CKB

Functionⁱ

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255).

Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity).

During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity).

By similarityCurated1 Publication

Catalytic activityⁱ

ATP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
creatine
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
=
ADP
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
H⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
N-phosphocreatine
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
PROSITE-ProRule annotation
Manual assertion according to rulesⁱ
- PROSITE-ProRule:PRU10029
1 Publication
Manual assertion based on experiment inⁱ
- Ref.14
  "Determination of the catalytic site of creatine kinase by site-directed mutagenesis."
  Lin L., Perryman M.B., Friedman D., Roberts R., Ma T.S.
  Biochim. Biophys. Acta 1206:97-104(1994) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, MUTAGENESIS OF CYS-283; ARG-292 AND ASP-340.
EC:
2.7.3.2
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
- Search reactions for this EC number in Rhea.
PROSITE-ProRule annotation
Manual assertion according to rulesⁱ
- PROSITE-ProRule:PRU10029
1 Publication
Manual assertion based on experiment inⁱ
- Ref.14
  "Determination of the catalytic site of creatine kinase by site-directed mutagenesis."
  Lin L., Perryman M.B., Friedman D., Roberts R., Ma T.S.
  Biochim. Biophys. Acta 1206:97-104(1994) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, MUTAGENESIS OF CYS-283; ARG-292 AND ASP-340.
This reaction proceeds in the
forward
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.14
  "Determination of the catalytic site of creatine kinase by site-directed mutagenesis."
  Lin L., Perryman M.B., Friedman D., Roberts R., Ma T.S.
  Biochim. Biophys. Acta 1206:97-104(1994) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, MUTAGENESIS OF CYS-283; ARG-292 AND ASP-340.
direction.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
ATP
+
creatine
zoom
=
ADP
+
H⁺
+
N-phosphocreatine
zoom

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	72	creatine; via amide nitrogen1 Publication	1
Binding siteⁱ	130	ATP1 Publication	1
Binding siteⁱ	132	ATP1 Publication	1
Binding siteⁱ	191	ATP1 Publication	1
Binding siteⁱ	232	creatine1 Publication	1
Binding siteⁱ	236	ATP1 Publication	1
Binding siteⁱ	285	creatine1 Publication	1
Binding siteⁱ	292	ATP1 Publication	1
Binding siteⁱ	320	ATP1 Publication	1
Binding siteⁱ	335	ATP1 Publication	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	128 – 132	ATP1 Publication		5
Nucleotide bindingⁱ	320 – 325	ATP1 Publication		6

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Transferase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS09344-MONOMER
BRENDAⁱ	2.7.3.2, 2681
PathwayCommonsⁱ	P12277
Reactomeⁱ	R-HSA-71288, Creatine metabolism R-HSA-9696264, RND3 GTPase cycle
SABIO-RKⁱ	P12277

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Creatine kinase B-typeCurated (EC:2.7.3.21 Publication) Alternative name(s): Brain creatine kinase1 Publication Short name: B-CK Creatine kinase B chain1 Publication Creatine phosphokinase B-type Short name: CPK-B
Gene namesⁱ	Name:CKBImported Synonyms:CKBB
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1991, CKB
MIMⁱ	123280, gene
neXtProtⁱ	NX_P12277
VEuPathDBⁱ	HostDB:ENSG00000166165

Keywords - Cellular componentⁱ

Cytoplasm, Mitochondrion

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	283	C → S or Y: Complete loss of activity. 1 Publication	1
Mutagenesisⁱ	292	R → H, L or Q: Complete loss of activity. 1 Publication	1
Mutagenesisⁱ	292	R → K: 42% of wild-type activity. 1 Publication	1
Mutagenesisⁱ	340	D → E: No change in activity. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1152
Open Targets More...OpenTargetsⁱ	ENSG00000166165
PharmGKBⁱ	PA26528

