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Protein

High affinity immunoglobulin gamma Fc receptor I

Gene

FCGR1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.5 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIgG-binding protein, Receptor
Biological processImmunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-2029481 FCGR activation
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029485 Role of phospholipids in phagocytosis
R-HSA-877300 Interferon gamma signaling
SignaLinkiP12314
SIGNORiP12314

Names & Taxonomyi

Protein namesi
Recommended name:
High affinity immunoglobulin gamma Fc receptor I
Short name:
IgG Fc receptor I
Alternative name(s):
Fc-gamma RI
Short name:
FcRI
Fc-gamma RIA
Short name:
FcgammaRIa
CD_antigen: CD64
Gene namesi
Name:FCGR1A
Synonyms:FCG1, FCGR1, IGFR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000150337.13
HGNCiHGNC:3613 FCGR1A
MIMi146760 gene
neXtProtiNX_P12314

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini16 – 292ExtracellularSequence analysisAdd BLAST277
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21
Topological domaini314 – 374CytoplasmicSequence analysisAdd BLAST61

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi306N → D: Decreases cell membrane expression by 50% in absence of FCER1G. 1 Publication1
Mutagenesisi306N → G: Increases cell membrane expression in absence of FCER1G. 1 Publication1

Organism-specific databases

DisGeNETi2209
OpenTargetsiENSG00000150337
PharmGKBiPA28060

Chemistry databases

ChEMBLiCHEMBL5349
DrugBankiDB00054 Abciximab
DB00051 Adalimumab
DB00092 Alefacept
DB00087 Alemtuzumab
DB00074 Basiliximab
DB00112 Bevacizumab
DB00002 Cetuximab
DB00111 Daclizumab
DB00095 Efalizumab
DB00005 Etanercept
DB00056 Gemtuzumab ozogamicin
DB00078 Ibritumomab tiuxetan
DB00028 Immune Globulin Human
DB00992 Methyl aminolevulinate
DB00075 Muromonab
DB00108 Natalizumab
DB00110 Palivizumab
DB00707 Porfimer
DB00073 Rituximab
DB00081 Tositumomab
DB00072 Trastuzumab

Polymorphism and mutation databases

BioMutaiFCGR1A
DMDMi50403717

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 151 PublicationAdd BLAST15
ChainiPRO_000001513916 – 374High affinity immunoglobulin gamma Fc receptor IAdd BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 85PROSITE-ProRule annotation1 Publication
Glycosylationi59N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi78N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi124 ↔ 168PROSITE-ProRule annotation1 Publication
Glycosylationi152N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi159N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi163N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi195N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi212 ↔ 260PROSITE-ProRule annotation1 Publication
Glycosylationi240N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylated on serine residues.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP12314
PaxDbiP12314
PeptideAtlasiP12314
PRIDEiP12314
ProteomicsDBi52847
52848 [P12314-2]

PTM databases

iPTMnetiP12314
PhosphoSitePlusiP12314

Expressioni

Tissue specificityi

Monocyte/macrophage specific.

Gene expression databases

BgeeiENSG00000150337 Expressed in 90 organ(s), highest expression level in substantia nigra
CleanExiHS_FCGR1A
ExpressionAtlasiP12314 baseline and differential
GenevisibleiP12314 HS

Interactioni

Subunit structurei

Interacts with FCERG1; forms a functional signaling complex. Interacts with FLNA; prevents FCGR1A degradation. Interacts with EPB41L2, LAT and PPL. Interacts with HCK and LYN.7 Publications

Protein-protein interaction databases

BioGridi108503, 20 interactors
CORUMiP12314
IntActiP12314, 17 interactors
MINTiP12314
STRINGi9606.ENSP00000358165

Chemistry databases

BindingDBiP12314

Structurei

Secondary structure

1374
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP12314
SMRiP12314
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 101Ig-like C2-type 1Add BLAST80
Domaini95 – 184Ig-like C2-type 2Add BLAST90
Domaini190 – 277Ig-like C2-type 3Add BLAST88

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni312 – 332Interaction with EPB41L21 PublicationAdd BLAST21

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVK2 Eukaryota
ENOG410YF57 LUCA
GeneTreeiENSGT00760000119130
HOGENOMiHOG000251632
HOVERGENiHBG051602
InParanoidiP12314
KOiK06498
OMAiFYMGSKT
OrthoDBiEOG091G0ETN
PhylomeDBiP12314
TreeFamiTF335097

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: P12314-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWFLTTLLLW VPVDGQVDTT KAVITLQPPW VSVFQEETVT LHCEVLHLPG
60 70 80 90 100
SSSTQWFLNG TATQTSTPSY RITSASVNDS GEYRCQRGLS GRSDPIQLEI
110 120 130 140 150
HRGWLLLQVS SRVFTEGEPL ALRCHAWKDK LVYNVLYYRN GKAFKFFHWN
160 170 180 190 200
SNLTILKTNI SHNGTYHCSG MGKHRYTSAG ISVTVKELFP APVLNASVTS
210 220 230 240 250
PLLEGNLVTL SCETKLLLQR PGLQLYFSFY MGSKTLRGRN TSSEYQILTA
260 270 280 290 300
RREDSGLYWC EAATEDGNVL KRSPELELQV LGLQLPTPVW FHVLFYLAVG
310 320 330 340 350
IMFLVNTVLW VTIRKELKRK KKWDLEISLD SGHEKKVISS LQEDRHLEEE
360 370
LKCQEQKEEQ LQEGVHRKEP QGAT
Length:374
Mass (Da):42,632
Last modified:July 19, 2004 - v2
Checksum:iD33D59398CEEA699
GO
Isoform 2 (identifier: P12314-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     333-374: HEKKVISSLQEDRHLEEELKCQEQKEEQLQEGVHRKEPQGAT → GQALEAPTQGCA

