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UniProtKB - P12757 (SKIL_HUMAN)

Entry version 180 (03 Jul 2019)
Sequence version 2 (30 Nov 2010)
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Protein

Ski-like protein

Gene

SKIL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May have regulatory role in cell division or differentiation in response to extracellular signals.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P12757

SIGNOR Signaling Network Open Resource

More...SIGNORi		P12757

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ski-like protein
Alternative name(s):
Ski-related oncogene
Ski-related protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SKIL
Synonyms:SNO
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10897 SKIL

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		165340 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P12757

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6498

Open Targets

More...OpenTargetsi		ENSG00000136603

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35797

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SKIL

Domain mapping of disease mutations (DMDM)

More...DMDMi		313104010

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001293871 – 684Ski-like proteinAdd BLAST684

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki50Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki70Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei452PhosphoserineCombined sources1
Cross-linki489Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki527Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by RNF111 and RNF165, promoting proteasomal degradation, leading to enhance the BMP-Smad signaling.1 Publication

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P12757

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P12757

MaxQB - The MaxQuant DataBase

More...MaxQBi		P12757

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P12757

PeptideAtlas

More...PeptideAtlasi		P12757

PRoteomics IDEntifications database

More...PRIDEi		P12757

ProteomicsDB human proteome resource

More...ProteomicsDBi		52866
52867 [P12757-2]
52868 [P12757-3]
52869 [P12757-4]
52870 [P12757-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P12757

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P12757

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000136603 Expressed in 221 organ(s), highest expression level in tendon of biceps brachii

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P12757 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P12757 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA008472

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CPNE4 (via VWFA domain) (By similarity).

Interacts with SMAD2, SMAD3 and RNF111 (PubMed:17591695). Isoform 1 interacts with WWP1 (PubMed:15221015).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		112389, 99 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P12757

Database of interacting proteins

More...DIPi		DIP-42138N

Protein interaction database and analysis system

More...IntActi		P12757, 86 interactors

Molecular INTeraction database

More...MINTi		P12757

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000415243

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1684
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P12757

Database of comparative protein structure models

More...ModBasei		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P12757

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili536 – 684Sequence analysisAdd BLAST149

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SKI family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IFDK Eukaryota
ENOG410Y8AU LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158435

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000039989

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P12757

KEGG Orthology (KO)

More...KOi		K18499

Identification of Orthologs from Complete Genome Data

More...OMAi		ECYGMFS

Database of Orthologous Groups

More...OrthoDBi		1148296at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P12757

TreeFam database of animal gene trees

More...TreeFami		TF324133

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.10.260.20, 1 hit
3.10.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR014890 c-SKI_SMAD4-bd_dom
IPR009061 DNA-bd_dom_put_sf
IPR010919 SAND-like_dom_sf
IPR028373 Ski-rel_Sno
IPR003380 SKI/SNO/DAC
IPR037000 Ski_DNA-bd_sf
IPR023216 Tscrpt_reg_SKI_SnoN

The PANTHER Classification System

More...PANTHERi		PTHR10005 PTHR10005, 1 hit
PTHR10005:SF3 PTHR10005:SF3, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08782 c-SKI_SMAD_bind, 1 hit
PF02437 Ski_Sno, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01046 c-SKI_SMAD_bind, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46955 SSF46955, 1 hit
SSF63763 SSF63763, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform SNON (identifier: P12757-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MENLQTNFSL VQGSTKKLNG MGDDGSPPAK KMITDIHANG KTINKVPTVK 
        60         70         80         90        100
KEHLDDYGEA PVETDGEHVK RTCTSVPETL HLNPSLKHTL AQFHLSSQSS 
       110        120        130        140        150
LGGPAAFSAR HSQESMSPTV FLPLPSPQVL PGPLLIPSDS STELTQTVLE 
       160        170        180        190        200
GESISCFQVG GEKRLCLPQV LNSVLREFTL QQINTVCDEL YIYCSRCTSD 
       210        220        230        240        250
QLHILKVLGI LPFNAPSCGL ITLTDAQRLC NALLRPRTFP QNGSVLPAKS 
       260        270        280        290        300
SLAQLKETGS AFEVEHECLG KCQGLFAPQF YVQPDAPCIQ CLECCGMFAP 
       310        320        330        340        350
QTFVMHSHRS PDKRTCHWGF ESAKWHCYLH VNQKYLGTPE EKKLKIILEE 
       360        370        380        390        400
MKEKFSMRSG KRNQSKTDAP SGMELQSWYP VIKQEGDHVS QTHSFLHPSY 
       410        420        430        440        450
YLYMCDKVVA PNVSLTSAVS QSKELTKTEA SKSISRQSEK AHSSGKLQKT 
       460        470        480        490        500
VSYPDVSLEE QEKMDLKTSR ELCSRLDASI SNNSTSKRKS ESATCNLVRD 
       510        520        530        540        550
INKVGIGLVA AASSPLLVKD VICEDDKGKI MEEVMRTYLK QQEKLNLILQ 
       560        570        580        590        600
KKQQLQMEVK MLSSSKSMKE LTEEQQNLQK ELESLQNEHA QRMEEFYVEQ 
       610        620        630        640        650
KDLEKKLEQI MKQKCTCDSN LEKDKEAEYA GQLAELRQRL DHAEADRQEL 
       660        670        680 
QDELRQEREA RQKLEMMIKE LKLQILKSSK TAKE
Length:684
Mass (Da):76,976
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6A04D4ECEC214CF1
GO
Isoform SNOA (identifier: P12757-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     367-415: TDAPSGMELQ...DKVVAPNVSL → ASFLYQFLIM...YRLIYLYCSF
     416-684: Missing.