Miscellaneous databases

Pharosⁱ	P12277, Tbio

Pharosⁱ

P12277, Tbio

Chemistry databases

ChEMBLⁱ	CHEMBL6049
Drug and drug target database More...DrugBankⁱ	DB00787, Acyclovir DB00148, Creatine DB13749, Magnesium gluconate DB13191, Phosphocreatine DB00300, Tenofovir disoproxil

Genetic variation databases

BioMutaⁱ	CKB
DMDMⁱ	125294

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed2 Publications
ChainⁱPRO_0000211966	2 – 381	Creatine kinase B-typeAdd BLAST		380

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	4	PhosphoserineCombined sources	1
Modified residueⁱ	35	PhosphothreonineCombined sources	1
Modified residueⁱ	125	PhosphotyrosineBy similarity	1
Modified residueⁱ	199	PhosphoserineCombined sources	1
Modified residueⁱ	269	3'-nitrotyrosineBy similarity	1
Modified residueⁱ	309	PhosphoserineBy similarity	1
Modified residueⁱ	322	PhosphothreonineBy similarity	1

Keywords - PTMⁱ

Nitration, Phosphoprotein

Proteomic databases

The CPTAC Assay portal More...CPTACⁱ	CPTAC-476 CPTAC-477
EPDⁱ	P12277
jPOSTⁱ	P12277
MassIVEⁱ	P12277
PaxDbⁱ	P12277
PeptideAtlas More...PeptideAtlasⁱ	P12277
PRIDEⁱ	P12277
ProteomicsDBⁱ	52846
TopDownProteomicsⁱ	P12277

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00022977 P12277
UCD-2DPAGEⁱ	P12277

PTM databases

CarbonylDBⁱ	P12277
GlyGenⁱ	P12277, 1 site, 1 O-linked glycan (1 site)
iPTMnetⁱ	P12277
PhosphoSitePlusⁱ	P12277
SwissPalmⁱ	P12277

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000166165, Expressed in ventricular zone and 131 other tissues
ExpressionAtlasⁱ	P12277, baseline and differential
Genevisibleⁱ	P12277, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000166165, Tissue enhanced (brain)

HPAⁱ

ENSG00000166165, Tissue enhanced (brain)

Interactionⁱ

Subunit structureⁱ

Dimer of identical or non-identical chains, which can be either B (brain type) or M (muscle type). With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain.

1 Publication

Binary interactionsⁱ

Hide details

P12277

With	#Exp.	IntAct
ASB9 [Q96DX5]	10	EBI-357706,EBI-745641
Non-structural protein 4A (PRO_0000278738) from Hepatitis C virus genotype 1b (isolate HC-J1).	3	EBI-357706,EBI-9081620

GO - Molecular functionⁱ

ubiquitin protein ligase binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- "Proteomic analysis of increased Parkin expression and its interactants provides evidence for a role in modulation of mitochondrial function."
  Davison E.J., Pennington K., Hung C.C., Peng J., Rafiq R., Ostareck-Lederer A., Ostareck D.H., Ardley H.C., Banks R.E., Robinson P.A.
  Proteomics 9:4284-4297(2009) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	107572, 162 interactors
CORUMⁱ	P12277
Database of interacting proteins More...DIPⁱ	DIP-52968N
IntActⁱ	P12277, 72 interactors
Molecular INTeraction database More...MINTⁱ	P12277
STRINGⁱ	9606.ENSP00000299198

