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Protein

Protein Vpx

Gene

vpx

Organism
Simian immunodeficiency virus (isolate F236/smH4) (SIV-sm) (Simian immunodeficiency virus sooty mangabey monkey)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Vpx
Alternative name(s):
Viral protein X
X ORF protein
Gene namesi
Name:vpx
OrganismiSimian immunodeficiency virus (isolate F236/smH4) (SIV-sm) (Simian immunodeficiency virus sooty mangabey monkey)
Taxonomic identifieri11737 [NCBI]
Taxonomic lineageiVirusesOrterviralesRetroviridaeOrthoretrovirinaeLentivirus
Virus hostiCercopithecidae (Old World monkeys) [TaxID: 9527]
Proteomesi
  • UP000008173 Componenti: Genome

Subcellular locationi

  • Virion
  • Host nucleus
  • Note: Nuclear just after virion uncoating, or if expressed in the absence of unprocessed GAG.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000854061 – 112Protein VpxAdd BLAST112

Interactioni

Subunit structurei

Interacts with the P6 region of unprocessed GAG. Interacts with host VPRBP/DCAF1, leading to change substrate specificity of the CUL4A-DDB1 E3 ligase complex (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP12514
SMRiP12514
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi65 – 72Nuclear localization signalBy similarity8

Sequence similaritiesi

Belongs to the lentivirus VPX protein family.Curated

Phylogenomic databases

OrthoDBiVOG090001GG

Family and domain databases

InterProiView protein in InterPro
IPR000012 RetroV_VpR/X
PfamiView protein in Pfam
PF00522 VPR, 1 hit

Sequencei

Sequence statusi: Complete.

P12514-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDPRERIPP GNSGEETIGK AFEWLNRTVE EINRAAVNHL PRELIFQVWR
60 70 80 90 100
RSWEYWHDEM GMSESYTKYR YLCLIQKALF VHCKKGCRCL GEEHGAGGWR
110
TGPPPPPPPG LA
Length:112
Mass (Da):12,923
Last modified:February 1, 1991 - v2
Checksum:i48923AB423B4C598
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14307 Genomic DNA Translation: CAA32485.1
PIRiS07990

Similar proteinsi

Entry informationi

Entry nameiVPX_SIVS4
AccessioniPrimary (citable) accession number: P12514
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: February 1, 1991
Last modified: June 20, 2018
This is version 59 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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