Calbindin

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• calcium ion binding Source: SynGO <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Structural characterization of the conformational change in calbindin-D28k upon calcium binding using differential surface modification analyzed by mass spectrometry."
    Hobbs C.A., Deterding L.J., Perera L., Bobay B.G., Thompson R.J., Darden T.A., Cavanagh J., Tomer K.B.
    Biochemistry 48:8603-8614(2009) [PubMed] [Europe PMC] [Abstract]
• calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration Source: SynGOInferred from direct assayⁱ
  • "Ataxia and altered dendritic calcium signaling in mice carrying a targeted null mutation of the calbindin D28k gene."
    Airaksinen M.S., Eilers J., Garaschuk O., Thoenen H., Konnerth A., Meyer M.
    Proc. Natl. Acad. Sci. U.S.A. 94:1488-1493(1997) [PubMed] [Europe PMC] [Abstract]
• calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration Source: SynGO <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Ca2+ buffer saturation underlies paired pulse facilitation in calbindin-D28k-containing terminals."
    Blatow M., Caputi A., Burnashev N., Monyer H., Rozov A.
    Neuron 38:79-88(2003) [PubMed] [Europe PMC] [Abstract]
• vitamin D binding Source: UniProtKB-KW
• zinc ion binding Source: MGI

GO - Biological processⁱ

• cellular response to organic substance Source: MGIInferred from direct assayⁱ
  • "The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice."
    Pickford F., Masliah E., Britschgi M., Lucin K., Narasimhan R., Jaeger P.A., Small S., Spencer B., Rockenstein E., Levine B., Wyss-Coray T.
    J. Clin. Invest. 118:2190-2199(2008) [PubMed] [Europe PMC] [Abstract]
• cochlea development Source: Ensembl
• locomotory behavior Source: MGIInferred from mutant phenotypeⁱ
  • "Calbindin in cerebellar Purkinje cells is a critical determinant of the precision of motor coordination."
    Barski J.J., Hartmann J., Rose C.R., Hoebeek F., Morl K., Noll-Hussong M., De Zeeuw C.I., Konnerth A., Meyer M.
    J. Neurosci. 23:3469-3477(2003) [PubMed] [Europe PMC] [Abstract]
• long-term memory Source: MGI
• metanephric collecting duct development Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney."
    Georgas K., Rumballe B., Wilkinson L., Chiu H.S., Lesieur E., Gilbert T., Little M.H.
    Histochem. Cell Biol. 130:927-942(2008) [PubMed] [Europe PMC] [Abstract]
• metanephric connecting tubule development Source: UniProtKBInferred from expression patternⁱ
  • "Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney."
    Georgas K., Rumballe B., Wilkinson L., Chiu H.S., Lesieur E., Gilbert T., Little M.H.
    Histochem. Cell Biol. 130:927-942(2008) [PubMed] [Europe PMC] [Abstract]
• metanephric distal convoluted tubule development Source: UniProtKBInferred from expression patternⁱ
  • "Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney."
    Georgas K., Rumballe B., Wilkinson L., Chiu H.S., Lesieur E., Gilbert T., Little M.H.
    Histochem. Cell Biol. 130:927-942(2008) [PubMed] [Europe PMC] [Abstract]
• metanephric part of ureteric bud development Source: UniProtKBInferred from expression patternⁱ
  • "Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney."
    Georgas K., Rumballe B., Wilkinson L., Chiu H.S., Lesieur E., Gilbert T., Little M.H.
    Histochem. Cell Biol. 130:927-942(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of cytosolic calcium ion concentration Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of long-term synaptic potentiation Source: SynGOInferred from mutant phenotypeⁱ
  • "Decrease in calbindin content significantly alters LTP but not NMDA receptor and calcium channel properties."
    Jouvenceau A., Potier B., Poindessous-Jazat F., Dutar P., Slama A., Epelbaum J., Billard J.M.
    Neuropharmacology 42:444-458(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of presynaptic cytosolic calcium ion concentration Source: MGI
• regulation of synaptic plasticity Source: MGI
• retina development in camera-type eye Source: UniProtKBInferred from expression patternⁱ
  • "Specific expression of the LIM/homeodomain protein Lim-1 in horizontal cells during retinogenesis."
    Liu W., Wang J.H., Xiang M.
    Dev. Dyn. 217:320-325(2000) [PubMed] [Europe PMC] [Abstract]
• retina layer formation Source: UniProtKBInferred from expression patternⁱ
  • "Specific expression of the LIM/homeodomain protein Lim-1 in horizontal cells during retinogenesis."
    Liu W., Wang J.H., Xiang M.
    Dev. Dyn. 217:320-325(2000) [PubMed] [Europe PMC] [Abstract]
• short-term memory Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MAESHLQSSL ITASQFFEIW LHFDADGSGY LEGKELQNLI QELLQARKKA 
        60         70         80         90        100
GLELSPEMKS FVDQYGQRDD GKIGIVELAH VLPTEENFLL LFRCQQLKSC 
       110        120        130        140        150
EEFMKTWRKY DTDHSGFIET EELKNFLKDL LEKANKTVDD TKLAEYTDLM 
       160        170        180        190        200
LKLFDSNNDG KLELTEMARL LPVQENFLLK FQGIKMCGKE FNKAFELYDQ 
       210        220        230        240        250
DGNGYIDENE LDALLKDLCE KNKQELDINN ITTYKKNIMA LSDGGKLYRT 
       260 
DLALILSAGD N                                           

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot