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Protein

Prolactin-inducible protein

Gene

PIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: UniProtKB
  • aspartic-type endopeptidase activity Source: UniProtKB
  • IgG binding Source: UniProtKB
  • protein dimerization activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5223345 Miscellaneous transport and binding events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prolactin-inducible protein
Alternative name(s):
Gross cystic disease fluid protein 15
Short name:
GCDFP-15
Prolactin-induced protein
Secretory actin-binding protein
Short name:
SABP
gp17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PIP
Synonyms:GCDFP15, GPIP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000159763.3

Human Gene Nomenclature Database

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HGNCi
HGNC:8993 PIP

Online Mendelian Inheritance in Man (OMIM)

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MIMi
176720 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P12273

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5304

Open Targets

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OpenTargetsi
ENSG00000159763

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA33326

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
PIP

Domain mapping of disease mutations (DMDM)

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DMDMi
134170

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 282 PublicationsAdd BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002428829 – 146Prolactin-inducible protein1 PublicationAdd BLAST118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei29Pyrrolidone carboxylic acid2 Publications1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi65 ↔ 911 Publication
Disulfide bondi89 ↔ 1231 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi105N-linked (GlcNAc...) asparagine4 Publications1

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P12273

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P12273

MaxQB - The MaxQuant DataBase

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MaxQBi
P12273

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P12273

PeptideAtlas

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PeptideAtlasi
P12273

PRoteomics IDEntifications database

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PRIDEi
P12273

ProteomicsDB human proteome resource

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ProteomicsDBi
52845

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1636

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P12273

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P12273

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P12273

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in pathological conditions of the mammary gland and in several exocrine tissues, such as the lacrimal, salivary, and sweat glands.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By prolactin and androgen; inhibited by estrogen.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000159763 Expressed in 130 organ(s), highest expression level in seminal vesicle

CleanEx database of gene expression profiles

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CleanExi
HS_PIP

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P12273 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB002661
HPA009177

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Interacts with AZGP1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111321, 114 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P12273

Protein interaction database and analysis system

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IntActi
P12273, 18 interactors

Molecular INTeraction database

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MINTi
P12273

STRING: functional protein association networks

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STRINGi
9606.ENSP00000291009

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1146
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ES6X-ray3.23B29-146[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P12273

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P12273

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P12273

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PIP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IZUS Eukaryota
ENOG41116UQ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000002099

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000253013

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG065978

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P12273

Identification of Orthologs from Complete Genome Data

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OMAi
IRELGIC

Database of Orthologous Groups

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OrthoDBi
1459895at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P12273

TreeFam database of animal gene trees

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TreeFami
TF336919

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR007990 PIP

The PANTHER Classification System

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PANTHERi
PTHR15096 PTHR15096, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF05326 SVA, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF002572 PIP-GCDFP-15, 1 hit

