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Protein

Fibroleukin

Gene

Fgl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Converts prothrombin to thrombin.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCytolysis

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroleukin
Alternative name(s):
Cytotoxic T-lymphocyte-specific protein
Fibrinogen-like protein 2
Prothrombinase
Gene namesi
Name:Fgl2
Synonyms:Fiblp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:103266 Fgl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000000910720 – 432FibroleukinAdd BLAST413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi206 ↔ 235PROSITE-ProRule annotation
Glycosylationi228N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi256N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi329N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi364 ↔ 377PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP12804
PaxDbiP12804
PeptideAtlasiP12804
PRIDEiP12804

PTM databases

PhosphoSitePlusiP12804

Expressioni

Tissue specificityi

Constitutively expressed in cytotoxic T-cells.

Inductioni

In macrophages, during infection by mouse hepatitis virus strain 3 (MHV-3).1 Publication

Gene expression databases

BgeeiENSMUSG00000039899 Expressed in 200 organ(s), highest expression level in aorta
CleanExiMM_FGL2
ExpressionAtlasiP12804 baseline and differential
GenevisibleiP12804 MM

Interactioni

Subunit structurei

Homotetramer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046131

Structurei

3D structure databases

ProteinModelPortaliP12804
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini197 – 429Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST233

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili71 – 157Sequence analysisAdd BLAST87

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00930000150824
HOGENOMiHOG000252953
HOVERGENiHBG105002
InParanoidiP12804
OMAiYRLHIGN
OrthoDBiEOG091G03M1
PhylomeDBiP12804
TreeFamiTF336658

Family and domain databases

CDDicd00087 FReD, 1 hit
InterProiView protein in InterPro
IPR033083 Fgl2
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PANTHERiPTHR19143:SF189 PTHR19143:SF189, 1 hit
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12804-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLPGWLWLS SAVLAACRAV EEHNLTEGLE DASAQAACPA RLEGSGRCEG
60 70 80 90 100
SQCPFQLTLP TLTIQLPRQL GSMEEVLKEV RTLKEAVDSL KKSCQDCKLQ
110 120 130 140 150
ADDHRDPGGN GGNGAETAED SRVQELESQV NKLSSELKNA KDQIQGLQGR
160 170 180 190 200
LETLHLVNMN NIENYVDNKV ANLTVVVNSL DGKCSKCPSQ EHMQSQPVQH
210 220 230 240 250
LIYKDCSDHY VLGRRSSGAY RVTPDHRNSS FEVYCDMETM GGGWTVLQAR
260 270 280 290 300
LDGSTNFTRE WKDYKAGFGN LEREFWLGND KIHLLTKSKE MILRIDLEDF
310 320 330 340 350
NGLTLYALYD QFYVANEFLK YRLHIGNYNG TAGDALRFSR HYNHDLRFFT
360 370 380 390 400
TPDRDNDRYP SGNCGLYYSS GWWFDSCLSA NLNGKYYHQK YKGVRNGIFW
410 420 430
GTWPGINQAQ PGGYKSSFKQ AKMMIRPKNF KP
Length:432
Mass (Da):48,951
Last modified:October 1, 1989 - v1
Checksum:i2B297F69CCB4A782
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti332A → G in AAB34823 (PubMed:7609073).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16238, M15761 Genomic DNA Translation: AAA37624.1
S78773 mRNA Translation: AAB34823.1
BC028893 mRNA Translation: AAH28893.1
CCDSiCCDS19103.1
PIRiA27447
I56934
RefSeqiNP_032039.2, NM_008013.4
UniGeneiMm.292100

Genome annotation databases

EnsembliENSMUST00000035799; ENSMUSP00000046131; ENSMUSG00000039899
GeneIDi14190
KEGGimmu:14190
UCSCiuc008wom.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16238, M15761 Genomic DNA Translation: AAA37624.1
S78773 mRNA Translation: AAB34823.1
BC028893 mRNA Translation: AAH28893.1
CCDSiCCDS19103.1
PIRiA27447
I56934
RefSeqiNP_032039.2, NM_008013.4
UniGeneiMm.292100

3D structure databases

ProteinModelPortaliP12804
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046131

PTM databases

PhosphoSitePlusiP12804

Proteomic databases

EPDiP12804
PaxDbiP12804
PeptideAtlasiP12804
PRIDEiP12804

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035799; ENSMUSP00000046131; ENSMUSG00000039899
GeneIDi14190
KEGGimmu:14190
UCSCiuc008wom.2 mouse

Organism-specific databases

CTDi10875
MGIiMGI:103266 Fgl2

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00930000150824
HOGENOMiHOG000252953
HOVERGENiHBG105002
InParanoidiP12804
OMAiYRLHIGN
OrthoDBiEOG091G03M1
PhylomeDBiP12804
TreeFamiTF336658

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

PROiPR:P12804
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039899 Expressed in 200 organ(s), highest expression level in aorta
CleanExiMM_FGL2
ExpressionAtlasiP12804 baseline and differential
GenevisibleiP12804 MM

Family and domain databases

CDDicd00087 FReD, 1 hit
InterProiView protein in InterPro
IPR033083 Fgl2
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PANTHERiPTHR19143:SF189 PTHR19143:SF189, 1 hit
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFGL2_MOUSE
AccessioniPrimary (citable) accession number: P12804
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 7, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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