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Protein

Cytochrome c oxidase subunit 5A, mitochondrial

Gene

Cox5a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 5A, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide Va
Gene namesi
Name:Cox5a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:88474 Cox5a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 37MitochondrionAdd BLAST37
ChainiPRO_000000610138 – 146Cytochrome c oxidase subunit 5A, mitochondrialAdd BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei83N6-acetyllysineCombined sources1
Modified residuei109N6-acetyllysineCombined sources1
Modified residuei137PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP12787
MaxQBiP12787
PaxDbiP12787
PeptideAtlasiP12787
PRIDEiP12787
TopDownProteomicsiP12787

2D gel databases

SWISS-2DPAGEiP12787
UCD-2DPAGEiP12787

PTM databases

iPTMnetiP12787
PhosphoSitePlusiP12787
SwissPalmiP12787

Expressioni

Gene expression databases

BgeeiENSMUSG00000000088 Expressed in 283 organ(s), highest expression level in atrioventricular valve
CleanExiMM_COX5A
GenevisibleiP12787 MM

Interactioni

Subunit structurei

Interacts with AFG1L.By similarity

Protein-protein interaction databases

BioGridi198841, 5 interactors
CORUMiP12787
IntActiP12787, 10 interactors
MINTiP12787
STRINGi10090.ENSMUSP00000000090

Structurei

3D structure databases

ProteinModelPortaliP12787
SMRiP12787
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4077 Eukaryota
ENOG4111MPD LUCA
GeneTreeiENSGT00390000001424
HOGENOMiHOG000160656
HOVERGENiHBG051088
InParanoidiP12787
KOiK02264
OMAiLNNCFAH
OrthoDBiEOG091G0FVR
PhylomeDBiP12787
TreeFamiTF105062

Family and domain databases

CDDicd00923 Cyt_c_Oxidase_Va, 1 hit
Gene3Di1.25.40.40, 1 hit
InterProiView protein in InterPro
IPR003204 Cyt_c_oxidase_su5A/6
IPR036545 Cyt_c_oxidase_su5A/6_sf
PANTHERiPTHR14200 PTHR14200, 1 hit
PfamiView protein in Pfam
PF02284 COX5A, 1 hit
SUPFAMiSSF48479 SSF48479, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12787-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLAAALRRCT AAAAARGLLH PASAPSPAAA VCSIRCYSHG SHETDEEFDA
60 70 80 90 100
RWVTYFNKPD IDAWELRKGM NTLVGYDLVP EPKIIDAALR ACRRLNDFAS
110 120 130 140
AVRILEVVKD KAGPHKEIYP YVIQELRPTL NELGISTPEE LGLDKV
Length:146
Mass (Da):16,101
Last modified:February 5, 2008 - v2
Checksum:i8F6AFF91B5C6160F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11Missing in CAA34085 (PubMed:2550898).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15963 mRNA Translation: CAA34085.1
AK018723 mRNA Translation: BAB31369.1
BC034302 mRNA Translation: AAH34302.1
CCDSiCCDS23223.1
PIRiS05495
RefSeqiNP_031773.2, NM_007747.2
UniGeneiMm.273403

Genome annotation databases

EnsembliENSMUST00000000090; ENSMUSP00000000090; ENSMUSG00000000088
GeneIDi12858
KEGGimmu:12858
UCSCiuc009puz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15963 mRNA Translation: CAA34085.1
AK018723 mRNA Translation: BAB31369.1
BC034302 mRNA Translation: AAH34302.1
CCDSiCCDS23223.1
PIRiS05495
RefSeqiNP_031773.2, NM_007747.2
UniGeneiMm.273403

3D structure databases

ProteinModelPortaliP12787
SMRiP12787
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198841, 5 interactors
CORUMiP12787
IntActiP12787, 10 interactors
MINTiP12787
STRINGi10090.ENSMUSP00000000090

PTM databases

iPTMnetiP12787
PhosphoSitePlusiP12787
SwissPalmiP12787

2D gel databases

SWISS-2DPAGEiP12787
UCD-2DPAGEiP12787

Proteomic databases

EPDiP12787
MaxQBiP12787
PaxDbiP12787
PeptideAtlasiP12787
PRIDEiP12787
TopDownProteomicsiP12787

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000090; ENSMUSP00000000090; ENSMUSG00000000088
GeneIDi12858
KEGGimmu:12858
UCSCiuc009puz.1 mouse

Organism-specific databases

CTDi9377
MGIiMGI:88474 Cox5a

Phylogenomic databases

eggNOGiKOG4077 Eukaryota
ENOG4111MPD LUCA
GeneTreeiENSGT00390000001424
HOGENOMiHOG000160656
HOVERGENiHBG051088
InParanoidiP12787
KOiK02264
OMAiLNNCFAH
OrthoDBiEOG091G0FVR
PhylomeDBiP12787
TreeFamiTF105062

Miscellaneous databases

PROiPR:P12787
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000088 Expressed in 283 organ(s), highest expression level in atrioventricular valve
CleanExiMM_COX5A
GenevisibleiP12787 MM

Family and domain databases

CDDicd00923 Cyt_c_Oxidase_Va, 1 hit
Gene3Di1.25.40.40, 1 hit
InterProiView protein in InterPro
IPR003204 Cyt_c_oxidase_su5A/6
IPR036545 Cyt_c_oxidase_su5A/6_sf
PANTHERiPTHR14200 PTHR14200, 1 hit
PfamiView protein in Pfam
PF02284 COX5A, 1 hit
SUPFAMiSSF48479 SSF48479, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOX5A_MOUSE
AccessioniPrimary (citable) accession number: P12787
Secondary accession number(s): Q9D2W1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: February 5, 2008
Last modified: September 12, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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