Miscellaneous databases

RNActⁱ	P12277, protein

RNActⁱ

P12277, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	7 – 11	Combined sources	5
Helixⁱ	16 – 19	Combined sources	4
Helixⁱ	29 – 33	Combined sources	5
Helixⁱ	36 – 42	Combined sources	7
Helixⁱ	53 – 62	Combined sources	10
Beta strandⁱ	67 – 69	Combined sources	3
Helixⁱ	81 – 84	Combined sources	4
Helixⁱ	86 – 96	Combined sources	11
Helixⁱ	112 – 114	Combined sources	3
Turnⁱ	123 – 125	Combined sources	3
Beta strandⁱ	126 – 135	Combined sources	10
Turnⁱ	143 – 145	Combined sources	3
Helixⁱ	148 – 162	Combined sources	15
Helixⁱ	167 – 169	Combined sources	3
Beta strandⁱ	171 – 176	Combined sources	6
Helixⁱ	181 – 189	Combined sources	9
Helixⁱ	200 – 203	Combined sources	4
Turnⁱ	204 – 214	Combined sources	11
Beta strandⁱ	216 – 220	Combined sources	5
Beta strandⁱ	223 – 244	Combined sources	22
Helixⁱ	246 – 266	Combined sources	21
Turnⁱ	275 – 277	Combined sources	3
Helixⁱ	284 – 286	Combined sources	3
Beta strandⁱ	292 – 298	Combined sources	7
Helixⁱ	300 – 303	Combined sources	4
Helixⁱ	308 – 314	Combined sources	7
Beta strandⁱ	317 – 321	Combined sources	5
Helixⁱ	325 – 330	Combined sources	6
Beta strandⁱ	333 – 338	Combined sources	6
Beta strandⁱ	342 – 344	Combined sources	3
Helixⁱ	346 – 368	Combined sources	23
Helixⁱ	374 – 376	Combined sources	3

Show more details

3D structure databases

SMRⁱ	P12277
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P12277

EvolutionaryTraceⁱ

P12277

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	11 – 98	Phosphagen kinase N-terminalPROSITE-ProRule annotationAdd BLAST		88
Domainⁱ	125 – 367	Phosphagen kinase C-terminalPROSITE-ProRule annotationAdd BLAST		243

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	96 – 122	DisorderedSequence analysisAdd BLAST		27
Regionⁱ	130 – 138	Internal MTS-like signalBy similarity		9

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	96 – 113	Basic and acidic residuesSequence analysisAdd BLAST		18

Domainⁱ

The internal MTS-like signal (iMTS-L) mediates targeting to mitochondria thermogenic fat cells.By similarity

Sequence similaritiesⁱ

Belongs to the ATP:guanido phosphotransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG3581, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00950000182772
HOGENOMⁱ	CLU_019868_4_2_1
InParanoidⁱ	P12277
OMAⁱ	DMMPEQK
PhylomeDBⁱ	P12277
TreeFamⁱ	TF314214

Family and domain databases

Gene3Dⁱ	1.10.135.10, 1 hit
InterProⁱ	View protein in InterPro IPR000749, ATP-guanido_PTrfase IPR022415, ATP-guanido_PTrfase_AS IPR022414, ATP-guanido_PTrfase_cat IPR022413, ATP-guanido_PTrfase_N IPR036802, ATP-guanido_PTrfase_N_sf IPR014746, Gln_synth/guanido_kin_cat_dom
PANTHERⁱ	PTHR11547, PTHR11547, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00217, ATP-gua_Ptrans, 1 hit PF02807, ATP-gua_PtransN, 1 hit
SUPFAMⁱ	SSF48034, SSF48034, 1 hit SSF55931, SSF55931, 1 hit
PROSITEⁱ	View protein in PROSITE PS00112, PHOSPHAGEN_KINASE, 1 hit PS51510, PHOSPHAGEN_KINASE_C, 1 hit PS51509, PHOSPHAGEN_KINASE_N, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show all Align All

P12277-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPFSNSHNAL KLRFPAEDEF PDLSAHNNHM AKVLTPELYA ELRAKSTPSG 
        60         70         80         90        100
FTLDDVIQTG VDNPGHPYIM TVGCVAGDEE SYEVFKDLFD PIIEDRHGGY 
       110        120        130        140        150
KPSDEHKTDL NPDNLQGGDD LDPNYVLSSR VRTGRSIRGF CLPPHCSRGE 
       160        170        180        190        200
RRAIEKLAVE ALSSLDGDLA GRYYALKSMT EAEQQQLIDD HFLFDKPVSP 
       210        220        230        240        250
LLLASGMARD WPDARGIWHN DNKTFLVWVN EEDHLRVISM QKGGNMKEVF 
       260        270        280        290        300
TRFCTGLTQI ETLFKSKDYE FMWNPHLGYI LTCPSNLGTG LRAGVHIKLP 
       310        320        330        340        350
NLGKHEKFSE VLKRLRLQKR GTGGVDTAAV GGVFDVSNAD RLGFSEVELV 
       360        370        380 
QMVVDGVKLL IEMEQRLEQG QAIDDLMPAQ K

Length:381

Mass (Da):42,644

Last modified:October 1, 1989 - v1

Checksum:ⁱ637AA67A86AE3059

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G3V4N7	G3V4N7_HUMAN	Creatine kinase Creatine kinase, EC 2.7.3.2	CKB	217	Annotation score:
H0YJG0	H0YJG0_HUMAN	Creatine kinase Creatine kinase, EC 2.7.3.2	CKB	179	Annotation score:
G3V461	G3V461_HUMAN	Creatine kinase Creatine kinase, EC 2.7.3.2	CKB	128	Annotation score:
H0YJK0	H0YJK0_HUMAN	Creatine kinase Creatine kinase, EC 2.7.3.2	CKB	90	Annotation score:
H0YJJ7	H0YJJ7_HUMAN	Creatine kinase B-type Creatine kinase B-type	CKB	20	Annotation score:
G3V2I1	G3V2I1_HUMAN	Creatine kinase B-type Creatine kinase B-type	CKB	58	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	41 – 42	EL → DV in AAA76851 (PubMed:3034271).Curated	2
Sequence conflictⁱ	78	D → G in AAA76850 (PubMed:2883200).Curated	1
Sequence conflictⁱ	78	D → G in AAA52024 (PubMed:2828370).Curated	1
Sequence conflictⁱ	98 – 99	GG → RR in AAA76851 (PubMed:3034271).Curated	2
Sequence conflictⁱ	105 – 106	EH → DD in AAA76851 (PubMed:3034271).Curated	2
Sequence conflictⁱ	130	R → G in AAA76850 (PubMed:2883200).Curated	1
Sequence conflictⁱ	132	R → A in AAA76851 (PubMed:3034271).Curated	1
Sequence conflictⁱ	144	P → Q in CAG47064 (Ref. 6) Curated	1
Sequence conflictⁱ	203	L → S in AAC31758 (PubMed:3692484).Curated	1
Sequence conflictⁱ	215 – 216	RG → AR in AAA76851 (PubMed:3034271).Curated	2
Sequence conflictⁱ	296	H → D in AAA76851 (PubMed:3034271).Curated	1
Sequence conflictⁱ	358	K → R in BAG35211 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_025838	177	K → R1 PublicationCorresponds to variant dbSNP:rs36002620Ensembl.	1
Natural variantⁱVAR_025839	309	S → L1 PublicationCorresponds to variant dbSNP:rs35156510Ensembl.	1
Natural variantⁱVAR_049674	360	L → F. Corresponds to variant dbSNP:rs12505Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M16451 mRNA Translation: AAA76851.1 M21243 M21242 Genomic DNA Translation: AAC31758.1 L47647 mRNA Translation: AAA76852.1 M16364 mRNA Translation: AAA76850.1 X15334 Genomic DNA Translation: CAA33389.1 AK290101 mRNA Translation: BAF82790.1 AK312282 mRNA Translation: BAG35211.1 CR542268 mRNA Translation: CAG47064.1 DQ333313 Genomic DNA Translation: ABC67465.1 CH471061 Genomic DNA Translation: EAW81822.1 BC001190 mRNA Translation: AAH01190.1 BC004914 mRNA Translation: AAH04914.1 BC008323 mRNA Translation: AAH08323.1 BC010002 mRNA Translation: AAH10002.1 BC019259 mRNA Translation: AAH19259.1 BC019281 mRNA Translation: AAH19281.1 M22356, M22355 Genomic DNA Translation: AAA52024.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9981.1
PIRⁱ	S15935, KIHUCB
NCBI Reference Sequences More...RefSeqⁱ	NP_001814.2, NM_001823.4

