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UniProtKB - P12430 (GP_BUNGE)
Protein
Envelopment polyprotein
Gene
GP
Organism
Bunyavirus germiston
Status
Functioni
Glycoprotein C and Glycoprotein N interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion (By similarity).
By similarityGO - Biological processi
- fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
- modulation by virus of host process Source: InterPro
- virion attachment to host cell Source: UniProtKB-KW
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: Envelopment polyproteinAlternative name(s): M polyprotein Cleaved into the following 3 chains: Alternative name(s): Glycoprotein G2 Alternative name(s): Glycoprotein G1 |
Gene namesi | Name:GP |
Organismi | Bunyavirus germiston |
Taxonomic identifieri | 11574 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Negarnaviricota › Polyploviricotina › Ellioviricetes › Bunyavirales › Peribunyaviridae › Orthobunyavirus › |
Virus hosti | Culex [TaxID: 53527] |
Subcellular locationi
- Virion membrane Curated; Single-pass type I membrane protein Curated
- Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated
- Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated Note: Glycoprotein C alone is retained in the membrane of the endoplasmic reticulum, but not transported to the Golgi. Coexpression of Glycoprotein C and Glycoprotein N results in efficient transport of Glycoprotein C to the Golgi complex, indicating that their interaction is essential for proper targeting to this organelle, where virion budding occurs (By similarity).By similarity
- Virion membrane Curated; Single-pass type I membrane protein Curated
- Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated Note: Glycoprotein N is retained in the Golgi complex through a Golgi retention signal, which resides in the Glycoprotein N transmembrane region.By similarity
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 207 | LumenalSequence analysisAdd BLAST | 186 | |
Transmembranei | 208 – 228 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 229 – 312 | CytoplasmicSequence analysisAdd BLAST | 84 | |
Transmembranei | 313 – 333 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 334 – 373 | LumenalSequence analysisAdd BLAST | 40 | |
Transmembranei | 374 – 394 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 395 – 460 | CytoplasmicSequence analysisAdd BLAST | 66 | |
Transmembranei | 461 – 481 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 482 – 1391 | LumenalSequence analysisAdd BLAST | 910 | |
Transmembranei | 1392 – 1412 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1413 – 1437 | CytoplasmicSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000036786 | 22 – 1437 | Envelopment polyproteinAdd BLAST | 1416 | |
ChainiPRO_0000036787 | 22 – 306 | Glycoprotein NBy similarityAdd BLAST | 285 | |
ChainiPRO_0000036788 | 307 – 481 | Non-structural protein MBy similarityAdd BLAST | 175 | |
ChainiPRO_0000036789 | 482 – 1437 | Glycoprotein CBy similarityAdd BLAST | 956 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 65 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 88 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 627 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 | |
Glycosylationi | 1173 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 |
Post-translational modificationi
Specific enzymatic cleavages in vivo yield mature proteins including nonstructural protein NSm, Glycoprotein C, and Glycoprotein N.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 481 – 482 | Cleavage; by host signal peptidaseBy similarity | 2 |
Keywords - PTMi
GlycoproteinInteractioni
Subunit structurei
Glycoprotein C and Glycoprotein N interact with each other.
