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UniProtKB - P12277 (KCRB_HUMAN)

Entry version 216 (02 Jun 2021)
Sequence version 1 (01 Oct 1989)
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Protein

Creatine kinase B-type

Gene

CKB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei72Substrate; via amide nitrogen1 Publication1
Binding sitei130ATP1 Publication1
Binding sitei132ATP1 Publication1
Binding sitei191ATP1 Publication1
Binding sitei232Substrate1 Publication1
Binding sitei236ATP1 Publication1
Binding sitei285Substrate1 Publication1
Binding sitei292ATP1 Publication1
Binding sitei320ATP1 Publication1
Binding sitei335ATP1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi128 – 132ATP1 Publication5
Nucleotide bindingi320 – 325ATP1 Publication6

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS09344-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.3.2, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P12277

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-71288, Creatine metabolism

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P12277

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Creatine kinase B-typeCurated (EC:2.7.3.2)
Alternative name(s):
Brain creatine kinase1 Publication
Short name:
B-CK
Creatine kinase B chain1 Publication
Creatine phosphokinase B-type
Short name:
CPK-B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CKB
Synonyms:CKBB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1991, CKB

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		123280, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P12277

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000166165.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi283C → S or Y: Complete loss of activity. 1 Publication1
Mutagenesisi292R → H, L or Q: Complete loss of activity. 1 Publication1
Mutagenesisi292R → K: 42% of wild-type activity. 1 Publication1
Mutagenesisi340D → E: No change in activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		1152

Open Targets

More...OpenTargetsi		ENSG00000166165

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26528

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P12277, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL6049

Drug and drug target database

More...DrugBanki		DB00787, Acyclovir
DB00148, Creatine
DB13749, Magnesium gluconate
DB13191, Phosphocreatine
DB00300, Tenofovir disoproxil

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CKB

Domain mapping of disease mutations (DMDM)

More...DMDMi		125294

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved2 Publications
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002119662 – 381Creatine kinase B-typeAdd BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei4PhosphoserineCombined sources1
Modified residuei35PhosphothreonineCombined sources1
Modified residuei125PhosphotyrosineBy similarity1
Modified residuei199PhosphoserineCombined sources1
Modified residuei2693'-nitrotyrosineBy similarity1
Modified residuei309PhosphoserineBy similarity1
Modified residuei322PhosphothreonineBy similarity1

Keywords - PTMi

Nitration, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-476
CPTAC-477

Encyclopedia of Proteome Dynamics

More...EPDi		P12277

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P12277

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P12277

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P12277

PeptideAtlas

More...PeptideAtlasi		P12277

PRoteomics IDEntifications database

More...PRIDEi		P12277

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52846

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P12277

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00022977
P12277

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		P12277

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P12277

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P12277

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P12277

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P12277

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000166165, Expressed in ventricular zone and 131 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P12277, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P12277, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000166165, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Dimer of identical or non-identical chains, which can be either B (brain type) or M (muscle type). With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107572, 140 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P12277

Database of interacting proteins

More...DIPi		DIP-52968N

Protein interaction database and analysis system

More...IntActi		P12277, 72 interactors

Molecular INTeraction database

More...MINTi		P12277

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000299198

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P12277, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1381
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P12277

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P12277

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 98Phosphagen kinase N-terminalPROSITE-ProRule annotationAdd BLAST88
Domaini125 – 367Phosphagen kinase C-terminalPROSITE-ProRule annotationAdd BLAST243

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni96 – 122DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi96 – 113Basic and acidic residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATP:guanido phosphotransferase family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3581, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182772

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_019868_4_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P12277

Identification of Orthologs from Complete Genome Data

More...OMAi		RGHEFMW

Database for complete collections of gene phylogenies

More...PhylomeDBi		P12277

TreeFam database of animal gene trees

More...TreeFami		TF314214

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.135.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000749, ATP-guanido_PTrfase
IPR022415, ATP-guanido_PTrfase_AS
IPR022414, ATP-guanido_PTrfase_cat
IPR022413, ATP-guanido_PTrfase_N
IPR036802, ATP-guanido_PTrfase_N_sf
IPR014746, Gln_synth/guanido_kin_cat_dom

