Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Thyrotropin subunit beta

Gene

Tshb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Indispensable for the control of thyroid structure and metabolism.

GO - Molecular functioni

GO - Biological processi

  • hormone-mediated signaling pathway Source: GO_Central

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Thyrotropin subunit beta
Alternative name(s):
Thyroid-stimulating hormone subunit beta
Short name:
TSH-B
Short name:
TSH-beta
Thyrotropin beta chain
Gene namesi
Name:Tshb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:98848 Tshb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001175021 – 132Thyrotropin subunit betaAdd BLAST112
PropeptideiPRO_0000011751133 – 1386

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi22 ↔ 72By similarity
Disulfide bondi36 ↔ 87By similarity
Disulfide bondi39 ↔ 125By similarity
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi47 ↔ 103By similarity
Disulfide bondi51 ↔ 105By similarity
Disulfide bondi108 ↔ 115By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP12656
PRIDEiP12656

Expressioni

Gene expression databases

CleanExiMM_TSHB

Interactioni

Subunit structurei

Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029450

Structurei

3D structure databases

ProteinModelPortaliP12656
SMRiP12656
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXJG Eukaryota
ENOG410YSY0 LUCA
HOGENOMiHOG000116098
HOVERGENiHBG006698
InParanoidiP12656
PhylomeDBiP12656

Family and domain databases

CDDicd00069 GHB_like, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR006208 Glyco_hormone_CN
IPR001545 Gonadotropin_bsu
IPR018245 Gonadotropin_bsu_CS
PANTHERiPTHR11515 PTHR11515, 1 hit
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
SMARTiView protein in SMART
SM00068 GHB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00261 GLYCO_HORMONE_BETA_1, 1 hit
PS00689 GLYCO_HORMONE_BETA_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P12656-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAAVLLSVL FALACGQAAS FCIPTEYTMY VDRRECAYCL TINTTICAGY
60 70 80 90 100
CMTRDINGKL FLPKYALSQD VCTYRDFIYR TVEIPGCPHH VTPYFSFPVA
110 120 130
VSCKCGKCNT DNSDCIHEAV RTNYCTKPQS FYLGGFSV
Length:138
Mass (Da):15,373
Last modified:October 1, 1989 - v1
Checksum:i44386FF3E17C5BEB
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q4F3E9Q4F3_MOUSE
Thyroid stimulating hormone beta su...
Tshb
138Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20537, M20536 Genomic DNA Translation: AAA40494.1
M22740 Genomic DNA Translation: AAA40493.1
M35719 mRNA Translation: AAA37307.1
M35720 mRNA Translation: AAA37308.1
M35721 mRNA Translation: AAA37309.1
M35723 mRNA Translation: AAA37310.1
M54943 mRNA Translation: AAA40492.1
CCDSiCCDS17689.1
PIRiA29479
UniGeneiMm.110730

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20537, M20536 Genomic DNA Translation: AAA40494.1
M22740 Genomic DNA Translation: AAA40493.1
M35719 mRNA Translation: AAA37307.1
M35720 mRNA Translation: AAA37308.1
M35721 mRNA Translation: AAA37309.1
M35723 mRNA Translation: AAA37310.1
M54943 mRNA Translation: AAA40492.1
CCDSiCCDS17689.1
PIRiA29479
UniGeneiMm.110730

3D structure databases

ProteinModelPortaliP12656
SMRiP12656
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029450

Proteomic databases

PaxDbiP12656
PRIDEiP12656

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:98848 Tshb

Phylogenomic databases

eggNOGiENOG410IXJG Eukaryota
ENOG410YSY0 LUCA
HOGENOMiHOG000116098
HOVERGENiHBG006698
InParanoidiP12656
PhylomeDBiP12656

Miscellaneous databases

PROiPR:P12656
SOURCEiSearch...

Gene expression databases

CleanExiMM_TSHB

Family and domain databases

CDDicd00069 GHB_like, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR006208 Glyco_hormone_CN
IPR001545 Gonadotropin_bsu
IPR018245 Gonadotropin_bsu_CS
PANTHERiPTHR11515 PTHR11515, 1 hit
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
SMARTiView protein in SMART
SM00068 GHB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00261 GLYCO_HORMONE_BETA_1, 1 hit
PS00689 GLYCO_HORMONE_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTSHB_MOUSE
AccessioniPrimary (citable) accession number: P12656
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again