Genome annotation databases

Ensemblⁱ	ENST00000348956; ENSP00000299198; ENSG00000166165
GeneIDⁱ	1152
KEGGⁱ	hsa:1152

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P12277	Creatine kinase		HUMAN		381	UniRef100_P12277
Creatine kinase		PANTR		381
Creatine kinase (Fragment)		PONAB		217
Creatine kinase		PANTR		381
Creatine kinase (Fragment)		HUMAN		217
+1

Protein	Similar proteins		Species	Score	Length	Source
P12277	Creatine kinase B-type	)	BOVIN		381	UniRef90_P12277
Creatine kinase B-type		CANLF		381
Creatine kinase B-type		RABIT		381
Creatine kinase B-type		MOUSE		381
Creatine kinase B-type		RAT		381
+136

Protein	Similar proteins		Species	Score	Length	Source
P12277	Creatine kinase B-type		PIG		381	UniRef50_P12277
Creatine kinase B-type	)	BOVIN		381
Creatine kinase B-type		RAT		381
Creatine kinase B-type		MOUSE		381
Creatine kinase B-type		RABIT		381
+551

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Wikipedia

Creatine kinase entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M16451 mRNA Translation: AAA76851.1 M21243 M21242 Genomic DNA Translation: AAC31758.1 L47647 mRNA Translation: AAA76852.1 M16364 mRNA Translation: AAA76850.1 X15334 Genomic DNA Translation: CAA33389.1 AK290101 mRNA Translation: BAF82790.1 AK312282 mRNA Translation: BAG35211.1 CR542268 mRNA Translation: CAG47064.1 DQ333313 Genomic DNA Translation: ABC67465.1 CH471061 Genomic DNA Translation: EAW81822.1 BC001190 mRNA Translation: AAH01190.1 BC004914 mRNA Translation: AAH04914.1 BC008323 mRNA Translation: AAH08323.1 BC010002 mRNA Translation: AAH10002.1 BC019259 mRNA Translation: AAH19259.1 BC019281 mRNA Translation: AAH19281.1 M22356, M22355 Genomic DNA Translation: AAA52024.1
CCDSⁱ	CCDS9981.1
PIRⁱ	S15935, KIHUCB
RefSeqⁱ	NP_001814.2, NM_001823.4

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3B6R	X-ray	2.00	A/B	1-381	[»]
	3DRB	X-ray	2.00	A/B	1-381	[»]
	3DRE	X-ray	2.20	A/B	1-381	[»]
	6V9H	electron microscopy	4.10	A/B	1-381	[»]
SMRⁱ	P12277
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	107572, 162 interactors
CORUMⁱ	P12277
DIPⁱ	DIP-52968N
IntActⁱ	P12277, 72 interactors
MINTⁱ	P12277
STRINGⁱ	9606.ENSP00000299198

Chemistry databases

ChEMBLⁱ	CHEMBL6049
DrugBankⁱ	DB00787, Acyclovir DB00148, Creatine DB13749, Magnesium gluconate DB13191, Phosphocreatine DB00300, Tenofovir disoproxil

PTM databases

CarbonylDBⁱ	P12277
GlyGenⁱ	P12277, 1 site, 1 O-linked glycan (1 site)
iPTMnetⁱ	P12277
PhosphoSitePlusⁱ	P12277
SwissPalmⁱ	P12277

Genetic variation databases

BioMutaⁱ	CKB
DMDMⁱ	125294

2D gel databases

REPRODUCTION-2DPAGEⁱ	IPI00022977 P12277
UCD-2DPAGEⁱ	P12277

Proteomic databases

CPTACⁱ	CPTAC-476 CPTAC-477
EPDⁱ	P12277
jPOSTⁱ	P12277
MassIVEⁱ	P12277
PaxDbⁱ	P12277
PeptideAtlasⁱ	P12277
PRIDEⁱ	P12277
ProteomicsDBⁱ	52846
TopDownProteomicsⁱ	P12277

