Nuclear receptor subfamily 4 group A member 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Melanocortin-1 receptor signaling markedly induces the expression of the NR4A nuclear receptor subgroup in melanocytic cells."
    Smith A.G., Luk N., Newton R.A., Roberts D.W., Sturm R.A., Muscat G.E.
    J. Biol. Chem. 283:12564-12570(2008) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGIInferred from direct assayⁱ
  • "Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis."
    Cheng L.E., Chan F.K., Cado D., Winoto A.
    EMBO J. 16:1865-1875(1997) [PubMed] [Europe PMC] [Abstract]
• glucocorticoid receptor binding Source: MGI
• nuclear receptor activity Source: InterPro
• protein heterodimerization activity Source: MGI
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "Developmental dependence on NurRE and EboxNeuro for expression of pituitary proopiomelanocortin."
    Lavoie P.L., Budry L., Balsalobre A., Drouin J.
    Mol. Endocrinol. 22:1647-1657(2008) [PubMed] [Europe PMC] [Abstract]
  • "Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1."
    Zetterstrom R.H., Solomin L., Mitsiadis T., Olson L., Perlmann T.
    Mol. Endocrinol. 10:1656-1666(1996) [PubMed] [Europe PMC] [Abstract]
• steroid hormone receptor activity Source: InterPro
• transcription factor binding Source: MGI
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• apoptotic process Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Contribution of the orphan nuclear receptor Nur77 to the apoptotic action of IGFBP-3."
    Lee K.W., Cobb L.J., Paharkova-Vatchkova V., Liu B., Milbrandt J., Cohen P.
    Carcinogenesis 28:1653-1658(2007) [PubMed] [Europe PMC] [Abstract]
• cell migration involved in sprouting angiogenesis Source: MGI
• cellular response to corticotropin-releasing hormone stimulus Source: UniProtKBInferred from direct assayⁱ
  • "Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation."
    Maira M., Martens C., Philips A., Drouin J.
    Mol. Cell. Biol. 19:7549-7557(1999) [PubMed] [Europe PMC] [Abstract]
• cellular response to fibroblast growth factor stimulus Source: MGI
• cellular response to organic substance Source: MGIInferred from direct assayⁱ
  • "Regulation of GATA-3 expression during CD4 lineage differentiation."
    Gimferrer I., Hu T., Simmons A., Wang C., Souabni A., Busslinger M., Bender T.P., Hernandez-Hoyos G., Alberola-Ila J.
    J. Immunol. 186:3892-3898(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to vascular endothelial growth factor stimulus Source: MGI
• endothelial cell chemotaxis Source: MGI
• fat cell differentiation Source: UniProtKBInferred from direct assayⁱ
  • "Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1."
    Chao L.C., Bensinger S.J., Villanueva C.J., Wroblewski K., Tontonoz P.
    Mol. Endocrinol. 22:2596-2608(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell cycle Source: UniProtKBInferred from direct assayⁱ
  • "Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1."
    Chao L.C., Bensinger S.J., Villanueva C.J., Wroblewski K., Tontonoz P.
    Mol. Endocrinol. 22:2596-2608(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGIInferred from direct assayⁱ
  • "Nur77 as a survival factor in tumor necrosis factor signaling."
    Suzuki S., Suzuki N., Mirtsos C., Horacek T., Lye E., Noh S.K., Ho A., Bouchard D., Mak T.W., Yeh W.C.
    Proc. Natl. Acad. Sci. U.S.A. 100:8276-8280(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of apoptotic process Source: MGIInferred from direct assayⁱ
  • "Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor."
    Rajpal A., Cho Y.A., Yelent B., Koza-Taylor P.H., Li D., Chen E., Whang M., Kang C., Turi T.G., Winoto A.
    EMBO J. 22:6526-6536(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of endothelial cell proliferation Source: MGI
• positive regulation of transcription, DNA-templated Source: MGIInferred from direct assayⁱ
  • "Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor."