ProDom; a protein domain database

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ProDomi
View protein in ProDom or Entries sharing at least one domain
PD021604 SV_autoAg, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81296 SSF81296, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P12273-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLLQLLFRA SPATLLLVLC LQLGANKAQD NTRKIIIKNF DIPKSVRPND
60 70 80 90 100
EVTAVLAVQT ELKECMVVKT YLISSIPLQG AFNYKYTACL CDDNPKTFYW
110 120 130 140
DFYTNRTVQI AAVVDVIREL GICPDDAAVI PIKNNRFYTI EILKVE
Length:146
Mass (Da):16,572
Last modified:October 1, 1989 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i93F3DA201133F03C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J03460 mRNA Translation: AAA60091.1
X51501, X51502, X51504 Genomic DNA Translation: CAA35870.1
Y10179 mRNA Translation: CAA71252.1
AK312227 mRNA Translation: BAG35160.1
CH236959 Genomic DNA Translation: EAL23781.1
CH471198 Genomic DNA Translation: EAW51887.1
BC010950 mRNA Translation: AAH10950.1
BC010951 mRNA Translation: AAH10951.1
AB267097 Genomic DNA Translation: BAF35627.1
AB267098 Genomic DNA Translation: BAF35628.1
AB267099 Genomic DNA Translation: BAF35629.1
AB267100 Genomic DNA Translation: BAF35630.1
AB267101 Genomic DNA Translation: BAF35631.1
AB267102 Genomic DNA Translation: BAF35632.1
AB267103 Genomic DNA Translation: BAF35633.1
AB267104 Genomic DNA Translation: BAF35634.1
AB267105 Genomic DNA Translation: BAF35635.1
AB267106 Genomic DNA Translation: BAF35636.1
AB267107 Genomic DNA Translation: BAF35637.1
AB267108 Genomic DNA Translation: BAF35638.1
AB267109 Genomic DNA Translation: BAF35639.1
AB267110 Genomic DNA Translation: BAF35640.1
AB267111 Genomic DNA Translation: BAF35641.1
AB267112 Genomic DNA Translation: BAF35642.1
AB267113 Genomic DNA Translation: BAF35643.1
AB267114 Genomic DNA Translation: BAF35644.1
AB267115 Genomic DNA Translation: BAF35645.1
AB267116 Genomic DNA Translation: BAF35646.1
AB267117 Genomic DNA Translation: BAF35647.1
AB267118 Genomic DNA Translation: BAF35648.1
AB267119 Genomic DNA Translation: BAF35649.1
AB267120 Genomic DNA Translation: BAF35650.1
AB267121 Genomic DNA Translation: BAF35651.1
AB267122 Genomic DNA Translation: BAF35652.1
AB267123 Genomic DNA Translation: BAF35653.1
AB267124 Genomic DNA Translation: BAF35654.1
AB267125 Genomic DNA Translation: BAF35655.1
AB267126 Genomic DNA Translation: BAF35656.1
AB267127 Genomic DNA Translation: BAF35657.1
AB267128 Genomic DNA Translation: BAF35658.1
AB267129 Genomic DNA Translation: BAF35659.1
AB267130 Genomic DNA Translation: BAF35660.1
AB267131 Genomic DNA Translation: BAF35661.1
AB267132 Genomic DNA Translation: BAF35662.1
AB267133 Genomic DNA Translation: BAF35663.1
AB267134 Genomic DNA Translation: BAF35664.1
AB267135 Genomic DNA Translation: BAF35665.1
AB267136 Genomic DNA Translation: BAF35666.1
AB267137 Genomic DNA Translation: BAF35667.1
AB267138 Genomic DNA Translation: BAF35668.1
AB267139 Genomic DNA Translation: BAF35669.1
AB267140 Genomic DNA Translation: BAF35670.1
AB267141 Genomic DNA Translation: BAF35671.1
AB267142 Genomic DNA Translation: BAF35672.1
AB267143 Genomic DNA Translation: BAF35673.1
AB267144 Genomic DNA Translation: BAF35674.1
AB267145 Genomic DNA Translation: BAF35675.1
AB267146 Genomic DNA Translation: BAF35676.1
AB267147 Genomic DNA Translation: BAF35677.1
AB267148 Genomic DNA Translation: BAF35678.1
AB267149 Genomic DNA Translation: BAF35679.1
AB267150 Genomic DNA Translation: BAF35680.1
AB267151 Genomic DNA Translation: BAF35681.1
AB267152 Genomic DNA Translation: BAF35682.1
AB267153 Genomic DNA Translation: BAF35683.1
AB267154 Genomic DNA Translation: BAF35684.1
AB267155 Genomic DNA Translation: BAF35685.1
AB267156 Genomic DNA Translation: BAF35686.1
AB267157 Genomic DNA Translation: BAF35687.1
AB267158 Genomic DNA Translation: BAF35688.1
AB267159 Genomic DNA Translation: BAF35689.1
AB267160 Genomic DNA Translation: BAF35690.1
AB267161 Genomic DNA Translation: BAF35691.1
AB267162 Genomic DNA Translation: BAF35692.1
AB267163 Genomic DNA Translation: BAF35693.1
AB267164 Genomic DNA Translation: BAF35694.1
AB267165 Genomic DNA Translation: BAF35695.1
AB267166 Genomic DNA Translation: BAF35696.1
AB267167 Genomic DNA Translation: BAF35697.1
AB267168 Genomic DNA Translation: BAF35698.1
AB267169 Genomic DNA Translation: BAF35699.1
AB267170 Genomic DNA Translation: BAF35700.1
AB267171 Genomic DNA Translation: BAF35701.1
AB267172 Genomic DNA Translation: BAF35702.1
AB267173 Genomic DNA Translation: BAF35703.1
AB267174 Genomic DNA Translation: BAF35704.1
AB267175 Genomic DNA Translation: BAF35705.1
AB267176 Genomic DNA Translation: BAF35706.1
AB267177 Genomic DNA Translation: BAF35707.1
AB267178 Genomic DNA Translation: BAF35708.1
AB267179 Genomic DNA Translation: BAF35709.1
AB267180 Genomic DNA Translation: BAF35710.1
AB267181 Genomic DNA Translation: BAF35711.1
AB267182 Genomic DNA Translation: BAF35712.1
AB267183 Genomic DNA Translation: BAF35713.1
AB267184 Genomic DNA Translation: BAF35714.1
AB267185 Genomic DNA Translation: BAF35715.1
AB267186 Genomic DNA Translation: BAF35716.1
AB267187 Genomic DNA Translation: BAF35717.1
AB267188 Genomic DNA Translation: BAF35718.1
AB267189 Genomic DNA Translation: BAF35719.1
AB267190 Genomic DNA Translation: BAF35720.1
AB267191 Genomic DNA Translation: BAF35721.1
AB267192 Genomic DNA Translation: BAF35722.1
AB267193 Genomic DNA Translation: BAF35723.1
AB267194 Genomic DNA Translation: BAF35724.1
AB267195 Genomic DNA Translation: BAF35725.1
AB267196 Genomic DNA Translation: BAF35726.1
AB267197 Genomic DNA Translation: BAF35727.1
AB267198 Genomic DNA Translation: BAF35728.1
AB267199 Genomic DNA Translation: BAF35729.1
AB267200 Genomic DNA Translation: BAF35730.1
AB267201 Genomic DNA Translation: BAF35731.1
AB267202 Genomic DNA Translation: BAF35732.1
AB267203 Genomic DNA Translation: BAF35733.1
AB267204 Genomic DNA Translation: BAF35734.1
AB267205 Genomic DNA Translation: BAF35735.1
AB267206 Genomic DNA Translation: BAF35736.1
AB267207 Genomic DNA Translation: BAF35737.1
AB267208 Genomic DNA Translation: BAF35738.1
AB267209 Genomic DNA Translation: BAF35739.1
AB267210 Genomic DNA Translation: BAF35740.1
AB267211 Genomic DNA Translation: BAF35741.1
AB267212 Genomic DNA Translation: BAF35742.1
AB267213 Genomic DNA Translation: BAF35743.1
AB267214 Genomic DNA Translation: BAF35744.1
AB267215 Genomic DNA Translation: BAF35745.1
AB267216 Genomic DNA Translation: BAF35746.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS34768.1

