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Protein

Hemagglutinin-neuraminidase

Gene

HN

Organism
Newcastle disease virus (strain Chicken/United States(TX)/GB/48) (NDV) (Newcastle disease virus (strain Texas g.b./48))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).By similarity
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.By similarity

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHemagglutinin, Hydrolase
Biological processHost-virus interaction, Viral attachment to host cell, Virus entry into host cell

Protein family/group databases

CAZyiGH83 Glycoside Hydrolase Family 83

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-neuraminidase (EC:3.2.1.18)
Gene namesi
Name:HN
OrganismiNewcastle disease virus (strain Chicken/United States(TX)/GB/48) (NDV) (Newcastle disease virus (strain Texas g.b./48))
Taxonomic identifieri11189 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeAvulavirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26IntravirionSequence analysisAdd BLAST26
Transmembranei27 – 47HelicalSequence analysisAdd BLAST21
Topological domaini48 – 577Virion surfaceSequence analysisAdd BLAST530

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001426191 – 577Hemagglutinin-neuraminidaseAdd BLAST577

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi119N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi341N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi433N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi481N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi538N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP12553

Structurei

3D structure databases

ProteinModelPortaliP12553
SMRiP12553
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

CDDicd15469 HN, 1 hit
InterProiView protein in InterPro
IPR016285 Hemagglutn-neuramid
IPR000665 Hemagglutn/HN
IPR036278 Sialidase_sf
PfamiView protein in Pfam
PF00423 HN, 1 hit
PIRSFiPIRSF001072 Hemagglut-neuramid_paramyxoV, 1 hit
SUPFAMiSSF50939 SSF50939, 1 hit

Sequencei

Sequence statusi: Complete.

P12553-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRAVSQVAL ENDEREAKNT WRLIFRIAIL LLTVVTLATS VASLVYSMGA
60 70 80 90 100
STPSDLVGIP TRISRAEEKI TSALGSNQDV VDRIYKQVAL ESPLALLNTE
110 120 130 140 150
TTIMNAITSL SYQINGAANN SGWGAPIHDP DFIGGIGKEL IVDDASDVTS
160 170 180 190 200
FYPSAFQEHH NFIPAPTTGS GCIRIPSFDM SATHYCYTHN IISSGCRDHS
210 220 230 240 250
HSYQYLALGV LRTSATGRIF FSTLRSINLD DTQNRKSCSV SATPLGCDML
260 270 280 290 300
CSKVTETEEE DYNSAVPTLM VHGRLGFDGQ YHEKDLDVTT LFEDWVANYP
310 320 330 340 350
GVGGGSFIDS RVWFSVYGGL KPNSPSDTVQ EEKYVIYKRY NDTCPDEQDY
360 370 380 390 400
QIRMAKSSYK PGRFGGKRIQ QAILSIKVST SLGEDPVLTV PPNTVTLMGA
410 420 430 440 450
EGRILTVGTS HFLYQRGSSY FSPALLYPMT VSNKTATLHS PYTFNAFTRP
460 470 480 490 500
GSIPCQASAR CPNSCVTGVY TDPYPLIFYR NHTLRGVFGT MLDGEQARLN
510 520 530 540 550
PASAVFDSTS RSRITRVSSS STKAAYTTST CFKVVKTNKT YCLSIAEISN
560 570
TLFGEFRIVP LLVEILKNDG VREARSG
Length:577
Mass (Da):63,275
Last modified:October 1, 1989 - v1
Checksum:i75CC2A5255626140
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti160H → L. 1
Natural varianti332E → R. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21409 Genomic RNA Translation: AAA46669.1
M24711 Genomic RNA Translation: AAA46661.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21409 Genomic RNA Translation: AAA46669.1
M24711 Genomic RNA Translation: AAA46661.1

3D structure databases

ProteinModelPortaliP12553
SMRiP12553
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH83 Glycoside Hydrolase Family 83

Proteomic databases

PRIDEiP12553

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd15469 HN, 1 hit
InterProiView protein in InterPro
IPR016285 Hemagglutn-neuramid
IPR000665 Hemagglutn/HN
IPR036278 Sialidase_sf
PfamiView protein in Pfam
PF00423 HN, 1 hit
PIRSFiPIRSF001072 Hemagglut-neuramid_paramyxoV, 1 hit
SUPFAMiSSF50939 SSF50939, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHN_NDVTG
AccessioniPrimary (citable) accession number: P12553
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: September 12, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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Main funding by: National Institutes of Health

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