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Protein

Plasminogen activator inhibitor 2, macrophage

Gene

Serpinb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. Not required for normal murine development or survival.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei380 – 381Reactive bond2

GO - Molecular functioni

  • serine-type endopeptidase inhibitor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor
Biological processPlasminogen activation

Enzyme and pathway databases

ReactomeiR-MMU-75205 Dissolution of Fibrin Clot

Protein family/group databases

MEROPSiI04.007

Names & Taxonomyi

Protein namesi
Recommended name:
Plasminogen activator inhibitor 2, macrophage
Short name:
PAI-2
Alternative name(s):
Serpin B2
Gene namesi
Name:Serpinb2
Synonyms:Pai2, Planh2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:97609 Serpinb2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002232971 – 415Plasminogen activator inhibitor 2, macrophageAdd BLAST415
Signal peptidei1 – ?Not cleaved

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi261N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi339N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The signal sequence is not cleaved.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP12388
PeptideAtlasiP12388
PRIDEiP12388

PTM databases

PhosphoSitePlusiP12388

Expressioni

Gene expression databases

BgeeiENSMUSG00000062345 Expressed in 65 organ(s), highest expression level in skin epidermis
ExpressionAtlasiP12388 baseline and differential
GenevisibleiP12388 MM

Interactioni

Subunit structurei

Interacts with PSMB1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009356

Structurei

3D structure databases

ProteinModelPortaliP12388
SMRiP12388
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118789
HOVERGENiHBG005957
InParanoidiP12388
KOiK19821
OMAiFIMHKIT
OrthoDBiEOG091G0ION
PhylomeDBiP12388
TreeFamiTF352619

Family and domain databases

InterProiView protein in InterPro
IPR015556 PAI-2
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PTHR11461:SF61 PTHR11461:SF61, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P12388-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEELSMANTM FALNLLKQIE KSNSTQNIFI SPWSISSTLA IVLLGAGGNT
60 70 80 90 100
EQQMAKVLQF NEIGSYGITT RNPENFSGCD FAQQIQKENY PSAILQAQAG
110 120 130 140 150
DKIHSAFSSL SSTINTPQGD YLLESANKLF GEKSARFKEE YIQLSKKYYS
160 170 180 190 200
TEPEAVDFLE CAEEAREKIN SWVKTQTKGE IPNLLPEGSV DEDTKMVLVN
210 220 230 240 250
AVYFKGKWKT PFEKKLNGLY PFRVNSHESI PVQMMFLHAK LNIGYIKDLK
260 270 280 290 300
TQILELPHTG NISMLLLLPD EIEDASTGLE LLESEINFAN FNKWISKDTL
310 320 330 340 350
DEDDVVVYIP KFKLAQSYEL KSILQSMGME DAFNKGKANF SGMSERNDLF
360 370 380 390 400
LSEVFHQASV DVTEEGTVAA GGTGAVMTGR TGHGGPQFVA DHPFLFFIMD
410
KITHTILFVG RFSSP
Length:415
Mass (Da):46,292
Last modified:October 1, 1989 - v1
Checksum:iC4FC78C5C3CA7D8B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6ZFV0F6ZFV0_MOUSE
Plasminogen activator inhibitor 2, ...
Serpinb2
189Annotation score:
F6QN99F6QN99_MOUSE
Plasminogen activator inhibitor 2, ...
Serpinb2
35Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55A → T (Ref. 3) Curated1
Sequence conflicti55A → T (PubMed:9892694).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti239A → E1 Publication1
Natural varianti258H → Y1 Publication1
Natural varianti259T → I1 Publication1
Natural varianti284S → R1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16490 mRNA Translation: CAA34507.1
AJ000386, AJ000384, AJ000385 Genomic DNA Translation: CAA04047.1
AF069683 Genomic DNA Translation: AAD08915.1
AF069685, AF069684 Genomic DNA Translation: AAD08916.1
AF069687, AF069686 Genomic DNA Translation: AAD08917.1
AF069689, AF069688 Genomic DNA Translation: AAD08918.1
AF069690 Genomic DNA Translation: AAD08919.1
AF069692, AF069691 Genomic DNA Translation: AAD08920.1
AF069694, AF069693 Genomic DNA Translation: AAD08921.1
CCDSiCCDS15219.1
PIRiS20047
RefSeqiNP_001167641.1, NM_001174170.1
NP_035241.1, NM_011111.4
UniGeneiMm.271870

Genome annotation databases

EnsembliENSMUST00000009356; ENSMUSP00000009356; ENSMUSG00000062345
ENSMUST00000064916; ENSMUSP00000065277; ENSMUSG00000062345
GeneIDi18788
KEGGimmu:18788
UCSCiuc007chn.2 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16490 mRNA Translation: CAA34507.1
AJ000386, AJ000384, AJ000385 Genomic DNA Translation: CAA04047.1
AF069683 Genomic DNA Translation: AAD08915.1
AF069685, AF069684 Genomic DNA Translation: AAD08916.1
AF069687, AF069686 Genomic DNA Translation: AAD08917.1
AF069689, AF069688 Genomic DNA Translation: AAD08918.1
AF069690 Genomic DNA Translation: AAD08919.1
AF069692, AF069691 Genomic DNA Translation: AAD08920.1
AF069694, AF069693 Genomic DNA Translation: AAD08921.1
CCDSiCCDS15219.1
PIRiS20047
RefSeqiNP_001167641.1, NM_001174170.1
NP_035241.1, NM_011111.4
UniGeneiMm.271870

3D structure databases

ProteinModelPortaliP12388
SMRiP12388
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000009356

Protein family/group databases

MEROPSiI04.007

PTM databases

PhosphoSitePlusiP12388

Proteomic databases

PaxDbiP12388
PeptideAtlasiP12388
PRIDEiP12388

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000009356; ENSMUSP00000009356; ENSMUSG00000062345
ENSMUST00000064916; ENSMUSP00000065277; ENSMUSG00000062345
GeneIDi18788
KEGGimmu:18788
UCSCiuc007chn.2 mouse

Organism-specific databases

CTDi5055
MGIiMGI:97609 Serpinb2

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118789
HOVERGENiHBG005957
InParanoidiP12388
KOiK19821
OMAiFIMHKIT
OrthoDBiEOG091G0ION
PhylomeDBiP12388
TreeFamiTF352619

Enzyme and pathway databases

ReactomeiR-MMU-75205 Dissolution of Fibrin Clot

Miscellaneous databases

ChiTaRSiSerpinb2 mouse
PROiPR:P12388
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062345 Expressed in 65 organ(s), highest expression level in skin epidermis
ExpressionAtlasiP12388 baseline and differential
GenevisibleiP12388 MM

Family and domain databases

InterProiView protein in InterPro
IPR015556 PAI-2
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PTHR11461:SF61 PTHR11461:SF61, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAI2_MOUSE
AccessioniPrimary (citable) accession number: P12388
Secondary accession number(s): O35687
, Q9QWP6, Q9QWP7, Q9QWP8, Q9QWP9, Q9QWQ0, Q9QWZ5, Q9QWZ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 7, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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