Show »
Length:415
Mass (Da):46,335
Checksum:iA2F3E39AE47BB69E
GO
Isoform SNON2 (identifier: P12757-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     431-431: S → N
     432-477: Missing.

Show »
Length:638
Mass (Da):71,767
Checksum:i3963A1976EF1673C
GO
Isoform SNOI (identifier: P12757-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     400-684: Missing.

Show »
Length:399
Mass (Da):44,203
Checksum:i0AFD7E54B7AB5139
GO
Isoform 5 (identifier: P12757-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.

Note: No experimental confirmation available.
Show »
Length:664
Mass (Da):74,784
Checksum:iA9B843A38DAF1ED5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J8R9C9J8R9_HUMAN
Ski-like protein
SKIL
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4V3H7C4V3_HUMAN
Ski-like protein
SKIL
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti13G → R in CAA79636 (PubMed:8233802).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01167738A → V3 PublicationsCorresponds to variant dbSNP:rs3772173Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0400991 – 20Missing in isoform 5. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_004392367 – 415TDAPS…PNVSL → ASFLYQFLIMVMVYFEMKIL CLVCNLTCMLNIAHATTTKY RLIYLYCSF in isoform SNOA. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_004393400 – 684Missing in isoform SNOI. 1 PublicationAdd BLAST285
Alternative sequenceiVSP_004394416 – 684Missing in isoform SNOA. 1 PublicationAdd BLAST269
Alternative sequenceiVSP_004395431S → N in isoform SNON2. 1 Publication1
Alternative sequenceiVSP_004396432 – 477Missing in isoform SNON2. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X15219 mRNA Translation: CAA33289.1
X15217 mRNA Translation: CAA33287.1
U70730 mRNA Translation: AAB65850.1
AK300053 mRNA Translation: BAG61862.1
AC073288 Genomic DNA No translation available.
BC059386 mRNA Translation: AAH59386.1
Z19588 mRNA Translation: CAA79636.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33890.1 [P12757-1]
CCDS46953.1 [P12757-3]
CCDS46954.1 [P12757-5]

Protein sequence database of the Protein Information Resource

More...PIRi		S06052 TVHUSN
S06054 TVHUSA

NCBI Reference Sequences

More...RefSeqi		NP_001138569.1, NM_001145097.2 [P12757-3]
NP_001138570.1, NM_001145098.2 [P12757-5]
NP_001234937.1, NM_001248008.1 [P12757-1]
NP_005405.2, NM_005414.4 [P12757-1]
XP_005247778.1, XM_005247721.1 [P12757-1]
XP_006713798.1, XM_006713735.1 [P12757-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000259119; ENSP00000259119; ENSG00000136603 [P12757-1]
ENST00000413427; ENSP00000400193; ENSG00000136603 [P12757-3]
ENST00000426052; ENSP00000406520; ENSG00000136603 [P12757-5]
ENST00000458537; ENSP00000415243; ENSG00000136603 [P12757-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6498