    Rajpal A., Cho Y.A., Yelent B., Koza-Taylor P.H., Li D., Chen E., Whang M., Kang C., Turi T.G., Winoto A.
    EMBO J. 22:6526-6536(2003) [PubMed] [Europe PMC] [Abstract]
  • "Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1."
    Zetterstrom R.H., Solomin L., Mitsiadis T., Olson L., Perlmann T.
    Mol. Endocrinol. 10:1656-1666(1996) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "The atypical orphan nuclear receptor DAX-1 interacts with orphan nuclear receptor Nur77 and represses its transactivation."
    Song K.H., Park Y.Y., Park K.C., Hong C.Y., Park J.H., Shong M., Lee K., Choi H.S.
    Mol. Endocrinol. 18:1929-1940(2004) [PubMed] [Europe PMC] [Abstract]
  • "Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1."
    Zetterstrom R.H., Solomin L., Mitsiadis T., Olson L., Perlmann T.
    Mol. Endocrinol. 10:1656-1666(1996) [PubMed] [Europe PMC] [Abstract]
  • "Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis."
    Cheng L.E., Chan F.K., Cado D., Winoto A.
    EMBO J. 16:1865-1875(1997) [PubMed] [Europe PMC] [Abstract]
• regulation of type B pancreatic cell proliferation Source: UniProtKB
• response to electrical stimulus Source: Ensembl
• response to inorganic substance Source: MGIInferred from sequence orthologyⁱ
  • "Identification of a new brain-specific transcription factor, NURR1."
    Law S.W., Conneely O.M., DeMayo F.J., O'Malley B.W.
    Mol. Endocrinol. 6:2129-2135(1992) [PubMed] [Europe PMC] [Abstract]
• response to lipopolysaccharide Source: Ensembl
• skeletal muscle cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation."
    Rajan S., Chu Pham Dang H., Djambazian H., Zuzan H., Fedyshyn Y., Ketela T., Moffat J., Hudson T.J., Sladek R.
    Physiol. Genomics 44:183-197(2012) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• glucocorticoid receptor binding Source: MGI
• protein heterodimerization activity Source: MGI
• transcription factor binding Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MPCIQAQYGT PATSPGPRDH LTGDPLALEF GKPTMDLASP ETAPAAPATL 
        60         70         80         90        100
PSFSTFMDGY TGEFDTFLYQ LPGTTQPCSS ACSSASSTSS SSSSATSPAS 
       110        120        130        140        150
ASFKFEDFQV YGCYPGTLSG PLDETLSSSG SEYYGSPCSA PSPSTPNFQP 
       160        170        180        190        200
SQLSPWDGSF GHFSPSQTYE GLWAWTEQLP KASSGPPPPP TFFSFSPPTG 
       210        220        230        240        250
PSPSLAQSSL KLFPPPATHQ LGEGESYSMP AAFPGLAPTS PNRDTSGILD 
       260        270        280        290        300
APVTSTKSRS GASGGSEGRC AVCGDNASCQ HYGVRTCEGC KGFFKRTVQK 
       310        320        330        340        350
SAKYICLANK DCPVDKRRRN RCQFCRFQKC LAVGMVKEVV RTDSLKGRRG 
       360        370        380        390        400
RLPSKPKQPP DASPTNLLTS LIRAHLDSGP STAKLDYSKF QELVLPRFGK 
       410        420        430        440        450
EDAGDVQQFY DLLSGSLDVI RKWAEKIPGF IELCPGDQDL LLESAFLELF 
       460        470        480        490        500
ILRLAYRSKP GEGKLIFCSG LVLHQLQCAR GFGDWIDNIL AFSRSLHSLG 
       510        520        530        540        550
VDVPAFACLS ALVLITDRHG LQDPRRVEEL QNRIASCLKE HMATVAGDPQ 
       560        570        580        590        600
PASCLSRLLG KLPELRTLCT QGLQRIFCLK LEDLVPPPPI VDKIFMDTLS 

F                                                      

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot