UniProtKB - P12757 (SKIL_HUMAN)
Ski-like protein
SKIL
Functioni
GO - Molecular functioni
- chromatin binding Source: Ensembl
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- identical protein binding Source: UniProtKB
- protein-containing complex binding Source: UniProtKB
- protein domain specific binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- SMAD binding Source: UniProtKB
GO - Biological processi
- blastocyst formation Source: Ensembl
- cell cycle arrest Source: Ensembl
- lens fiber cell differentiation Source: Ensembl
- lymphocyte homeostasis Source: Ensembl
- negative regulation of BMP signaling pathway Source: GO_Central
- negative regulation of cell differentiation Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
- positive regulation of axonogenesis Source: UniProtKB
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
- positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
- response to antibiotic Source: UniProtKB
- response to cytokine Source: Ensembl
- response to growth factor Source: UniProtKB
- skeletal muscle tissue development Source: UniProtKB
- spermatogenesis Source: Ensembl
- transforming growth factor beta receptor signaling pathway Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | P12757 |
Reactomei | R-HSA-2173795, Downregulation of SMAD2/3:SMAD4 transcriptional activity |
SignaLinki | P12757 |
SIGNORi | P12757 |
Names & Taxonomyi
Protein namesi | Recommended name: Ski-like proteinAlternative name(s): Ski-related oncogene Ski-related protein |
Gene namesi | Name:SKIL Synonyms:SNO |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10897, SKIL |
MIMi | 165340, gene |
neXtProti | NX_P12757 |
VEuPathDBi | HostDB:ENSG00000136603.13 |
Subcellular locationi
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
- PML body Source: UniProtKB
Other locations
- acrosomal vesicle Source: Ensembl
- cytoplasm Source: UniProtKB
- protein-containing complex Source: MGI
- transcription regulator complex Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 6498 |
OpenTargetsi | ENSG00000136603 |
PharmGKBi | PA35797 |
Miscellaneous databases
Pharosi | P12757, Tbio |
Genetic variation databases
BioMutai | SKIL |
DMDMi | 313104010 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000129387 | 1 – 684 | Ski-like proteinAdd BLAST | 684 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 50 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 70 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 452 | PhosphoserineCombined sources | 1 | |
Cross-linki | 489 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 527 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P12757 |
jPOSTi | P12757 |
MassIVEi | P12757 |
MaxQBi | P12757 |
PaxDbi | P12757 |
PeptideAtlasi | P12757 |
PRIDEi | P12757 |
ProteomicsDBi | 52866 [P12757-1] 52867 [P12757-2] 52868 [P12757-3] 52869 [P12757-4] 52870 [P12757-5] |
PTM databases
iPTMneti | P12757 |
PhosphoSitePlusi | P12757 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000136603, Expressed in tendon of biceps brachii and 234 other tissues |
ExpressionAtlasi | P12757, baseline and differential |
Genevisiblei | P12757, HS |
Organism-specific databases
HPAi | ENSG00000136603, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsP12757
GO - Molecular functioni
- identical protein binding Source: UniProtKB
- protein domain specific binding Source: UniProtKB
- SMAD binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 112389, 103 interactors |
CORUMi | P12757 |
DIPi | DIP-42138N |
IntActi | P12757, 93 interactors |
MINTi | P12757 |
STRINGi | 9606.ENSP00000415243 |
Miscellaneous databases
RNActi | P12757, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P12757 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P12757 |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 536 – 684 | Sequence analysisAdd BLAST | 149 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QT5P, Eukaryota |
GeneTreei | ENSGT00940000158435 |
HOGENOMi | CLU_025786_0_0_1 |
InParanoidi | P12757 |
OMAi | ECYGMFS |
OrthoDBi | 1148296at2759 |
PhylomeDBi | P12757 |
TreeFami | TF324133 |
Family and domain databases
Gene3Di | 3.10.260.20, 1 hit 3.10.390.10, 1 hit |
InterProi | View protein in InterPro IPR014890, c-SKI_SMAD4-bd_dom IPR009061, DNA-bd_dom_put_sf IPR010919, SAND-like_dom_sf IPR028373, Ski-rel_Sno IPR003380, SKI/SNO/DAC IPR037000, Ski_DNA-bd_sf IPR023216, Tscrpt_reg_SKI_SnoN |
PANTHERi | PTHR10005, PTHR10005, 1 hit PTHR10005:SF3, PTHR10005:SF3, 1 hit |
Pfami | View protein in Pfam PF08782, c-SKI_SMAD_bind, 1 hit PF02437, Ski_Sno, 1 hit |
SMARTi | View protein in SMART SM01046, c-SKI_SMAD_bind, 1 hit |
SUPFAMi | SSF46955, SSF46955, 1 hit SSF63763, SSF63763, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MENLQTNFSL VQGSTKKLNG MGDDGSPPAK KMITDIHANG KTINKVPTVK
60 70 80 90 100
KEHLDDYGEA PVETDGEHVK RTCTSVPETL HLNPSLKHTL AQFHLSSQSS
110 120 130 140 150
LGGPAAFSAR HSQESMSPTV FLPLPSPQVL PGPLLIPSDS STELTQTVLE
160 170 180 190 200
GESISCFQVG GEKRLCLPQV LNSVLREFTL QQINTVCDEL YIYCSRCTSD
210 220 230 240 250
QLHILKVLGI LPFNAPSCGL ITLTDAQRLC NALLRPRTFP QNGSVLPAKS
260 270 280 290 300
SLAQLKETGS AFEVEHECLG KCQGLFAPQF YVQPDAPCIQ CLECCGMFAP
310 320 330 340 350
QTFVMHSHRS PDKRTCHWGF ESAKWHCYLH VNQKYLGTPE EKKLKIILEE
360 370 380 390 400
MKEKFSMRSG KRNQSKTDAP SGMELQSWYP VIKQEGDHVS QTHSFLHPSY
410 420 430 440 450
YLYMCDKVVA PNVSLTSAVS QSKELTKTEA SKSISRQSEK AHSSGKLQKT
460 470 480 490 500
VSYPDVSLEE QEKMDLKTSR ELCSRLDASI SNNSTSKRKS ESATCNLVRD
510 520 530 540 550
INKVGIGLVA AASSPLLVKD VICEDDKGKI MEEVMRTYLK QQEKLNLILQ
560 570 580 590 600
KKQQLQMEVK MLSSSKSMKE LTEEQQNLQK ELESLQNEHA QRMEEFYVEQ
610 620 630 640 650
KDLEKKLEQI MKQKCTCDSN LEKDKEAEYA GQLAELRQRL DHAEADRQEL
660 670 680
QDELRQEREA RQKLEMMIKE LKLQILKSSK TAKE
The sequence of this isoform differs from the canonical sequence as follows:
367-415: TDAPSGMELQ...DKVVAPNVSL → ASFLYQFLIM...YRLIYLYCSF
416-684: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
431-431: S → N
432-477: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
400-684: Missing.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J8R9 | C9J8R9_HUMAN | Ski-like protein | SKIL | 123 | Annotation score: | ||
H7C4V3 | H7C4V3_HUMAN | Ski-like protein | SKIL | 111 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 13 | G → R in CAA79636 (PubMed:8233802).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_011677 | 38 | A → V3 PublicationsCorresponds to variant dbSNP:rs3772173Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040099 | 1 – 20 | Missing in isoform 5. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_004392 | 367 – 415 | TDAPS…PNVSL → ASFLYQFLIMVMVYFEMKIL CLVCNLTCMLNIAHATTTKY RLIYLYCSF in isoform SNOA. 1 PublicationAdd BLAST | 49 | |
Alternative sequenceiVSP_004393 | 400 – 684 | Missing in isoform SNOI. 1 PublicationAdd BLAST | 285 | |
Alternative sequenceiVSP_004394 | 416 – 684 | Missing in isoform SNOA. 1 PublicationAdd BLAST | 269 | |
Alternative sequenceiVSP_004395 | 431 | S → N in isoform SNON2. 1 Publication | 1 | |
Alternative sequenceiVSP_004396 | 432 – 477 | Missing in isoform SNON2. 1 PublicationAdd BLAST | 46 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15219 mRNA Translation: CAA33289.1 X15217 mRNA Translation: CAA33287.1 U70730 mRNA Translation: AAB65850.1 AK300053 mRNA Translation: BAG61862.1 AC073288 Genomic DNA No translation available. BC059386 mRNA Translation: AAH59386.1 Z19588 mRNA Translation: CAA79636.1 |
CCDSi | CCDS33890.1 [P12757-1] CCDS46953.1 [P12757-3] CCDS46954.1 [P12757-5] |
PIRi | S06052, TVHUSN S06054, TVHUSA |
RefSeqi | NP_001138569.1, NM_001145097.2 [P12757-3] NP_001138570.1, NM_001145098.2 [P12757-5] NP_001234937.1, NM_001248008.1 [P12757-1] NP_005405.2, NM_005414.4 [P12757-1] XP_005247778.1, XM_005247721.1 [P12757-1] XP_006713798.1, XM_006713735.1 [P12757-1] |
Genome annotation databases
Ensembli | ENST00000259119; ENSP00000259119; ENSG00000136603 [P12757-1] ENST00000413427; ENSP00000400193; ENSG00000136603 [P12757-3] ENST00000426052; ENSP00000406520; ENSG00000136603 [P12757-5] ENST00000458537; ENSP00000415243; ENSG00000136603 [P12757-1] |
GeneIDi | 6498 |
KEGGi | hsa:6498 |
