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Entry version 140 (08 May 2019)
Sequence version 2 (23 Jan 2007)
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Protein

50S ribosomal protein L23

Gene

rpl23

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to a specific region on the 23S rRNA. Located at the polypeptide exit tunnel on the outside of the subunit.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
50S ribosomal protein L23UniRule annotation
Alternative name(s):
Hl25
Hmal23
L21
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rpl23UniRule annotation
Ordered Locus Names:rrnAC1609
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri272569 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaStenosarchaea groupHalobacteriaHalobacterialesHaloarculaceaeHaloarcula
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001169 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved2 Publications
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001294352 – 8550S ribosomal protein L23Add BLAST84

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the 50S ribosomal subunit. Interacts with protein L29 and weakly with protein L39e.UniRule annotation2 Publications

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
272569.rrnAC1609

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

185
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FFKX-ray2.40P2-85[»]
1JJ2X-ray2.40R2-85[»]
1K73X-ray3.01T2-85[»]
1K8AX-ray3.00T2-85[»]
1K9MX-ray3.00T2-85[»]
1KC8X-ray3.01T2-85[»]
1KD1X-ray3.00T2-85[»]
1KQSX-ray3.10R2-85[»]
1M1KX-ray3.20T2-85[»]
1M90X-ray2.80T2-85[»]
1N8RX-ray3.00T2-85[»]
1NJIX-ray3.00T2-85[»]
1Q7YX-ray3.20T2-85[»]
1Q81X-ray2.95T2-85[»]
1Q82X-ray2.98T2-85[»]
1Q86X-ray3.00T2-85[»]
1QVFX-ray3.10R2-85[»]
1QVGX-ray2.90R2-85[»]
1S72X-ray2.40S1-85[»]
1VQ4X-ray2.70S1-85[»]
1VQ5X-ray2.60S1-85[»]
1VQ6X-ray2.70S1-85[»]
1VQ7X-ray2.50S1-85[»]
1VQ8X-ray2.20S1-85[»]
1VQ9X-ray2.40S1-85[»]
1VQKX-ray2.30S1-85[»]
1VQLX-ray2.30S1-85[»]
1VQMX-ray2.30S1-85[»]
1VQNX-ray2.40S1-85[»]
1VQOX-ray2.20S1-85[»]
1VQPX-ray2.25S1-85[»]
1W2BX-ray3.50R2-85[»]
1YHQX-ray2.40S1-85[»]
1YI2X-ray2.65S1-85[»]
1YIJX-ray2.60S1-85[»]
1YITX-ray2.80S1-85[»]
1YJ9X-ray2.90S1-85[»]
1YJNX-ray3.00S1-85[»]
1YJWX-ray2.90S1-85[»]
2OTJX-ray2.90S1-85[»]
2OTLX-ray2.70S1-85[»]
2QA4X-ray3.00S1-85[»]
2QEXX-ray2.90S1-85[»]
3CC2X-ray2.40S1-85[»]
3CC4X-ray2.70S1-85[»]
3CC7X-ray2.70S1-85[»]
3CCEX-ray2.75S1-85[»]
3CCJX-ray2.70S1-85[»]
3CCLX-ray2.90S1-85[»]
3CCMX-ray2.55S1-85[»]
3CCQX-ray2.90S1-85[»]
3CCRX-ray3.00S1-85[»]
3CCSX-ray2.95S1-85[»]
3CCUX-ray2.80S1-85[»]
3CCVX-ray2.90S1-85[»]
3CD6X-ray2.75S1-85[»]
3CMAX-ray2.80S1-85[»]
3CMEX-ray2.95S1-85[»]
3CPWX-ray2.70R1-85[»]
3CXCX-ray3.00R2-85[»]
3G4SX-ray3.20S2-82[»]
3G6EX-ray2.70S2-82[»]
3G71X-ray2.85S2-82[»]
3I55X-ray3.11S1-85[»]
3I56X-ray2.90S1-85[»]
3OW2X-ray2.70R2-82[»]
4ADXelectron microscopy6.60S1-85[»]
4V4SX-ray6.76X2-85[»]
4V4TX-ray6.46X2-85[»]
4V9FX-ray2.40S1-85[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P12732

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P12732

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the universal ribosomal protein uL23 family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
arCOG04072 Archaea
COG0089 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231364

KEGG Orthology (KO)

More...
KOi
K02892

Identification of Orthologs from Complete Genome Data

More...
OMAi
MDPYKVI

Database of Orthologous Groups

More...
OrthoDBi
113971at2157

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01369_A Ribosomal_L23_A, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR019985 Ribosomal_L23
IPR012678 Ribosomal_L23/L15e_core_dom_sf
IPR001014 Ribosomal_L23/L25_CS
IPR013025 Ribosomal_L25/23

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00276 Ribosomal_L23, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54189 SSF54189, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03636 uL23_arch, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00050 RIBOSOMAL_L23, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P12732-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSWDVIKHPH VTEKAMNDMD FQNKLQFAVD DRASKGEVAD AVEEQYDVTV
60 70 80
EQVNTQNTMD GEKKAVVRLS EDDDAQEVAS RIGVF
Length:85
Mass (Da):9,602
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2A2E869D640D5B60
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J05222 Genomic DNA Translation: AAA86861.1
AY596297 Genomic DNA Translation: AAV46526.1

