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Protein

Ski oncogene

Gene

SKI

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-201451 Signaling by BMP
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P12755

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P12755

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ski oncogene
Alternative name(s):
Proto-oncogene c-Ski
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SKI
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000157933.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10896 SKI

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
164780 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P12755

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Shprintzen-Goldberg craniosynostosis syndrome (SGS)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA very rare syndrome characterized by a marfanoid habitus, craniosynostosis, characteristic dysmorphic facial features, skeletal and cardiovascular abnormalities, mental retardation, developmental delay and learning disabilities.
See also OMIM:182212
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07117021L → R in SGS. 1 PublicationCorresponds to variant dbSNP:rs869312902EnsemblClinVar.1
Natural variantiVAR_07165928S → T in SGS. 1 Publication1
Natural variantiVAR_07117131S → L in SGS. 2 Publications1
Natural variantiVAR_07117232L → P in SGS. 1 Publication1
Natural variantiVAR_07117332L → V in SGS. 3 PublicationsCorresponds to variant dbSNP:rs387907304EnsemblClinVar.1
Natural variantiVAR_07166034G → A in SGS. 1 Publication1
Natural variantiVAR_07117434G → C in SGS. 2 PublicationsCorresponds to variant dbSNP:rs387907306EnsemblClinVar.1
Natural variantiVAR_07117534G → D in SGS. 2 PublicationsCorresponds to variant dbSNP:rs387907305EnsemblClinVar.1
Natural variantiVAR_07117634G → S in SGS. 3 PublicationsCorresponds to variant dbSNP:rs387907306EnsemblClinVar.1
Natural variantiVAR_07117734G → V in SGS. 2 PublicationsCorresponds to variant dbSNP:rs387907305EnsemblClinVar.1
Natural variantiVAR_07117835P → Q in SGS. 1 PublicationCorresponds to variant dbSNP:rs397514589EnsemblClinVar.1
Natural variantiVAR_07117935P → S in SGS. 4 PublicationsCorresponds to variant dbSNP:rs397514590EnsemblClinVar.1
Natural variantiVAR_07118094 – 97Missing in SGS. 1 Publication4
Natural variantiVAR_07118195 – 97Missing in SGS. 2 Publications3
Natural variantiVAR_071182116G → E in SGS. 2 PublicationsCorresponds to variant dbSNP:rs387907303EnsemblClinVar.1
Natural variantiVAR_071183117G → R in SGS. 1 PublicationCorresponds to variant dbSNP:rs869312901EnsemblClinVar.1

Keywords - Diseasei

Craniosynostosis, Disease mutation, Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
6497

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
SKI

MalaCards human disease database

More...
MalaCardsi
SKI
MIMi182212 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000157933

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1606 1p36 deletion syndrome
2462 Shprintzen-Goldberg syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35796

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SKI

Domain mapping of disease mutations (DMDM)

More...
DMDMi
134517

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001293821 – 728Ski oncogeneAdd BLAST728

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei383PhosphoserineCombined sources1
Modified residuei432PhosphoserineCombined sources1
Modified residuei480PhosphoserineCombined sources1
Modified residuei720PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by RNF165, promoting proteasomal degradation, leading to enhance the BMP-Smad signaling.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P12755

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P12755

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P12755

PeptideAtlas

More...
PeptideAtlasi
P12755

PRoteomics IDEntifications database

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PRIDEi
P12755

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52865

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P12755

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P12755

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000157933 Expressed in 213 organ(s), highest expression level in cerebellar hemisphere

CleanEx database of gene expression profiles

More...
CleanExi
HS_SKI

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P12755 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB010449
HPA066567

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SMAD2, SMAD3 and SMAD4. Interacts with HIPK2. Part of a complex with HIPK2 and SMAD1/2/3. Interacts with PRDM16 and SMAD3; the interaction with PRDM16 promotes the recruitment SMAD3-HDAC1 complex on the promoter of TGF-beta target genes.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112388, 125 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P12755

Database of interacting proteins

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DIPi
DIP-31514N

Protein interaction database and analysis system

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IntActi
P12755, 17 interactors

Molecular INTeraction database

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MINTi
P12755

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000367797

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1728
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P12755

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P12755

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P12755

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili536 – 710Sequence analysisAdd BLAST175

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SKI family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IFDK Eukaryota
ENOG410Y8AU LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160546