By similarityFamily & Domainsi
Sequence similaritiesi
Belongs to the orthobunyavirus envelope glycoprotein family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixFamily and domain databases
InterProi | View protein in InterPro IPR005167, Bunya_G1 IPR005168, Bunya_G2 IPR026400, Bunya_nonstruc_pro_NSm IPR014413, M_poly_OrthobunV |
Pfami | View protein in Pfam PF03557, Bunya_G1, 1 hit PF03563, Bunya_G2, 1 hit |
PIRSFi | PIRSF003944, M_poly_OrthobunV, 1 hit |
TIGRFAMsi | TIGR04210, bunya_NSm, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P12430-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAISTSLLIV ALLIKLCLVN TAPPISKCFQ DGILIAELKS SSGISEFCIK
60 70 80 90 100
DDISILKSEI TYSKNDTGIF MHSKVFRHWT VADWKQCNHT SAGGSTNVLE
110 120 130 140 150
VDKNLNLVAK NYMCTRPCVI TIDKENAQLL FQTEQLNQFE VTGTTISTGW
160 170 180 190 200
FKSKTSVSLD NTCEHIKVTC GKKSLQFHAC FKQHMSCVRF LHRSVLPGYM
210 220 230 240 250
ASSICQNIEL IIIIILTLAI FIFMCIITRT YICYLMLPLF APIAYLYGWL
260 270 280 290 300
YNRSCKKCIC CGLAYHPFTN CGSYCVCGSR FETSDRMRLH RESGLCQGFK
310 320 330 340 350
SLRVARSLCK SKGSSLVISI LTAMLILSFI TPLEAMTTNY PDDKKFTLKE
360 370 380 390 400
VNDIVLGRDM EQELKSSILI LMSICGIGII LIFFGLTVLL EIVLELIAKR
410 420 430 440 450
STIFCKECNL IHDKKSMTYR GDFTNKCGFC PCGELEDPEG LVIHTTRKSC
460 470 480 490 500
TYYIKIRNLK LIMLIFSIVI LMQNATMLVV AGENCWTNTE IKADCVGPLI
510 520 530 540 550
GPSACTNKGS KTYKTVAQEL VTASKITQLD ADKYVLLGDT IESALDAITS
560 570 580 590 600
QKHYSAMHLL ETMFLMKHCD YYKVYEHNSG YSQTKWRLIA IANSFDICTN
610 620 630 640 650
TPTPNFCKCL SDSSCSTTTL NFATSMNATY TSKVEFFNHD FTLFLDIFEA
660 670 680 690 700
AFPGSATAFL FKKIKEKNPY QAFEMMGKIA NKYPNNKLLV VILKYGQYMV
710 720 730 740 750
GLSHASTYQL KQEWVAKSLS LTRAQRTGLK MSMANAEPGP ATKECSDAKT
760 770 780 790 800
IACLTPKFQV EVNNLMSCGA SPNFKIYVKT GELYKAHDRN SVWCLNDMHC
810 820 830 840 850
LTPYTPANAE IITTMKKMDC WQDNPKQPTD EYAIPKRSCQ MKDRGLCNSG
860 870 880 890 900
ADKWKIIKCD NHKLFYTDAL ERRDPASIVG SNHCFSEKCQ IERYPINPTS
910 920 930 940 950
LTNCEWLYRA VRPEYIKKLS LQTIEEYKKA IADKLTHTLQ LYHFAPLLEN
960 970 980 990 1000
LPHIKPTYKY ITAQGTYTAD GIEGASITTS IPALSGTSVG FKINAKDGTD
1010 1020 1030 1040 1050
LLDIVVYIKA SVVKSIYNHI YDTGPTININ SKHDELCTGQ CPKKIPADPN
1060 1070 1080 1090 1100
WLTFSQERTS RWGCEEFGCL AINTGCVYGS CQDVIRTETK VYRKANEETV
1110 1120 1130 1140 1150
MLTVCITYPG HTFCTDVNAH EPKITDELEL QFKTIDIKSL PNLVAVTNHK
1160 1170 1180 1190 1200
LYTGQINDLG TFGQMCGNVQ KTNTSHTGAG TPKFDYTCYS ASRKDIIIRR
1210 1220 1230 1240 1250
CYNNNYDSCR LLNQESDLLF DDNHETLVVY NNKRLNGELA LKLLLGDIQY
1260 1270 1280 1290 1300
KLYTENMELE LEAKCVGCVG CFESYQCNLQ ITSSLDETAL YLVPVSHFHD
1310 1320 1330 1340 1350
RIQIKTTKKD YAMKISCTRD PGDKASFRVC GKSYDFNFHT VPKNDKIEVN
1360 1370 1380 1390 1400
VGDETSYIKE KDNRCGRWLC RVRDEGLSVI FEPLNNFFGN YLNMFLYILG
1410 1420 1430
GIILLFLALY ILMPMCARLR DELKRNERLH QMEMKKR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M21951 Genomic RNA Translation: AAA42778.1 |
PIRi | S07430 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M21951 Genomic RNA Translation: AAA42778.1 |
PIRi | S07430 |
3D structure databases
SMRi | P12430 |
ModBasei | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR005167, Bunya_G1 IPR005168, Bunya_G2 IPR026400, Bunya_nonstruc_pro_NSm IPR014413, M_poly_OrthobunV |
Pfami | View protein in Pfam PF03557, Bunya_G1, 1 hit PF03563, Bunya_G2, 1 hit |
PIRSFi | PIRSF003944, M_poly_OrthobunV, 1 hit |
TIGRFAMsi | TIGR04210, bunya_NSm, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GP_BUNGE | |
Accessioni | P12430Primary (citable) accession number: P12430 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | October 1, 1989 | |
Last modified: | December 2, 2020 | |
This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |