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Protein

Low affinity immunoglobulin gamma Fc region receptor II-a

Gene

FCGR2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIgG-binding protein, Receptor
Biological processImmunity

Enzyme and pathway databases

ReactomeiR-HSA-2029481 FCGR activation
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029485 Role of phospholipids in phagocytosis
R-HSA-6798695 Neutrophil degranulation
SIGNORiP12318

Names & Taxonomyi

Protein namesi
Recommended name:
Low affinity immunoglobulin gamma Fc region receptor II-a
Short name:
IgG Fc receptor II-a
Alternative name(s):
CDw32
Fc-gamma RII-a
Short name:
Fc-gamma-RIIa
Short name:
FcRII-a
CD_antigen: CD32
Gene namesi
Name:FCGR2A
Synonyms:CD32, FCG2, FCGR2A1, IGFR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143226.13
HGNCiHGNC:3616 FCGR2A
MIMi146790 gene
neXtProtiNX_P12318

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini34 – 217ExtracellularSequence analysisAdd BLAST184
Transmembranei218 – 240HelicalSequence analysisAdd BLAST23
Topological domaini241 – 317CytoplasmicSequence analysisAdd BLAST77

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2212
MalaCardsiFCGR2A
OpenTargetsiENSG00000143226
PharmGKBiPA28063

Chemistry databases

ChEMBLiCHEMBL5841
DrugBankiDB00054 Abciximab
DB00051 Adalimumab
DB00092 Alefacept
DB00087 Alemtuzumab
DB00074 Basiliximab
DB00112 Bevacizumab
DB00002 Cetuximab
DB00111 Daclizumab
DB00095 Efalizumab
DB00005 Etanercept
DB00056 Gemtuzumab ozogamicin
DB00078 Ibritumomab tiuxetan
DB00028 Immune Globulin Human
DB00075 Muromonab
DB00108 Natalizumab
DB00110 Palivizumab
DB00073 Rituximab
DB00081 Tositumomab
DB00072 Trastuzumab

Polymorphism and mutation databases

BioMutaiFCGR2A
DMDMi160332371

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 331 PublicationAdd BLAST33
ChainiPRO_000001514534 – 317Low affinity immunoglobulin gamma Fc region receptor II-aAdd BLAST284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi62 ↔ 104Combined sources3 Publications
Glycosylationi97N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi143 ↔ 187Combined sources3 Publications
Glycosylationi178N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei288Phosphotyrosine; by SRC-type Tyr-kinases1 Publication1
Modified residuei304Phosphotyrosine; by SRC-type Tyr-kinases1 Publication1

Post-translational modificationi

Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN, HCK and SYK.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP12318
PaxDbiP12318
PeptideAtlasiP12318
PRIDEiP12318
ProteomicsDBi52849
52850 [P12318-2]

PTM databases

iPTMnetiP12318
PhosphoSitePlusiP12318

Expressioni

Tissue specificityi

Found on monocytes, neutrophils and eosinophil platelets.

Gene expression databases

BgeeiENSG00000143226
CleanExiHS_FCGR2A
ExpressionAtlasiP12318 baseline and differential
GenevisibleiP12318 HS

Organism-specific databases

HPAiHPA010718
HPA014730

Interactioni

Subunit structurei

Interacts with INPP5D/SHIP1 and INPPL1/SHIP2, regulating its function. Interacts with APCS and FGR. Interacts with HCK.4 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi108506, 32 interactors
ELMiP12318
IntActiP12318, 3 interactors
MINTiP12318
STRINGi9606.ENSP00000271450

