SKIL

Functionⁱ

May have regulatory role in cell division or differentiation in response to extracellular signals.

GO - Molecular functionⁱ

chromatin binding Source: Ensembl
DNA-binding transcription factor activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from sequence modelⁱ
- 19274049
DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 10531062
protein-containing complex binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18334480
protein domain specific binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18334480
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 10531062
SMAD binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12764135
- 17469184
transcription corepressor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10531062

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blastocyst formation Source: Ensembl
cell cycle arrest Source: Ensembl
lens fiber cell differentiation Source: Ensembl
lymphocyte homeostasis Source: Ensembl
negative regulation of BMP signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
negative regulation of transforming growth factor beta receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 17469184
- 19383336
neuron development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of axonogenesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16675394
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
protein heterotrimerization
Source: UniProtKB
Inferred from direct assayⁱ
- 8514802
protein homotrimerization
Source: UniProtKB
Inferred from direct assayⁱ
- 8514802
response to antibiotic
Source: UniProtKB
Inferred from expression patternⁱ
- 15967445
response to cytokine Source: Ensembl
response to growth factor
Source: UniProtKB
Inferred from direct assayⁱ
- 19383336
skeletal muscle tissue development
Source: UniProtKB
Inferred from direct assayⁱ
- 17202138
spermatogenesis Source: Ensembl
transforming growth factor beta receptor signaling pathway Source: Ensembl

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
SignaLinkⁱ	P12757
SIGNORⁱ	P12757

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ski-like protein Alternative name(s): Ski-related oncogene Ski-related protein
Gene namesⁱ	Name:SKIL Synonyms:SNO
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000136603.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10897 SKIL
MIMⁱ	165340 gene
neXtProtⁱ	NX_P12757

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6498
Open Targets More...OpenTargetsⁱ	ENSG00000136603
PharmGKBⁱ	PA35797

Polymorphism and mutation databases

BioMutaⁱ	SKIL
DMDMⁱ	313104010

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000129387	1 – 684	Ski-like proteinAdd BLAST		684

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	50	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	70	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	452	PhosphoserineCombined sources	1
Cross-linkⁱ	489	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	527	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationⁱ

Ubiquitinated by RNF111 and RNF165, promoting proteasomal degradation, leading to enhance the BMP-Smad signaling.1 Publication

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P12757
jPOSTⁱ	P12757
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P12757
PaxDbⁱ	P12757
PeptideAtlas More...PeptideAtlasⁱ	P12757
PRIDEⁱ	P12757
ProteomicsDBⁱ	52866 52867 [P12757-2] 52868 [P12757-3] 52869 [P12757-4] 52870 [P12757-5]

PTM databases

iPTMnetⁱ	P12757
PhosphoSitePlusⁱ	P12757

Expressionⁱ

Tissue specificityⁱ

Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000136603 Expressed in 221 organ(s), highest expression level in tendon of biceps brachii
CleanExⁱ	HS_SKIL
ExpressionAtlasⁱ	P12757 baseline and differential
Genevisibleⁱ	P12757 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA008472

HPAⁱ

HPA008472

Interactionⁱ

Subunit structureⁱ

Interacts with CPNE4 (via VWFA domain) (By similarity). Interacts with SMAD2, SMAD3 and RNF111 (PubMed:17591695). Isoform 1 interacts with WWP1 (PubMed:15221015).By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
AES	Q08117	3	EBI-2902468,EBI-717810
DRG1	Q9Y295	3	EBI-2902468,EBI-719554
Ncor1	Q60974	2	EBI-2902468,EBI-349004	From Mus musculus.
NEFL	P07196	3	EBI-2902468,EBI-475646
NXF3	Q9H4D5	3	EBI-2902468,EBI-750038
OIP5	O43482	3	EBI-2902468,EBI-536879
SMAD4	Q13485	3	EBI-2902468,EBI-347263
SMUG1	Q53HV7	3	EBI-2902468,EBI-749970
STK16	O75716	3	EBI-2902468,EBI-749295
VPS28	Q548N1	3	EBI-2902468,EBI-10243107
VPS28	Q9UK41	4	EBI-2902468,EBI-727424

