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Protein

Ski-like protein

Gene

SKIL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have regulatory role in cell division or differentiation in response to extracellular signals.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
SignaLinkiP12757
SIGNORiP12757

Names & Taxonomyi

Protein namesi
Recommended name:
Ski-like protein
Alternative name(s):
Ski-related oncogene
Ski-related protein
Gene namesi
Name:SKIL
Synonyms:SNO
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000136603.13
HGNCiHGNC:10897 SKIL
MIMi165340 gene
neXtProtiNX_P12757

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6498
OpenTargetsiENSG00000136603
PharmGKBiPA35797

Polymorphism and mutation databases

BioMutaiSKIL
DMDMi313104010

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001293871 – 684Ski-like proteinAdd BLAST684

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki50Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki70Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei452PhosphoserineCombined sources1
Cross-linki489Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki527Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationi

Ubiquitinated by RNF111 and RNF165, promoting proteasomal degradation, leading to enhance the BMP-Smad signaling.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP12757
MaxQBiP12757
PaxDbiP12757
PeptideAtlasiP12757
PRIDEiP12757
ProteomicsDBi52866
52867 [P12757-2]
52868 [P12757-3]
52869 [P12757-4]
52870 [P12757-5]

PTM databases

iPTMnetiP12757
PhosphoSitePlusiP12757

Expressioni

Tissue specificityi

Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000136603 Expressed in 221 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_SKIL
ExpressionAtlasiP12757 baseline and differential
GenevisibleiP12757 HS

Organism-specific databases

HPAiHPA008472

Interactioni

Subunit structurei

Interacts with CPNE4 (via VWFA domain) (By similarity). Interacts with SMAD2, SMAD3 and RNF111 (PubMed:17591695). Isoform 1 interacts with WWP1 (PubMed:15221015).By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112389, 96 interactors
CORUMiP12757
DIPiDIP-42138N
IntActiP12757, 83 interactors
MINTiP12757
STRINGi9606.ENSP00000259119

Structurei

Secondary structure

1684
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP12757
SMRiP12757
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12757

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili536 – 684Sequence analysisAdd BLAST149

Sequence similaritiesi

Belongs to the SKI family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFDK Eukaryota
ENOG410Y8AU LUCA
GeneTreeiENSGT00530000063040
HOGENOMiHOG000039989
HOVERGENiHBG006599
InParanoidiP12757
KOiK18499
OMAiMEEFYIE
OrthoDBiEOG091G0O02
PhylomeDBiP12757
TreeFamiTF324133

Family and domain databases

Gene3Di3.10.260.20, 1 hit
3.10.390.10, 1 hit
InterProiView protein in InterPro
IPR014890 c-SKI_SMAD4-bd_dom
IPR009061 DNA-bd_dom_put_sf
IPR010919 SAND-like_dom_sf
IPR028373 Ski-rel_Sno
IPR003380 SKI/SNO/DAC
IPR037000 Ski_DNA-bd_sf
IPR023216 Tscrpt_reg_SKI_SnoN
PANTHERiPTHR10005 PTHR10005, 1 hit
PTHR10005:SF3 PTHR10005:SF3, 1 hit
PfamiView protein in Pfam
PF08782 c-SKI_SMAD_bind, 1 hit
PF02437 Ski_Sno, 1 hit
SMARTiView protein in SMART
SM01046 c-SKI_SMAD_bind, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
SSF63763 SSF63763, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform SNON (identifier: P12757-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MENLQTNFSL VQGSTKKLNG MGDDGSPPAK KMITDIHANG KTINKVPTVK
60 70 80 90 100
KEHLDDYGEA PVETDGEHVK RTCTSVPETL HLNPSLKHTL AQFHLSSQSS
110 120 130 140 150
LGGPAAFSAR HSQESMSPTV FLPLPSPQVL PGPLLIPSDS STELTQTVLE
160 170 180 190 200
GESISCFQVG GEKRLCLPQV LNSVLREFTL QQINTVCDEL YIYCSRCTSD
210 220 230 240 250
QLHILKVLGI LPFNAPSCGL ITLTDAQRLC NALLRPRTFP QNGSVLPAKS
260 270 280 290 300
SLAQLKETGS AFEVEHECLG KCQGLFAPQF YVQPDAPCIQ CLECCGMFAP
310 320 330 340 350
QTFVMHSHRS PDKRTCHWGF ESAKWHCYLH VNQKYLGTPE EKKLKIILEE
360 370 380 390 400
MKEKFSMRSG KRNQSKTDAP SGMELQSWYP VIKQEGDHVS QTHSFLHPSY
410 420 430 440 450
YLYMCDKVVA PNVSLTSAVS QSKELTKTEA SKSISRQSEK AHSSGKLQKT
460 470 480 490 500
VSYPDVSLEE QEKMDLKTSR ELCSRLDASI SNNSTSKRKS ESATCNLVRD
510 520 530 540 550
INKVGIGLVA AASSPLLVKD VICEDDKGKI MEEVMRTYLK QQEKLNLILQ
560 570 580 590 600
KKQQLQMEVK MLSSSKSMKE LTEEQQNLQK ELESLQNEHA QRMEEFYVEQ
610 620 630 640 650
KDLEKKLEQI MKQKCTCDSN LEKDKEAEYA GQLAELRQRL DHAEADRQEL
660 670 680
QDELRQEREA RQKLEMMIKE LKLQILKSSK TAKE
Length:684
Mass (Da):76,976
Last modified:November 30, 2010 - v2
Checksum:i6A04D4ECEC214CF1
GO
Isoform SNOA (identifier: P12757-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     367-415: TDAPSGMELQ...DKVVAPNVSL → ASFLYQFLIM...YRLIYLYCSF
     416-684: Missing.

