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Protein

Molybdopterin molybdenumtransferase

Gene

moeA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.1 Publication

Catalytic activityi

Adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP.

Cofactori

Mg2+1 PublicationNote: Binds 1 Mg2+ ion per subunit.1 Publication

Pathwayi: molybdopterin biosynthesis

This protein is involved in the pathway molybdopterin biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway molybdopterin biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • metal ion binding Source: UniProtKB-KW
  • molybdopterin adenylyltransferase activity Source: GO_Central
  • molybdopterin molybdotransferase activity Source: EcoCyc

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMolybdenum cofactor biosynthesis
LigandMagnesium, Metal-binding, Molybdenum

Enzyme and pathway databases

BioCyciEcoCyc:EG10153-MONOMER
MetaCyc:EG10153-MONOMER
BRENDAi2.10.1.1 2026
UniPathwayi
UPA00344

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdopterin molybdenumtransferase (EC:2.10.1.1)
Short name:
MPT Mo-transferase
Gene namesi
Name:moeA
Synonyms:bisB, chlE, narE
Ordered Locus Names:b0827, JW0811
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10153 moeA

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001709891 – 411Molybdopterin molybdenumtransferaseAdd BLAST411

Proteomic databases

EPDiP12281
PaxDbiP12281
PRIDEiP12281

Interactioni

Subunit structurei

Homodimer. Interacts with MobA, MogA and MobB in vivo.3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi4259979, 41 interactors
DIPiDIP-10240N
IntActiP12281, 8 interactors
STRINGi316385.ECDH10B_0896

Structurei

Secondary structure

1411
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP12281
SMRiP12281
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12281

Family & Domainsi

Sequence similaritiesi

Belongs to the MoeA family.Curated

Phylogenomic databases

eggNOGiENOG4105CVM Bacteria
COG0303 LUCA
HOGENOMiHOG000280652
InParanoidiP12281
KOiK03750
PhylomeDBiP12281

Family and domain databases

CDDicd00887 MoeA, 1 hit
Gene3Di2.40.340.10, 1 hit
3.40.980.10, 1 hit
InterProiView protein in InterPro
IPR036425 MoaB/Mog-like_dom_sf
IPR001453 MoaB/Mog_dom
IPR008284 MoCF_biosynth_CS
IPR038987 MoeA-like
IPR005111 MoeA_C_domain_IV
IPR036688 MoeA_C_domain_IV_sf
IPR005110 MoeA_linker/N
IPR036135 MoeA_linker/N_sf
PANTHERiPTHR10192 PTHR10192, 1 hit
PfamiView protein in Pfam
PF00994 MoCF_biosynth, 1 hit
PF03454 MoeA_C, 1 hit
PF03453 MoeA_N, 1 hit
SMARTiView protein in SMART
SM00852 MoCF_biosynth, 1 hit
SUPFAMiSSF53218 SSF53218, 1 hit
SSF63867 SSF63867, 1 hit
SSF63882 SSF63882, 1 hit
TIGRFAMsiTIGR00177 molyb_syn, 1 hit
PROSITEiView protein in PROSITE
PS01079 MOCF_BIOSYNTHESIS_2, 1 hit

Sequencei

Sequence statusi: Complete.

P12281-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEFTTGLMSL DTALNEMLSR VTPLTAQETL PLVQCFGRIL ASDVVSPLDV
60 70 80 90 100
PGFDNSAMDG YAVRLADIAS GQPLPVAGKS FAGQPYHGEW PAGTCIRIMT
110 120 130 140 150
GAPVPEGCEA VVMQEQTEQM DNGVRFTAEV RSGQNIRRRG EDISAGAVVF
160 170 180 190 200
PAGTRLTTAE LPVIASLGIA EVPVIRKVRV ALFSTGDELQ LPGQPLGDGQ
210 220 230 240 250
IYDTNRLAVH LMLEQLGCEV INLGIIRDDP HALRAAFIEA DSQADVVISS
260 270 280 290 300
GGVSVGEADY TKTILEELGE IAFWKLAIKP GKPFAFGKLS NSWFCGLPGN
310 320 330 340 350
PVSATLTFYQ LVQPLLAKLS GNTASGLPAR QRVRTASRLK KTPGRLDFQR
360 370 380 390 400
GVLQRNADGE LEVTTTGHQG SHIFSSFSLG NCFIVLERDR GNVEVGEWVE
410
VEPFNALFGG L
Length:411
Mass (Da):44,067
Last modified:October 1, 1989 - v1
Checksum:i6DBBC2B4191F5951
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21151 Genomic DNA Translation: AAA23579.1
U00096 Genomic DNA Translation: AAC73914.1
AP009048 Genomic DNA Translation: BAA35515.1
PIRiA32352
RefSeqiNP_415348.1, NC_000913.3
WP_000397340.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73914; AAC73914; b0827
BAA35515; BAA35515; BAA35515
GeneIDi945454
KEGGiecj:JW0811
eco:b0827
PATRICifig|1411691.4.peg.1451

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21151 Genomic DNA Translation: AAA23579.1
U00096 Genomic DNA Translation: AAC73914.1
AP009048 Genomic DNA Translation: BAA35515.1
PIRiA32352
RefSeqiNP_415348.1, NC_000913.3
WP_000397340.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FC5X-ray2.20A/B1-411[»]
1G8LX-ray1.95A/B1-411[»]
1G8RX-ray2.65A/B1-411[»]
2NQKX-ray2.90A/B1-411[»]
2NQMX-ray3.00A/B1-411[»]
2NQNX-ray2.20A/B1-411[»]
2NQQX-ray2.40A/B/C/D1-411[»]
2NQRX-ray2.20A/B1-411[»]
2NQSX-ray2.50A/B1-411[»]
2NQUX-ray2.70A/B1-411[»]
2NQVX-ray2.82A/B1-411[»]
2NROX-ray2.50A/B1-411[»]
2NRPX-ray3.00A/B1-411[»]
2NRSX-ray2.80A/B1-411[»]
ProteinModelPortaliP12281
SMRiP12281
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259979, 41 interactors
DIPiDIP-10240N
IntActiP12281, 8 interactors
STRINGi316385.ECDH10B_0896

Proteomic databases

EPDiP12281
PaxDbiP12281
PRIDEiP12281

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73914; AAC73914; b0827
BAA35515; BAA35515; BAA35515
GeneIDi945454
KEGGiecj:JW0811
eco:b0827
PATRICifig|1411691.4.peg.1451

Organism-specific databases

EchoBASEiEB0151
EcoGeneiEG10153 moeA

Phylogenomic databases

eggNOGiENOG4105CVM Bacteria
COG0303 LUCA
HOGENOMiHOG000280652
InParanoidiP12281
KOiK03750
PhylomeDBiP12281

Enzyme and pathway databases

UniPathwayi
UPA00344

BioCyciEcoCyc:EG10153-MONOMER
MetaCyc:EG10153-MONOMER
BRENDAi2.10.1.1 2026

Miscellaneous databases

EvolutionaryTraceiP12281
PROiPR:P12281

Family and domain databases

CDDicd00887 MoeA, 1 hit
Gene3Di2.40.340.10, 1 hit
3.40.980.10, 1 hit
InterProiView protein in InterPro
IPR036425 MoaB/Mog-like_dom_sf
IPR001453 MoaB/Mog_dom
IPR008284 MoCF_biosynth_CS
IPR038987 MoeA-like
IPR005111 MoeA_C_domain_IV
IPR036688 MoeA_C_domain_IV_sf
IPR005110 MoeA_linker/N
IPR036135 MoeA_linker/N_sf
PANTHERiPTHR10192 PTHR10192, 1 hit
PfamiView protein in Pfam
PF00994 MoCF_biosynth, 1 hit
PF03454 MoeA_C, 1 hit
PF03453 MoeA_N, 1 hit
SMARTiView protein in SMART
SM00852 MoCF_biosynth, 1 hit
SUPFAMiSSF53218 SSF53218, 1 hit
SSF63867 SSF63867, 1 hit
SSF63882 SSF63882, 1 hit
TIGRFAMsiTIGR00177 molyb_syn, 1 hit
PROSITEiView protein in PROSITE
PS01079 MOCF_BIOSYNTHESIS_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMOEA_ECOLI
AccessioniPrimary (citable) accession number: P12281
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 7, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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