GO - Molecular functionⁱ

protein domain specific binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 18334480
SMAD binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 12764135
- 17469184

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112389, 96 interactors
CORUMⁱ	P12757
Database of interacting proteins More...DIPⁱ	DIP-42138N
IntActⁱ	P12757, 83 interactors
Molecular INTeraction database More...MINTⁱ	P12757
STRINGⁱ	9606.ENSP00000259119

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	137 – 139	Combined sources	3
Beta strandⁱ	145 – 149	Combined sources	5
Beta strandⁱ	152 – 159	Combined sources	8
Beta strandⁱ	162 – 166	Combined sources	5
Helixⁱ	167 – 172	Combined sources	6
Turnⁱ	173 – 177	Combined sources	5
Helixⁱ	180 – 190	Combined sources	11
Helixⁱ	199 – 207	Combined sources	9
Beta strandⁱ	219 – 222	Combined sources	4
Helixⁱ	223 – 234	Combined sources	12
Beta strandⁱ	262 – 266	Combined sources	5
Beta strandⁱ	272 – 276	Combined sources	5
Helixⁱ	278 – 280	Combined sources	3
Beta strandⁱ	289 – 291	Combined sources	3
Turnⁱ	292 – 294	Combined sources	3
Helixⁱ	300 – 303	Combined sources	4
Beta strandⁱ	313 – 319	Combined sources	7
Helixⁱ	322 – 324	Combined sources	3
Helixⁱ	325 – 328	Combined sources	4
Beta strandⁱ	335 – 338	Combined sources	4
Helixⁱ	341 – 352	Combined sources	12

Show more details

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3EQ5	X-ray	2.45	A/B/C/D/E/F/G/H/I/J/K/L	137-238	[»]
	5C4V	X-ray	2.60	B/D/F	238-356	[»]
ProteinModelPortalⁱ	P12757
SMRⁱ	P12757
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P12757

EvolutionaryTraceⁱ

P12757

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	536 – 684	Sequence analysisAdd BLAST		149

Sequence similaritiesⁱ

Belongs to the SKI family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IFDK Eukaryota ENOG410Y8AU LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000158435
HOGENOMⁱ	HOG000039989
HOVERGENⁱ	HBG006599
InParanoidⁱ	P12757
KEGG Orthology (KO) More...KOⁱ	K18499
OMAⁱ	KPESTTC
Database of Orthologous Groups More...OrthoDBⁱ	1148296at2759
PhylomeDBⁱ	P12757
TreeFamⁱ	TF324133