Show »
Length:415
Mass (Da):46,335
Checksum:iA2F3E39AE47BB69E
GO
Isoform SNON2 (identifier: P12757-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     431-431: S → N
     432-477: Missing.

Show »
Length:638
Mass (Da):71,767
Checksum:i3963A1976EF1673C
GO
Isoform SNOI (identifier: P12757-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     400-684: Missing.

Show »
Length:399
Mass (Da):44,203
Checksum:i0AFD7E54B7AB5139
GO
Isoform 5 (identifier: P12757-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.

Note: No experimental confirmation available.
Show »
Length:664
Mass (Da):74,784
Checksum:iA9B843A38DAF1ED5
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C4V3H7C4V3_HUMAN
Ski-like protein
SKIL
111Annotation score:
C9J8R9C9J8R9_HUMAN
Ski-like protein
SKIL
123Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13G → R in CAA79636 (PubMed:8233802).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01167738A → V3 PublicationsCorresponds to variant dbSNP:rs3772173Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0400991 – 20Missing in isoform 5. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_004392367 – 415TDAPS…PNVSL → ASFLYQFLIMVMVYFEMKIL CLVCNLTCMLNIAHATTTKY RLIYLYCSF in isoform SNOA. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_004393400 – 684Missing in isoform SNOI. 1 PublicationAdd BLAST285
Alternative sequenceiVSP_004394416 – 684Missing in isoform SNOA. 1 PublicationAdd BLAST269
Alternative sequenceiVSP_004395431S → N in isoform SNON2. 1 Publication1
Alternative sequenceiVSP_004396432 – 477Missing in isoform SNON2. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15219 mRNA Translation: CAA33289.1
X15217 mRNA Translation: CAA33287.1
U70730 mRNA Translation: AAB65850.1
AK300053 mRNA Translation: BAG61862.1
AC073288 Genomic DNA No translation available.
BC059386 mRNA Translation: AAH59386.1
Z19588 mRNA Translation: CAA79636.1
CCDSiCCDS33890.1 [P12757-1]
CCDS46953.1 [P12757-3]
CCDS46954.1 [P12757-5]
PIRiS06052 TVHUSN
S06054 TVHUSA
RefSeqiNP_001138569.1, NM_001145097.2 [P12757-3]
NP_001138570.1, NM_001145098.2 [P12757-5]
NP_001234937.1, NM_001248008.1 [P12757-1]
NP_005405.2, NM_005414.4 [P12757-1]
XP_005247778.1, XM_005247721.1 [P12757-1]
XP_006713798.1, XM_006713735.1 [P12757-1]
UniGeneiHs.536655
Hs.581632