UCSCi | uc003fgu.4, human [P12757-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15219 mRNA Translation: CAA33289.1 X15217 mRNA Translation: CAA33287.1 U70730 mRNA Translation: AAB65850.1 AK300053 mRNA Translation: BAG61862.1 AC073288 Genomic DNA No translation available. BC059386 mRNA Translation: AAH59386.1 Z19588 mRNA Translation: CAA79636.1 |
CCDSi | CCDS33890.1 [P12757-1] CCDS46953.1 [P12757-3] CCDS46954.1 [P12757-5] |
PIRi | S06052, TVHUSN S06054, TVHUSA |
RefSeqi | NP_001138569.1, NM_001145097.2 [P12757-3] NP_001138570.1, NM_001145098.2 [P12757-5] NP_001234937.1, NM_001248008.1 [P12757-1] NP_005405.2, NM_005414.4 [P12757-1] XP_005247778.1, XM_005247721.1 [P12757-1] XP_006713798.1, XM_006713735.1 [P12757-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3EQ5 | X-ray | 2.45 | A/B/C/D/E/F/G/H/I/J/K/L | 137-238 | [»] | |
5C4V | X-ray | 2.60 | B/D/F | 238-356 | [»] | |
SMRi | P12757 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112389, 103 interactors |
CORUMi | P12757 |
DIPi | DIP-42138N |
IntActi | P12757, 93 interactors |
MINTi | P12757 |
STRINGi | 9606.ENSP00000415243 |
PTM databases
iPTMneti | P12757 |
PhosphoSitePlusi | P12757 |
Genetic variation databases
BioMutai | SKIL |
DMDMi | 313104010 |
Proteomic databases
EPDi | P12757 |
jPOSTi | P12757 |
MassIVEi | P12757 |
MaxQBi | P12757 |
PaxDbi | P12757 |
PeptideAtlasi | P12757 |
PRIDEi | P12757 |
ProteomicsDBi | 52866 [P12757-1] 52867 [P12757-2] 52868 [P12757-3] 52869 [P12757-4] 52870 [P12757-5] |
Protocols and materials databases
Antibodypediai | 1923, 519 antibodies |
DNASUi | 6498 |
Genome annotation databases
Ensembli | ENST00000259119; ENSP00000259119; ENSG00000136603 [P12757-1] ENST00000413427; ENSP00000400193; ENSG00000136603 [P12757-3] ENST00000426052; ENSP00000406520; ENSG00000136603 [P12757-5] ENST00000458537; ENSP00000415243; ENSG00000136603 [P12757-1] |
GeneIDi | 6498 |
KEGGi | hsa:6498 |
UCSCi | uc003fgu.4, human [P12757-1] |
Organism-specific databases
CTDi | 6498 |
DisGeNETi | 6498 |
GeneCardsi | SKIL |
HGNCi | HGNC:10897, SKIL |
HPAi | ENSG00000136603, Low tissue specificity |
MIMi | 165340, gene |
neXtProti | NX_P12757 |
OpenTargetsi | ENSG00000136603 |
PharmGKBi | PA35797 |
VEuPathDBi | HostDB:ENSG00000136603.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QT5P, Eukaryota |
GeneTreei | ENSGT00940000158435 |
HOGENOMi | CLU_025786_0_0_1 |
InParanoidi | P12757 |
OMAi | ECYGMFS |
OrthoDBi | 1148296at2759 |
PhylomeDBi | P12757 |
TreeFami | TF324133 |
Enzyme and pathway databases
PathwayCommonsi | P12757 |
Reactomei | R-HSA-2173795, Downregulation of SMAD2/3:SMAD4 transcriptional activity |
SignaLinki | P12757 |
SIGNORi | P12757 |
Miscellaneous databases
BioGRID-ORCSi | 6498, 14 hits in 999 CRISPR screens |
ChiTaRSi | SKIL, human |
EvolutionaryTracei | P12757 |
GeneWikii | SKIL |
GenomeRNAii | 6498 |
Pharosi | P12757, Tbio |
PROi | PR:P12757 |
RNActi | P12757, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000136603, Expressed in tendon of biceps brachii and 234 other tissues |
ExpressionAtlasi | P12757, baseline and differential |
Genevisiblei | P12757, HS |
Family and domain databases
Gene3Di | 3.10.260.20, 1 hit 3.10.390.10, 1 hit |
InterProi | View protein in InterPro IPR014890, c-SKI_SMAD4-bd_dom IPR009061, DNA-bd_dom_put_sf IPR010919, SAND-like_dom_sf IPR028373, Ski-rel_Sno IPR003380, SKI/SNO/DAC IPR037000, Ski_DNA-bd_sf IPR023216, Tscrpt_reg_SKI_SnoN |
PANTHERi | PTHR10005, PTHR10005, 1 hit PTHR10005:SF3, PTHR10005:SF3, 1 hit |
Pfami | View protein in Pfam PF08782, c-SKI_SMAD_bind, 1 hit PF02437, Ski_Sno, 1 hit |
SMARTi | View protein in SMART SM01046, c-SKI_SMAD_bind, 1 hit |
SUPFAMi | SSF46955, SSF46955, 1 hit SSF63763, SSF63763, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SKIL_HUMAN | |
Accessioni | P12757Primary (citable) accession number: P12757 Secondary accession number(s): A6NGT1 Q07501 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | November 30, 2010 | |
Last modified: | April 7, 2021 | |
This is version 192 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families