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Protein

Eosinophil cationic protein

Gene

RNASE3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei42Proton acceptor1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei60May be involved in LPS-binding1
Sitei62May be involved in LPS- and LTA-binding1
Active sitei155Proton donor1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • endonuclease activity Source: UniProtKB-KW
  • lipopolysaccharide binding Source: UniProtKB
  • nucleic acid binding Source: InterPro
  • ribonuclease activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntibiotic, Antimicrobial, Endonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695 Neutrophil degranulation
R-HSA-6803157 Antimicrobial peptides

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eosinophil cationic protein (EC:3.1.27.-)
Short name:
ECP
Alternative name(s):
Ribonuclease 3
Short name:
RNase 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RNASE3
Synonyms:ECP, RNS3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000169397.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10046 RNASE3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
131398 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P12724

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi40I → A: Loss of in vitro formation of amyloid-like aggregates. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
6037

Open Targets

More...
OpenTargetsi
ENSG00000169397

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34414

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB02098 Adenosine-2'-5'-Diphosphate
DB04272 Citric Acid
DB01411 Pranlukast

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RNASE3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
147744558

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 272 PublicationsAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003086228 – 160Eosinophil cationic proteinAdd BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi50 ↔ 110
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei60Nitrated tyrosine1 Publication1
Disulfide bondi64 ↔ 123
Disulfide bondi82 ↔ 138
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi89 ↔ 98
Glycosylationi92N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Nitration

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P12724

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P12724

PeptideAtlas

More...
PeptideAtlasi
P12724

PRoteomics IDEntifications database

More...
PRIDEi
P12724

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52864

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P12724

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P12724

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000169397 Expressed in 85 organ(s), highest expression level in bone marrow

CleanEx database of gene expression profiles

More...
CleanExi
HS_RNASE3

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P12724 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA056183

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA). In vitro interacts with and insert into lipid bilayers composed of dioleoyl phosphatidylcholine and dioleoyl phosphatidylglycerol. In vitro, tends to form amyloid-like aggregates at pH 3, but not at pH 5, nor 7.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111966, 14 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000302324

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1160
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P12724

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P12724

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P12724

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni28 – 72Required for nearly all of the bactericidal activity; partially involved in LPS-binding and bacterial membrane depolarizationAdd BLAST45
Regioni65 – 69Substrate binding5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the pancreatic ribonuclease family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JDT3 Eukaryota
ENOG411136R LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162253

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000276882

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG008396

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P12724

KEGG Orthology (KO)

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KOi
K10787

Identification of Orthologs from Complete Genome Data

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OMAi
NQSIRCP

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0SFK

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P12724

TreeFam database of animal gene trees

More...
TreeFami
TF333393

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.130.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001427 RNaseA
IPR036816 RNaseA-like_dom_sf
IPR023411 RNaseA_AS
IPR023412 RNaseA_domain

The PANTHER Classification System

More...
PANTHERi
PTHR11437 PTHR11437, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00074 RnaseA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00794 RIBONUCLEASE

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD000535 RNaseA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00092 RNAse_Pc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54076 SSF54076, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00127 RNASE_PANCREATIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P12724-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVPKLFTSQI CLLLLLGLMG VEGSLHARPP QFTRAQWFAI QHISLNPPRC
60 70 80 90 100
TIAMRAINNY RWRCKNQNTF LRTTFANVVN VCGNQSIRCP HNRTLNNCHR
110 120 130 140 150
SRFRVPLLHC DLINPGAQNI SNCTYADRPG RRFYVVACDN RDPRDSPRYP
160
VVPVHLDTTI
Length:160
Mass (Da):18,385
Last modified:May 15, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD7BED24F67B23FA9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01410972R → C1 PublicationCorresponds to variant dbSNP:rs151169198Ensembl.1
Natural variantiVAR_013149124T → R7 PublicationsCorresponds to variant dbSNP:rs2073342Ensembl.1
Natural variantiVAR_029017130G → R. Corresponds to variant dbSNP:rs12147890Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X15161 mRNA Translation: CAA33251.1
M28128 mRNA Translation: AAA50283.1
X16545 Genomic DNA Translation: CAA34545.1
X55990 Genomic DNA Translation: CAA39462.1
AF294019 Genomic DNA Translation: AAG31589.1
AF294020 Genomic DNA Translation: AAG31590.1
AF294021 Genomic DNA Translation: AAG31591.1
AF294022 Genomic DNA Translation: AAG31592.1
AF294023 Genomic DNA Translation: AAG31593.1
AF294024 Genomic DNA Translation: AAG31594.1
AF294025 Genomic DNA Translation: AAG31595.1
AF294026 Genomic DNA Translation: AAG31596.1
AL133371 Genomic DNA No translation available.
BC096060 mRNA Translation: AAH96060.1
BC096061 mRNA Translation: AAH96061.1
BC096062 mRNA Translation: AAH96062.1
AF441204 Genomic DNA Translation: AAL35279.1
AF441205 Genomic DNA Translation: AAL35280.1
AF441206 Genomic DNA Translation: AAL35281.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9560.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B35328 JL0106