Family and domain databases

Gene3Dⁱ	3.10.260.20, 1 hit 3.10.390.10, 1 hit
InterProⁱ	View protein in InterPro IPR014890 c-SKI_SMAD4-bd_dom IPR009061 DNA-bd_dom_put_sf IPR010919 SAND-like_dom_sf IPR028373 Ski-rel_Sno IPR003380 SKI/SNO/DAC IPR037000 Ski_DNA-bd_sf IPR023216 Tscrpt_reg_SKI_SnoN
PANTHERⁱ	PTHR10005 PTHR10005, 1 hit PTHR10005:SF3 PTHR10005:SF3, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08782 c-SKI_SMAD_bind, 1 hit PF02437 Ski_Sno, 1 hit
SMARTⁱ	View protein in SMART SM01046 c-SKI_SMAD_bind, 1 hit
SUPFAMⁱ	SSF46955 SSF46955, 1 hit SSF63763 SSF63763, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform SNON (identifier: P12757-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MENLQTNFSL VQGSTKKLNG MGDDGSPPAK KMITDIHANG KTINKVPTVK 
        60         70         80         90        100
KEHLDDYGEA PVETDGEHVK RTCTSVPETL HLNPSLKHTL AQFHLSSQSS 
       110        120        130        140        150
LGGPAAFSAR HSQESMSPTV FLPLPSPQVL PGPLLIPSDS STELTQTVLE 
       160        170        180        190        200
GESISCFQVG GEKRLCLPQV LNSVLREFTL QQINTVCDEL YIYCSRCTSD 
       210        220        230        240        250
QLHILKVLGI LPFNAPSCGL ITLTDAQRLC NALLRPRTFP QNGSVLPAKS 
       260        270        280        290        300
SLAQLKETGS AFEVEHECLG KCQGLFAPQF YVQPDAPCIQ CLECCGMFAP 
       310        320        330        340        350
QTFVMHSHRS PDKRTCHWGF ESAKWHCYLH VNQKYLGTPE EKKLKIILEE 
       360        370        380        390        400
MKEKFSMRSG KRNQSKTDAP SGMELQSWYP VIKQEGDHVS QTHSFLHPSY 
       410        420        430        440        450
YLYMCDKVVA PNVSLTSAVS QSKELTKTEA SKSISRQSEK AHSSGKLQKT 
       460        470        480        490        500
VSYPDVSLEE QEKMDLKTSR ELCSRLDASI SNNSTSKRKS ESATCNLVRD 
       510        520        530        540        550
INKVGIGLVA AASSPLLVKD VICEDDKGKI MEEVMRTYLK QQEKLNLILQ 
       560        570        580        590        600
KKQQLQMEVK MLSSSKSMKE LTEEQQNLQK ELESLQNEHA QRMEEFYVEQ 
       610        620        630        640        650
KDLEKKLEQI MKQKCTCDSN LEKDKEAEYA GQLAELRQRL DHAEADRQEL 
       660        670        680 
QDELRQEREA RQKLEMMIKE LKLQILKSSK TAKE

Length:684

Mass (Da):76,976

Last modified:November 30, 2010 - v2

Checksum:ⁱ6A04D4ECEC214CF1

GO

Isoform SNOA (identifier: P12757-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
367-415: TDAPSGMELQ...DKVVAPNVSL → ASFLYQFLIM...YRLIYLYCSF
416-684: Missing.

« Hide

        10         20         30         40         50
MENLQTNFSL VQGSTKKLNG MGDDGSPPAK KMITDIHANG KTINKVPTVK 
        60         70         80         90        100
KEHLDDYGEA PVETDGEHVK RTCTSVPETL HLNPSLKHTL AQFHLSSQSS 
       110        120        130        140        150
LGGPAAFSAR HSQESMSPTV FLPLPSPQVL PGPLLIPSDS STELTQTVLE 
       160        170        180        190        200
GESISCFQVG GEKRLCLPQV LNSVLREFTL QQINTVCDEL YIYCSRCTSD 
       210        220        230        240        250
QLHILKVLGI LPFNAPSCGL ITLTDAQRLC NALLRPRTFP QNGSVLPAKS 
       260        270        280        290        300
SLAQLKETGS AFEVEHECLG KCQGLFAPQF YVQPDAPCIQ CLECCGMFAP 
       310        320        330        340        350
QTFVMHSHRS PDKRTCHWGF ESAKWHCYLH VNQKYLGTPE EKKLKIILEE 
       360        370        380        390        400
MKEKFSMRSG KRNQSKASFL YQFLIMVMVY FEMKILCLVC NLTCMLNIAH 
       410 
ATTTKYRLIY LYCSF

Show »

Length:415

Mass (Da):46,335

Checksum:ⁱA2F3E39AE47BB69E

GO

Isoform SNON2 (identifier: P12757-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
431-431: S → N
432-477: Missing.

