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UniProtKB - P12653 (GSTF1_MAIZE)
Protein
Glutathione S-transferase 1
Gene
GST1
Organism
Zea mays (Maize)
Status
Functioni
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the detoxification of certain herbicides.
Catalytic activityi
- EC:2.5.1.18
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 12 | GlutathioneBy similarity | 1 |
GO - Molecular functioni
- glutathione binding Source: GO_Central
- glutathione transferase activity Source: AgBase
GO - Biological processi
- glutathione metabolic process Source: InterPro
- response to herbicide Source: AgBase
- response to hydrogen peroxide Source: AgBase
- response to reactive oxygen species Source: AgBase
- response to salicylic acid Source: AgBase
- response to xenobiotic stimulus Source: AgBase
Keywordsi
Molecular function | Transferase |
Enzyme and pathway databases
BRENDAi | 2.5.1.18, 6752 |
SABIO-RKi | P12653 |
Names & Taxonomyi
Protein namesi | Recommended name: Glutathione S-transferase 1 (EC:2.5.1.18)Alternative name(s): GST class-phi member 1 GST-29 GST-I |
Gene namesi | Name:GST1 |
Organismi | Zea mays (Maize) |
Taxonomic identifieri | 4577 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Liliopsida › Poales › Poaceae › PACMAD clade › Panicoideae › Andropogonodae › Andropogoneae › Tripsacinae › Zea |
Proteomesi |
|
Organism-specific databases
MaizeGDBi | 65344 |
Subcellular locationi
Other locations
- cytoplasm Source: GO_Central
- protein-containing complex Source: AgBase
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000185841 | 2 – 214 | Glutathione S-transferase 1Add BLAST | 213 |
Proteomic databases
PaxDbi | P12653 |
Expressioni
Tissue specificityi
Expressed in the stem and leaves, lower levels are seen in the pollen and endosperm.
Gene expression databases
ExpressionAtlasi | P12653, baseline and differential |
Interactioni
Subunit structurei
Homodimer or heterodimer of GST-I and GST-IV (=GST-II).
2 PublicationsProtein-protein interaction databases
STRINGi | 4577.GRMZM2G116273_P01 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P12653 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P12653 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 83 | GST N-terminalAdd BLAST | 82 | |
Domaini | 88 – 214 | GST C-terminalAdd BLAST | 127 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 41 – 42 | Glutathione binding | 2 | |
Regioni | 54 – 55 | Glutathione binding | 2 | |
Regioni | 67 – 68 | Glutathione binding | 2 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0867, Eukaryota |
OrthoDBi | 1231780at2759 |
Family and domain databases
CDDi | cd03187, GST_C_Phi, 1 hit |
InterProi | View protein in InterPro IPR010987, Glutathione-S-Trfase_C-like IPR036282, Glutathione-S-Trfase_C_sf IPR040079, Glutathione_S-Trfase IPR004045, Glutathione_S-Trfase_N IPR004046, GST_C IPR034347, GST_Phi_C IPR036249, Thioredoxin-like_sf |
Pfami | View protein in Pfam PF00043, GST_C, 1 hit PF02798, GST_N, 1 hit |
SFLDi | SFLDS00019, Glutathione_Transferase_(cytos, 1 hit |
SUPFAMi | SSF47616, SSF47616, 1 hit SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS50405, GST_CTER, 1 hit PS50404, GST_NTER, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P12653-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPMKLYGAV MSWNLTRCAT ALEEAGSDYE IVPINFATAE HKSPEHLVRN
60 70 80 90 100
PFGQVPALQD GDLYLFESRA ICKYAARKNK PELLREGNLE EAAMVDVWIE
110 120 130 140 150
VEANQYTAAL NPILFQVLIS PMLGGTTDQK VVDENLEKLK KVLEVYEARL
160 170 180 190 200
TKCKYLAGDF LSLADLNHVS VTLCLFATPY ASVLDAYPHV KAWWSGLMER
210
PSVQKVAALM KPSA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 15 | L → V in AAA33470 (Ref. 2) Curated | 1 | |
Sequence conflicti | 15 | L → V in AAA33469 (Ref. 2) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X06754 mRNA Translation: CAA29928.1 M16901 mRNA Translation: AAA33470.1 M16902, M16900 Genomic DNA Translation: AAA33469.1 |
PIRi | S03726, XUZM1 |
RefSeqi | NP_001105412.1, NM_001111942.1 |
Genome annotation databases
GeneIDi | 542366 |
KEGGi | zma:542366 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X06754 mRNA Translation: CAA29928.1 M16901 mRNA Translation: AAA33470.1 M16902, M16900 Genomic DNA Translation: AAA33469.1 |
PIRi | S03726, XUZM1 |
RefSeqi | NP_001105412.1, NM_001111942.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AXD | X-ray | 2.50 | A/B | 2-210 | [»] | |
1BYE | X-ray | 2.80 | A/B/C/D | 2-214 | [»] | |
SMRi | P12653 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 4577.GRMZM2G116273_P01 |
Proteomic databases
PaxDbi | P12653 |
Genome annotation databases
GeneIDi | 542366 |
KEGGi | zma:542366 |
Organism-specific databases
MaizeGDBi | 65344 |
Phylogenomic databases
eggNOGi | KOG0867, Eukaryota |
OrthoDBi | 1231780at2759 |
Enzyme and pathway databases
BRENDAi | 2.5.1.18, 6752 |
SABIO-RKi | P12653 |
Miscellaneous databases
EvolutionaryTracei | P12653 |
Gene expression databases
ExpressionAtlasi | P12653, baseline and differential |
Family and domain databases
CDDi | cd03187, GST_C_Phi, 1 hit |
InterProi | View protein in InterPro IPR010987, Glutathione-S-Trfase_C-like IPR036282, Glutathione-S-Trfase_C_sf IPR040079, Glutathione_S-Trfase IPR004045, Glutathione_S-Trfase_N IPR004046, GST_C IPR034347, GST_Phi_C IPR036249, Thioredoxin-like_sf |
Pfami | View protein in Pfam PF00043, GST_C, 1 hit PF02798, GST_N, 1 hit |
SFLDi | SFLDS00019, Glutathione_Transferase_(cytos, 1 hit |
SUPFAMi | SSF47616, SSF47616, 1 hit SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS50405, GST_CTER, 1 hit PS50404, GST_NTER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GSTF1_MAIZE | |
Accessioni | P12653Primary (citable) accession number: P12653 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 138 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families