UniProtKB - P12643 (BMP2_HUMAN)
Bone morphogenetic protein 2
BMP2
Functioni
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis (PubMed:18436533, PubMed:31019025, PubMed:24362451).
Induces cartilage and bone formation (PubMed:3201241).
Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:15064755, PubMed:17295905, PubMed:18436533).
Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A (PubMed:7791754).
In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation (PubMed:20851880, PubMed:16771708).
Stimulates also the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation (PubMed:24362451).
8 PublicationsGO - Molecular functioni
- BMP receptor binding Source: MGI
- co-receptor binding Source: BHF-UCL
- cytokine activity Source: BHF-UCL
- growth factor activity Source: UniProtKB-KW
- phosphatase activator activity Source: MGI
- protein serine/threonine kinase activator activity Source: Ensembl
- signaling receptor binding Source: ProtInc
- SMAD binding Source: BHF-UCL
GO - Biological processi
- animal organ morphogenesis Source: UniProtKB
- aortic valve development Source: BHF-UCL
- atrioventricular canal morphogenesis Source: BHF-UCL
- atrioventricular valve morphogenesis Source: UniProtKB
- BMP signaling pathway Source: UniProtKB
- BMP signaling pathway involved in heart development Source: BHF-UCL
- BMP signaling pathway involved in heart induction Source: BHF-UCL
- bone mineralization Source: UniProtKB
- bone mineralization involved in bone maturation Source: BHF-UCL
- branching involved in ureteric bud morphogenesis Source: UniProtKB
- cardiac atrium formation Source: BHF-UCL
- cardiac epithelial to mesenchymal transition Source: BHF-UCL
- cardiac jelly development Source: BHF-UCL
- cardiac muscle cell differentiation Source: BHF-UCL
- cardiac muscle tissue morphogenesis Source: UniProtKB
- cardiocyte differentiation Source: MGI
- cell-cell signaling Source: ProtInc
- cell fate commitment Source: UniProtKB
- cellular response to BMP stimulus Source: BHF-UCL
- cellular response to organic cyclic compound Source: Ensembl
- chondrocyte differentiation Source: AgBase
- corticotropin hormone secreting cell differentiation Source: UniProtKB
- embryonic heart tube anterior/posterior pattern specification Source: UniProtKB
- endocardial cushion formation Source: BHF-UCL
- endocardial cushion morphogenesis Source: UniProtKB
- epithelial to mesenchymal transition Source: BHF-UCL
- heart development Source: UniProtKB
- inflammatory response Source: UniProtKB
- inner ear development Source: UniProtKB
- in utero embryonic development Source: UniProtKB
- mesenchymal cell differentiation Source: UniProtKB
- mesenchymal cell proliferation involved in ureteric bud development Source: UniProtKB
- mesenchyme development Source: BHF-UCL
- negative regulation of aldosterone biosynthetic process Source: BHF-UCL
- negative regulation of calcium-independent cell-cell adhesion Source: AgBase
- negative regulation of canonical Wnt signaling pathway Source: AgBase
- negative regulation of cardiac muscle cell differentiation Source: BHF-UCL
- negative regulation of cell cycle Source: HGNC-UCL
- negative regulation of cell population proliferation Source: BHF-UCL
- negative regulation of cortisol biosynthetic process Source: BHF-UCL
- negative regulation of gene expression Source: BHF-UCL
- negative regulation of insulin-like growth factor receptor signaling pathway Source: BHF-UCL
- negative regulation of MAP kinase activity Source: BHF-UCL
- negative regulation of smooth muscle cell proliferation Source: BHF-UCL
- negative regulation of steroid biosynthetic process Source: BHF-UCL
