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Protein

Cytochrome P450 2B9

Gene

Cyp2b9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi436Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-211935 Fatty acids
R-MMU-211981 Xenobiotics
R-MMU-211999 CYP2E1 reactions

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2B9 (EC:1.14.14.1)
Alternative name(s):
CYPIIB9
Cytochrome P450 clone PF26
Cytochrome P450-16-alpha
Testosterone 16-alpha hydroxylase
Gene namesi
Name:Cyp2b9
Synonyms:Cyp2b-9, Rip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:88600 Cyp2b9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Chemistry databases

DrugBankiDB08834 Tauroursodeoxycholic acid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000516841 – 491Cytochrome P450 2B9Add BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei128Phosphoserine; by PKABy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP12790
PeptideAtlasiP12790
PRIDEiP12790
TopDownProteomicsiP12790

PTM databases

iPTMnetiP12790
PhosphoSitePlusiP12790
SwissPalmiP12790

Expressioni

Gene expression databases

BgeeiENSMUSG00000040660 Expressed in 27 organ(s), highest expression level in liver
GenevisibleiP12790 MM

Interactioni

Protein-protein interaction databases

IntActiP12790, 1 interactor
MINTiP12790
STRINGi10090.ENSMUSP00000080846

Structurei

3D structure databases

ProteinModelPortaliP12790
SMRiP12790
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00880000137861
HOGENOMiHOG000036992
HOVERGENiHBG015789
InParanoidiP12790
KOiK07412
OMAiHYRYANS
OrthoDBiEOG091G0BT8
TreeFamiTF352043

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008068 Cyt_P450_E_grp-I_CYP2B-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01685 EP450ICYP2B
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

P12790-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPSVLLLLA VLLSLFLLLV RGHAKIHGHL PPGPHPLPLL GNLLQMDRGG
60 70 80 90 100
LLKCFIQLQE KHGDVFTVHL GPRPVVVLCG TQTIREALVD HAEAFSGRGT
110 120 130 140 150
IAAAQLVMQD YGIFFASGQR WKTLRRFSLA TMKEFGMGKR SVEERIKEEA
160 170 180 190 200
QCLVEELKKY QGVPLDPTFL FQCITANIIC SIVFGERFDY TDDQFLHLLN
210 220 230 240 250
LMYKIFSLLS SFSGQMFELF SGFLKYFPGV HRQIVKKQQE LLDYIAHSVE
260 270 280 290 300
KHKATLDPSA PRDYIDTYLL RMEKEKSNHN TEFHHQNLMM SVLSLFFAGT
310 320 330 340 350
ETTSATLHYG VLLMLKYPHV TEKVQKEIDQ VIGSHRLPTL DDRTKMPYTD
360 370 380 390 400
AVIHEIQRFS DLVPIGLPHK VIKDTLFRGY LLPKNTEVYP VLSSALHDPQ
410 420 430 440 450
YFEQPDKFNP EHFLDANGAL KKCEAFLPFS TGKRICLGES IARNELFIFF
460 470 480 490
TTILQNFSVA SPVAPKDIDL TPKESGIGKI PPAHQIYFLA R
Length:491
Mass (Da):55,741
Last modified:September 18, 2013 - v2
Checksum:iC1E790A7DD1A7298
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti298A → V in AAA40424 (PubMed:3219345).Curated1
Sequence conflicti412H → Q in AAA40424 (PubMed:3219345).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21855 mRNA Translation: AAA40424.1
M60273
, M60267, M60268, M60269, M60270, M60271, M60272 Genomic DNA Translation: AAA03648.1
AC157782 Genomic DNA No translation available.
BC120525 mRNA Translation: AAI20526.1
BC120527 mRNA Translation: AAI20528.1
CCDSiCCDS21001.1
PIRiA31047
I84735
RefSeqiNP_034130.1, NM_010000.2
UniGeneiMm.14413

Genome annotation databases

EnsembliENSMUST00000082214; ENSMUSP00000080846; ENSMUSG00000040660
GeneIDi13094
KEGGimmu:13094
UCSCiuc009fuh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21855 mRNA Translation: AAA40424.1
M60273
, M60267, M60268, M60269, M60270, M60271, M60272 Genomic DNA Translation: AAA03648.1
AC157782 Genomic DNA No translation available.
BC120525 mRNA Translation: AAI20526.1
BC120527 mRNA Translation: AAI20528.1
CCDSiCCDS21001.1
PIRiA31047
I84735
RefSeqiNP_034130.1, NM_010000.2
UniGeneiMm.14413

3D structure databases

ProteinModelPortaliP12790
SMRiP12790
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP12790, 1 interactor
MINTiP12790
STRINGi10090.ENSMUSP00000080846

Chemistry databases

DrugBankiDB08834 Tauroursodeoxycholic acid

PTM databases

iPTMnetiP12790
PhosphoSitePlusiP12790
SwissPalmiP12790

Proteomic databases

PaxDbiP12790
PeptideAtlasiP12790
PRIDEiP12790
TopDownProteomicsiP12790

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000082214; ENSMUSP00000080846; ENSMUSG00000040660
GeneIDi13094
KEGGimmu:13094
UCSCiuc009fuh.1 mouse

Organism-specific databases

CTDi13094
MGIiMGI:88600 Cyp2b9

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00880000137861
HOGENOMiHOG000036992
HOVERGENiHBG015789
InParanoidiP12790
KOiK07412
OMAiHYRYANS
OrthoDBiEOG091G0BT8
TreeFamiTF352043

Enzyme and pathway databases

ReactomeiR-MMU-211935 Fatty acids
R-MMU-211981 Xenobiotics
R-MMU-211999 CYP2E1 reactions

Miscellaneous databases

PROiPR:P12790
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040660 Expressed in 27 organ(s), highest expression level in liver
GenevisibleiP12790 MM

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008068 Cyt_P450_E_grp-I_CYP2B-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01685 EP450ICYP2B
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCP2B9_MOUSE
AccessioniPrimary (citable) accession number: P12790
Secondary accession number(s): Q64463
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: September 18, 2013
Last modified: November 7, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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