Genome annotation databases

EnsembliENST00000259119; ENSP00000259119; ENSG00000136603 [P12757-1]
ENST00000413427; ENSP00000400193; ENSG00000136603 [P12757-3]
ENST00000426052; ENSP00000406520; ENSG00000136603 [P12757-5]
ENST00000458537; ENSP00000415243; ENSG00000136603 [P12757-1]
GeneIDi6498
KEGGihsa:6498
UCSCiuc003fgu.4 human [P12757-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15219 mRNA Translation: CAA33289.1
X15217 mRNA Translation: CAA33287.1
U70730 mRNA Translation: AAB65850.1
AK300053 mRNA Translation: BAG61862.1
AC073288 Genomic DNA No translation available.
BC059386 mRNA Translation: AAH59386.1
Z19588 mRNA Translation: CAA79636.1
CCDSiCCDS33890.1 [P12757-1]
CCDS46953.1 [P12757-3]
CCDS46954.1 [P12757-5]
PIRiS06052 TVHUSN
S06054 TVHUSA
RefSeqiNP_001138569.1, NM_001145097.2 [P12757-3]
NP_001138570.1, NM_001145098.2 [P12757-5]
NP_001234937.1, NM_001248008.1 [P12757-1]
NP_005405.2, NM_005414.4 [P12757-1]
XP_005247778.1, XM_005247721.1 [P12757-1]
XP_006713798.1, XM_006713735.1 [P12757-1]
UniGeneiHs.536655
Hs.581632

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EQ5X-ray2.45A/B/C/D/E/F/G/H/I/J/K/L137-238[»]
5C4VX-ray2.60B/D/F238-356[»]
ProteinModelPortaliP12757
SMRiP12757
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112389, 96 interactors
CORUMiP12757
DIPiDIP-42138N
IntActiP12757, 83 interactors
MINTiP12757
STRINGi9606.ENSP00000259119

PTM databases

iPTMnetiP12757
PhosphoSitePlusiP12757

Polymorphism and mutation databases

BioMutaiSKIL
DMDMi313104010

Proteomic databases

EPDiP12757
MaxQBiP12757
PaxDbiP12757
PeptideAtlasiP12757
PRIDEiP12757
ProteomicsDBi52866
52867 [P12757-2]
52868 [P12757-3]
52869 [P12757-4]
52870 [P12757-5]

Protocols and materials databases

DNASUi6498
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259119; ENSP00000259119; ENSG00000136603 [P12757-1]
ENST00000413427; ENSP00000400193; ENSG00000136603 [P12757-3]
ENST00000426052; ENSP00000406520; ENSG00000136603 [P12757-5]
ENST00000458537; ENSP00000415243; ENSG00000136603 [P12757-1]
GeneIDi6498
KEGGihsa:6498
UCSCiuc003fgu.4 human [P12757-1]

Organism-specific databases

CTDi6498
DisGeNETi6498
EuPathDBiHostDB:ENSG00000136603.13
GeneCardsiSKIL
HGNCiHGNC:10897 SKIL
HPAiHPA008472
MIMi165340 gene
neXtProtiNX_P12757
OpenTargetsiENSG00000136603
PharmGKBiPA35797
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFDK Eukaryota
ENOG410Y8AU LUCA
GeneTreeiENSGT00530000063040
HOGENOMiHOG000039989
HOVERGENiHBG006599
InParanoidiP12757
KOiK18499
OMAiMEEFYIE
OrthoDBiEOG091G0O02
PhylomeDBiP12757
TreeFamiTF324133

Enzyme and pathway databases

ReactomeiR-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
SignaLinkiP12757
SIGNORiP12757

Miscellaneous databases

ChiTaRSiSKIL human
EvolutionaryTraceiP12757
GeneWikiiSKIL
GenomeRNAii6498
PROiPR:P12757
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136603 Expressed in 221 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_SKIL
ExpressionAtlasiP12757 baseline and differential
GenevisibleiP12757 HS

Family and domain databases

Gene3Di3.10.260.20, 1 hit
3.10.390.10, 1 hit
InterProiView protein in InterPro
IPR014890 c-SKI_SMAD4-bd_dom
IPR009061 DNA-bd_dom_put_sf
IPR010919 SAND-like_dom_sf
IPR028373 Ski-rel_Sno
IPR003380 SKI/SNO/DAC
IPR037000 Ski_DNA-bd_sf
IPR023216 Tscrpt_reg_SKI_SnoN
PANTHERiPTHR10005 PTHR10005, 1 hit
PTHR10005:SF3 PTHR10005:SF3, 1 hit
PfamiView protein in Pfam
PF08782 c-SKI_SMAD_bind, 1 hit
PF02437 Ski_Sno, 1 hit
SMARTiView protein in SMART
SM01046 c-SKI_SMAD_bind, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
SSF63763 SSF63763, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSKIL_HUMAN
AccessioniPrimary (citable) accession number: P12757
Secondary accession number(s): A6NGT1
, B4DT50, O00464, P12756, Q07501
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: November 30, 2010
Last modified: September 12, 2018
This is version 173 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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