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000039989

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG006599

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P12755

Identification of Orthologs from Complete Genome Data

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OMAi
QEQLWPK

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0O02

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P12755

TreeFam database of animal gene trees

More...
TreeFami
TF324133

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.10.260.20, 1 hit
3.10.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR014890 c-SKI_SMAD4-bd_dom
IPR009061 DNA-bd_dom_put_sf
IPR010919 SAND-like_dom_sf
IPR028760 Ski
IPR003380 SKI/SNO/DAC
IPR037000 Ski_DNA-bd_sf
IPR023216 Tscrpt_reg_SKI_SnoN

The PANTHER Classification System

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PANTHERi
PTHR10005 PTHR10005, 1 hit
PTHR10005:SF15 PTHR10005:SF15, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08782 c-SKI_SMAD_bind, 1 hit
PF02437 Ski_Sno, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01046 c-SKI_SMAD_bind, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46955 SSF46955, 1 hit
SSF63763 SSF63763, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P12755-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAAAGGRGC FQPHPGLQKT LEQFHLSSMS SLGGPAAFSA RWAQEAYKKE
60 70 80 90 100
SAKEAGAAAV PAPVPAATEP PPVLHLPAIQ PPPPVLPGPF FMPSDRSTER
110 120 130 140 150
CETVLEGETI SCFVVGGEKR LCLPQILNSV LRDFSLQQIN AVCDELHIYC
160 170 180 190 200
SRCTADQLEI LKVMGILPFS APSCGLITKT DAERLCNALL YGGAYPPPCK
210 220 230 240 250
KELAASLALG LELSERSVRV YHECFGKCKG LLVPELYSSP SAACIQCLDC
260 270 280 290 300
RLMYPPHKFV VHSHKALENR TCHWGFDSAN WRAYILLSQD YTGKEEQARL
310 320 330 340 350
GRCLDDVKEK FDYGNKYKRR VPRVSSEPPA SIRPKTDDTS SQSPAPSEKD
360 370 380 390 400
KPSSWLRTLA GSSNKSLGCV HPRQRLSAFR PWSPAVSASE KELSPHLPAL
410 420 430 440 450
IRDSFYSYKS FETAVAPNVA LAPPAQQKVV SSPPCAAAVS RAPEPLATCT
460 470 480 490 500
QPRKRKLTVD TPGAPETLAP VAAPEEDKDS EAEVEVESRE EFTSSLSSLS
510 520 530 540 550
SPSFTSSSSA KDLGSPGARA LPSAVPDAAA PADAPSGLEA ELEHLRQALE
560 570 580 590 600
GGLDTKEAKE KFLHEVVKMR VKQEEKLSAA LQAKRSLHQE LEFLRVAKKE
610 620 630 640 650
KLREATEAKR NLRKEIERLR AENEKKMKEA NESRLRLKRE LEQARQARVC
660 670 680 690 700
DKGCEAGRLR AKYSAQIEDL QVKLQHAEAD REQLRADLLR EREAREHLEK
710 720
VVKELQEQLW PRARPEAAGS EGAAELEP
Length:728
Mass (Da):80,005
Last modified:October 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9B78C4840A28C2DA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07117021L → R in SGS. 1 PublicationCorresponds to variant dbSNP:rs869312902EnsemblClinVar.1
Natural variantiVAR_07165928S → T in SGS. 1 Publication1
Natural variantiVAR_07117131S → L in SGS. 2 Publications1
Natural variantiVAR_07117232L → P in SGS. 1 Publication1
Natural variantiVAR_07117332L → V in SGS. 3 PublicationsCorresponds to variant dbSNP:rs387907304EnsemblClinVar.1
Natural variantiVAR_07166034G → A in SGS. 1 Publication1
Natural variantiVAR_07117434G → C in SGS. 2 PublicationsCorresponds to variant dbSNP:rs387907306EnsemblClinVar.1
Natural variantiVAR_07117534G → D in SGS. 2 PublicationsCorresponds to variant dbSNP:rs387907305EnsemblClinVar.1
Natural variantiVAR_07117634G → S in SGS. 3 PublicationsCorresponds to variant dbSNP:rs387907306EnsemblClinVar.1
Natural variantiVAR_07117734G → V in SGS. 2 PublicationsCorresponds to variant dbSNP:rs387907305EnsemblClinVar.1
Natural variantiVAR_07117835P → Q in SGS. 1 PublicationCorresponds to variant dbSNP:rs397514589EnsemblClinVar.1
Natural variantiVAR_07117935P → S in SGS. 4 PublicationsCorresponds to variant dbSNP:rs397514590EnsemblClinVar.1
Natural variantiVAR_07118094 – 97Missing in SGS. 1 Publication4
Natural variantiVAR_07118195 – 97Missing in SGS. 2 Publications3
Natural variantiVAR_071182116G → E in SGS. 2 PublicationsCorresponds to variant dbSNP:rs387907303EnsemblClinVar.1
Natural variantiVAR_071183117G → R in SGS. 1 PublicationCorresponds to variant dbSNP:rs869312901EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X15218 mRNA Translation: CAA33288.1
AL590822 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS39.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S06053 TVHUSK

