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UniProtKB - P12685 (TRK1_YEAST)
Protein
High-affinity potassium transport protein
Gene
TRK1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
This protein is required for high-affinity potassium transport.
GO - Molecular functioni
- cation transmembrane transporter activity Source: GO_Central
- high-affinity potassium ion transmembrane transporter activity Source: GO_Central
- potassium ion transmembrane transporter activity Source: SGD
GO - Biological processi
- cellular potassium ion homeostasis Source: SGD
- potassium ion import across plasma membrane Source: GO_Central
Keywordsi
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Potassium |
Protein family/group databases
TCDBi | 2.A.38.2.1, the k(+) transporter (trk) family |
Names & Taxonomyi
Protein namesi | Recommended name: High-affinity potassium transport protein |
Gene namesi | Name:TRK1 Ordered Locus Names:YJL129C ORF Names:J0693 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003665, TRK1 |
VEuPathDBi | FungiDB:YJL129C |
Subcellular locationi
Other locations
Plasma Membrane
- integral component of plasma membrane Source: InterPro
- plasma membrane Source: SGD
Other locations
- cell periphery Source: SGD
- membrane raft Source: SGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 49 – 70 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 78 – 98 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 107 – 127 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 778 – 800 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 813 – 834 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 838 – 858 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 862 – 882 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 898 – 918 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 923 – 943 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 971 – 991 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1078 – 1098 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1111 – 1131 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070462 | 1 – 1235 | High-affinity potassium transport proteinAdd BLAST | 1235 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 15 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 100 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 169 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 222 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 227 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 251 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 369 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 383 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 414 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 497 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 501 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 532 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 534 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 580 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 677 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 919 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1030 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1135 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P12685 |
PRIDEi | P12685 |
PTM databases
iPTMneti | P12685 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 33627, 127 interactors |
DIPi | DIP-7454N |
IntActi | P12685, 1 interactor |
MINTi | P12685 |
STRINGi | 4932.YJL129C |
Miscellaneous databases
RNActi | P12685, protein |
Structurei
3D structure databases
AlphaFoldDBi | P12685 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 161 – 310 | DisorderedSequence analysisAdd BLAST | 150 | |
Regioni | 323 – 344 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 361 – 441 | DisorderedSequence analysisAdd BLAST | 81 | |
Regioni | 488 – 565 | DisorderedSequence analysisAdd BLAST | 78 | |
Regioni | 671 – 706 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 1003 – 1063 | DisorderedSequence analysisAdd BLAST | 61 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 180 – 214 | Basic and acidic residuesSequence analysisAdd BLAST | 35 | |
Compositional biasi | 215 – 232 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 248 – 275 | Polar residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 277 – 307 | Basic and acidic residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 371 – 420 | Polar residuesSequence analysisAdd BLAST | 50 | |
Compositional biasi | 488 – 505 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 510 – 534 | Acidic residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 535 – 558 | Basic and acidic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 683 – 706 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 1011 – 1032 | Acidic residuesSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the TrkH potassium transport family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1341, Eukaryota |
GeneTreei | ENSGT00940000176441 |
HOGENOMi | CLU_005947_0_0_1 |
InParanoidi | P12685 |
OMAi | SGKMVNR |
Family and domain databases
InterProi | View protein in InterPro IPR003445, Cat_transpt IPR004773, K/Na_transp_Trk/HKT IPR015958, Trk_fungi |
Pfami | View protein in Pfam PF02386, TrkH, 1 hit |
PIRSFi | PIRSF002450, K+_transpter_TRK, 1 hit |
TIGRFAMsi | TIGR00934, 2a38euk, 1 hit |
i Sequence
Sequence statusi: Complete.
