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Protein

43 kDa receptor-associated protein of the synapse

Gene

Rapsn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri363 – 403RING-typePROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
43 kDa receptor-associated protein of the synapse
Short name:
RAPsyn
Alternative name(s):
43 kDa postsynaptic protein
Acetylcholine receptor-associated 43 kDa protein
Gene namesi
Name:Rapsn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:99422 Rapsn

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001675922 – 41243 kDa receptor-associated protein of the synapseAdd BLAST411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei196PhosphotyrosineSequence analysis1
Modified residuei405PhosphoserineSequence analysis1

Post-translational modificationi

Ubiquitinated by the BCR(KLHL8) complex, leading to its degradation.By similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP12672
PRIDEiP12672

PTM databases

iPTMnetiP12672
PhosphoSitePlusiP12672

Expressioni

Gene expression databases

BgeeiENSMUSG00000002104
CleanExiMM_RAPSN
ExpressionAtlasiP12672 baseline and differential
GenevisibleiP12672 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202585, 1 interactor
IntActiP12672, 1 interactor
MINTiP12672
STRINGi10090.ENSMUSP00000054150

Structurei

3D structure databases

ProteinModelPortaliP12672
SMRiP12672
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 39TPR 1Add BLAST34
Repeati83 – 116TPR 2Add BLAST34
Repeati123 – 156TPR 3Add BLAST34
Repeati163 – 196TPR 4Add BLAST34
Repeati206 – 239TPR 5Add BLAST34
Repeati246 – 279TPR 6Add BLAST34
Repeati286 – 319TPR 7Add BLAST34

Domaini

A cysteine-rich region homologous to part of the regulatory domain of protein kinase C may be important in interactions of this protein with the lipid bilayer.

Sequence similaritiesi

Belongs to the RAPsyn family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri363 – 403RING-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Repeat, TPR repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1941 Eukaryota
ENOG41103HX LUCA
GeneTreeiENSGT00390000016785
HOGENOMiHOG000231395
HOVERGENiHBG061484
InParanoidiP12672
OMAiAHNNDDK
OrthoDBiEOG091G03VV
TreeFamiTF328344

Family and domain databases

Gene3Di1.25.40.10, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001237 Postsynaptic
IPR018293 Postsynaptic_CS
IPR019568 Rapsyn_myristoylation/link_N
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF10579 Rapsyn_N, 1 hit
PF13181 TPR_8, 1 hit
PF13639 zf-RING_2, 1 hit
PRINTSiPR00217 POSTSYNAPTIC
SMARTiView protein in SMART
SM00184 RING, 1 hit
SM00028 TPR, 7 hits
SUPFAMiSSF48452 SSF48452, 3 hits
PROSITEiView protein in PROSITE
PS00405 43_KD_POSTSYNAPTIC, 1 hit
PS50005 TPR, 5 hits
PS50293 TPR_REGION, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12672-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQDQTKQQI EKGLQLYQSN QTEKALQVWM KVLEKGSDLV GRFRVLGCLV
60 70 80 90 100
TAHSEMGRYK EMLKFAVVQI DTARGLEDAD FLLESYLNLA RSNEKLCEFH
110 120 130 140 150
KTISYCKTCL GLPGTRAGAQ LGGQVSLSMG NAFLGLSLFQ KALESFEKAL
160 170 180 190 200
RYAHNNDDTM LECRVCCSLG SFYAQVKDYE KALFFPCKAA ELVNDYGKGW
210 220 230 240 250
SLKYRAMSQY HMAVAYRLLG HLGSAMECCE ESMKIALQHG DRPLQALCLL
260 270 280 290 300
CFADIHRSRG DLETAFPRYD SAMSIMTEIG NRLGQVHVLL GVAKCWMARK
310 320 330 340 350
VQDKALDAIE KAQDLAEEVG NKLSQLKLHC LSESIYRSKG LQRELRTHVV
360 370 380 390 400
RFHECVEETE LYCGLCGESI GERNSRLQAL PCSHIFHLRC LQNNGTRSCP
410
NCRRSSMKPG FV
Length:412
Mass (Da):46,393
Last modified:July 27, 2011 - v4
Checksum:iEB5C656229AB0D15
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti344 – 345EL → DV in CAA33789 (PubMed:2737281).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15788 mRNA Translation: CAA33789.1
J03962 mRNA Translation: AAA40030.1
AL672241 Genomic DNA Translation: CAM15326.1
CH466519 Genomic DNA Translation: EDL27517.1
BC111863 mRNA Translation: AAI11864.1
CCDSiCCDS16422.1
PIRiA31995
RefSeqiNP_033049.2, NM_009023.3
UniGeneiMm.1272

Genome annotation databases

EnsembliENSMUST00000050323; ENSMUSP00000054150; ENSMUSG00000002104
ENSMUST00000215408; ENSMUSP00000149267; ENSMUSG00000111579
GeneIDi19400
KEGGimmu:19400
UCSCiuc008kud.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRAPSN_MOUSE
AccessioniPrimary (citable) accession number: P12672
Secondary accession number(s): Q2M2N6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 167 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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