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Protein

Tubulin beta-1 chain

Gene

mec-7

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Tubulin is the major constituent of microtubules (Probable). It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (Probable). Plays a role in mechanosensory transduction (touch sensitivity) (PubMed:19652181).Curated1 Publication
Mec-7 beta-tubulin is required for the production of 15-protofilament microtubules.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi140 – 146GTPSequence analysis7

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-5620924 Intraflagellar transport
R-CEL-6807878 COPI-mediated anterograde transport
R-CEL-6811436 COPI-independent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin beta-1 chain
Alternative name(s):
Beta-1-tubulin
Gene namesi
Name:mec-7
ORF Names:ZK154.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiZK154.3 ; CE15257 ; WBGene00003171 ; mec-7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Disruption phenotypei

Defective touch receptor neuron synaptic transmission with reduced levels of rab-3 at synapses, conferring touch insensitivity. Irregular touch receptor neuron shape. The heterozygous mutant, but not the null mutant, rescues the touch sensitivity defect in the mec-15 single mutant.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000482861 – 441Tubulin beta-1 chainAdd BLAST441

Proteomic databases

EPDiP12456
PaxDbiP12456
PeptideAtlasiP12456
PRIDEiP12456

Expressioni

Tissue specificityi

Expressed primarily in touch receptor neurons.1 Publication

Gene expression databases

BgeeiWBGene00003171 Expressed in 17 organ(s), highest expression level in multi-cellular organism

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

Protein-protein interaction databases

BioGridi45960, 1 interactor
STRINGi6239.ZK154.3

Structurei

3D structure databases

ProteinModelPortaliP12456
SMRiP12456
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

eggNOGiKOG1375 Eukaryota
COG5023 LUCA
GeneTreeiENSGT00760000119061
HOGENOMiHOG000165710
InParanoidiP12456
KOiK07375
OMAiFRDRISM
OrthoDBiEOG091G06U2
PhylomeDBiP12456

Family and domain databases

Gene3Di1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR013838 Beta-tubulin_BS
IPR002453 Beta_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PTHR11588:SF256 PTHR11588:SF256, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01163 BETATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit
PS00228 TUBULIN_B_AUTOREG, 1 hit

Sequencei

Sequence statusi: Complete.

P12456-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MREIVHIQAG QCGNQIGSKF WEVISDEHGI DPSGQYVGDS DLQLERINVY
60 70 80 90 100
YNEAGSNKYV PRAVLVDLEP GTMDSVRSGP FGQLFRPDNY VFGQSGAGNN
110 120 130 140 150
WAKGHYTEGA ELVDNVLDVV RKEAESTDCL QGFQLTHSLG GGTGSGMGTL
160 170 180 190 200
LISKIREEYP DRIMNTFSVV PSPKVSDTVV EPYNATLSVH QLVENTDSTF
210 220 230 240 250
CIDNEALYDI CFRTLKLTTP TYGDLNHLVS ATMSGVTTCL RFPGQLNADL
260 270 280 290 300
RKLAVNMVPF PRLHFFMPGF APLTSRSNQQ YRAITVPELT QQCFDAKNMM
310 320 330 340 350
AACDPRHGRY LTAAAIFRGR MSMKEVDEQM LNIQNKNSSY FVDWIPNNVK
360 370 380 390 400
TAVCDIPPRG LKMSATFIGN STAIQELFKR ISEQFTAMFR RKAFLHWYTG
410 420 430 440
EGMDEMEFTE AESNMNDLVS EYQQYQEAAA DEDAAEAFDG E
Length:441
Mass (Da):49,260
Last modified:October 1, 1989 - v1
Checksum:iF01403CFD069F4D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15242 Genomic DNA Translation: CAA33320.1
FO080892 Genomic DNA Translation: CCD67558.1
PIRiS05956
RefSeqiNP_509313.1, NM_076912.3
UniGeneiCel.6646

Genome annotation databases

EnsemblMetazoaiZK154.3; ZK154.3; WBGene00003171
GeneIDi181036
KEGGicel:CELE_ZK154.3
UCSCiZK154.3 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15242 Genomic DNA Translation: CAA33320.1
FO080892 Genomic DNA Translation: CCD67558.1
PIRiS05956
RefSeqiNP_509313.1, NM_076912.3
UniGeneiCel.6646

3D structure databases

ProteinModelPortaliP12456
SMRiP12456
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi45960, 1 interactor
STRINGi6239.ZK154.3

Proteomic databases

EPDiP12456
PaxDbiP12456
PeptideAtlasiP12456
PRIDEiP12456

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK154.3; ZK154.3; WBGene00003171
GeneIDi181036
KEGGicel:CELE_ZK154.3
UCSCiZK154.3 c. elegans

Organism-specific databases

CTDi181036
WormBaseiZK154.3 ; CE15257 ; WBGene00003171 ; mec-7

Phylogenomic databases

eggNOGiKOG1375 Eukaryota
COG5023 LUCA
GeneTreeiENSGT00760000119061
HOGENOMiHOG000165710
InParanoidiP12456
KOiK07375
OMAiFRDRISM
OrthoDBiEOG091G06U2
PhylomeDBiP12456

Enzyme and pathway databases

ReactomeiR-CEL-5620924 Intraflagellar transport
R-CEL-6807878 COPI-mediated anterograde transport
R-CEL-6811436 COPI-independent Golgi-to-ER retrograde traffic

Miscellaneous databases

PROiPR:P12456

Gene expression databases

BgeeiWBGene00003171 Expressed in 17 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR013838 Beta-tubulin_BS
IPR002453 Beta_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PTHR11588:SF256 PTHR11588:SF256, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01163 BETATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit
PS00228 TUBULIN_B_AUTOREG, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTBB1_CAEEL
AccessioniPrimary (citable) accession number: P12456
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: September 12, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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Main funding by: National Institutes of Health

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