- negative regulation of transcription, DNA-templated Source: BHF-UCL
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- negative regulation of transforming growth factor beta receptor signaling pathway Source: ARUK-UCL
- negative regulation of Wnt signaling pathway involved in heart development Source: BHF-UCL
- Notch signaling pathway Source: UniProtKB
- odontogenesis of dentin-containing tooth Source: UniProtKB
- osteoblast differentiation Source: MGI
- pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
- pericardium development Source: UniProtKB
- positive regulation of apoptotic process Source: MGI
- positive regulation of astrocyte differentiation Source: UniProtKB
- positive regulation of bone mineralization Source: BHF-UCL
- positive regulation of cartilage development Source: MGI
- positive regulation of cell migration Source: UniProtKB
- positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
- positive regulation of endothelial cell proliferation Source: UniProtKB
- positive regulation of epithelial to mesenchymal transition Source: BHF-UCL
- positive regulation of ERK1 and ERK2 cascade Source: DFLAT
- positive regulation of extracellular matrix constituent secretion Source: BHF-UCL
- positive regulation of fat cell differentiation Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
- positive regulation of MAPK cascade Source: DFLAT
- positive regulation of neuron differentiation Source: UniProtKB
- positive regulation of odontogenesis Source: UniProtKB
- positive regulation of ossification Source: MGI
- positive regulation of osteoblast differentiation Source: BHF-UCL
- positive regulation of osteoblast proliferation Source: UniProtKB
- positive regulation of p38MAPK cascade Source: DFLAT
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
- positive regulation of peroxisome proliferator activated receptor signaling pathway Source: ARUK-UCL
- positive regulation of phosphatase activity Source: MGI
- positive regulation of pri-miRNA transcription by RNA polymerase II Source: Ensembl
- positive regulation of protein binding Source: BHF-UCL
- positive regulation of protein phosphorylation Source: UniProtKB
- positive regulation of SMAD protein signal transduction Source: BHF-UCL
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus Source: BHF-UCL
- positive regulation of Wnt signaling pathway Source: UniProtKB
- positive regulation of Wnt signaling pathway by BMP signaling pathway Source: UniProtKB
- protein destabilization Source: Ensembl
- protein phosphorylation Source: DFLAT
- proteoglycan metabolic process Source: Ensembl
- regulation of odontogenesis of dentin-containing tooth Source: Ensembl
- regulation of transcription, DNA-templated Source: HGNC-UCL
- response to bacterium Source: Ensembl
- response to hypoxia Source: UniProtKB
- skeletal system development Source: ProtInc
- SMAD protein signal transduction Source: UniProtKB
- telencephalon development Source: MGI
- telencephalon regionalization Source: UniProtKB
- thyroid-stimulating hormone-secreting cell differentiation Source: UniProtKB
Keywordsi
Molecular function | Cytokine, Developmental protein, Growth factor |
Biological process | Chondrogenesis, Differentiation, Osteogenesis |
Enzyme and pathway databases
PathwayCommonsi | P12643 |
Reactomei | R-HSA-201451, Signaling by BMP R-HSA-2129379, Molecules associated with elastic fibres R-HSA-8878166, Transcriptional regulation by RUNX2 R-HSA-8939902, Regulation of RUNX2 expression and activity |
SignaLinki | P12643 |
SIGNORi | P12643 |
Names & Taxonomyi
Protein namesi | Recommended name: Bone morphogenetic protein 2Short name: BMP-2 Alternative name(s): Bone morphogenetic protein 2A Short name: BMP-2A |
Gene namesi | Name:BMP2 Synonyms:BMP2A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1069, BMP2 |
MIMi | 112261, gene |
neXtProti | NX_P12643 |
VEuPathDBi | HostDB:ENSG00000125845 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: BHF-UCL
Plasma Membrane
- BMP receptor complex Source: BHF-UCL
Other locations
- cell surface Source: UniProtKB
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Brachydactyly A2 (BDA2)2 Publications
Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies (SSFSC)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080742 | 27 – 396 | Missing in SSFSC. 1 PublicationAdd BLAST | 370 | |
Natural variantiVAR_080743 | 154 – 396 | Missing in SSFSC. 1 PublicationAdd BLAST | 243 | |
Natural variantiVAR_080744 | 329 – 396 | Missing in SSFSC. 1 PublicationAdd BLAST | 68 |
Pharmaceutical usei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 333 | L → P: Complete loss of type I receptor binding. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, DwarfismOrganism-specific databases
DisGeNETi | 650 |
MalaCardsi | BMP2 |
MIMi | 112600, phenotype 617877, phenotype |
OpenTargetsi | ENSG00000125845 |
Orphaneti | 261295, 20p12.3 microdeletion syndrome 93396, Brachydactyly type A2 |
PharmGKBi | PA25379 |
Miscellaneous databases
Pharosi | P12643, Tbio |
Chemistry databases
ChEMBLi | CHEMBL1926496 |
Genetic variation databases
BioMutai | BMP2 |
DMDMi | 115068 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
PropeptideiPRO_0000033824 | 24 – 282 | Cleaved by PCSK5Add BLAST | 259 | |
ChainiPRO_0000033825 | 283 – 396 | Bone morphogenetic protein 2Add BLAST | 114 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 87 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 135 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 163 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 164 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 200 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 296 ↔ 361 | |||
Disulfide bondi | 325 ↔ 393 | |||
Disulfide bondi | 329 ↔ 395 | |||
Glycosylationi | 338 | N-linked (GlcNAc...) (high mannose) asparagine1 Publication | 1 | |
Disulfide bondi | 360 | Interchain |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | P12643 |
MassIVEi | P12643 |
PaxDbi | P12643 |
PeptideAtlasi | P12643 |
PRIDEi | P12643 |
ProteomicsDBi | 52860 |
PTM databases
GlyGeni | P12643, 5 sites |
iPTMneti | P12643 |
PhosphoSitePlusi | P12643 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000125845, Expressed in thyroid gland and 201 other tissues |
ExpressionAtlasi | P12643, baseline and differential |
Genevisiblei | P12643, HS |
Organism-specific databases
HPAi | ENSG00000125845, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer; disulfide-linked (PubMed:10074410).
Interacts with SOSTDC1 (PubMed:15020244).
Interacts with GREM2, RGMA, RGMB and RGMC.
Interacts with ASPN (By similarity).
Interacts with MAFP5 (By similarity).
Interacts with FBN1 (via N-terminal domain) and FBN2 (PubMed:18339631).
Interacts with type I receptor BMPR1A (PubMed:15064755).
Interacts with type II receptor BMPR2 (PubMed:7791754).
Interacts with SCUBE3 (PubMed:33308444).
Interacts with TNFAIP6 (primarily via Link domain); this interaction is inhibited by hyaluronan.
By similarity5 PublicationsBinary interactionsi
P12643
Bone morphogenetic protein 2 (PRO_0000033825)
With | #Exp. | IntAct |
---|---|---|
TNFAIP6 [P98066] | 3 | EBI-9697918,EBI-11700693 |
GO - Molecular functioni
- BMP receptor binding Source: MGI
- co-receptor binding Source: BHF-UCL
- cytokine activity Source: BHF-UCL
- growth factor activity Source: UniProtKB-KW
- signaling receptor binding Source: ProtInc
- SMAD binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 107118, 16 interactors |
CORUMi | P12643 |
DIPi | DIP-5792N |
IntActi | P12643, 18 interactors |
MINTi | P12643 |
STRINGi | 9606.ENSP00000368104 |
Chemistry databases
BindingDBi | P12643 |
Miscellaneous databases
RNActi | P12643, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P12643 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P12643 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 84 – 121 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 271 – 293 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 98 – 121 | Basic and acidic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 275 – 293 | Basic residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000155666 |
HOGENOMi | CLU_020515_4_2_1 |
InParanoidi | P12643 |
OMAi | WTSGKGH |
OrthoDBi | 962484at2759 |
PhylomeDBi | P12643 |
TreeFami | TF351789 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
IDEALi | IID00354 |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MVAGTRCLLA LLLPQVLLGG AAGLVPELGR RKFAAASSGR PSSQPSDEVL
60 70 80 90 100
SEFELRLLSM FGLKQRPTPS RDAVVPPYML DLYRRHSGQP GSPAPDHRLE
110 120 130 140 150
RAASRANTVR SFHHEESLEE LPETSGKTTR RFFFNLSSIP TEEFITSAEL
160 170 180 190 200
QVFREQMQDA LGNNSSFHHR INIYEIIKPA TANSKFPVTR LLDTRLVNQN
210 220 230 240 250
ASRWESFDVT PAVMRWTAQG HANHGFVVEV AHLEEKQGVS KRHVRISRSL
260 270 280 290 300
HQDEHSWSQI RPLLVTFGHD GKGHPLHKRE KRQAKHKQRK RLKSSCKRHP
310 320 330 340 350
LYVDFSDVGW NDWIVAPPGY HAFYCHGECP FPLADHLNST NHAIVQTLVN
360 370 380 390
SVNSKIPKAC CVPTELSAIS MLYLDENEKV VLKNYQDMVV EGCGCR
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080742 | 27 – 396 | Missing in SSFSC. 1 PublicationAdd BLAST | 370 | |
Natural variantiVAR_020061 | 37 | S → A. Corresponds to variant dbSNP:rs2273073EnsemblClinVar. | 1 | |
Natural variantiVAR_052568 | 77 | P → S. Corresponds to variant dbSNP:rs36105541Ensembl. | 1 | |
Natural variantiVAR_020062 | 106 | A → T. Corresponds to variant dbSNP:rs2273074Ensembl. | 1 | |
Natural variantiVAR_080743 | 154 – 396 | Missing in SSFSC. 1 PublicationAdd BLAST | 243 | |
Natural variantiVAR_052569 | 161 | L → S. Corresponds to variant dbSNP:rs34183594EnsemblClinVar. | 1 | |
Natural variantiVAR_024232 | 190 | R → S. Corresponds to variant dbSNP:rs235768EnsemblClinVar. | 1 | |
Natural variantiVAR_080744 | 329 – 396 | Missing in SSFSC. 1 PublicationAdd BLAST | 68 | |
Natural variantiVAR_052570 | 387 | D → G. Corresponds to variant dbSNP:rs11545591Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M22489 mRNA Translation: AAA51834.1 AF040249 Genomic DNA Translation: AAF21646.1 AL035668 Genomic DNA No translation available. |
CCDSi | CCDS13099.1 |
PIRi | B37278, BMHU2 |
RefSeqi | NP_001191.1, NM_001200.3 |
Genome annotation databases
Ensembli | ENST00000378827; ENSP00000368104; ENSG00000125845 |
GeneIDi | 650 |
KEGGi | hsa:650 |
MANE-Selecti | ENST00000378827.5; ENSP00000368104.3; NM_001200.4; NP_001191.1 |
UCSCi | uc002wmu.2, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Bone morphogenetic protein 2 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M22489 mRNA Translation: AAA51834.1 AF040249 Genomic DNA Translation: AAF21646.1 AL035668 Genomic DNA No translation available. |
CCDSi | CCDS13099.1 |
PIRi | B37278, BMHU2 |
RefSeqi | NP_001191.1, NM_001200.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1ES7 | X-ray | 2.90 | A/C | 283-396 | [»] | |