The PANTHER Classification System

More...PANTHERi		PTHR11547, PTHR11547, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00217, ATP-gua_Ptrans, 1 hit
PF02807, ATP-gua_PtransN, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48034, SSF48034, 1 hit
SSF55931, SSF55931, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00112, PHOSPHAGEN_KINASE, 1 hit
PS51510, PHOSPHAGEN_KINASE_C, 1 hit
PS51509, PHOSPHAGEN_KINASE_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P12277-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPFSNSHNAL KLRFPAEDEF PDLSAHNNHM AKVLTPELYA ELRAKSTPSG 
        60         70         80         90        100
FTLDDVIQTG VDNPGHPYIM TVGCVAGDEE SYEVFKDLFD PIIEDRHGGY 
       110        120        130        140        150
KPSDEHKTDL NPDNLQGGDD LDPNYVLSSR VRTGRSIRGF CLPPHCSRGE 
       160        170        180        190        200
RRAIEKLAVE ALSSLDGDLA GRYYALKSMT EAEQQQLIDD HFLFDKPVSP 
       210        220        230        240        250
LLLASGMARD WPDARGIWHN DNKTFLVWVN EEDHLRVISM QKGGNMKEVF 
       260        270        280        290        300
TRFCTGLTQI ETLFKSKDYE FMWNPHLGYI LTCPSNLGTG LRAGVHIKLP 
       310        320        330        340        350
NLGKHEKFSE VLKRLRLQKR GTGGVDTAAV GGVFDVSNAD RLGFSEVELV 
       360        370        380 
QMVVDGVKLL IEMEQRLEQG QAIDDLMPAQ K
Length:381
Mass (Da):42,644
Last modified:October 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i637AA67A86AE3059
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V4N7G3V4N7_HUMAN
Creatine kinase
CKB
217Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJG0H0YJG0_HUMAN
Creatine kinase
CKB
179Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V461G3V461_HUMAN
Creatine kinase
CKB
128Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJK0H0YJK0_HUMAN
Creatine kinase
CKB
90Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJJ7H0YJJ7_HUMAN
Creatine kinase B-type
CKB
20Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2I1G3V2I1_HUMAN
Creatine kinase B-type
CKB
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti41 – 42EL → DV in AAA76851 (PubMed:3034271).Curated2
Sequence conflicti78D → G in AAA76850 (PubMed:2883200).Curated1
Sequence conflicti78D → G in AAA52024 (PubMed:2828370).Curated1
Sequence conflicti98 – 99GG → RR in AAA76851 (PubMed:3034271).Curated2
Sequence conflicti105 – 106EH → DD in AAA76851 (PubMed:3034271).Curated2
Sequence conflicti130R → G in AAA76850 (PubMed:2883200).Curated1
Sequence conflicti132R → A in AAA76851 (PubMed:3034271).Curated1
Sequence conflicti144P → Q in CAG47064 (Ref. 6) Curated1
Sequence conflicti203L → S in AAC31758 (PubMed:3692484).Curated1
Sequence conflicti215 – 216RG → AR in AAA76851 (PubMed:3034271).Curated2
Sequence conflicti296H → D in AAA76851 (PubMed:3034271).Curated1
Sequence conflicti358K → R in BAG35211 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_025838177K → R1 PublicationCorresponds to variant dbSNP:rs36002620Ensembl.1
Natural variantiVAR_025839309S → L1 PublicationCorresponds to variant dbSNP:rs35156510Ensembl.1
Natural variantiVAR_049674360L → F. Corresponds to variant dbSNP:rs12505Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M16451 mRNA Translation: AAA76851.1
M21243 M21242 Genomic DNA Translation: AAC31758.1
L47647 mRNA Translation: AAA76852.1
M16364 mRNA Translation: AAA76850.1
X15334 Genomic DNA Translation: CAA33389.1
AK290101 mRNA Translation: BAF82790.1
AK312282 mRNA Translation: BAG35211.1
CR542268 mRNA Translation: CAG47064.1
DQ333313 Genomic DNA Translation: ABC67465.1
CH471061 Genomic DNA Translation: EAW81822.1
BC001190 mRNA Translation: AAH01190.1
BC004914 mRNA Translation: AAH04914.1
BC008323 mRNA Translation: AAH08323.1
BC010002 mRNA Translation: AAH10002.1
BC019259 mRNA Translation: AAH19259.1
BC019281 mRNA Translation: AAH19281.1
M22356, M22355 Genomic DNA Translation: AAA52024.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9981.1

Protein sequence database of the Protein Information Resource

More...PIRi		S15935, KIHUCB

NCBI Reference Sequences

More...RefSeqi		NP_001814.2, NM_001823.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000348956; ENSP00000299198; ENSG00000166165