Show »
Length:344
Mass (Da):38,795
Checksum:iDDBE5DE64A66F6B8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JSN8C9JSN8_HUMAN
High affinity immunoglobulin gamma ...
FCGR1A
240Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25T → S in CAA32537 (PubMed:2974947).Curated1
Sequence conflicti115T → M in AAA58414 (PubMed:1402657).Curated1
Sequence conflicti183V → QY in AAA58414 (PubMed:1402657).Curated1
Sequence conflicti284Q → R in AAA58414 (PubMed:1402657).Curated1
Sequence conflicti324D → N in AAA58414 (PubMed:1402657).Curated1
Sequence conflicti338I → T (PubMed:2974947).Curated1
Sequence conflicti338I → T (PubMed:2911749).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019522105L → P. Corresponds to variant dbSNP:rs619322Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002637333 – 374HEKKV…PQGAT → GQALEAPTQGCA in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14356 mRNA Translation: CAA32537.1
X14355 mRNA Translation: CAA32536.1
L03418 mRNA Translation: AAA36049.1
M91555
, M91550, M91551, M91552, M91553, M91554 Genomic DNA Translation: AAA58414.1
AL591493 Genomic DNA Translation: CAI12557.1
CCDSiCCDS933.1 [P12314-1]
PIRiA39878
A41357
RefSeqiNP_000557.1, NM_000566.3 [P12314-1]
UniGeneiHs.534956
Hs.77424

Genome annotation databases

EnsembliENST00000369168; ENSP00000358165; ENSG00000150337 [P12314-1]
GeneIDi2209
KEGGihsa:2209
UCSCiuc001esp.5 human [P12314-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

FCGR1Abase

FCGR1A mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14356 mRNA Translation: CAA32537.1
X14355 mRNA Translation: CAA32536.1
L03418 mRNA Translation: AAA36049.1
M91555
, M91550, M91551, M91552, M91553, M91554 Genomic DNA Translation: AAA58414.1
AL591493 Genomic DNA Translation: CAI12557.1
CCDSiCCDS933.1 [P12314-1]
PIRiA39878
A41357
RefSeqiNP_000557.1, NM_000566.3 [P12314-1]
UniGeneiHs.534956
Hs.77424

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RJDX-ray2.65A21-282[»]
4W4OX-ray1.80C16-289[»]
4X4MX-ray3.48E/F21-289[»]
4ZNEX-ray2.42A16-282[»]
ProteinModelPortaliP12314
SMRiP12314
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108503, 20 interactors
CORUMiP12314
IntActiP12314, 17 interactors
MINTiP12314
STRINGi9606.ENSP00000358165

Chemistry databases

BindingDBiP12314
ChEMBLiCHEMBL5349
DrugBankiDB00054 Abciximab
DB00051 Adalimumab
DB00092 Alefacept
DB00087 Alemtuzumab
DB00074 Basiliximab
DB00112 Bevacizumab
DB00002 Cetuximab
DB00111 Daclizumab
DB00095 Efalizumab
DB00005 Etanercept
DB00056 Gemtuzumab ozogamicin
DB00078 Ibritumomab tiuxetan
DB00028 Immune Globulin Human
DB00992 Methyl aminolevulinate
DB00075 Muromonab
DB00108 Natalizumab
DB00110 Palivizumab
DB00707 Porfimer
DB00073 Rituximab
DB00081 Tositumomab
DB00072 Trastuzumab

PTM databases

iPTMnetiP12314
PhosphoSitePlusiP12314

Polymorphism and mutation databases

BioMutaiFCGR1A
DMDMi50403717

Proteomic databases

EPDiP12314
PaxDbiP12314
PeptideAtlasiP12314
PRIDEiP12314
ProteomicsDBi52847
52848 [P12314-2]

Protocols and materials databases

DNASUi2209
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369168; ENSP00000358165; ENSG00000150337 [P12314-1]
GeneIDi2209
KEGGihsa:2209
UCSCiuc001esp.5 human [P12314-1]

Organism-specific databases

CTDi2209
DisGeNETi2209
EuPathDBiHostDB:ENSG00000150337.13
GeneCardsiFCGR1A
H-InvDBiHIX0000999
HGNCiHGNC:3613 FCGR1A
MIMi146760 gene
neXtProtiNX_P12314
OpenTargetsiENSG00000150337
PharmGKBiPA28060
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVK2 Eukaryota
ENOG410YF57 LUCA
GeneTreeiENSGT00760000119130
HOGENOMiHOG000251632
HOVERGENiHBG051602
InParanoidiP12314
KOiK06498
OMAiFYMGSKT
OrthoDBiEOG091G0ETN
PhylomeDBiP12314
TreeFamiTF335097

Enzyme and pathway databases

ReactomeiR-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-2029481 FCGR activation
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029485 Role of phospholipids in phagocytosis
R-HSA-877300 Interferon gamma signaling
SignaLinkiP12314
SIGNORiP12314

Miscellaneous databases

GeneWikiiFCGR1A
GenomeRNAii2209
PROiPR:P12314
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000150337 Expressed in 90 organ(s), highest expression level in substantia nigra
CleanExiHS_FCGR1A
ExpressionAtlasiP12314 baseline and differential
GenevisibleiP12314 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
PfamiView protein in Pfam
PF00047 ig, 1 hit
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFCGR1_HUMAN
AccessioniPrimary (citable) accession number: P12314
Secondary accession number(s): P12315
, Q5QNW7, Q92495, Q92663
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: July 19, 2004
Last modified: September 12, 2018
This is version 188 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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