Chemistry databases

BindingDBiP12318

Structurei

Secondary structure

1317
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi42 – 47Combined sources6
Beta strandi50 – 53Combined sources4
Beta strandi57 – 64Combined sources8
Beta strandi68 – 71Combined sources4
Beta strandi73 – 77Combined sources5
Beta strandi80 – 82Combined sources3
Beta strandi87 – 93Combined sources7
Helixi96 – 98Combined sources3
Beta strandi100 – 106Combined sources7
Beta strandi107 – 110Combined sources4
Beta strandi115 – 120Combined sources6
Beta strandi123 – 127Combined sources5
Beta strandi131 – 133Combined sources3
Beta strandi139 – 145Combined sources7
Helixi146 – 148Combined sources3
Beta strandi151 – 158Combined sources8
Beta strandi161 – 168Combined sources8
Beta strandi171 – 176Combined sources6
Helixi179 – 181Combined sources3
Beta strandi183 – 191Combined sources9
Beta strandi194 – 197Combined sources4
Beta strandi201 – 205Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FCGX-ray2.00A34-207[»]
1H9VX-ray3.00A37-208[»]
3D5OX-ray2.80F37-207[»]
3RY4X-ray1.50A37-206[»]
3RY5X-ray2.30A37-206[»]
3RY6X-ray3.80C40-206[»]
ProteinModelPortaliP12318
SMRiP12318
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12318

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 118Ig-like C2-type 1Add BLAST80
Domaini122 – 204Ig-like C2-type 2Add BLAST83

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9AP Eukaryota
ENOG410YXNK LUCA
GeneTreeiENSGT00760000119130
HOGENOMiHOG000251632
HOVERGENiHBG051602
InParanoidiP12318
KOiK06472
OMAiLGDMLLW
OrthoDBiEOG091G0JSA
PhylomeDBiP12318
TreeFamiTF335097

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SM00408 IGc2, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P12318-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTMETQMSQN VCPRNLWLLQ PLTVLLLLAS ADSQAAAPPK AVLKLEPPWI
60 70 80 90 100
NVLQEDSVTL TCQGARSPES DSIQWFHNGN LIPTHTQPSY RFKANNNDSG
110 120 130 140 150
EYTCQTGQTS LSDPVHLTVL SEWLVLQTPH LEFQEGETIM LRCHSWKDKP
160 170 180 190 200
LVKVTFFQNG KSQKFSHLDP TFSIPQANHS HSGDYHCTGN IGYTLFSSKP
210 220 230 240 250
VTITVQVPSM GSSSPMGIIV AVVIATAVAA IVAAVVALIY CRKKRISANS
260 270 280 290 300
TDPVKAAQFE PPGRQMIAIR KRQLEETNND YETADGGYMT LNPRAPTDDD
310
KNIYLTLPPN DHVNSNN
Length:317
Mass (Da):35,001
Last modified:November 13, 2007 - v4
Checksum:i07F73F3BB282DFF6
GO
Isoform 2 (identifier: P12318-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-35: Missing.

Show »
Length:316
Mass (Da):34,930
Checksum:i3B4B813ECF6DCFCD
GO

Sequence cautioni

The sequence AAA35932 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2T → A in AAA35827 (PubMed:2529342).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05485763Q → R. Corresponds to variant dbSNP:rs9427398Ensembl.1
Natural variantiVAR_054858140M → V. Corresponds to variant dbSNP:rs4986941Ensembl.1
Natural variantiVAR_003955167H → R May be associated with susceptibility to lupus nephritis; does not efficiently recognize IgG2. 6 PublicationsCorresponds to variant dbSNP:rs1801274Ensembl.1
Natural variantiVAR_054859218I → V1 PublicationCorresponds to variant dbSNP:rs17851834Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03686535Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00644 mRNA Translation: CAA68672.1
M31932 mRNA Translation: AAA35827.1
AL590385 Genomic DNA No translation available.
BC019931 mRNA Translation: AAH19931.1
BC020823 mRNA Translation: AAH20823.1
J03619 mRNA Translation: AAA35932.1 Different initiation.
CCDSiCCDS30922.1 [P12318-2]
CCDS44264.1 [P12318-1]
PIRiJL0118
RefSeqiNP_001129691.1, NM_001136219.1 [P12318-1]
NP_067674.2, NM_021642.3 [P12318-2]
UniGeneiHs.352642

Genome annotation databases

EnsembliENST00000271450; ENSP00000271450; ENSG00000143226 [P12318-1]
ENST00000367972; ENSP00000356949; ENSG00000143226 [P12318-2]
GeneIDi2212
KEGGihsa:2212
UCSCiuc001gam.4 human [P12318-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFCG2A_HUMAN
AccessioniPrimary (citable) accession number: P12318
Secondary accession number(s): Q8WUN1, Q8WW64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: November 13, 2007
Last modified: June 20, 2018
This is version 199 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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