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6498

UCSC genome browser

More...UCSCi		uc003fgu.4 human [P12757-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15219 mRNA Translation: CAA33289.1
X15217 mRNA Translation: CAA33287.1
U70730 mRNA Translation: AAB65850.1
AK300053 mRNA Translation: BAG61862.1
AC073288 Genomic DNA No translation available.
BC059386 mRNA Translation: AAH59386.1
Z19588 mRNA Translation: CAA79636.1
CCDSiCCDS33890.1 [P12757-1]
CCDS46953.1 [P12757-3]
CCDS46954.1 [P12757-5]
PIRiS06052 TVHUSN
S06054 TVHUSA
RefSeqiNP_001138569.1, NM_001145097.2 [P12757-3]
NP_001138570.1, NM_001145098.2 [P12757-5]
NP_001234937.1, NM_001248008.1 [P12757-1]
NP_005405.2, NM_005414.4 [P12757-1]
XP_005247778.1, XM_005247721.1 [P12757-1]
XP_006713798.1, XM_006713735.1 [P12757-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EQ5X-ray2.45A/B/C/D/E/F/G/H/I/J/K/L137-238[»]
5C4VX-ray2.60B/D/F238-356[»]
SMRiP12757
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112389, 99 interactors
CORUMiP12757
DIPiDIP-42138N
IntActiP12757, 86 interactors
MINTiP12757
STRINGi9606.ENSP00000415243

PTM databases

iPTMnetiP12757
PhosphoSitePlusiP12757

Polymorphism and mutation databases

BioMutaiSKIL
DMDMi313104010

Proteomic databases

EPDiP12757
jPOSTiP12757
MaxQBiP12757
PaxDbiP12757
PeptideAtlasiP12757
PRIDEiP12757
ProteomicsDBi52866
52867 [P12757-2]
52868 [P12757-3]
52869 [P12757-4]
52870 [P12757-5]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		6498
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259119; ENSP00000259119; ENSG00000136603 [P12757-1]
ENST00000413427; ENSP00000400193; ENSG00000136603 [P12757-3]
ENST00000426052; ENSP00000406520; ENSG00000136603 [P12757-5]
ENST00000458537; ENSP00000415243; ENSG00000136603 [P12757-1]
GeneIDi6498
KEGGihsa:6498
UCSCiuc003fgu.4 human [P12757-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6498
DisGeNETi6498

GeneCards: human genes, protein and diseases

More...GeneCardsi		SKIL
HGNCiHGNC:10897 SKIL
HPAiHPA008472
MIMi165340 gene
neXtProtiNX_P12757
OpenTargetsiENSG00000136603
PharmGKBiPA35797

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IFDK Eukaryota
ENOG410Y8AU LUCA
GeneTreeiENSGT00940000158435
HOGENOMiHOG000039989
InParanoidiP12757
KOiK18499
OMAiECYGMFS
OrthoDBi1148296at2759
PhylomeDBiP12757
TreeFamiTF324133

Enzyme and pathway databases

ReactomeiR-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
SignaLinkiP12757
SIGNORiP12757

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SKIL human
EvolutionaryTraceiP12757

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SKIL

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6498

Protein Ontology

More...PROi		PR:P12757

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000136603 Expressed in 221 organ(s), highest expression level in tendon of biceps brachii
ExpressionAtlasiP12757 baseline and differential
GenevisibleiP12757 HS

Family and domain databases

Gene3Di3.10.260.20, 1 hit
3.10.390.10, 1 hit
InterProiView protein in InterPro
IPR014890 c-SKI_SMAD4-bd_dom
IPR009061 DNA-bd_dom_put_sf
IPR010919 SAND-like_dom_sf
IPR028373 Ski-rel_Sno
IPR003380 SKI/SNO/DAC
IPR037000 Ski_DNA-bd_sf
IPR023216 Tscrpt_reg_SKI_SnoN
PANTHERiPTHR10005 PTHR10005, 1 hit
PTHR10005:SF3 PTHR10005:SF3, 1 hit
PfamiView protein in Pfam
PF08782 c-SKI_SMAD_bind, 1 hit
PF02437 Ski_Sno, 1 hit
SMARTiView protein in SMART
SM01046 c-SKI_SMAD_bind, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
SSF63763 SSF63763, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSKIL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P12757
Secondary accession number(s): A6NGT1
, B4DT50, O00464, P12756, Q07501
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: November 30, 2010
Last modified: July 3, 2019
This is version 180 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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