UniProtKB - P12701 (COX2_PARLI)
Protein
Cytochrome c oxidase subunit 2
Gene
COII
Organism
Paracentrotus lividus (Common sea urchin)
Status
Functioni
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Catalytic activityi
- EC:1.9.3.1
Cofactori
Cu cationNote: Binds a copper A center.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 161 | Copper ACurated | 1 | |
Metal bindingi | 196 | Copper ACurated | 1 | |
Metal bindingi | 200 | Copper ACurated | 1 | |
Metal bindingi | 204 | Copper ACurated | 1 |
GO - Molecular functioni
- copper ion binding Source: InterPro
- cytochrome-c oxidase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Electron transport, Respiratory chain, Transport |
Ligand | Copper, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome c oxidase subunit 2 (EC:1.9.3.1)Alternative name(s): Cytochrome c oxidase polypeptide II |
Gene namesi | Name:COII |
Encoded oni | Mitochondrion |
Organismi | Paracentrotus lividus (Common sea urchin) |
Taxonomic identifieri | 7656 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Echinodermata › Eleutherozoa › Echinozoa › Echinoidea › Euechinoidea › Echinacea › Echinoida › Echinidae › Paracentrotus |
Subcellular locationi
Mitochondrion
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
- respirasome Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 26 | Mitochondrial intermembraneSequence analysisAdd BLAST | 26 | |
Transmembranei | 27 – 48 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 49 – 62 | Mitochondrial matrixSequence analysisAdd BLAST | 14 | |
Transmembranei | 63 – 82 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 83 – 229 | Mitochondrial intermembraneSequence analysisAdd BLAST | 147 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000183651 | 1 – 229 | Cytochrome c oxidase subunit 2Add BLAST | 229 |
Structurei
3D structure databases
ProteinModelPortali | P12701 |
SMRi | P12701 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome c oxidase subunit 2 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
CDDi | cd13912 CcO_II_C, 1 hit |
Gene3Di | 1.10.287.90, 1 hit 2.60.40.420, 1 hit |
InterProi | View protein in InterPro IPR002429 CcO_II-like_C IPR034210 CcO_II_C IPR001505 Copper_CuA IPR008972 Cupredoxin IPR014222 Cyt_c_oxidase_su2 IPR011759 Cyt_c_oxidase_su2_TM_dom IPR036257 Cyt_c_oxidase_su2_TM_sf |
Pfami | View protein in Pfam PF00116 COX2, 1 hit PF02790 COX2_TM, 1 hit |
SUPFAMi | SSF49503 SSF49503, 1 hit SSF81464 SSF81464, 1 hit |
TIGRFAMsi | TIGR02866 CoxB, 1 hit |
PROSITEi | View protein in PROSITE PS00078 COX2, 1 hit PS50857 COX2_CUA, 1 hit PS50999 COX2_TM, 1 hit |
i Sequence
Sequence statusi: Complete.
P12701-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATWAQFGLQ DASSPLMEEL TYFHDYALIV LTLITILVFY GLVSLLLSSS
60 70 80 90 100
TNRFFLEGQE LETIWTVVPA FILIFIALPS LQLLYLMDEV NNPFLTIKAI
110 120 130 140 150
GHQWYWSYEY TDYNDLEFDS YMVPTSDVSL GNPRLLEVDN RLILPMQNPI
160 170 180 190 200
RVLVSSADVL HSWAVPSLGV KMDAVPGRLN QTTFFAARAG LFYGQCSEIC
210 220
GANHSFMPIL IESVPFSNFE NWVAQYIEE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 9 | L → P (PubMed:3596250).Curated | 1 | |
Sequence conflicti | 11 | D → H (PubMed:3596250).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04815 Genomic DNA Translation: AAA68137.1 M16520 Genomic DNA Translation: AAA31991.1 |
PIRi | E34284 |
RefSeqi | NP_008125.1, NC_001572.1 |
Genome annotation databases
GeneIDi | 807715 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04815 Genomic DNA Translation: AAA68137.1 M16520 Genomic DNA Translation: AAA31991.1 |
PIRi | E34284 |
RefSeqi | NP_008125.1, NC_001572.1 |
3D structure databases
ProteinModelPortali | P12701 |
SMRi | P12701 |
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
GeneIDi | 807715 |
Organism-specific databases
CTDi | 4513 |
Family and domain databases
CDDi | cd13912 CcO_II_C, 1 hit |
Gene3Di | 1.10.287.90, 1 hit 2.60.40.420, 1 hit |
InterProi | View protein in InterPro IPR002429 CcO_II-like_C IPR034210 CcO_II_C IPR001505 Copper_CuA IPR008972 Cupredoxin IPR014222 Cyt_c_oxidase_su2 IPR011759 Cyt_c_oxidase_su2_TM_dom IPR036257 Cyt_c_oxidase_su2_TM_sf |
Pfami | View protein in Pfam PF00116 COX2, 1 hit PF02790 COX2_TM, 1 hit |
SUPFAMi | SSF49503 SSF49503, 1 hit SSF81464 SSF81464, 1 hit |
TIGRFAMsi | TIGR02866 CoxB, 1 hit |
PROSITEi | View protein in PROSITE PS00078 COX2, 1 hit PS50857 COX2_CUA, 1 hit PS50999 COX2_TM, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | COX2_PARLI | |
Accessioni | P12701Primary (citable) accession number: P12701 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | October 1, 1989 | |
Last modified: | January 16, 2019 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |