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Entry version 98 (11 Dec 2019)
Sequence version 2 (01 May 1991)
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Protein

Hemocyanin A-type, units Ode to Odg

Gene
N/A
Organism
Enteroctopus dofleini (North Pacific giant octopus) (Octopus dofleini)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Cu2+Note: Binds 2 copper ions per heterodimer.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi45Copper ABy similarity1
Metal bindingi65Copper ABy similarity1
Metal bindingi74Copper ABy similarity1
Metal bindingi186Copper BBy similarity1
Metal bindingi190Copper BBy similarity1
Metal bindingi217Copper BBy similarity1
Metal bindingi463Copper ABy similarity1
Metal bindingi481Copper ABy similarity1
Metal bindingi490Copper ABy similarity1
Metal bindingi599Copper BBy similarity1
Metal bindingi603Copper BBy similarity1
Metal bindingi630Copper BBy similarity1
Metal bindingi880Copper ABy similarity1
Metal bindingi899Copper ABy similarity1
Metal bindingi908Copper ABy similarity1
Metal bindingi1008Copper BBy similarity1
Metal bindingi1012Copper BBy similarity1
Metal bindingi1039Copper BBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processOxygen transport, Transport
LigandCopper, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hemocyanin A-type, units Ode to Odg
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEnteroctopus dofleini (North Pacific giant octopus) (Octopus dofleini)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri267067 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaCephalopodaColeoideaNeocoleoideaOctopodiformesOctopodaIncirrataOctopodidaeEnteroctopus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000204300‹1 – 1233Hemocyanin A-type, units Ode to OdgAdd BLAST›1233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi51 ↔ 62By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki63 ↔ 652'-(S-cysteinyl)-histidine (Cys-His)By similarity
Disulfide bondi176 ↔ 243By similarity
Disulfide bondi334 ↔ 340By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi392N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi468 ↔ 478By similarity
Cross-linki479 ↔ 4812'-(S-cysteinyl)-histidine (Cys-His)By similarity
Glycosylationi538N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi589 ↔ 656By similarity
Disulfide bondi743 ↔ 748By similarity
Disulfide bondi886 ↔ 896By similarity
Glycosylationi890N-linked (GlcNAc...) asparagineSequence analysis1
Cross-linki897 ↔ 8992'-(S-cysteinyl)-histidine (Cys-His)By similarity
Disulfide bondi998 ↔ 1065By similarity
Disulfide bondi1152 ↔ 1158By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Thioether bond

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Decamers of large identical subunits (350 kDa), each containing 7 globular oxygen-binding domains: ODA, ODB, ODC, ODD, ODE, ODF, and ODG.

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P12659

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni‹1 – 4ODD›4
Regioni5 – 422ODEAdd BLAST418
Regioni423 – 839ODFAdd BLAST417
Regioni840 – 1233ODGAdd BLAST394

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tyrosinase family. Hemocyanin subfamily.Curated

Keywords - Domaini

Repeat

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1280.10, 3 hits
2.60.310.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028999 Haemocyanin_beta-sandwich
IPR036848 Haemocyanin_C_sf
IPR002227 Tyrosinase_Cu-bd
IPR008922 Unchr_di-copper_centre

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14830 Haemocyan_bet_s, 3 hits
PF00264 Tyrosinase, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00092 TYROSINASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48056 SSF48056, 3 hits
SSF81277 SSF81277, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00497 TYROSINASE_1, 3 hits
PS00498 TYROSINASE_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

