSPSQTYE GLWAWTEQLP KASSGPPPPP TFFSFSPPTG
210 220 230 240 250
PSPSLAQSSL KLFPPPATHQ LGEGESYSMP AAFPGLAPTS PNRDTSGILD
260 270 280 290 300
APVTSTKSRS GASGGSEGRC AVCGDNASCQ HYGVRTCEGC KGFFKRTVQK
310 320 330 340 350
SAKYICLANK DCPVDKRRRN RCQFCRFQKC LAVGMVKEVV RTDSLKGRRG
360 370 380 390 400
RLPSKPKQPP DASPTNLLTS LIRAHLDSGP STAKLDYSKF QELVLPRFGK
410 420 430 440 450
EDAGDVQQFY DLLSGSLDVI RKWAEKIPGF IELCPGDQDL LLESAFLELF
460 470 480 490 500
ILRLAYRSKP GEGKLIFCSG LVLHQLQCAR GFGDWIDNIL AFSRSLHSLG
510 520 530 540 550
VDVPAFACLS ALVLITDRHG LQDPRRVEEL QNRIASCLKE HMATVAGDPQ
560 570 580 590 600
PASCLSRLLG KLPELRTLCT QGLQRIFCLK LEDLVPPPPI VDKIFMDTLS

F
Length:601
Mass (Da):64,738
Last modified:October 1, 1989 - v1
Checksum:i8CFF45B58253887B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8VJZ1A0A2R8VJZ1_MOUSE
Nuclear receptor subfamily 4 group ...
Nr4a1
13Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45A → T in CAA42718 (PubMed:2555161).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04113 mRNA Translation: AAA39843.1
X16995 Genomic DNA Translation: CAA34862.1
X60132 mRNA Translation: CAA42718.1
BC004770 mRNA Translation: AAH04770.1
CCDSiCCDS27848.1
PIRiS06953 QRMSN1
RefSeqiNP_034574.1, NM_010444.2
XP_006520519.1, XM_006520456.1
XP_006520521.1, XM_006520458.1
XP_006520522.1, XM_006520459.3
XP_017171925.1, XM_017316436.1
UniGeneiMm.119

Genome annotation databases

EnsembliENSMUST00000023779; ENSMUSP00000023779; ENSMUSG00000023034
ENSMUST00000228985; ENSMUSP00000155225; ENSMUSG00000023034
GeneIDi15370
KEGGimmu:15370
UCSCiuc007xsv.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04113 mRNA Translation: AAA39843.1
X16995 Genomic DNA Translation: CAA34862.1
X60132 mRNA Translation: CAA42718.1
BC004770 mRNA Translation: AAH04770.1
CCDSiCCDS27848.1
PIRiS06953 QRMSN1
RefSeqiNP_034574.1, NM_010444.2
XP_006520519.1, XM_006520456.1
XP_006520521.1, XM_006520458.1
XP_006520522.1, XM_006520459.3
XP_017171925.1, XM_017316436.1
UniGeneiMm.119

3D structure databases

ProteinModelPortaliP12813
SMRiP12813
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200346, 4 interactors
CORUMiP12813
DIPiDIP-61643N
ELMiP12813
IntActiP12813, 16 interactors
STRINGi10090.ENSMUSP00000023779

Chemistry databases

ChEMBLiCHEMBL3308901

PTM databases

iPTMnetiP12813
PhosphoSitePlusiP12813

Proteomic databases

PaxDbiP12813
PRIDEiP12813

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023779; ENSMUSP00000023779; ENSMUSG00000023034
ENSMUST00000228985; ENSMUSP00000155225; ENSMUSG00000023034
GeneIDi15370
KEGGimmu:15370
UCSCiuc007xsv.2 mouse

Organism-specific databases

CTDi3164
MGIiMGI:1352454 Nr4a1

Phylogenomic databases

eggNOGiKOG4217 Eukaryota
ENOG410YWNC LUCA
GeneTreeiENSGT00760000118887
HOGENOMiHOG000230925
HOVERGENiHBG052663
InParanoidiP12813
KOiK04465
OMAiELSKPTM
OrthoDBiEOG091G0GUM
PhylomeDBiP12813
TreeFamiTF315430

Enzyme and pathway databases

ReactomeiR-MMU-198693 AKT phosphorylates targets in the nucleus
R-MMU-383280 Nuclear Receptor transcription pathway

Miscellaneous databases

PROiPR:P12813
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023034 Expressed in 271 organ(s), highest expression level in adrenal gland
CleanExiMM_NR4A1
ExpressionAtlasiP12813 baseline and differential
GenevisibleiP12813 MM

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR003071 Nuc_orp_HMR_rcpt
IPR003070 Nuc_orph_rcpt
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01285 HMRNUCRECPTR
PR01284 NUCLEARECPTR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNR4A1_MOUSE
AccessioniPrimary (citable) accession number: P12813
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 7, 2018
This is version 183 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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