NCBI Reference Sequences

More...
RefSeqi
NP_002926.2, NM_002935.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.73839

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000304639; ENSP00000302324; ENSG00000169397

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6037

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6037

UCSC genome browser

More...
UCSCi
uc001vyj.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15161 mRNA Translation: CAA33251.1
M28128 mRNA Translation: AAA50283.1
X16545 Genomic DNA Translation: CAA34545.1
X55990 Genomic DNA Translation: CAA39462.1
AF294019 Genomic DNA Translation: AAG31589.1
AF294020 Genomic DNA Translation: AAG31590.1
AF294021 Genomic DNA Translation: AAG31591.1
AF294022 Genomic DNA Translation: AAG31592.1
AF294023 Genomic DNA Translation: AAG31593.1
AF294024 Genomic DNA Translation: AAG31594.1
AF294025 Genomic DNA Translation: AAG31595.1
AF294026 Genomic DNA Translation: AAG31596.1
AL133371 Genomic DNA No translation available.
BC096060 mRNA Translation: AAH96060.1
BC096061 mRNA Translation: AAH96061.1
BC096062 mRNA Translation: AAH96062.1
AF441204 Genomic DNA Translation: AAL35279.1
AF441205 Genomic DNA Translation: AAL35280.1
AF441206 Genomic DNA Translation: AAL35281.1
CCDSiCCDS9560.1
PIRiB35328 JL0106
RefSeqiNP_002926.2, NM_002935.2
UniGeneiHs.73839

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DYTX-ray1.75A/B28-160[»]
1H1HX-ray2.00A28-160[»]
1QMTX-ray2.40A28-160[»]
2KB5NMR-A28-160[»]
2LVZNMR-A28-160[»]
4A2OX-ray1.69A/B28-160[»]
4A2YX-ray1.70A/B28-160[»]
4OWZX-ray1.47A/B28-160[»]
4OXBX-ray1.50A/B28-160[»]
4OXFX-ray1.50A/B28-160[»]
4X08X-ray1.34A/B28-160[»]
ProteinModelPortaliP12724
SMRiP12724
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111966, 14 interactors
STRINGi9606.ENSP00000302324

Chemistry databases

DrugBankiDB02098 Adenosine-2'-5'-Diphosphate
DB04272 Citric Acid
DB01411 Pranlukast

PTM databases

iPTMnetiP12724
PhosphoSitePlusiP12724

Polymorphism and mutation databases

BioMutaiRNASE3
DMDMi147744558

Proteomic databases

EPDiP12724
PaxDbiP12724
PeptideAtlasiP12724
PRIDEiP12724
ProteomicsDBi52864

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304639; ENSP00000302324; ENSG00000169397
GeneIDi6037
KEGGihsa:6037
UCSCiuc001vyj.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6037
DisGeNETi6037
EuPathDBiHostDB:ENSG00000169397.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RNASE3

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0037784
HGNCiHGNC:10046 RNASE3
HPAiHPA056183
MIMi131398 gene
neXtProtiNX_P12724
OpenTargetsiENSG00000169397
PharmGKBiPA34414

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JDT3 Eukaryota
ENOG411136R LUCA
GeneTreeiENSGT00940000162253
HOGENOMiHOG000276882
HOVERGENiHBG008396
InParanoidiP12724
KOiK10787
OMAiNQSIRCP
OrthoDBiEOG091G0SFK
PhylomeDBiP12724
TreeFamiTF333393

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-6803157 Antimicrobial peptides

Miscellaneous databases

EvolutionaryTraceiP12724

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Eosinophil_cationic_protein

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6037

Protein Ontology

More...
PROi
PR:P12724

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000169397 Expressed in 85 organ(s), highest expression level in bone marrow
CleanExiHS_RNASE3
GenevisibleiP12724 HS

Family and domain databases

Gene3Di3.10.130.10, 1 hit
InterProiView protein in InterPro
IPR001427 RNaseA
IPR036816 RNaseA-like_dom_sf
IPR023411 RNaseA_AS
IPR023412 RNaseA_domain
PANTHERiPTHR11437 PTHR11437, 1 hit
PfamiView protein in Pfam
PF00074 RnaseA, 1 hit
PRINTSiPR00794 RIBONUCLEASE
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000535 RNaseA, 1 hit
SMARTiView protein in SMART
SM00092 RNAse_Pc, 1 hit
SUPFAMiSSF54076 SSF54076, 1 hit
PROSITEiView protein in PROSITE
PS00127 RNASE_PANCREATIC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiECP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P12724
Secondary accession number(s): Q4VBC1
, Q8WTP7, Q8WZ62, Q9GZN9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: May 15, 2007
Last modified: December 5, 2018
This is version 182 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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