« Hide

        10         20         30         40         50
MENLQTNFSL VQGSTKKLNG MGDDGSPPAK KMITDIHANG KTINKVPTVK 
        60         70         80         90        100
KEHLDDYGEA PVETDGEHVK RTCTSVPETL HLNPSLKHTL AQFHLSSQSS 
       110        120        130        140        150
LGGPAAFSAR HSQESMSPTV FLPLPSPQVL PGPLLIPSDS STELTQTVLE 
       160        170        180        190        200
GESISCFQVG GEKRLCLPQV LNSVLREFTL QQINTVCDEL YIYCSRCTSD 
       210        220        230        240        250
QLHILKVLGI LPFNAPSCGL ITLTDAQRLC NALLRPRTFP QNGSVLPAKS 
       260        270        280        290        300
SLAQLKETGS AFEVEHECLG KCQGLFAPQF YVQPDAPCIQ CLECCGMFAP 
       310        320        330        340        350
QTFVMHSHRS PDKRTCHWGF ESAKWHCYLH VNQKYLGTPE EKKLKIILEE 
       360        370        380        390        400
MKEKFSMRSG KRNQSKTDAP SGMELQSWYP VIKQEGDHVS QTHSFLHPSY 
       410        420        430        440        450
YLYMCDKVVA PNVSLTSAVS QSKELTKTEA NASISNNSTS KRKSESATCN 
       460        470        480        490        500
LVRDINKVGI GLVAAASSPL LVKDVICEDD KGKIMEEVMR TYLKQQEKLN 
       510        520        530        540        550
LILQKKQQLQ MEVKMLSSSK SMKELTEEQQ NLQKELESLQ NEHAQRMEEF 
       560        570        580        590        600
YVEQKDLEKK LEQIMKQKCT CDSNLEKDKE AEYAGQLAEL RQRLDHAEAD 
       610        620        630 
RQELQDELRQ EREARQKLEM MIKELKLQIL KSSKTAKE

Show »

Length:638

Mass (Da):71,767

Checksum:ⁱ3963A1976EF1673C

GO

Isoform SNOI (identifier: P12757-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
400-684: Missing.

« Hide

        10         20         30         40         50
MENLQTNFSL VQGSTKKLNG MGDDGSPPAK KMITDIHANG KTINKVPTVK 
        60         70         80         90        100
KEHLDDYGEA PVETDGEHVK RTCTSVPETL HLNPSLKHTL AQFHLSSQSS 
       110        120        130        140        150
LGGPAAFSAR HSQESMSPTV FLPLPSPQVL PGPLLIPSDS STELTQTVLE 
       160        170        180        190        200
GESISCFQVG GEKRLCLPQV LNSVLREFTL QQINTVCDEL YIYCSRCTSD 
       210        220        230        240        250
QLHILKVLGI LPFNAPSCGL ITLTDAQRLC NALLRPRTFP QNGSVLPAKS 
       260        270        280        290        300
SLAQLKETGS AFEVEHECLG KCQGLFAPQF YVQPDAPCIQ CLECCGMFAP 
       310        320        330        340        350
QTFVMHSHRS PDKRTCHWGF ESAKWHCYLH VNQKYLGTPE EKKLKIILEE 
       360        370        380        390 
MKEKFSMRSG KRNQSKTDAP SGMELQSWYP VIKQEGDHVS QTHSFLHPS

Show »

Length:399

Mass (Da):44,203

Checksum:ⁱ0AFD7E54B7AB5139

GO

Isoform 5 (identifier: P12757-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-20: Missing.