Protein sequence database of the Protein Information Resource

More...
PIRi
E35063 R5HS23

NCBI Reference Sequences

More...
RefSeqi
WP_004591553.1, NC_006396.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAV46526; AAV46526; rrnAC1609

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
35220742

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hma:rrnAC1609

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|272569.17.peg.2299

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05222 Genomic DNA Translation: AAA86861.1
AY596297 Genomic DNA Translation: AAV46526.1
PIRiE35063 R5HS23
RefSeqiWP_004591553.1, NC_006396.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FFKX-ray2.40P2-85[»]
1JJ2X-ray2.40R2-85[»]
1K73X-ray3.01T2-85[»]
1K8AX-ray3.00T2-85[»]
1K9MX-ray3.00T2-85[»]
1KC8X-ray3.01T2-85[»]
1KD1X-ray3.00T2-85[»]
1KQSX-ray3.10R2-85[»]
1M1KX-ray3.20T2-85[»]
1M90X-ray2.80T2-85[»]
1N8RX-ray3.00T2-85[»]
1NJIX-ray3.00T2-85[»]
1Q7YX-ray3.20T2-85[»]
1Q81X-ray2.95T2-85[»]
1Q82X-ray2.98T2-85[»]
1Q86X-ray3.00T2-85[»]
1QVFX-ray3.10R2-85[»]
1QVGX-ray2.90R2-85[»]
1S72X-ray2.40S1-85[»]
1VQ4X-ray2.70S1-85[»]
1VQ5X-ray2.60S1-85[»]
1VQ6X-ray2.70S1-85[»]
1VQ7X-ray2.50S1-85[»]
1VQ8X-ray2.20S1-85[»]
1VQ9X-ray2.40S1-85[»]
1VQKX-ray2.30S1-85[»]
1VQLX-ray2.30S1-85[»]
1VQMX-ray2.30S1-85[»]
1VQNX-ray2.40S1-85[»]
1VQOX-ray2.20S1-85[»]
1VQPX-ray2.25S1-85[»]
1W2BX-ray3.50R2-85[»]
1YHQX-ray2.40S1-85[»]
1YI2X-ray2.65S1-85[»]
1YIJX-ray2.60S1-85[»]
1YITX-ray2.80S1-85[»]
1YJ9X-ray2.90S1-85[»]
1YJNX-ray3.00S1-85[»]
1YJWX-ray2.90S1-85[»]
2OTJX-ray2.90S1-85[»]
2OTLX-ray2.70S1-85[»]
2QA4X-ray3.00S1-85[»]
2QEXX-ray2.90S1-85[»]
3CC2X-ray2.40S1-85[»]
3CC4X-ray2.70S1-85[»]
3CC7X-ray2.70S1-85[»]
3CCEX-ray2.75S1-85[»]
3CCJX-ray2.70S1-85[»]
3CCLX-ray2.90S1-85[»]
3CCMX-ray2.55S1-85[»]
3CCQX-ray2.90S1-85[»]
3CCRX-ray3.00S1-85[»]
3CCSX-ray2.95S1-85[»]
3CCUX-ray2.80S1-85[»]
3CCVX-ray2.90S1-85[»]
3CD6X-ray2.75S1-85[»]
3CMAX-ray2.80S1-85[»]
3CMEX-ray2.95S1-85[»]
3CPWX-ray2.70R1-85[»]
3CXCX-ray3.00R2-85[»]
3G4SX-ray3.20S2-82[»]
3G6EX-ray2.70S2-82[»]
3G71X-ray2.85S2-82[»]
3I55X-ray3.11S1-85[»]
3I56X-ray2.90S1-85[»]
3OW2X-ray2.70R2-82[»]
4ADXelectron microscopy6.60S1-85[»]
4V4SX-ray6.76X2-85[»]
4V4TX-ray6.46X2-85[»]
4V9FX-ray2.40S1-85[»]
SMRiP12732
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272569.rrnAC1609

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV46526; AAV46526; rrnAC1609
GeneIDi35220742
KEGGihma:rrnAC1609
PATRICifig|272569.17.peg.2299

Phylogenomic databases

eggNOGiarCOG04072 Archaea
COG0089 LUCA
HOGENOMiHOG000231364
KOiK02892
OMAiMDPYKVI
OrthoDBi113971at2157

Miscellaneous databases

EvolutionaryTraceiP12732

Family and domain databases

Gene3Di3.30.70.330, 1 hit
HAMAPiMF_01369_A Ribosomal_L23_A, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR019985 Ribosomal_L23
IPR012678 Ribosomal_L23/L15e_core_dom_sf
IPR001014 Ribosomal_L23/L25_CS
IPR013025 Ribosomal_L25/23
PfamiView protein in Pfam
PF00276 Ribosomal_L23, 1 hit
SUPFAMiSSF54189 SSF54189, 1 hit
TIGRFAMsiTIGR03636 uL23_arch, 1 hit
PROSITEiView protein in PROSITE
PS00050 RIBOSOMAL_L23, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRL23_HALMA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P12732
Secondary accession number(s): Q5V1S6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: May 8, 2019
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
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