UniProtKB - P12522 (ATXB_LEIDO)
Protein
Probable proton ATPase 1B
Gene
H1B
Organism
Leishmania donovani
Status
Functioni
Catalytic activityi
- EC:7.1.2.1
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 351 | 4-aspartylphosphate intermediate | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- proton-exporting ATPase activity, phosphorylative mechanism Source: UniProtKB-EC
GO - Biological processi
- proton export across plasma membrane Source: InterPro
Keywordsi
Molecular function | Translocase |
Biological process | Hydrogen ion transport, Ion transport, Transport |
Ligand | ATP-binding, Magnesium, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:H1B |
Organismi | Leishmania donovani |
Taxonomic identifieri | 5661 [NCBI] |
Taxonomic lineagei | Eukaryota › Discoba › Euglenozoa › Kinetoplastea › Metakinetoplastina › Trypanosomatida › Trypanosomatidae › Leishmaniinae › Leishmania › |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 93 – 112 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 118 – 137 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 265 – 286 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 295 – 321 | HelicalSequence analysisAdd BLAST | 27 | |
Transmembranei | 631 – 651 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 662 – 684 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 698 – 712 | HelicalSequence analysisAdd BLAST | 15 | |
Transmembranei | 738 – 761 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 813 – 840 | HelicalSequence analysisAdd BLAST | 28 | |
Transmembranei | 869 – 887 | HelicalSequence analysisAdd BLAST | 19 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046181 | 1 – 974 | Probable proton ATPase 1BAdd BLAST | 974 |
Keywords - PTMi
PhosphoproteinExpressioni
Developmental stagei
More abundant in amastigotes than promastigotes.1 Publication
Family & Domainsi
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
CDDi | cd02076, P-type_ATPase_H, 1 hit |
Gene3Di | 3.40.1110.10, 2 hits 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006534, P-type_ATPase_IIIA IPR001757, P_typ_ATPase |
Pfami | View protein in Pfam PF00690, Cation_ATPase_N, 1 hit |
PRINTSi | PR00120, HATPASE |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01647, ATPase-IIIA_H, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
i Sequence
Sequence statusi: Complete.
P12522-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSKKYELDA AAFEDKPESH SDAEMTPQKP QRRQSVLSKA VSEHDERATG
60 70 80 90 100
PATDLLPPSK GLTTEEAEEL LKKYGRNELP EKKTPSWLIY VRGLWGPMPA
110 120 130 140 150
ALWIAIIIEF ALENWPDGAI LFAIQIANAT IGWYETIKAG DAVAALKNSL
160 170 180 190 200
KPTATVYRDS KWQQIDAAVL VPGDLVKLAS GSAVPADCSI NEGVIDVDEA
210 220 230 240 250
ALTGESLPVT MGPEHMPKMG SNVVRGEVEG TVQYTGSLTF FGKTAALLQS
260 270 280 290 300
VESDLGNIHV ILRRVMLALC AISFILCMCC FIYLLARFYE TFRHALQFAV
310 320 330 340 350
VVLVVSIPIA LEIVVTTTLA VGSKHLSKHK IIVTKLSAIE MMSGVNMLCS
360 370 380 390 400
DKTGTLTLNK MEIQEQCFTF EEGNDLKSTL VLAALAAKWR EPPRDALDTM
410 420 430 440 450
VLGAADLDEC DNYQQLNFVP FDPTTKRTAA TLVDRRSGEK FDVTKGAPHV
460 470 480 490 500
ILQMVYNQDE INDEVVDIID SLAARGVRCL SVAKTDQQGR WHMAGILTFL
510 520 530 540 550
DPPRPDTKDT IRRSKEYGVD VKMITGDHLL IAKEMCRMLD LDPNILTADK
560 570 580 590 600
LPQIKDANDL PEDLGEKYGD MMLSVGGFAQ VFPEHKFMIV ETLRQRGYTC
610 620 630 640 650
AMTGDGVNDA PALKRADVGI AVHGATDAAR AAADMVLTEP GLSVVVEAML
660 670 680 690 700
VSREVFQRML SFLTYRISAT LQLVCFFFIA CFSLTPKAYG SVDPNFQFFH
710 720 730 740 750
LPVLMFMLIT LLNDGCLMTI GYDHVIPSER PQKWNLPVVF VSASILAAVA
760 770 780 790 800
CGSSLMLLWI GLEGYSSQYY ENSWFHRLGL AQLPQGKLVT MMYLKISISD
810 820 830 840 850
FLTLFSSRTG GHFFFYVPPS PILFCGAIIS LLVSTMAASF WHKSRPDNVL
860 870 880 890 900
TEGLAWGQTN AEKLLPLWVW IYCIVWWFVQ DVVKVLAHIC MDAVDLFGCV
910 920 930 940 950
SDASGSGPIK PYSDDMKVNG FEPVKKPAEK STEKALNLSV SSGPHKALEG
960 970
LREDTHVLNE STSPVNAFSP KVKK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF109296 Genomic DNA Translation: AAA29228.1 |
Genome annotation databases
GeneDBi | LdBPK_181510.1.1:pep |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF109296 Genomic DNA Translation: AAA29228.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneDBi | LdBPK_181510.1.1:pep |
Family and domain databases
CDDi | cd02076, P-type_ATPase_H, 1 hit |
Gene3Di | 3.40.1110.10, 2 hits 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006534, P-type_ATPase_IIIA IPR001757, P_typ_ATPase |
Pfami | View protein in Pfam PF00690, Cation_ATPase_N, 1 hit |
PRINTSi | PR00120, HATPASE |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01647, ATPase-IIIA_H, 1 hit TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ATXB_LEIDO | |
Accessioni | P12522Primary (citable) accession number: P12522 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | October 1, 1989 | |
Last modified: | December 2, 2020 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |