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Protein

T-complex protein 1 subunit alpha

Gene

TCP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.

GO - Molecular functioni

GO - Biological processi

  • 'de novo' protein folding Source: GO_Central
  • chaperone-mediated protein folding Source: GO_Central
  • protein folding Source: SGD

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29794-MONOMER
ReactomeiR-SCE-390471 Association of TriC/CCT with target proteins during biosynthesis
R-SCE-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit alpha
Short name:
TCP-1-alpha
Alternative name(s):
CCT-alpha
Gene namesi
Name:TCP1
Synonyms:CCT1
Ordered Locus Names:YDR212W
ORF Names:YD8142.13, YD8142B.04
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR212W
SGDiS000002620 TCP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi48G → E: Temperature-sensitive. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001283152 – 559T-complex protein 1 subunit alphaAdd BLAST558

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP12612
PaxDbiP12612
PRIDEiP12612

PTM databases

iPTMnetiP12612

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein binding involved in protein folding Source: GO_Central
  • unfolded protein binding Source: SGD

Protein-protein interaction databases

BioGridi32266, 503 interactors
ComplexPortaliCPX-2156 Chaperonin-containing T-complex
DIPiDIP-2965N
IntActiP12612, 109 interactors
MINTiP12612
STRINGi4932.YDR212W

Structurei

3D structure databases

ProteinModelPortaliP12612
SMRiP12612
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

GeneTreeiENSGT00550000074878
HOGENOMiHOG000226729
InParanoidiP12612
KOiK09493
OMAiIMRIDTL
OrthoDBiEOG092C1WYZ

Family and domain databases

CDDicd03335 TCP1_alpha, 1 hit
Gene3Di1.10.560.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012715 Chap_CCT_alpha
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02340 chap_CCT_alpha, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12612-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQLFNNSRS DTLFLGGEKI SGDDIRNQNV LATMAVANVV KSSLGPVGLD
60 70 80 90 100
KMLVDDIGDF TVTNDGATIL SLLDVQHPAG KILVELAQQQ DREIGDGTTS
110 120 130 140 150
VVIIASELLK RANELVKNKI HPTTIITGFR VALREAIRFI NEVLSTSVDT
160 170 180 190 200
LGKETLINIA KTSMSSKIIG ADSDFFSNMV VDALLAVKTQ NSKGEIKYPV
210 220 230 240 250
KAVNVLKAHG KSATESLLVP GYALNCTVAS QAMPKRIAGG NVKIACLDLN
260 270 280 290 300
LQKARMAMGV QINIDDPEQL EQIRKREAGI VLERVKKIID AGAQVVLTTK
310 320 330 340 350
GIDDLCLKEF VEAKIMGVRR CKKEDLRRIA RATGATLVSS MSNLEGEETF
360 370 380 390 400
ESSYLGLCDE VVQAKFSDDE CILIKGTSKH SSSSIILRGA NDYSLDEMER
410 420 430 440 450
SLHDSLSVVK RTLESGNVVP GGGCVEAALN IYLDNFATTV GSREQLAIAE
460 470 480 490 500
FAAALLIIPK TLAVNAAKDS SELVAKLRSY HAASQMAKPE DVKRRSYRNY
510 520 530 540 550
GLDLIRGKIV DEIHAGVLEP TISKVKSLKS ALEACVAILR IDTMITVDPE

PPKEDPHDH
Length:559
Mass (Da):60,481
Last modified:October 1, 1996 - v2
Checksum:i02C625D329359E61
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti530S → L in AAA35139 (PubMed:1901944).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21160 Genomic DNA Translation: AAA35139.1
Z68194 Genomic DNA Translation: CAA92355.1
Z68195 Genomic DNA Translation: CAA92363.1
BK006938 Genomic DNA Translation: DAA12056.1
PIRiA39793
RefSeqiNP_010498.1, NM_001180520.1

Genome annotation databases

EnsemblFungiiYDR212W; YDR212W; YDR212W
GeneIDi851798
KEGGisce:YDR212W

Similar proteinsi

Entry informationi

Entry nameiTCPA_YEAST
AccessioniPrimary (citable) accession number: P12612
Secondary accession number(s): D6VSJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1996
Last modified: July 18, 2018
This is version 176 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

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