P12659-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
EGNEYLVRKN VERLSLSEMN SLIHAFRRMQ KDKSSDGFEA IASFHALPPL
60 70 80 90 100
CPSPTAKHRH ACCLHGMATF PHWHRLYVVQ FEQALHRHGA TVGVPYWDWT
110 120 130 140 150
RPISKIPDFI ASEKYSDPFT KIEVYNPFNH GHISFISEDT TTKREVSEYL
160 170 180 190 200
FEHPVLGKQT WLFDNIALAL EQTDYCDFEI QLEIVHNAIH SWIGGKEEHS
210 220 230 240 250
LNHLHYAAYD PIFYLHHSNV DRLWVIWQEL QKLRGLNAYE SHCALELMKV
260 270 280 290 300
PLKPFSFGAP YNLNDLTTKL SKPEDMFRYK DNFHYEYDIL DINSMSINQI
310 320 330 340 350
ESSYIRHQKD HDRVFAGFLL SGFGSSAYAT FEICIEGGEC HEGSHFAVLG
360 370 380 390 400
GSTEMPWAFD RLYKIEITDV LSDMHLAFDS AFTIKTKIVA QNGTELPASI
410 420 430 440 450
LPEATVIRIP PSKQDADIDI PLNHIRRNVE SLDERDIQNL MAALTRVKKD
460 470 480 490 500
ESDHGFQTIA SYHGSTLCPS PEEPKYACCL HGMPVFPHWH RVYLLHFEDS
510 520 530 540 550
MRRHGSSVAT PYWDWTQPGT KLPRLLADSD YYDAWTDNVT ENPFLRGYIT
560 570 580 590 600
SEDTYTVRDV KPELFEIGGG EGSTLYQQVL LMLEQEDYCD FEVQFEVVHN
610 620 630 640 650
SIHYLVGGHQ KYAMSSLVYS SFDPIFYVHH SMVDRLWAIW QALQEHRHLP
660 670 680 690 700
FDKAYCALEQ LSFPMKPFVW ESNPNLHTRA ASTPQHLFDY NKLGYKYDDL
710 720 730 740 750
EFHGMNIDQL ENAIHKTQNK DRVFASFLLF GIKTSADVHL KLCKDETCED
760 770 780 790 800
AGVVFVLGGD NEMPWPFDRT YKMDITNVLH KMHIPLEDLY VHGSTIHLEV
810 820 830 840 850
KIESVDGKVL DSSSLPVPSM IYVPAKEFTK EIEKEAVRGT IIRKNVNSLT
860 870 880 890 900
PSDIKELRDA MAKVQADTSD NGYQKIASYH GIPLSCHYEN GTAYACCQHG
910 920 930 940 950
MVTFPNWHRL LTKQMEDALV AKGSHVGIPY WDWTTTFANL PVLVTEEKDN
960 970 980 990 1000
SFHHAHIDVA NTDTTRSPRA QLFDDPEKGD KSFFYRQIAL ALEQTDFCDF
1010 1020 1030 1040 1050
EIQFEIGHNA IHSWVGGSSP YGMSTLHYTS YDPLFYLHHS NTDRIWSVWQ
1060 1070 1080 1090 1100
ALQKYRGLPY NTANCEINKL VKPLKPFNLD TNPNAVTKAH STGATSFDYH
1110 1120 1130 1140 1150
KLGYDYDNLN FHGMTIPELE EHLKEIQHED RVFAGFLLRT IGQSADVNFD
1160 1170 1180 1190 1200
VCTKDGECTF GGTFCILGGE HEMFWAFDRP FKYDITTSLK HLRLDAHDDF
1210 1220 1230
DIKVTIKGID GHVLSNKYLS PPTVFLAPAK TTH
Length:1,233
Mass (Da):141,524
Last modified:May 1, 1991 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i90B6C6063C95D524
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M57288 mRNA Translation: AAA29391.1
J02835 mRNA Translation: AAA29390.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A31137
S13442

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57288 mRNA Translation: AAA29391.1
J02835 mRNA Translation: AAA29390.1
PIRiA31137
S13442

3D structure databases

SMRiP12659
ModBaseiSearch...

Family and domain databases

Gene3Di1.10.1280.10, 3 hits
2.60.310.10, 3 hits
InterProiView protein in InterPro
IPR028999 Haemocyanin_beta-sandwich
IPR036848 Haemocyanin_C_sf
IPR002227 Tyrosinase_Cu-bd
IPR008922 Unchr_di-copper_centre
PfamiView protein in Pfam
PF14830 Haemocyan_bet_s, 3 hits
PF00264 Tyrosinase, 3 hits
PRINTSiPR00092 TYROSINASE
SUPFAMiSSF48056 SSF48056, 3 hits
SSF81277 SSF81277, 3 hits
PROSITEiView protein in PROSITE
PS00497 TYROSINASE_1, 3 hits
PS00498 TYROSINASE_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHCYA_ENTDO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P12659
Secondary accession number(s): Q25585
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: May 1, 1991
Last modified: December 11, 2019
This is version 98 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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