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Protein

Neuronal acetylcholine receptor subunit beta-3

Gene

Chrnb3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

  • acetylcholine binding Source: RGD
  • acetylcholine-gated cation-selective channel activity Source: RGD
  • drug binding Source: RGD
  • transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
R-RNO-629597 Highly calcium permeable nicotinic acetylcholine receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit beta-3
Gene namesi
Name:Chrnb3
Synonyms:Acrb3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi621544 Chrnb3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 238ExtracellularSequence analysisAdd BLAST208
Transmembranei239 – 263HelicalSequence analysisAdd BLAST25
Transmembranei271 – 288HelicalSequence analysisAdd BLAST18
Transmembranei305 – 326HelicalSequence analysisAdd BLAST22
Topological domaini327 – 434CytoplasmicSequence analysisAdd BLAST108
Transmembranei435 – 453HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3883329

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000000038631 – 464Neuronal acetylcholine receptor subunit beta-3Add BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi159 ↔ 173By similarity
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP12391

PTM databases

PhosphoSitePlusiP12391

Expressioni

Gene expression databases

BgeeiENSRNOG00000012448 Expressed in 2 organ(s), highest expression level in testis
GenevisibleiP12391 RN

Interactioni

Subunit structurei

Neuronal AChR seems to be composed of two different types of subunits: alpha and beta.

Protein-protein interaction databases

ComplexPortaliCPX-203 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta2-beta3
STRINGi10116.ENSRNOP00000016656

Chemistry databases

BindingDBiP12391

Structurei

3D structure databases

ProteinModelPortaliP12391
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00760000118930
HOGENOMiHOG000006756
HOVERGENiHBG003756
InParanoidiP12391
KOiK04814
OMAiLLCMKGH
OrthoDBiEOG091G0R20
PhylomeDBiP12391
TreeFamiTF315605

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 2 hits
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12391-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGFLRVFLV LSATLSGSWV TLTATAGLSS VAEHEDALLR HLFQGYQKWV
60 70 80 90 100
RPVLNSSDII KVYFGLKISQ LVDVDEKNQL MTTNVWLKQE WTDQKLRWNP
110 120 130 140 150
EEYGGINSIK VPSESLWLPD IVLFENADGR FEGSLMTKAI VKSSGTVSWT
160 170 180 190 200
PPASYKSSCT MDVTFFPFDR QNCSMKFGSW TYDGTMVDLI LINENVDRKD
210 220 230 240 250
FFDNGEWEIL NAKGMKGNRR EGFYSYPFVT YSFVLRRLPL FYTLFLIIPC
260 270 280 290 300
LGLSFLTVLV FYLPSDEGEK LSLSTSVLVS LTVFLLVIEE IIPSSSKVIP
310 320 330 340 350
LIGEYLLFIM IFVTLSIIVT VFVINVHHRS SSTYHPMAPW VKRLFLQRLP
360 370 380 390 400
RWLCMKDPMD RFSFPDGKES DTAVRGKVSG KRKQTPASDG ERVLVAFLEK
410 420 430 440 450
ASESIRYISR HVKKEHFISQ VVQDWKFVAQ VLDRIFLWLF LIASVLGSIL
460
IFIPALKMWI HRFH
Length:464
Mass (Da):53,261
Last modified:October 1, 1989 - v1
Checksum:i5D3B1F7DB934D1D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04636 mRNA Translation: AAC28887.1
PIRiA33523
RefSeqiNP_598281.1, NM_133597.1
UniGeneiRn.9694

Genome annotation databases

EnsembliENSRNOT00000016656; ENSRNOP00000016656; ENSRNOG00000012448
GeneIDi171131
KEGGirno:171131
UCSCiRGD:621544 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04636 mRNA Translation: AAC28887.1
PIRiA33523
RefSeqiNP_598281.1, NM_133597.1
UniGeneiRn.9694

3D structure databases

ProteinModelPortaliP12391
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-203 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta2-beta3
STRINGi10116.ENSRNOP00000016656

Chemistry databases

BindingDBiP12391
ChEMBLiCHEMBL3883329

PTM databases

PhosphoSitePlusiP12391

Proteomic databases

PaxDbiP12391

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016656; ENSRNOP00000016656; ENSRNOG00000012448
GeneIDi171131
KEGGirno:171131
UCSCiRGD:621544 rat

Organism-specific databases

CTDi1142
RGDi621544 Chrnb3

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00760000118930
HOGENOMiHOG000006756
HOVERGENiHBG003756
InParanoidiP12391
KOiK04814
OMAiLLCMKGH
OrthoDBiEOG091G0R20
PhylomeDBiP12391
TreeFamiTF315605

Enzyme and pathway databases

ReactomeiR-RNO-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
R-RNO-629597 Highly calcium permeable nicotinic acetylcholine receptors

Miscellaneous databases

PROiPR:P12391

Gene expression databases

BgeeiENSRNOG00000012448 Expressed in 2 organ(s), highest expression level in testis
GenevisibleiP12391 RN

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 2 hits
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACHB3_RAT
AccessioniPrimary (citable) accession number: P12391
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: October 10, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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