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Protein

Hemagglutinin glycoprotein

Gene

H

Organism
Rinderpest virus (strain Kabete O) (RDV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity). Down-regulates human MCP/CD46 cell surface expression.By similarity1 Publication

Caution

Morbiliviruses hemagglutinins have no neuraminidase activity.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHemagglutinin
Biological processHost-virus interaction, Viral attachment to host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin glycoprotein
Gene namesi
Name:H
OrganismiRinderpest virus (strain Kabete O) (RDV)
Taxonomic identifieri11242 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeMorbillivirus
Virus hostiBos indicus (Zebu) [TaxID: 9915]
Bos taurus (Bovine) [TaxID: 9913]
Bubalus bubalis (Domestic water buffalo) [TaxID: 89462]
Capra hircus (Goat) [TaxID: 9925]
Gazella (gazelles) [TaxID: 9933]
Giraffa camelopardalis (Giraffe) [TaxID: 9894]
Hippopotamus [TaxID: 9832]
Ovis aries (Sheep) [TaxID: 9940]
Suidae (pigs) [TaxID: 9821]

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34IntravirionSequence analysisAdd BLAST34
Transmembranei35 – 58Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST24
Topological domaini59 – 609Virion surfaceSequence analysisAdd BLAST551

GO - Cellular componenti

Keywords - Cellular componenti

Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001426331 – 609Hemagglutinin glycoproteinAdd BLAST609

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi168N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi187N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi200N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi215N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi395N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP12567
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

InterProiView protein in InterPro
IPR000665 Hemagglutn/HN
IPR036278 Sialidase_sf
PfamiView protein in Pfam
PF00423 HN, 1 hit
SUPFAMiSSF50939 SSF50939, 1 hit

Sequencei

Sequence statusi: Complete.

P12567-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPPRDRVDA YYKDNFQFKN TRVVLNKEQL LIERPCMLLT VLFVMFLSLV
60 70 80 90 100
GLLAIAGIRL HRAAVNTAKI NNDLTTSIDI TKSIEYQVKD VLTPLFKIIG
110 120 130 140 150
DEVGLRTPQR FTDLTKFISD KIKFLNPDKE YDFRDINWCI NPPERIKIDY
160 170 180 190 200
DQYCAHTAAE DLITMLVNSS LTGTTVLRTS LVNLRRNCTG PTTTKGQFSN
210 220 230 240 250
ISLTLSGIYS GRGYNISSMI TITGKGMYGS TYLVGKYNQR ARRPSIVWQQ
260 270 280 290 300
DYRVFEVGII RELGVGTPVF HMTNYLELPR QPELETCMLA LGESKLAALC
310 320 330 340 350
LADSPVALHY GRVGDDNKIR FVKLGVWASP ADRDTLATLS AIDPTLDGLY
360 370 380 390 400
ITTHRGIIAA GTAIWAVPVT RTDDQVKMGK CRLEACRDRP PPFCNSTDWE
410 420 430 440 450
PLEAGRIPAY GVLTIKLGLA DEPKVDIISE FGPLITHDSG MDLYTSFDGT
460 470 480 490 500
KYWLTTPPLQ NSALGTVNTL VLEPSLKISP NILTLPIRSG GGDCYTPTYL
510 520 530 540 550
SDRADDDVKL SSNLVILPSR DLQYVSATYD ISRVEHAIVY HIYSTGRLSS
560 570 580 590 600
YYYPFKLPIK GDPVSLQIEC FPWDRKLWCH HFCSVIDSGT GEQVTHIGVV

GIKITCNGK
Length:609
Mass (Da):67,998
Last modified:October 1, 1989 - v1
Checksum:i2AAD2753933D3402
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21513 Genomic RNA Translation: AAA47401.1
PIRiA31053 HMNZKA

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21513 Genomic RNA Translation: AAA47401.1
PIRiA31053 HMNZKA

3D structure databases

ProteinModelPortaliP12567
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR000665 Hemagglutn/HN
IPR036278 Sialidase_sf
PfamiView protein in Pfam
PF00423 HN, 1 hit
SUPFAMiSSF50939 SSF50939, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHEMA_RINDK
AccessioniPrimary (citable) accession number: P12567
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 7, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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