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Protein

Fatty acid-binding protein, liver

Gene

Fabp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes. Binds cholesterol. Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandLipid-binding, Selenium

Enzyme and pathway databases

ReactomeiR-MMU-163560 Triglyceride catabolism
R-MMU-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, liver
Alternative name(s):
14 kDa selenium-binding protein
Fatty acid-binding protein 1
Liver-type fatty acid-binding protein
Short name:
L-FABP
Gene namesi
Name:Fabp1
Synonyms:Fabpl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:95479 Fabp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi2531

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000673351 – 127Fatty acid-binding protein, liverAdd BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei11PhosphoserineCombined sources1
Modified residuei31N6-succinyllysineCombined sources1
Modified residuei36N6-succinyllysineCombined sources1
Modified residuei39PhosphoserineBy similarity1
Modified residuei46N6-succinyllysineCombined sources1
Modified residuei51PhosphothreonineBy similarity1
Modified residuei57N6-succinyllysineCombined sources1
Modified residuei78N6-succinyllysineCombined sources1
Modified residuei84N6-acetyllysine; alternateCombined sources1
Modified residuei84N6-succinyllysine; alternateCombined sources1
Modified residuei90N6-succinyllysineCombined sources1
Modified residuei100PhosphoserineCombined sources1
Modified residuei121N6-succinyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP12710
PeptideAtlasiP12710
PRIDEiP12710

2D gel databases

SWISS-2DPAGEiP12710

PTM databases

CarbonylDBiP12710
iPTMnetiP12710
PhosphoSitePlusiP12710

Expressioni

Gene expression databases

BgeeiENSMUSG00000054422 Expressed in 121 organ(s), highest expression level in jejunum
CleanExiMM_FABP1
ExpressionAtlasiP12710 baseline and differential
GenevisibleiP12710 MM

Interactioni

Protein-protein interaction databases

BioGridi199584, 3 interactors
IntActiP12710, 4 interactors
MINTiP12710
STRINGi10090.ENSMUSP00000064655

Chemistry databases

BindingDBiP12710

Structurei

3D structure databases

ProteinModelPortaliP12710
SMRiP12710
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00390000012034
HOGENOMiHOG000004830
HOVERGENiHBG005633
InParanoidiP12710
KOiK08750
OMAiFTLGEEC
OrthoDBiEOG091G16BV
PhylomeDBiP12710
TreeFamiTF330348

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR031276 Lb-FABP
PANTHERiPTHR11955 PTHR11955, 1 hit
PTHR11955:SF96 PTHR11955:SF96, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit

Sequencei

Sequence statusi: Complete.

P12710-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNFSGKYQLQ SQENFEPFMK AIGLPEDLIQ KGKDIKGVSE IVHEGKKIKL
60 70 80 90 100
TITYGPKVVR NEFTLGEECE LETMTGEKVK AVVKLEGDNK MVTTFKGIKS
110 120
VTELNGDTIT NTMTLGDIVY KRVSKRI
Length:127
Mass (Da):14,246
Last modified:December 15, 1998 - v2
Checksum:i2C787139174DD24D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14660 mRNA Translation: CAA74989.1
BC009812 mRNA Translation: AAH09812.1
CCDSiCCDS20226.1
PIRiA32640
RefSeqiNP_059095.1, NM_017399.4
UniGeneiMm.22126

Genome annotation databases

EnsembliENSMUST00000067492; ENSMUSP00000064655; ENSMUSG00000054422
GeneIDi14080
KEGGimmu:14080
UCSCiuc009cgh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14660 mRNA Translation: CAA74989.1
BC009812 mRNA Translation: AAH09812.1
CCDSiCCDS20226.1
PIRiA32640
RefSeqiNP_059095.1, NM_017399.4
UniGeneiMm.22126

3D structure databases

ProteinModelPortaliP12710
SMRiP12710
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199584, 3 interactors
IntActiP12710, 4 interactors
MINTiP12710
STRINGi10090.ENSMUSP00000064655

Chemistry databases

BindingDBiP12710
GuidetoPHARMACOLOGYi2531

PTM databases

CarbonylDBiP12710
iPTMnetiP12710
PhosphoSitePlusiP12710

2D gel databases

SWISS-2DPAGEiP12710

Proteomic databases

PaxDbiP12710
PeptideAtlasiP12710
PRIDEiP12710

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067492; ENSMUSP00000064655; ENSMUSG00000054422
GeneIDi14080
KEGGimmu:14080
UCSCiuc009cgh.1 mouse

Organism-specific databases

CTDi2168
MGIiMGI:95479 Fabp1

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00390000012034
HOGENOMiHOG000004830
HOVERGENiHBG005633
InParanoidiP12710
KOiK08750
OMAiFTLGEEC
OrthoDBiEOG091G16BV
PhylomeDBiP12710
TreeFamiTF330348

Enzyme and pathway databases

ReactomeiR-MMU-163560 Triglyceride catabolism
R-MMU-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

Miscellaneous databases

PROiPR:P12710
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054422 Expressed in 121 organ(s), highest expression level in jejunum
CleanExiMM_FABP1
ExpressionAtlasiP12710 baseline and differential
GenevisibleiP12710 MM

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR031276 Lb-FABP
PANTHERiPTHR11955 PTHR11955, 1 hit
PTHR11955:SF96 PTHR11955:SF96, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFABPL_MOUSE
AccessioniPrimary (citable) accession number: P12710
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: December 15, 1998
Last modified: September 12, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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