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Protein

cAMP-dependent protein kinase catalytic subunit 1

Gene

Pka-C1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase involved in memory formation (PubMed:29473541). Promotes long-term memory by phosphorylating meng and by regulating CrebB protein stability and activity (PubMed:29473541). As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology when anchored to the membrane (PubMed:29444420).2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Activity regulationi

Activated by cAMP.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei75ATPPROSITE-ProRule annotation1
Active sitei169Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi52 – 60ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, cAMP, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.11 1994
ReactomeiR-DME-163615 PKA activation
R-DME-164378 PKA activation in glucagon signalling
R-DME-180024 DARPP-32 events
R-DME-209159 Assembly of the CI containing complexes
R-DME-209190 Phosphorylation of CI
R-DME-209360 Ubiquitination and proteolysis of phosphorylated CI
R-DME-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-DME-392517 Rap1 signalling
R-DME-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-DME-4420097 VEGFA-VEGFR2 Pathway
R-DME-442720 CREB phosphorylation through the activation of Adenylate Cyclase
R-DME-5610785 GLI3 is processed to GLI3R by the proteasome
R-DME-5610787 Hedgehog 'off' state
R-DME-5621575 CD209 (DC-SIGN) signaling
R-DME-983231 Factors involved in megakaryocyte development and platelet production
SignaLinkiP12370

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-dependent protein kinase catalytic subunit 1Curated (EC:2.7.11.111 Publication)
Short name:
PKA C
Alternative name(s):
Protein kinase DC01 Publication
Gene namesi
Name:Pka-C1
Synonyms:CdkA, DC0
ORF Names:CG4379
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0000273 Pka-C1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000860692 – 353cAMP-dependent protein kinase catalytic subunit 1Add BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PaxDbiP12370
PRIDEiP12370

Expressioni

Tissue specificityi

More abundant in adult head than adult body.

Gene expression databases

BgeeiFBgn0000273 Expressed in 29 organ(s), highest expression level in head
GenevisibleiP12370 DM

Interactioni

Subunit structurei

Composed of two regulatory chains and two catalytic chains.

Binary interactionsi

Protein-protein interaction databases

BioGridi60383, 21 interactors
DIPiDIP-23727N
IntActiP12370, 7 interactors
MINTiP12370
STRINGi7227.FBpp0079448

Structurei

3D structure databases

ProteinModelPortaliP12370
SMRiP12370
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 300Protein kinasePROSITE-ProRule annotationAdd BLAST255
Domaini301 – 353AGC-kinase C-terminalAdd BLAST53

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0616 Eukaryota
ENOG410XPQQ LUCA
GeneTreeiENSGT00810000125385
InParanoidiP12370
KOiK04345
OMAiHSHDIIY
OrthoDBiEOG091G10O8
PhylomeDBiP12370

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR039811 cAMP/cGMP-dep_PK
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24353 PTHR24353, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12370-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNNATTSNK KVDAAETVKE FLEQAKEEFE DKWRRNPTNT AALDDFERIK
60 70 80 90 100
TLGTGSFGRV MIVQHKPTKD YYAMKILDKQ KVVKLKQVEH TLNEKRILQA
110 120 130 140 150
IQFPFLVSLR YHFKDNSNLY MVLEYVPGGE MFSHLRKVGR FSEPHSRFYA
160 170 180 190 200
AQIVLAFEYL HYLDLIYRDL KPENLLIDSQ GYLKVTDFGF AKRVKGRTWT
210 220 230 240 250
LCGTPEYLAP EIILSKGYNK AVDWWALGVL VYEMAAGYPP FFADQPIQIY
260 270 280 290 300
EKIVSGKVRF PSHFGSDLKD LLRNLLQVDL TKRYGNLKAG VNDIKNQKWF
310 320 330 340 350
ASTDWIAIFQ KKIEAPFIPR CKGPGDTSNF DDYEEEALRI SSTEKCAKEF

AEF
Length:353
Mass (Da):40,839
Last modified:January 23, 2007 - v3
Checksum:i9611D1001C791874
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18655 Genomic DNA Translation: AAA28412.1
X16969 Genomic DNA Translation: CAA34840.1
AE014134 Genomic DNA Translation: AAF52797.1
AE014134 Genomic DNA Translation: AAN10703.1
AE014134 Genomic DNA Translation: AAS64669.1
AY069425 mRNA Translation: AAL39570.1
PIRiC31751
RefSeqiNP_476977.1, NM_057629.4
NP_723479.1, NM_164866.3
NP_995672.1, NM_205950.3
UniGeneiDm.2136

Genome annotation databases

EnsemblMetazoaiFBtr0079851; FBpp0079448; FBgn0000273
FBtr0079852; FBpp0089382; FBgn0000273
FBtr0335495; FBpp0307466; FBgn0000273
GeneIDi34284
KEGGidme:Dmel_CG4379
UCSCiCG4379-RB d. melanogaster

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18655 Genomic DNA Translation: AAA28412.1
X16969 Genomic DNA Translation: CAA34840.1
AE014134 Genomic DNA Translation: AAF52797.1
AE014134 Genomic DNA Translation: AAN10703.1
AE014134 Genomic DNA Translation: AAS64669.1
AY069425 mRNA Translation: AAL39570.1
PIRiC31751
RefSeqiNP_476977.1, NM_057629.4
NP_723479.1, NM_164866.3
NP_995672.1, NM_205950.3
UniGeneiDm.2136

3D structure databases

ProteinModelPortaliP12370
SMRiP12370
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi60383, 21 interactors
DIPiDIP-23727N
IntActiP12370, 7 interactors
MINTiP12370
STRINGi7227.FBpp0079448

Proteomic databases

PaxDbiP12370
PRIDEiP12370

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0079851; FBpp0079448; FBgn0000273
FBtr0079852; FBpp0089382; FBgn0000273
FBtr0335495; FBpp0307466; FBgn0000273
GeneIDi34284
KEGGidme:Dmel_CG4379
UCSCiCG4379-RB d. melanogaster

Organism-specific databases

CTDi34284
FlyBaseiFBgn0000273 Pka-C1

Phylogenomic databases

eggNOGiKOG0616 Eukaryota
ENOG410XPQQ LUCA
GeneTreeiENSGT00810000125385
InParanoidiP12370
KOiK04345
OMAiHSHDIIY
OrthoDBiEOG091G10O8
PhylomeDBiP12370

Enzyme and pathway databases

BRENDAi2.7.11.11 1994
ReactomeiR-DME-163615 PKA activation
R-DME-164378 PKA activation in glucagon signalling
R-DME-180024 DARPP-32 events
R-DME-209159 Assembly of the CI containing complexes
R-DME-209190 Phosphorylation of CI
R-DME-209360 Ubiquitination and proteolysis of phosphorylated CI
R-DME-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-DME-392517 Rap1 signalling
R-DME-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-DME-4420097 VEGFA-VEGFR2 Pathway
R-DME-442720 CREB phosphorylation through the activation of Adenylate Cyclase
R-DME-5610785 GLI3 is processed to GLI3R by the proteasome
R-DME-5610787 Hedgehog 'off' state
R-DME-5621575 CD209 (DC-SIGN) signaling
R-DME-983231 Factors involved in megakaryocyte development and platelet production
SignaLinkiP12370

Miscellaneous databases

GenomeRNAii34284
PROiPR:P12370

Gene expression databases

BgeeiFBgn0000273 Expressed in 29 organ(s), highest expression level in head
GenevisibleiP12370 DM

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR039811 cAMP/cGMP-dep_PK
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24353 PTHR24353, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKAPC1_DROME
AccessioniPrimary (citable) accession number: P12370
Secondary accession number(s): A4V0I0, Q9VL99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 189 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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Main funding by: National Institutes of Health

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