« Hide

        10         20         30         40         50
MGDDGSPPAK KMITDIHANG KTINKVPTVK KEHLDDYGEA PVETDGEHVK 
        60         70         80         90        100
RTCTSVPETL HLNPSLKHTL AQFHLSSQSS LGGPAAFSAR HSQESMSPTV 
       110        120        130        140        150
FLPLPSPQVL PGPLLIPSDS STELTQTVLE GESISCFQVG GEKRLCLPQV 
       160        170        180        190        200
LNSVLREFTL QQINTVCDEL YIYCSRCTSD QLHILKVLGI LPFNAPSCGL 
       210        220        230        240        250
ITLTDAQRLC NALLRPRTFP QNGSVLPAKS SLAQLKETGS AFEVEHECLG 
       260        270        280        290        300
KCQGLFAPQF YVQPDAPCIQ CLECCGMFAP QTFVMHSHRS PDKRTCHWGF 
       310        320        330        340        350
ESAKWHCYLH VNQKYLGTPE EKKLKIILEE MKEKFSMRSG KRNQSKTDAP 
       360        370        380        390        400
SGMELQSWYP VIKQEGDHVS QTHSFLHPSY YLYMCDKVVA PNVSLTSAVS 
       410        420        430        440        450
QSKELTKTEA SKSISRQSEK AHSSGKLQKT VSYPDVSLEE QEKMDLKTSR 
       460        470        480        490        500
ELCSRLDASI SNNSTSKRKS ESATCNLVRD INKVGIGLVA AASSPLLVKD 
       510        520        530        540        550
VICEDDKGKI MEEVMRTYLK QQEKLNLILQ KKQQLQMEVK MLSSSKSMKE 
       560        570        580        590        600
LTEEQQNLQK ELESLQNEHA QRMEEFYVEQ KDLEKKLEQI MKQKCTCDSN 
       610        620        630        640        650
LEKDKEAEYA GQLAELRQRL DHAEADRQEL QDELRQEREA RQKLEMMIKE 
       660 
LKLQILKSSK TAKE

Note: No experimental confirmation available.

Show »

Length:664

Mass (Da):74,784

Checksum:ⁱA9B843A38DAF1ED5

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H7C4V3	H7C4V3_HUMAN	Ski-like protein Ski-like protein	SKIL	111	Annotation score:
C9J8R9	C9J8R9_HUMAN	Ski-like protein Ski-like protein	SKIL	123	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	13	G → R in CAA79636 (PubMed:8233802).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_011677	38	A → V3 PublicationsCorresponds to variant dbSNP:rs3772173Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_040099	1 – 20	Missing in isoform 5. 1 PublicationAdd BLAST	20
Alternative sequenceⁱVSP_004392	367 – 415	TDAPS…PNVSL → ASFLYQFLIMVMVYFEMKIL CLVCNLTCMLNIAHATTTKY RLIYLYCSF in isoform SNOA. 1 PublicationAdd BLAST	49
Alternative sequenceⁱVSP_004393	400 – 684	Missing in isoform SNOI. 1 PublicationAdd BLAST	285
Alternative sequenceⁱVSP_004394	416 – 684	Missing in isoform SNOA. 1 PublicationAdd BLAST	269
Alternative sequenceⁱVSP_004395	431	S → N in isoform SNON2. 1 Publication	1
Alternative sequenceⁱVSP_004396	432 – 477	Missing in isoform SNON2. 1 PublicationAdd BLAST	46

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X15219 mRNA Translation: CAA33289.1 X15217 mRNA Translation: CAA33287.1 U70730 mRNA Translation: AAB65850.1 AK300053 mRNA Translation: BAG61862.1 AC073288 Genomic DNA No translation available. BC059386 mRNA Translation: AAH59386.1 Z19588 mRNA Translation: CAA79636.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33890.1 [P12757-1] CCDS46953.1 [P12757-3] CCDS46954.1 [P12757-5]
PIRⁱ	S06052 TVHUSN S06054 TVHUSA
NCBI Reference Sequences More...RefSeqⁱ	NP_001138569.1, NM_001145097.2 [P12757-3] NP_001138570.1, NM_001145098.2 [P12757-5] NP_001234937.1, NM_001248008.1 [P12757-1] NP_005405.2, NM_005414.4 [P12757-1] XP_005247778.1, XM_005247721.1 [P12757-1] XP_006713798.1, XM_006713735.1 [P12757-1]
UniGeneⁱ	Hs.536655 Hs.581632

