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Protein

Bone morphogenetic protein 3

Gene

BMP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.2 Publications

GO - Molecular functioni

  • BMP receptor binding Source: MGI
  • cytokine activity Source: GO_Central
  • growth factor activity Source: UniProtKB-KW
  • signaling receptor binding Source: ProtInc
  • transforming growth factor beta receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCytokine, Developmental protein, Growth factor
Biological processChondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 3
Short name:
BMP-3
Alternative name(s):
Bone morphogenetic protein 3A
Short name:
BMP-3A
Osteogenin
Gene namesi
Name:BMP3
Synonyms:BMP3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000152785.6
HGNCiHGNC:1070 BMP3
MIMi112263 gene
neXtProtiNX_P12645

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi651
OpenTargetsiENSG00000152785
PharmGKBiPA25380

Polymorphism and mutation databases

BioMutaiBMP3
DMDMi215273985

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000003383623 – 362By similarityAdd BLAST340
ChainiPRO_0000033837363 – 472Bone morphogenetic protein 3Add BLAST110

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi175N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi370 ↔ 4371 Publication
Disulfide bondi399 ↔ 4691 Publication
Disulfide bondi403 ↔ 4711 Publication
Disulfide bondi436Interchain1 Publication
Glycosylationi463N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP12645
PeptideAtlasiP12645
PRIDEiP12645
ProteomicsDBi52862

PTM databases

iPTMnetiP12645
PhosphoSitePlusiP12645

Expressioni

Tissue specificityi

Expressed in adult and fetal cartilage.1 Publication

Inductioni

Highly expressed in fracture tissue, particularly in osteoblasts, osteoclasts and chondroblasts.1 Publication

Gene expression databases

BgeeiENSG00000152785 Expressed in 63 organ(s), highest expression level in lung
CleanExiHS_BMP3
GenevisibleiP12645 HS

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107119, 2 interactors
IntActiP12645, 4 interactors
MINTiP12645
STRINGi9606.ENSP00000282701

Structurei

Secondary structure

1472
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP12645
SMRiP12645
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12645

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00910000143982
HOGENOMiHOG000232003
HOVERGENiHBG004857
InParanoidiP12645
KOiK05496
OMAiVSEHMLR
OrthoDBiEOG091G0WGP
PhylomeDBiP12645
TreeFamiTF316134

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR017197 BMP3/BMP3B
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
PIRSFiPIRSF037403 BMP3/GDF10, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12645-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGASRLLFL WLGCFCVSLA QGERPKPPFP ELRKAVPGDR TAGGGPDSEL
60 70 80 90 100
QPQDKVSEHM LRLYDRYSTV QAARTPGSLE GGSQPWRPRL LREGNTVRSF
110 120 130 140 150
RAAAAETLER KGLYIFNLTS LTKSENILSA TLYFCIGELG NISLSCPVSG
160 170 180 190 200
GCSHHAQRKH IQIDLSAWTL KFSRNQSQLL GHLSVDMAKS HRDIMSWLSK
210 220 230 240 250
DITQLLRKAK ENEEFLIGFN ITSKGRQLPK RRLPFPEPYI LVYANDAAIS
260 270 280 290 300
EPESVVSSLQ GHRNFPTGTV PKWDSHIRAA LSIERRKKRS TGVLLPLQNN
310 320 330 340 350
ELPGAEYQYK KDEVWEERKP YKTLQAQAPE KSKNKKKQRK GPHRKSQTLQ
360 370 380 390 400
FDEQTLKKAR RKQWIEPRNC ARRYLKVDFA DIGWSEWIIS PKSFDAYYCS
410 420 430 440 450
GACQFPMPKS LKPSNHATIQ SIVRAVGVVP GIPEPCCVPE KMSSLSILFF
460 470
DENKNVVLKV YPNMTVESCA CR
Length:472
Mass (Da):53,372
Last modified:November 25, 2008 - v2
Checksum:i2809B7EF5E37596A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047418176Q → K. Corresponds to variant dbSNP:rs34213771Ensembl.1
Natural variantiVAR_047419176Q → L. Corresponds to variant dbSNP:rs34847147Ensembl.1
Natural variantiVAR_020063192R → Q. Corresponds to variant dbSNP:rs3733549Ensembl.1
Natural variantiVAR_047420205L → F3 PublicationsCorresponds to variant dbSNP:rs6831040Ensembl.1
Natural variantiVAR_047421222T → M. Corresponds to variant dbSNP:rs34505126Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22491 mRNA Translation: AAA51836.1
AC093883 Genomic DNA No translation available.
BC096269 mRNA Translation: AAH96269.1
BC096270 mRNA Translation: AAH96270.1
BC096271 mRNA Translation: AAH96271.1
BC117514 mRNA Translation: AAI17515.1
CCDSiCCDS3588.1
PIRiD37278 BMHU3
RefSeqiNP_001192.3, NM_001201.3
UniGeneiHs.387411

Genome annotation databases

EnsembliENST00000282701; ENSP00000282701; ENSG00000152785
GeneIDi651
KEGGihsa:651
UCSCiuc003hmg.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Bone morphogenetic protein 3 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22491 mRNA Translation: AAA51836.1
AC093883 Genomic DNA No translation available.
BC096269 mRNA Translation: AAH96269.1
BC096270 mRNA Translation: AAH96270.1
BC096271 mRNA Translation: AAH96271.1
BC117514 mRNA Translation: AAI17515.1
CCDSiCCDS3588.1
PIRiD37278 BMHU3
RefSeqiNP_001192.3, NM_001201.3
UniGeneiHs.387411

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QCQX-ray2.21A/B363-472[»]
ProteinModelPortaliP12645
SMRiP12645
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107119, 2 interactors
IntActiP12645, 4 interactors
MINTiP12645
STRINGi9606.ENSP00000282701

PTM databases

iPTMnetiP12645
PhosphoSitePlusiP12645

Polymorphism and mutation databases

BioMutaiBMP3
DMDMi215273985

Proteomic databases

PaxDbiP12645
PeptideAtlasiP12645
PRIDEiP12645
ProteomicsDBi52862

Protocols and materials databases

DNASUi651
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282701; ENSP00000282701; ENSG00000152785
GeneIDi651
KEGGihsa:651
UCSCiuc003hmg.4 human

Organism-specific databases

CTDi651
DisGeNETi651
EuPathDBiHostDB:ENSG00000152785.6
GeneCardsiBMP3
HGNCiHGNC:1070 BMP3
MIMi112263 gene
neXtProtiNX_P12645
OpenTargetsiENSG00000152785
PharmGKBiPA25380
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00910000143982
HOGENOMiHOG000232003
HOVERGENiHBG004857
InParanoidiP12645
KOiK05496
OMAiVSEHMLR
OrthoDBiEOG091G0WGP
PhylomeDBiP12645
TreeFamiTF316134

Miscellaneous databases

EvolutionaryTraceiP12645
GeneWikiiBone_morphogenetic_protein_3
GenomeRNAii651
PROiPR:P12645
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000152785 Expressed in 63 organ(s), highest expression level in lung
CleanExiHS_BMP3
GenevisibleiP12645 HS

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR017197 BMP3/BMP3B
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
PIRSFiPIRSF037403 BMP3/GDF10, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBMP3_HUMAN
AccessioniPrimary (citable) accession number: P12645
Secondary accession number(s): Q4VAS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 171 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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