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Entry version 170 (12 Aug 2020)
Sequence version 3 (09 Jan 2007)
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Protein

Serotransferrin

Gene

Tf

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi82Iron 1PROSITE-ProRule annotation1
Metal bindingi114Iron 1PROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei139Carbonate 1PROSITE-ProRule annotation1
Binding sitei143Carbonate 1PROSITE-ProRule annotation1
Binding sitei145Carbonate 1; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei146Carbonate 1; via amide nitrogenPROSITE-ProRule annotation1
Metal bindingi207Iron 1PROSITE-ProRule annotation1
Metal bindingi268Iron 1PROSITE-ProRule annotation1
Metal bindingi410Iron 2PROSITE-ProRule annotation1
Metal bindingi447Iron 2PROSITE-ProRule annotation1
Binding sitei473Carbonate 2PROSITE-ProRule annotation1
Binding sitei477Carbonate 2PROSITE-ProRule annotation1
Binding sitei479Carbonate 2; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei480Carbonate 2; via amide nitrogenPROSITE-ProRule annotation1
Metal bindingi536Iron 2PROSITE-ProRule annotation1
Metal bindingi604Iron 2PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-114608, Platelet degranulation
R-RNO-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-8856825, Cargo recognition for clathrin-mediated endocytosis
R-RNO-8856828, Clathrin-mediated endocytosis
R-RNO-8957275, Post-translational protein phosphorylation
R-RNO-917937, Iron uptake and transport
R-RNO-917977, Transferrin endocytosis and recycling

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S60.970

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serotransferrin
Short name:
Transferrin
Alternative name(s):
Beta-1 metal-binding globulin
Liver regeneration-related protein LRRG03
Siderophilin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tf
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Rat genome database

More...
RGDi
3845, Tf

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Protein family/group databases

Allergome; a platform for allergen knowledge

More...
Allergomei
1417, Rat n Transferrin

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 192 PublicationsAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003571820 – 698SerotransferrinAdd BLAST679

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi28 ↔ 67PROSITE-ProRule annotation
Disulfide bondi38 ↔ 58PROSITE-ProRule annotation
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei42Dimethylated arginine1 Publication1
Disulfide bondi137 ↔ 213PROSITE-ProRule annotation
Disulfide bondi156 ↔ 350PROSITE-ProRule annotation
Disulfide bondi177 ↔ 193PROSITE-ProRule annotation
Disulfide bondi180 ↔ 196PROSITE-ProRule annotation
Disulfide bondi190 ↔ 198PROSITE-ProRule annotation
Disulfide bondi246 ↔ 260PROSITE-ProRule annotation
Disulfide bondi363 ↔ 395PROSITE-ProRule annotation
Disulfide bondi373 ↔ 386PROSITE-ProRule annotation
Modified residuei388PhosphoserineBy similarity1
Disulfide bondi420 ↔ 693PROSITE-ProRule annotation
Disulfide bondi435 ↔ 656PROSITE-ProRule annotation
Disulfide bondi471 ↔ 542PROSITE-ProRule annotation
Disulfide bondi495 ↔ 684PROSITE-ProRule annotation
Disulfide bondi505 ↔ 519PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi512N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi516 ↔ 525PROSITE-ProRule annotation
Disulfide bondi582 ↔ 596PROSITE-ProRule annotation
Disulfide bondi634 ↔ 639PROSITE-ProRule annotation
Modified residuei685PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P12346

PRoteomics IDEntifications database

More...
PRIDEi
P12346

2D gel databases

The World-2DPAGE database

More...
World-2DPAGEi
0004:P12346

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
557, 6 N-Linked glycans

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P12346, 1 site, 5 N-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P12346

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P12346

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P12346

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000030625, Expressed in liver and 20 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P12346, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P12346, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
246945, 3 interactors

Protein interaction database and analysis system

More...
IntActi
P12346, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000012725

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P12346

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 347Transferrin-like 1PROSITE-ProRule annotationAdd BLAST323
Domaini360 – 683Transferrin-like 2PROSITE-ProRule annotationAdd BLAST324

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the transferrin family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0090, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154388

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011309_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P12346

KEGG Orthology (KO)

More...
KOi
K14736

Database of Orthologous Groups

More...
OrthoDBi
232859at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P12346

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030685, Serotransferrin_mammal
IPR016357, Transferrin
IPR001156, Transferrin-like_dom
IPR018195, Transferrin_Fe_BS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00405, Transferrin, 2 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF500682, Serotransferrin, 1 hit
PIRSF002549, Transferrin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00422, TRANSFERRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00094, TR_FER, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00205, TRANSFERRIN_LIKE_1, 1 hit
PS00206, TRANSFERRIN_LIKE_2, 2 hits
PS00207, TRANSFERRIN_LIKE_3, 2 hits
PS51408, TRANSFERRIN_LIKE_4, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P12346-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRFAVGALLA CAALGLCLAV PDKTVKWCAV SEHENTKCIS FRDHMKTVLP
60 70 80 90 100
ADGPRLACVK KTSYQDCIKA ISGGEADAIT LDGGWVYDAG LTPNNLKPVA
110 120 130 140 150
AEFYGSLEHP QTHYLAVAVV KKGTDFQLNQ LQGKKSCHTG LGRSAGWIIP
160 170 180 190 200
IGLLFCNLPE PRKPLEKAVA SFFSGSCVPC ADPVAFPQLC QLCPGCGCSP
210 220 230 240 250
TQPFFGYVGA FKCLRDGGGD VAFVKHTTIF EVLPQKADRD QYELLCLDNT
260 270 280 290 300
RKPVDQYEDC YLARIPSHAV VARNGDGKED LIWEILKVAQ EHFGKGKSKD
310 320 330 340 350
FQLFGSPLGK DLLFKDSAFG LLRVPPRMDY RLYLGHSYVT AIRNQREGVC
360 370 380 390 400
PEGSIDSAPV KWCALSHQER AKCDEWSVSS NGQIECESAE STEDCIDKIV
410 420 430 440 450
NGEADAMSLD GGHAYIAGQC GLVPVMAENY DISSCTNPQS DVFPKGYYAV
460 470 480 490 500
AVVKASDSSI NWNNLKGKKS CHTGVDRTAG WNIPMGLLFS RINHCKFDEF
510 520 530 540 550
FSQGCAPGYK KNSTLCDLCI GPAKCAPNNR EGYNGYTGAF QCLVEKGDVA
560 570 580 590 600
FVKHQTVLEN TNGKNTAAWA KDLKQEDFQL LCPDGTKKPV TEFATCHLAQ
610 620 630 640 650
APNHVVVSRK EKAARVSTVL TAQKDLFWKG DKDCTGNFCL FRSSTKDLLF
660 670 680 690
RDDTKCLTKL PEGTTYEEYL GAEYLQAVGN IRKCSTSRLL EACTFHKS
Length:698
Mass (Da):76,395
Last modified:January 9, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB91ABB41CA447194
GO
Isoform 2 (identifier: P12346-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     65-266: Missing.

Show »
Length:496
Mass (Da):54,524
Checksum:i7FADB62945314E20
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2QC06A0A0G2QC06_RAT
Signal recognition particle recepto...
Tf
979Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti57A → P in CAA54403 (PubMed:7717992).Curated1
Sequence conflicti110P → R in CAA54403 (PubMed:7717992).Curated1
Sequence conflicti318A → R in CAA54403 (PubMed:7717992).Curated1
Sequence conflicti321 – 323LLR → CYG in BAA07458 (PubMed:8829802).Curated3
Sequence conflicti324 – 354VPPRM…CPEGS → APKDGLQAVPRPQLCHCHSK SAGSCPDA in CAA54403 (PubMed:7717992).CuratedAdd BLAST31
Sequence conflicti353G → A in BAA07458 (PubMed:8829802).Curated1
Sequence conflicti379S → T in CAA54403 (PubMed:7717992).Curated1
Sequence conflicti379S → T in BAA07458 (PubMed:8829802).Curated1
Sequence conflicti380S → G in CAA54403 (PubMed:7717992).Curated1
Sequence conflicti691E → D in AAA42267 (PubMed:3023031).Curated1
Sequence conflicti696 – 697HK → TA in AAA42267 (PubMed:3023031).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01184065 – 266Missing in isoform 2. 1 PublicationAdd BLAST202

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X77158 mRNA Translation: CAA54403.1
D38380 mRNA Translation: BAA07458.1
AY327504 mRNA Translation: AAP97736.1
BC087021 mRNA Translation: AAH87021.1
M26113 mRNA Translation: AAA42266.1
M27966 mRNA Translation: AAA42267.1

Protein sequence database of the Protein Information Resource

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PIRi
S49163

NCBI Reference Sequences

More...
RefSeqi
NP_001013128.1, NM_001013110.1 [P12346-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000045628; ENSRNOP00000045637; ENSRNOG00000030625 [P12346-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
24825

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:24825

UCSC genome browser

More...
UCSCi
RGD:3845, rat [P12346-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77158 mRNA Translation: CAA54403.1
D38380 mRNA Translation: BAA07458.1
AY327504 mRNA Translation: AAP97736.1
BC087021 mRNA Translation: AAH87021.1
M26113 mRNA Translation: AAA42266.1
M27966 mRNA Translation: AAA42267.1
PIRiS49163
RefSeqiNP_001013128.1, NM_001013110.1 [P12346-1]

3D structure databases

SMRiP12346
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi246945, 3 interactors
IntActiP12346, 1 interactor
STRINGi10116.ENSRNOP00000012725

Protein family/group databases

Allergomei1417, Rat n Transferrin
MEROPSiS60.970

PTM databases

GlyConnecti557, 6 N-Linked glycans
GlyGeniP12346, 1 site, 5 N-linked glycans (1 site)
iPTMnetiP12346
PhosphoSitePlusiP12346
UniCarbKBiP12346

2D gel databases

World-2DPAGEi0004:P12346

Proteomic databases

PaxDbiP12346
PRIDEiP12346

Genome annotation databases

EnsembliENSRNOT00000045628; ENSRNOP00000045637; ENSRNOG00000030625 [P12346-1]
GeneIDi24825
KEGGirno:24825
UCSCiRGD:3845, rat [P12346-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7018
RGDi3845, Tf

Phylogenomic databases

eggNOGiKOG0090, Eukaryota
GeneTreeiENSGT00940000154388
HOGENOMiCLU_011309_1_0_1
InParanoidiP12346
KOiK14736
OrthoDBi232859at2759
PhylomeDBiP12346

Enzyme and pathway databases

ReactomeiR-RNO-114608, Platelet degranulation
R-RNO-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-8856825, Cargo recognition for clathrin-mediated endocytosis
R-RNO-8856828, Clathrin-mediated endocytosis
R-RNO-8957275, Post-translational protein phosphorylation
R-RNO-917937, Iron uptake and transport
R-RNO-917977, Transferrin endocytosis and recycling

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P12346

Gene expression databases

BgeeiENSRNOG00000030625, Expressed in liver and 20 other tissues
ExpressionAtlasiP12346, baseline and differential
GenevisibleiP12346, RN

Family and domain databases

InterProiView protein in InterPro
IPR030685, Serotransferrin_mammal
IPR016357, Transferrin
IPR001156, Transferrin-like_dom
IPR018195, Transferrin_Fe_BS
PfamiView protein in Pfam
PF00405, Transferrin, 2 hits
PIRSFiPIRSF500682, Serotransferrin, 1 hit
PIRSF002549, Transferrin, 1 hit
PRINTSiPR00422, TRANSFERRIN
SMARTiView protein in SMART
SM00094, TR_FER, 2 hits
PROSITEiView protein in PROSITE
PS00205, TRANSFERRIN_LIKE_1, 1 hit
PS00206, TRANSFERRIN_LIKE_2, 2 hits
PS00207, TRANSFERRIN_LIKE_3, 2 hits
PS51408, TRANSFERRIN_LIKE_4, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRFE_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P12346
Secondary accession number(s): Q63602
, Q64628, Q64630, Q7TNX0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 9, 2007
Last modified: August 12, 2020
This is version 170 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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