NCBI Reference Sequences

More...
RefSeqi
NP_003027.1, NM_003036.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.656507

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000378536; ENSP00000367797; ENSG00000157933

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6497

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6497

UCSC genome browser

More...
UCSCi
uc001aja.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15218 mRNA Translation: CAA33288.1
AL590822 Genomic DNA No translation available.
CCDSiCCDS39.1
PIRiS06053 TVHUSK
RefSeqiNP_003027.1, NM_003036.3
UniGeneiHs.656507

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MR1X-ray2.85C/D219-313[»]
1SBXX-ray1.65A91-192[»]
5XODX-ray1.85B15-40[»]
ProteinModelPortaliP12755
SMRiP12755
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112388, 125 interactors
CORUMiP12755
DIPiDIP-31514N
IntActiP12755, 17 interactors
MINTiP12755
STRINGi9606.ENSP00000367797

PTM databases

iPTMnetiP12755
PhosphoSitePlusiP12755

Polymorphism and mutation databases

BioMutaiSKI
DMDMi134517

Proteomic databases

EPDiP12755
MaxQBiP12755
PaxDbiP12755
PeptideAtlasiP12755
PRIDEiP12755
ProteomicsDBi52865

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378536; ENSP00000367797; ENSG00000157933
GeneIDi6497
KEGGihsa:6497
UCSCiuc001aja.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6497
DisGeNETi6497
EuPathDBiHostDB:ENSG00000157933.9

GeneCards: human genes, protein and diseases

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GeneCardsi
SKI
GeneReviewsiSKI
HGNCiHGNC:10896 SKI
HPAiCAB010449
HPA066567
MalaCardsiSKI
MIMi164780 gene
182212 phenotype
neXtProtiNX_P12755
OpenTargetsiENSG00000157933
Orphaneti1606 1p36 deletion syndrome
2462 Shprintzen-Goldberg syndrome
PharmGKBiPA35796

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IFDK Eukaryota
ENOG410Y8AU LUCA
GeneTreeiENSGT00940000160546
HOGENOMiHOG000039989
HOVERGENiHBG006599
InParanoidiP12755
OMAiQEQLWPK
OrthoDBiEOG091G0O02
PhylomeDBiP12755
TreeFamiTF324133

Enzyme and pathway databases

ReactomeiR-HSA-201451 Signaling by BMP
R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity
SignaLinkiP12755
SIGNORiP12755

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SKI human
EvolutionaryTraceiP12755

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SKI_protein

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6497

Protein Ontology

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PROi
PR:P12755

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000157933 Expressed in 213 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_SKI
GenevisibleiP12755 HS

Family and domain databases

Gene3Di3.10.260.20, 1 hit
3.10.390.10, 1 hit
InterProiView protein in InterPro
IPR014890 c-SKI_SMAD4-bd_dom
IPR009061 DNA-bd_dom_put_sf
IPR010919 SAND-like_dom_sf
IPR028760 Ski
IPR003380 SKI/SNO/DAC
IPR037000 Ski_DNA-bd_sf
IPR023216 Tscrpt_reg_SKI_SnoN
PANTHERiPTHR10005 PTHR10005, 1 hit
PTHR10005:SF15 PTHR10005:SF15, 1 hit
PfamiView protein in Pfam
PF08782 c-SKI_SMAD_bind, 1 hit
PF02437 Ski_Sno, 1 hit
SMARTiView protein in SMART
SM01046 c-SKI_SMAD_bind, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
SSF63763 SSF63763, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSKI_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P12755
Secondary accession number(s): Q5SYT7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: December 5, 2018
This is version 184 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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