Protocols and materials databases

Antibodypediaⁱ	28, 829 antibodies
The CPTC Antibody Portal More...CPTCⁱ	P12277, 3 antibodies
The DNASU plasmid repository More...DNASUⁱ	1152

Genome annotation databases

Ensemblⁱ	ENST00000348956; ENSP00000299198; ENSG00000166165
GeneIDⁱ	1152
KEGGⁱ	hsa:1152

Organism-specific databases

CTDⁱ	1152
DisGeNETⁱ	1152
GeneCardsⁱ	CKB
HGNCⁱ	HGNC:1991, CKB
HPAⁱ	ENSG00000166165, Tissue enhanced (brain)
MIMⁱ	123280, gene
neXtProtⁱ	NX_P12277
OpenTargetsⁱ	ENSG00000166165
PharmGKBⁱ	PA26528
VEuPathDBⁱ	HostDB:ENSG00000166165
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3581, Eukaryota
GeneTreeⁱ	ENSGT00950000182772
HOGENOMⁱ	CLU_019868_4_2_1
InParanoidⁱ	P12277
OMAⁱ	DMMPEQK
PhylomeDBⁱ	P12277
TreeFamⁱ	TF314214

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS09344-MONOMER
BRENDAⁱ	2.7.3.2, 2681
PathwayCommonsⁱ	P12277
Reactomeⁱ	R-HSA-71288, Creatine metabolism R-HSA-9696264, RND3 GTPase cycle
SABIO-RKⁱ	P12277

Miscellaneous databases

BioGRID-ORCSⁱ	1152, 1 hit in 1013 CRISPR screens
ChiTaRSⁱ	CKB, human
EvolutionaryTraceⁱ	P12277
GeneWikiⁱ	CKB_(gene)
GenomeRNAiⁱ	1152
Pharosⁱ	P12277, Tbio
Protein Ontology More...PROⁱ	PR:P12277
RNActⁱ	P12277, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000166165, Expressed in ventricular zone and 131 other tissues
ExpressionAtlasⁱ	P12277, baseline and differential
Genevisibleⁱ	P12277, HS

Family and domain databases

Gene3Dⁱ	1.10.135.10, 1 hit
InterProⁱ	View protein in InterPro IPR000749, ATP-guanido_PTrfase IPR022415, ATP-guanido_PTrfase_AS IPR022414, ATP-guanido_PTrfase_cat IPR022413, ATP-guanido_PTrfase_N IPR036802, ATP-guanido_PTrfase_N_sf IPR014746, Gln_synth/guanido_kin_cat_dom
PANTHERⁱ	PTHR11547, PTHR11547, 2 hits
Pfamⁱ	View protein in Pfam PF00217, ATP-gua_Ptrans, 1 hit PF02807, ATP-gua_PtransN, 1 hit
SUPFAMⁱ	SSF48034, SSF48034, 1 hit SSF55931, SSF55931, 1 hit
PROSITEⁱ	View protein in PROSITE PS00112, PHOSPHAGEN_KINASE, 1 hit PS51510, PHOSPHAGEN_KINASE_C, 1 hit PS51509, PHOSPHAGEN_KINASE_N, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KCRB_HUMAN
Accessionⁱ	P12277Primary (citable) accession number: P12277 Secondary accession number(s): A8K236 , B2R5R4, Q2LE07, Q6FG40, Q9UC66
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
	Last sequence update:	October 1, 1989
	Last modified:	September 29, 2021
	This is version 217 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing, Reference proteome

Documents

Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - P12277 (KCRB_HUMAN)

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Creatine kinase B-type

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Enzyme and pathway databases

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Organism-specific databases

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Proteomic databases

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PTM databases

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P12277

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Secondary structure

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Domains and Repeats

Region

Compositional bias

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Genome annotation databases

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Sequence databases

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