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UniProtKB - P12749 (RL26_RAT)
Protein
60S ribosomal protein L26
Gene
Rpl26
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- mRNA 5'-UTR binding Source: RGD
- RNA binding Source: GO_Central
- structural constituent of ribosome Source: RGD
GO - Biological processi
- cellular response to gamma radiation Source: RGD
- cellular response to ionizing radiation Source: RGD
- cellular response to UV Source: RGD
- cytoplasmic translation Source: GO_Central
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: RGD
- positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: RGD
- positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: RGD
- positive regulation of translation Source: RGD
- regulation of translation involved in cellular response to UV Source: RGD
- response to amino acid starvation Source: RGD
- ribosomal large subunit biogenesis Source: RGD
- rRNA processing Source: RGD
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
Reactomei | R-RNO-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-RNO-1799339, SRP-dependent cotranslational protein targeting to membrane R-RNO-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-RNO-72689, Formation of a pool of free 40S subunits R-RNO-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-RNO-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-RNO-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Names & Taxonomyi
Protein namesi | Recommended name: 60S ribosomal protein L26 |
Gene namesi | Name:Rpl26 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1310607, Rpl26 |
Subcellular locationi
Cytosol
- cytosolic large ribosomal subunit Source: RGD
- cytosolic ribosome Source: RGD
Nucleus
- nucleolus Source: RGD
- nucleoplasm Source: RGD
Other locations
- cytoplasm Source: RGD
- ribonucleoprotein complex Source: RGD
- terminal bouton Source: RGD
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000130790 | 1 – 145 | 60S ribosomal protein L26Add BLAST | 145 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 136 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 139 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Ufmylated by UFL1 in response to endoplasmic reticulum stress, promoting reticulophagy of endoplasmic reticulum sheets.By similarity
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | P12749 |
PaxDbi | P12749 |
PRIDEi | P12749 |
PTM databases
iPTMneti | P12749 |
PhosphoSitePlusi | P12749 |
Interactioni
Subunit structurei
Component of the large ribosomal subunit.
Interacts with DHX33.
By similarityProtein-protein interaction databases
IntActi | P12749, 3 interactors |
MINTi | P12749 |
STRINGi | 10116.ENSRNOP00000005588 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 21 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 122 – 145 | DisorderedSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Belongs to the universal ribosomal protein uL24 family.Curated
Phylogenomic databases
eggNOGi | KOG3401, Eukaryota |
InParanoidi | P12749 |
PhylomeDBi | P12749 |
Family and domain databases
CDDi | cd06089, KOW_RPL26, 1 hit |
Gene3Di | 2.30.30.30, 1 hit |
HAMAPi | MF_01326_A, Ribosomal_L24_A, 1 hit |
InterProi | View protein in InterPro IPR005824, KOW IPR041988, KOW_RPL26/RPL24 IPR014722, Rib_L2_dom2 IPR005825, Ribosomal_L24/26_CS IPR005756, Ribosomal_L26/L24P_euk/arc IPR008991, Translation_prot_SH3-like_sf |
PANTHERi | PTHR11143, PTHR11143, 1 hit |
Pfami | View protein in Pfam PF00467, KOW, 1 hit PF16906, Ribosomal_L26, 1 hit |
SMARTi | View protein in SMART SM00739, KOW, 1 hit |
SUPFAMi | SSF50104, SSF50104, 1 hit |
TIGRFAMsi | TIGR01080, rplX_A_E, 1 hit |
PROSITEi | View protein in PROSITE PS01108, RIBOSOMAL_L24, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P12749-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKFNPFVTSD RSKNRKRHFN APSHIRRKIM SSPLSKELRQ KYNVRSMPIR
60 70 80 90 100
KDDEVQVVRG HYKGQQIGKV VQVYRKKYVI YIERVQREKA NGTTVHVGIR
110 120 130 140
PSKVVITRLK LDKDRKKILE RKAKSRQVGK EKGKYKEETI EKMQE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V6I9 | G3V6I9_RAT | 60S ribosomal protein L26 | Rpl26 rCG_33968 | 145 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14671 mRNA Translation: CAA32801.1 |
PIRi | S05024, R5RT26 |
Genome annotation databases
UCSCi | RGD:1310607, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14671 mRNA Translation: CAA32801.1 |
PIRi | S05024, R5RT26 |
3D structure databases
SMRi | P12749 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P12749, 3 interactors |
MINTi | P12749 |
STRINGi | 10116.ENSRNOP00000005588 |
PTM databases
iPTMneti | P12749 |
PhosphoSitePlusi | P12749 |
Proteomic databases
jPOSTi | P12749 |
PaxDbi | P12749 |
PRIDEi | P12749 |
Genome annotation databases
UCSCi | RGD:1310607, rat |
Organism-specific databases
RGDi | 1310607, Rpl26 |
Phylogenomic databases
eggNOGi | KOG3401, Eukaryota |
InParanoidi | P12749 |
PhylomeDBi | P12749 |
Enzyme and pathway databases
Reactomei | R-RNO-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-RNO-1799339, SRP-dependent cotranslational protein targeting to membrane R-RNO-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-RNO-72689, Formation of a pool of free 40S subunits R-RNO-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-RNO-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-RNO-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Miscellaneous databases
PROi | PR:P12749 |
Family and domain databases
CDDi | cd06089, KOW_RPL26, 1 hit |
Gene3Di | 2.30.30.30, 1 hit |
HAMAPi | MF_01326_A, Ribosomal_L24_A, 1 hit |
InterProi | View protein in InterPro IPR005824, KOW IPR041988, KOW_RPL26/RPL24 IPR014722, Rib_L2_dom2 IPR005825, Ribosomal_L24/26_CS IPR005756, Ribosomal_L26/L24P_euk/arc IPR008991, Translation_prot_SH3-like_sf |
PANTHERi | PTHR11143, PTHR11143, 1 hit |
Pfami | View protein in Pfam PF00467, KOW, 1 hit PF16906, Ribosomal_L26, 1 hit |
SMARTi | View protein in SMART SM00739, KOW, 1 hit |
SUPFAMi | SSF50104, SSF50104, 1 hit |
TIGRFAMsi | TIGR01080, rplX_A_E, 1 hit |
PROSITEi | View protein in PROSITE PS01108, RIBOSOMAL_L24, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RL26_RAT | |
Accessioni | P12749Primary (citable) accession number: P12749 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | October 1, 1989 | |
Last modified: | June 2, 2021 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - SIMILARITY comments
Index of protein domains and families