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Protein

Putative myc-like protein MYCLP1

Gene

MYCLP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Caution

Could be the product of a pseudogene.Curated

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA-binding transcription factor activity Source: ProtInc
  • protein dimerization activity Source: InterPro

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative myc-like protein MYCLP1
Alternative name(s):
Protein L-Myc-2
V-myc myelocytomatosis viral oncogene homolog pseudogene 1
Gene namesi
Name:MYCLP1
Synonyms:MYCL1P1, MYCL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:7556 MYCLP1
MIMi310310 gene
neXtProtiNX_P12525

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4611

Polymorphism and mutation databases

DMDMi510120775

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001273351 – 358Putative myc-like protein MYCLP1Add BLAST358

Proteomic databases

PeptideAtlasiP12525
PRIDEiP12525
ProteomicsDBi52855

Expressioni

Tissue specificityi

Detected in adult testis.1 Publication

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX (By similarity).By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP12525
SMRiP12525
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini274 – 326bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

HOVERGENiHBG000472
InParanoidiP12525

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR002418 Tscrpt_reg_Myc
IPR012682 Tscrpt_reg_Myc_N
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF01056 Myc_N, 1 hit
PIRSFiPIRSF001705 Myc_protein, 1 hit
PRINTSiPR00044 LEUZIPPRMYC
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

P12525-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRDSYHHYF YDYDGGEDFY RSTTPSEDIW KKFELVPPPW DLGPAAGNPA
60 70 80 90 100
LSFGLLEPWP VGCAGDETES QDYWKAWDAN YASLIRRDCM WSGFSTQEPL
110 120 130 140 150
ERAVSDLLAV GAPSGYSPKE FATPDYTPEL EAGNLAPIFP CLLGEPKIQA
160 170 180 190 200
CSRSESPSDS EGEEIDVTVK KRQSLSTRKP VIIAVRADLL DPRMNLFHIS
210 220 230 240 250
IHQQQHNYAA PFPPESCFQE GAPKRMPPKE ALEREAPGGK DDKEDEEIVS
260 270 280 290 300
LPPVESEAAQ SCQPKPIHYD TENWTKKKYH SYLERKRRND QRSRFLALRD
310 320 330 340 350
EVPALASCSR VSKVMILVKA TEYLHELAEA EERMATEKRQ LECQRRQLQK

RIEYLSSY
Length:358
Mass (Da):40,868
Last modified:May 29, 2013 - v2
Checksum:iC6B5D65D90C2D843
GO

Sequence cautioni

The sequence AAA59883 differs from that shown. Reason: Frameshift at positions 40, 44 and 58.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03069 Genomic DNA Translation: AAA59883.1 Frameshift.
AC004081 Genomic DNA Translation: AAB97938.1
CH471120 Genomic DNA Translation: EAX02715.1
PIRiA30146 TVHUL2

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03069 Genomic DNA Translation: AAA59883.1 Frameshift.
AC004081 Genomic DNA Translation: AAB97938.1
CH471120 Genomic DNA Translation: EAX02715.1
PIRiA30146 TVHUL2

3D structure databases

ProteinModelPortaliP12525
SMRiP12525
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

DMDMi510120775

Proteomic databases

PeptideAtlasiP12525
PRIDEiP12525
ProteomicsDBi52855

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi4611
GeneCardsiMYCLP1
HGNCiHGNC:7556 MYCLP1
MIMi310310 gene
neXtProtiNX_P12525
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG000472
InParanoidiP12525

Miscellaneous databases

PROiPR:P12525
SOURCEiSearch...

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR002418 Tscrpt_reg_Myc
IPR012682 Tscrpt_reg_Myc_N
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF01056 Myc_N, 1 hit
PIRSFiPIRSF001705 Myc_protein, 1 hit
PRINTSiPR00044 LEUZIPPRMYC
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYCP1_HUMAN
AccessioniPrimary (citable) accession number: P12525
Secondary accession number(s): O43372
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: May 29, 2013
Last modified: September 12, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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