1REU | X-ray | 2.65 | A | 294-396 | [»] | |
1REW | X-ray | 1.86 | A/B | 283-396 | [»] | |
2GOO | X-ray | 2.20 | A/D | 283-396 | [»] | |
2H62 | X-ray | 1.85 | A/B | 283-396 | [»] | |
2H64 | X-ray | 1.92 | A | 283-396 | [»] | |
2QJ9 | X-ray | 2.44 | A/B | 283-396 | [»] | |
2QJA | X-ray | 2.60 | A/B | 283-396 | [»] | |
2QJB | X-ray | 2.50 | A/B | 283-396 | [»] | |
3BK3 | X-ray | 2.70 | A/B | 283-396 | [»] | |
3BMP | X-ray | 2.70 | A | 283-396 | [»] | |
4MID | X-ray | 2.14 | A | 283-314 | [»] | |
4N1D | X-ray | 1.91 | A | 283-305 | [»] | |
A | 362-396 | [»] | ||||
4UHY | X-ray | 3.20 | A/B | 283-396 | [»] | |
4UHZ | X-ray | 2.85 | A | 283-396 | [»] | |
4UI0 | X-ray | 2.80 | A/B | 283-396 | [»] | |
4UI1 | X-ray | 2.35 | A/B | 283-396 | [»] | |
4UI2 | X-ray | 3.15 | B | 283-396 | [»] | |
6OMN | X-ray | 2.68 | E/F/G/H | 289-396 | [»] | |
SMRi | P12643 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107118, 16 interactors |
CORUMi | P12643 |
DIPi | DIP-5792N |
IntActi | P12643, 18 interactors |
MINTi | P12643 |
STRINGi | 9606.ENSP00000368104 |
Chemistry databases
BindingDBi | P12643 |
ChEMBLi | CHEMBL1926496 |
PTM databases
GlyGeni | P12643, 5 sites |
iPTMneti | P12643 |
PhosphoSitePlusi | P12643 |
Genetic variation databases
BioMutai | BMP2 |
DMDMi | 115068 |
Proteomic databases
EPDi | P12643 |
MassIVEi | P12643 |
PaxDbi | P12643 |
PeptideAtlasi | P12643 |
PRIDEi | P12643 |
ProteomicsDBi | 52860 |
Protocols and materials databases
Antibodypediai | 8441, 994 antibodies from 42 providers |
DNASUi | 650 |
Genome annotation databases
Ensembli | ENST00000378827; ENSP00000368104; ENSG00000125845 |
GeneIDi | 650 |
KEGGi | hsa:650 |
MANE-Selecti | ENST00000378827.5; ENSP00000368104.3; NM_001200.4; NP_001191.1 |
UCSCi | uc002wmu.2, human |
Organism-specific databases
CTDi | 650 |
DisGeNETi | 650 |
GeneCardsi | BMP2 |
HGNCi | HGNC:1069, BMP2 |
HPAi | ENSG00000125845, Low tissue specificity |
MalaCardsi | BMP2 |
MIMi | 112261, gene 112600, phenotype 617877, phenotype |
neXtProti | NX_P12643 |
OpenTargetsi | ENSG00000125845 |
Orphaneti | 261295, 20p12.3 microdeletion syndrome 93396, Brachydactyly type A2 |
PharmGKBi | PA25379 |
VEuPathDBi | HostDB:ENSG00000125845 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000155666 |
HOGENOMi | CLU_020515_4_2_1 |
InParanoidi | P12643 |
OMAi | WTSGKGH |
OrthoDBi | 962484at2759 |
PhylomeDBi | P12643 |
TreeFami | TF351789 |
Enzyme and pathway databases
PathwayCommonsi | P12643 |
Reactomei | R-HSA-201451, Signaling by BMP R-HSA-2129379, Molecules associated with elastic fibres R-HSA-8878166, Transcriptional regulation by RUNX2 R-HSA-8939902, Regulation of RUNX2 expression and activity |
SignaLinki | P12643 |
SIGNORi | P12643 |
Miscellaneous databases
BioGRID-ORCSi | 650, 6 hits in 1043 CRISPR screens |
ChiTaRSi | BMP2, human |
EvolutionaryTracei | P12643 |
GeneWikii | Bone_morphogenetic_protein_2 |
GenomeRNAii | 650 |
Pharosi | P12643, Tbio |
PROi | PR:P12643 |
RNActi | P12643, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000125845, Expressed in thyroid gland and 201 other tissues |
ExpressionAtlasi | P12643, baseline and differential |
Genevisiblei | P12643, HS |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
IDEALi | IID00354 |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BMP2_HUMAN | |
Accessioni | P12643Primary (citable) accession number: P12643 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | October 1, 1989 | |
Last modified: | February 23, 2022 | |
This is version 231 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Pharmaceutical, Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families