Genome annotation databases

Ensemblⁱ	ENST00000259119; ENSP00000259119; ENSG00000136603 [P12757-1] ENST00000413427; ENSP00000400193; ENSG00000136603 [P12757-3] ENST00000426052; ENSP00000406520; ENSG00000136603 [P12757-5] ENST00000458537; ENSP00000415243; ENSG00000136603 [P12757-1]
GeneIDⁱ	6498
KEGGⁱ	hsa:6498
UCSC genome browser More...UCSCⁱ	uc003fgu.4 human [P12757-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
P12757	Isoform 5 of Ski-like protein		HUMAN		664	UniRef100_P12757
SKIL isoform 7 (Fragment)		PANTR		123
Isoform SNOI of Ski-like protein		HUMAN		399
Ski-like protein (Fragment)		HUMAN		123

Protein	Similar proteins		Species	Score	Length	Source
P12757	Isoform 5 of Ski-like protein		HUMAN		664	UniRef90_P12757
SKIL isoform 7 (Fragment)		PANTR		123
ski-like protein isoform X1		TARSY		694
ski-like protein isoform X2		ODORO		690
SKI like proto-oncogene		SHEEP		687
+103
P12757-2	Ski-like protein		FUKDA		374	UniRef90_P12757-2
Uncharacterized protein		MOUSE		369
P12757-3	ski-like protein isoform X4		ODORO		644	UniRef90_P12757-3
ski-like protein isoform X3		TARSY		638
SKI-like oncogene		PANTR		638
SKIL isoform 7		PONAB		638
ski-like protein isoform X4		LEPWE		638
+24

Protein	Similar proteins		Species	Score	Length	Source
P12757	Isoform 5 of Ski-like protein		HUMAN		664	UniRef50_P12757
SKIL isoform 7 (Fragment)		PANTR		123
ski-like protein isoform X1		TARSY		694
ski-like protein isoform X1		ODORO		690
SKI like proto-oncogene		SHEEP		687
+387
P12757-2	Ski-like protein		FUKDA		374	UniRef50_P12757-2
Uncharacterized protein		MOUSE		369
Uncharacterized protein		ONCMY		415
Uncharacterized protein		BAMTH		353
Uncharacterized protein		Limosa lapponica baueri		398
+9

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X15219 mRNA Translation: CAA33289.1 X15217 mRNA Translation: CAA33287.1 U70730 mRNA Translation: AAB65850.1 AK300053 mRNA Translation: BAG61862.1 AC073288 Genomic DNA No translation available. BC059386 mRNA Translation: AAH59386.1 Z19588 mRNA Translation: CAA79636.1
CCDSⁱ	CCDS33890.1 [P12757-1] CCDS46953.1 [P12757-3] CCDS46954.1 [P12757-5]
PIRⁱ	S06052 TVHUSN S06054 TVHUSA
RefSeqⁱ	NP_001138569.1, NM_001145097.2 [P12757-3] NP_001138570.1, NM_001145098.2 [P12757-5] NP_001234937.1, NM_001248008.1 [P12757-1] NP_005405.2, NM_005414.4 [P12757-1] XP_005247778.1, XM_005247721.1 [P12757-1] XP_006713798.1, XM_006713735.1 [P12757-1]
UniGeneⁱ	Hs.536655 Hs.581632

3D structure databases

Select the link destinations: PDBeⁱ RCSB PDBⁱ PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3EQ5	X-ray	2.45	A/B/C/D/E/F/G/H/I/J/K/L	137-238	[»]
	5C4V	X-ray	2.60	B/D/F	238-356	[»]
ProteinModelPortalⁱ	P12757
SMRⁱ	P12757
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112389, 96 interactors
CORUMⁱ	P12757
DIPⁱ	DIP-42138N
IntActⁱ	P12757, 83 interactors
MINTⁱ	P12757
STRINGⁱ	9606.ENSP00000259119

