UniProtKB - P12799 (FIBG_BOVIN)
Fibrinogen gamma-B chain
FGG
Functioni
Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 343 | CalciumBy similarity | 1 | |
Metal bindingi | 345 | CalciumBy similarity | 1 | |
Metal bindingi | 347 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 349 | Calcium; via carbonyl oxygenBy similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- signaling receptor binding Source: GO_Central
GO - Biological processi
- blood coagulation, fibrin clot formation Source: GO_Central
- cell-matrix adhesion Source: GO_Central
- platelet aggregation Source: GO_Central
- protein polymerization Source: InterPro
Keywordsi
Biological process | Blood coagulation, Hemostasis |
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Fibrinogen gamma-B chainShort name: Gamma' |
Gene namesi | Name:FGG |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular space Source: GO_Central
- fibrinogen complex Source: InterPro
Other locations
- collagen-containing extracellular matrix Source: GO_Central
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | 1 PublicationAdd BLAST | 24 | |
ChainiPRO_0000009098 | 25 – 444 | Fibrinogen gamma-B chainAdd BLAST | 420 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 32 | Interchain (with C-33)Combined sources1 Publication | ||
Disulfide bondi | 33 | Interchain (with C-32)Combined sources1 Publication | ||
Disulfide bondi | 43 | Interchain (with C-87 in beta chain)By similarity | ||
Disulfide bondi | 47 | Interchain (with C-67 in alpha chain)By similarity | ||
Glycosylationi | 76 | N-linked (GlcNAc...) asparagineCurated | 1 | |
Disulfide bondi | 159 | Interchain (with C-204 in beta chain)By similarity | ||
Disulfide bondi | 163 | Interchain (with C-183 in alpha chain)By similarity | ||
Disulfide bondi | 177 ↔ 205 | PROSITE-ProRule annotation | ||
Disulfide bondi | 351 ↔ 364 | PROSITE-ProRule annotation |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P12799 |
PeptideAtlasi | P12799 |
PRIDEi | P12799 |
Interactioni
Subunit structurei
Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
3 PublicationsGO - Molecular functioni
- signaling receptor binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000008877 |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P12799 |
SMRi | P12799 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P12799 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 168 – 415 | Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST | 248 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 25 – 165 | 1 PublicationAdd BLAST | 141 |
Domaini
Keywords - Domaini
Coiled coil, SignalPhylogenomic databases
eggNOGi | KOG2579, Eukaryota |
InParanoidi | P12799 |
OrthoDBi | 523014at2759 |
Family and domain databases
CDDi | cd00087, FReD, 1 hit |
Gene3Di | 3.90.215.10, 1 hit |
InterProi | View protein in InterPro IPR036056, Fibrinogen-like_C IPR014716, Fibrinogen_a/b/g_C_1 IPR002181, Fibrinogen_a/b/g_C_dom IPR012290, Fibrinogen_a/b/g_coil_dom IPR020837, Fibrinogen_CS IPR037581, Fibrinogen_gamma |
PANTHERi | PTHR19143:SF338, PTHR19143:SF338, 1 hit |
Pfami | View protein in Pfam PF08702, Fib_alpha, 1 hit PF00147, Fibrinogen_C, 1 hit |
SMARTi | View protein in SMART SM00186, FBG, 1 hit SM01212, Fib_alpha, 1 hit |
SUPFAMi | SSF56496, SSF56496, 1 hit |
PROSITEi | View protein in PROSITE PS00514, FIBRINOGEN_C_1, 1 hit PS51406, FIBRINOGEN_C_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MSWSSHPPSV IFYILSLLSS ACLAYVATRD NCCILDERFG SYCPTTCGIA
60 70 80 90 100
DFLNNYQTSV DKDLRTLEGI LYQVENKTSE ARELVKAIQI SYNPDQPSKP
110 120 130 140 150
NNIESATKNS KSMMEEIMKY ETLISTHEST IRFLQEVYNS NSQKIVNLRD
160 170 180 190 200
KVVQLEANCQ EPCQDTVKIH DVTGRDCQDV ANKGAKESGL YFIRPLKAKQ
210 220 230 240 250
FLVYCEIDGS GNGWTVFQKR LDGSLDFKKN WIQYKEGFGH LSPTGTGNTE
260 270 280 290 300
FWLGNEKIHL ISTQSSIPYV LRIQLEDWNG RTSTADYASF KVTGENDKYR
310 320 330 340 350
LTYAYFIGGD AGDAFDGYDF GDDSSDKFFT SHNGMQFSTW DSDNDKYDGN
360 370 380 390 400
CAEQVGIGWW MNKCHAGHLN GVYYQGGTYS KTSTPNGYDN GIIWATWKSR
410 420 430 440
WYSMKKTTMK IIPLNRLAIG EGQQHQLGGA KQVGVEHHVE IEYD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 433 – 436 | VGVE → AGDV AA sequence (PubMed:11946783).Curated | 4 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15556 mRNA Translation: CAA33562.1 |
PIRi | A05295 S05313 S69116 |
RefSeqi | NP_776336.1, NM_173911.2 |
Genome annotation databases
GeneIDi | 280792 |
KEGGi | bta:280792 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15556 mRNA Translation: CAA33562.1 |
PIRi | A05295 S05313 S69116 |
RefSeqi | NP_776336.1, NM_173911.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1DEQ | X-ray | 3.50 | C/F/P/S | 25-432 | [»] | |
1JY2 | X-ray | 1.40 | P/S | 25-72 | [»] | |
1JY3 | X-ray | 1.60 | P/S | 25-72 | [»] | |
AlphaFoldDBi | P12799 | |||||
SMRi | P12799 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000008877 |
Proteomic databases
PaxDbi | P12799 |
PeptideAtlasi | P12799 |
PRIDEi | P12799 |
Genome annotation databases
GeneIDi | 280792 |
KEGGi | bta:280792 |
Organism-specific databases
CTDi | 2266 |
Phylogenomic databases
eggNOGi | KOG2579, Eukaryota |
InParanoidi | P12799 |
OrthoDBi | 523014at2759 |
Miscellaneous databases
EvolutionaryTracei | P12799 |
Family and domain databases
CDDi | cd00087, FReD, 1 hit |
Gene3Di | 3.90.215.10, 1 hit |
InterProi | View protein in InterPro IPR036056, Fibrinogen-like_C IPR014716, Fibrinogen_a/b/g_C_1 IPR002181, Fibrinogen_a/b/g_C_dom IPR012290, Fibrinogen_a/b/g_coil_dom IPR020837, Fibrinogen_CS IPR037581, Fibrinogen_gamma |
PANTHERi | PTHR19143:SF338, PTHR19143:SF338, 1 hit |
Pfami | View protein in Pfam PF08702, Fib_alpha, 1 hit PF00147, Fibrinogen_C, 1 hit |
SMARTi | View protein in SMART SM00186, FBG, 1 hit SM01212, Fib_alpha, 1 hit |
SUPFAMi | SSF56496, SSF56496, 1 hit |
PROSITEi | View protein in PROSITE PS00514, FIBRINOGEN_C_1, 1 hit PS51406, FIBRINOGEN_C_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FIBG_BOVIN | |
Accessioni | P12799Primary (citable) accession number: P12799 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | October 1, 1989 | |
Last modified: | May 25, 2022 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references