P12685-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHFRRTMSRV PTLASLEIRY KKSFGHKFRD FIALCGHYFA PVKKYIFPSF
60 70 80 90 100
IAVHYFYTIS LTLITSILLY PIKNTRYIDT LFLAAGAVTQ GGLNTVDINN
110 120 130 140 150
LSLYQQIVLY IVCCISTPIA VHSCLAFVRL YWFERYFDGI RDSSRRNFKM
160 170 180 190 200
RRTKTILERE LTARTMTKNR TGTQRTSYPR KQAKTDDFQE KLFSGEMVNR
210 220 230 240 250
DEQDSVHSDQ NSHDISRDSS NNNTNHNGSS GSLDDFVKED ETDDNGEYQE
260 270 280 290 300
NNSYSTVGSS SNTVADESLN QKPKPSSLRF DEPHSKQRPA RVPSEKFAKR
310 320 330 340 350
RGSRDISPAD MYRSIMMLQG KHEATAEDEG PPLVIGSPAD GTRYKSNVNK
360 370 380 390 400
LKKATGINGN KIKIRDKGNE SNTDQNSVSS EANSTASVSD ESSLHTNFGN
410 420 430 440 450
KVPSLRTNTH RSNSGPIAIT DNAETDKKHG PSIQFDITKP PRKISKRVST
460 470 480 490 500
FDDLNPKSSV LYRKKASKKY LMKHFPKARR IRQQIKRRLS TGSIEKNSSN
510 520 530 540 550
NVSDRKPITD MDDDDDDDDN DGDNNEEYFA DNESGDEDER VQQSEPHSDS
560 570 580 590 600
ELKSHQQQQE KHQLQQNLHR MYKTKSFDDN RSRAVPMERS RTIDMAEAKD
610 620 630 640 650
LNELARTPDF QKMVYQNWKA HHRKKPNFRK RGWNNKIFEH GPYASDSDRN
660 670 680 690 700
YPDNSNTGNS ILHYAESILH HDGSHKNGSE EASSDSNENI YSTNGGSDHN
710 720 730 740 750
GLNNYPTYND DEEGYYGLHF DTDYDLDPRH DLSKGSGKTY LSWQPTIGRN
760 770 780 790 800
SNFLGLTRAQ KDELGGVEYR AIKLLCTILV VYYVGWHIVA FVMLVPWIIL
810 820 830 840 850
KKHYSEVVRD DGVSPTWWGF WTAMSAFNDL GLTLTPNSMM SFNKAVYPLI
860 870 880 890 900
VMIWFIIIGN TGFPILLRCI IWIMFKISPD LSQMRESLGF LLDHPRRCFT
910 920 930 940 950
LLFPKAATWW LLLTLAGLNI TDWILFIILD FGSTVVKSLS KGYRVLVGLF
960 970 980 990 1000
QSVSTRTAGF SVVDLSQLHP SIQVSYMLMM YVSVLPLAIS IRRTNVYEEQ
1010 1020 1030 1040 1050
SLGLYGDMGG EPEDTDTEDD GNDEDDDEEN ESHEGQSSQR SSSNNNNNNN
1060 1070 1080 1090 1100
RKKKKKKKTE NPNEISTKSF IGAHLRKQLS FDLWFLFLGL FIICICEGDK
1110 1120 1130 1140 1150
IKDVQEPNFN IFAILFEIVS AYGTVGLSLG YPDTNQSFSR QFTTLSKLVI
1160 1170 1180 1190 1200
IAMLIRGKNR GLPYSLDRAI ILPSDRLEHI DHLEGMKLKR QARTNTEDPM
1210 1220 1230
TEHFKRSFTD VKHRWGALKR KTTHSRNPKR SSTTL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M21328 Genomic DNA Translation: AAA34728.1 Z49404 Genomic DNA Translation: CAA89424.1 BK006943 Genomic DNA Translation: DAA08672.1 |
PIRi | S05849, PWBYH |
RefSeqi | NP_012406.1, NM_001181562.1 |
Genome annotation databases
EnsemblFungii | YJL129C_mRNA; YJL129C; YJL129C |
GeneIDi | 853312 |
KEGGi | sce:YJL129C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M21328 Genomic DNA Translation: AAA34728.1 Z49404 Genomic DNA Translation: CAA89424.1 BK006943 Genomic DNA Translation: DAA08672.1 |
PIRi | S05849, PWBYH |
RefSeqi | NP_012406.1, NM_001181562.1 |
3D structure databases
AlphaFoldDBi | P12685 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 33627, 127 interactors |
DIPi | DIP-7454N |
IntActi | P12685, 1 interactor |
MINTi | P12685 |
STRINGi | 4932.YJL129C |
Protein family/group databases
TCDBi | 2.A.38.2.1, the k(+) transporter (trk) family |
PTM databases
iPTMneti | P12685 |
Proteomic databases
PaxDbi | P12685 |
PRIDEi | P12685 |
Genome annotation databases
EnsemblFungii | YJL129C_mRNA; YJL129C; YJL129C |
GeneIDi | 853312 |
KEGGi | sce:YJL129C |
Organism-specific databases
SGDi | S000003665, TRK1 |
VEuPathDBi | FungiDB:YJL129C |
Phylogenomic databases
eggNOGi | KOG1341, Eukaryota |
GeneTreei | ENSGT00940000176441 |
HOGENOMi | CLU_005947_0_0_1 |
InParanoidi | P12685 |
OMAi | SGKMVNR |
Miscellaneous databases
PROi | PR:P12685 |
RNActi | P12685, protein |
Family and domain databases
InterProi | View protein in InterPro IPR003445, Cat_transpt IPR004773, K/Na_transp_Trk/HKT IPR015958, Trk_fungi |
Pfami | View protein in Pfam PF02386, TrkH, 1 hit |
PIRSFi | PIRSF002450, K+_transpter_TRK, 1 hit |
TIGRFAMsi | TIGR00934, 2a38euk, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TRK1_YEAST | |
Accessioni | P12685Primary (citable) accession number: P12685 Secondary accession number(s): D6VW56 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | October 1, 1989 | |
Last modified: | May 25, 2022 | |
This is version 171 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome X
Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names - SIMILARITY comments
Index of protein domains and families