PTM databases

iPTMnetⁱ	P12757
PhosphoSitePlusⁱ	P12757

Polymorphism and mutation databases

BioMutaⁱ	SKIL
DMDMⁱ	313104010

Proteomic databases

EPDⁱ	P12757
jPOSTⁱ	P12757
MaxQBⁱ	P12757
PaxDbⁱ	P12757
PeptideAtlasⁱ	P12757
PRIDEⁱ	P12757
ProteomicsDBⁱ	52866 52867 [P12757-2] 52868 [P12757-3] 52869 [P12757-4] 52870 [P12757-5]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6498
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000259119; ENSP00000259119; ENSG00000136603 [P12757-1] ENST00000413427; ENSP00000400193; ENSG00000136603 [P12757-3] ENST00000426052; ENSP00000406520; ENSG00000136603 [P12757-5] ENST00000458537; ENSP00000415243; ENSG00000136603 [P12757-1]
GeneIDⁱ	6498
KEGGⁱ	hsa:6498
UCSCⁱ	uc003fgu.4 human [P12757-1]

Organism-specific databases

CTDⁱ	6498
DisGeNETⁱ	6498
EuPathDBⁱ	HostDB:ENSG00000136603.13
GeneCardsⁱ	SKIL
HGNCⁱ	HGNC:10897 SKIL
HPAⁱ	HPA008472
MIMⁱ	165340 gene
neXtProtⁱ	NX_P12757
OpenTargetsⁱ	ENSG00000136603
PharmGKBⁱ	PA35797
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFDK Eukaryota ENOG410Y8AU LUCA
GeneTreeⁱ	ENSGT00940000158435
HOGENOMⁱ	HOG000039989
HOVERGENⁱ	HBG006599
InParanoidⁱ	P12757
KOⁱ	K18499
OMAⁱ	KPESTTC
OrthoDBⁱ	1148296at2759
PhylomeDBⁱ	P12757
TreeFamⁱ	TF324133

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
SignaLinkⁱ	P12757
SIGNORⁱ	P12757

Miscellaneous databases

ChiTaRSⁱ	SKIL human
EvolutionaryTraceⁱ	P12757
GeneWikiⁱ	SKIL
GenomeRNAiⁱ	6498
Protein Ontology More...PROⁱ	PR:P12757
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000136603 Expressed in 221 organ(s), highest expression level in tendon of biceps brachii
CleanExⁱ	HS_SKIL
ExpressionAtlasⁱ	P12757 baseline and differential
Genevisibleⁱ	P12757 HS

Family and domain databases

Gene3Dⁱ	3.10.260.20, 1 hit 3.10.390.10, 1 hit
InterProⁱ	View protein in InterPro IPR014890 c-SKI_SMAD4-bd_dom IPR009061 DNA-bd_dom_put_sf IPR010919 SAND-like_dom_sf IPR028373 Ski-rel_Sno IPR003380 SKI/SNO/DAC IPR037000 Ski_DNA-bd_sf IPR023216 Tscrpt_reg_SKI_SnoN
PANTHERⁱ	PTHR10005 PTHR10005, 1 hit PTHR10005:SF3 PTHR10005:SF3, 1 hit
Pfamⁱ	View protein in Pfam PF08782 c-SKI_SMAD_bind, 1 hit PF02437 Ski_Sno, 1 hit
SMARTⁱ	View protein in SMART SM01046 c-SKI_SMAD_bind, 1 hit
SUPFAMⁱ	SSF46955 SSF46955, 1 hit SSF63763 SSF63763, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SKIL_HUMAN
Accessionⁱ	P12757Primary (citable) accession number: P12757 Secondary accession number(s): A6NGT1 , B4DT50, O00464, P12756, Q07501
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
	Last sequence update:	November 30, 2010
	Last modified:	January 16, 2019
	This is version 176 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM

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UniProtKB - P12757 (SKIL_HUMAN)

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Ski-like protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

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Keywords - Technical termⁱ