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1152

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1152

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
Wikipedia

Creatine kinase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16451 mRNA Translation: AAA76851.1
M21243 M21242 Genomic DNA Translation: AAC31758.1
L47647 mRNA Translation: AAA76852.1
M16364 mRNA Translation: AAA76850.1
X15334 Genomic DNA Translation: CAA33389.1
AK290101 mRNA Translation: BAF82790.1
AK312282 mRNA Translation: BAG35211.1
CR542268 mRNA Translation: CAG47064.1
DQ333313 Genomic DNA Translation: ABC67465.1
CH471061 Genomic DNA Translation: EAW81822.1
BC001190 mRNA Translation: AAH01190.1
BC004914 mRNA Translation: AAH04914.1
BC008323 mRNA Translation: AAH08323.1
BC010002 mRNA Translation: AAH10002.1
BC019259 mRNA Translation: AAH19259.1
BC019281 mRNA Translation: AAH19281.1
M22356, M22355 Genomic DNA Translation: AAA52024.1
CCDSiCCDS9981.1
PIRiS15935, KIHUCB
RefSeqiNP_001814.2, NM_001823.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3B6RX-ray2.00A/B1-381[»]
3DRBX-ray2.00A/B1-381[»]
3DREX-ray2.20A/B1-381[»]
6V9Helectron microscopy4.10A/B1-381[»]
SMRiP12277
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107572, 140 interactors
CORUMiP12277
DIPiDIP-52968N
IntActiP12277, 72 interactors
MINTiP12277
STRINGi9606.ENSP00000299198

Chemistry databases

ChEMBLiCHEMBL6049
DrugBankiDB00787, Acyclovir
DB00148, Creatine
DB13749, Magnesium gluconate
DB13191, Phosphocreatine
DB00300, Tenofovir disoproxil

PTM databases

CarbonylDBiP12277
iPTMnetiP12277
PhosphoSitePlusiP12277
SwissPalmiP12277

Genetic variation databases

BioMutaiCKB
DMDMi125294

2D gel databases

REPRODUCTION-2DPAGEiIPI00022977
P12277
UCD-2DPAGEiP12277

Proteomic databases

CPTACiCPTAC-476
CPTAC-477
EPDiP12277
jPOSTiP12277
MassIVEiP12277
PaxDbiP12277
PeptideAtlasiP12277
PRIDEiP12277
ProteomicsDBi52846
TopDownProteomicsiP12277

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28, 823 antibodies

The CPTC Antibody Portal

More...CPTCi		P12277, 3 antibodies

The DNASU plasmid repository

More...DNASUi		1152

Genome annotation databases

EnsembliENST00000348956; ENSP00000299198; ENSG00000166165
GeneIDi1152
KEGGihsa:1152

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1152
DisGeNETi1152

GeneCards: human genes, protein and diseases

More...GeneCardsi		CKB
HGNCiHGNC:1991, CKB
HPAiENSG00000166165, Tissue enhanced (brain)
MIMi123280, gene
neXtProtiNX_P12277
OpenTargetsiENSG00000166165
PharmGKBiPA26528
VEuPathDBiHostDB:ENSG00000166165.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3581, Eukaryota
GeneTreeiENSGT00950000182772
HOGENOMiCLU_019868_4_2_1
InParanoidiP12277
OMAiRGHEFMW
PhylomeDBiP12277
TreeFamiTF314214

Enzyme and pathway databases

BioCyciMetaCyc:HS09344-MONOMER
BRENDAi2.7.3.2, 2681
PathwayCommonsiP12277
ReactomeiR-HSA-71288, Creatine metabolism
SABIO-RKiP12277

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1152, 1 hit in 991 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CKB, human
EvolutionaryTraceiP12277

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CKB_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1152
PharosiP12277, Tbio

Protein Ontology

More...PROi		PR:P12277
RNActiP12277, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000166165, Expressed in ventricular zone and 131 other tissues
ExpressionAtlasiP12277, baseline and differential
GenevisibleiP12277, HS

Family and domain databases

Gene3Di1.10.135.10, 1 hit
InterProiView protein in InterPro
IPR000749, ATP-guanido_PTrfase
IPR022415, ATP-guanido_PTrfase_AS
IPR022414, ATP-guanido_PTrfase_cat
IPR022413, ATP-guanido_PTrfase_N
IPR036802, ATP-guanido_PTrfase_N_sf
IPR014746, Gln_synth/guanido_kin_cat_dom
PANTHERiPTHR11547, PTHR11547, 2 hits
PfamiView protein in Pfam
PF00217, ATP-gua_Ptrans, 1 hit
PF02807, ATP-gua_PtransN, 1 hit
SUPFAMiSSF48034, SSF48034, 1 hit
SSF55931, SSF55931, 1 hit
PROSITEiView protein in PROSITE
PS00112, PHOSPHAGEN_KINASE, 1 hit
PS51510, PHOSPHAGEN_KINASE_C, 1 hit
PS51509, PHOSPHAGEN_KINASE_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCRB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P12277
Secondary accession number(s): A8K236
, B2R5R4, Q2LE07, Q6FG40, Q9UC66
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: June 2, 2021
This is version 216 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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