Protein sequence database of the Protein Information Resource

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PIRi
I37432 SQHUAC

NCBI Reference Sequences

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RefSeqi
NP_002643.1, NM_002652.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.99949

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000291009; ENSP00000291009; ENSG00000159763

Database of genes from NCBI RefSeq genomes

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GeneIDi
5304

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5304

UCSC genome browser

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UCSCi
uc003wcf.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03460 mRNA Translation: AAA60091.1
X51501, X51502, X51504 Genomic DNA Translation: CAA35870.1
Y10179 mRNA Translation: CAA71252.1
AK312227 mRNA Translation: BAG35160.1
CH236959 Genomic DNA Translation: EAL23781.1
CH471198 Genomic DNA Translation: EAW51887.1
BC010950 mRNA Translation: AAH10950.1
BC010951 mRNA Translation: AAH10951.1
AB267097 Genomic DNA Translation: BAF35627.1
AB267098 Genomic DNA Translation: BAF35628.1
AB267099 Genomic DNA Translation: BAF35629.1
AB267100 Genomic DNA Translation: BAF35630.1
AB267101 Genomic DNA Translation: BAF35631.1
AB267102 Genomic DNA Translation: BAF35632.1
AB267103 Genomic DNA Translation: BAF35633.1
AB267104 Genomic DNA Translation: BAF35634.1
AB267105 Genomic DNA Translation: BAF35635.1
AB267106 Genomic DNA Translation: BAF35636.1
AB267107 Genomic DNA Translation: BAF35637.1
AB267108 Genomic DNA Translation: BAF35638.1
AB267109 Genomic DNA Translation: BAF35639.1
AB267110 Genomic DNA Translation: BAF35640.1
AB267111 Genomic DNA Translation: BAF35641.1
AB267112 Genomic DNA Translation: BAF35642.1
AB267113 Genomic DNA Translation: BAF35643.1
AB267114 Genomic DNA Translation: BAF35644.1
AB267115 Genomic DNA Translation: BAF35645.1
AB267116 Genomic DNA Translation: BAF35646.1
AB267117 Genomic DNA Translation: BAF35647.1
AB267118 Genomic DNA Translation: BAF35648.1
AB267119 Genomic DNA Translation: BAF35649.1
AB267120 Genomic DNA Translation: BAF35650.1
AB267121 Genomic DNA Translation: BAF35651.1
AB267122 Genomic DNA Translation: BAF35652.1
AB267123 Genomic DNA Translation: BAF35653.1
AB267124 Genomic DNA Translation: BAF35654.1
AB267125 Genomic DNA Translation: BAF35655.1
AB267126 Genomic DNA Translation: BAF35656.1
AB267127 Genomic DNA Translation: BAF35657.1
AB267128 Genomic DNA Translation: BAF35658.1
AB267129 Genomic DNA Translation: BAF35659.1
AB267130 Genomic DNA Translation: BAF35660.1
AB267131 Genomic DNA Translation: BAF35661.1
AB267132 Genomic DNA Translation: BAF35662.1
AB267133 Genomic DNA Translation: BAF35663.1
AB267134 Genomic DNA Translation: BAF35664.1
AB267135 Genomic DNA Translation: BAF35665.1
AB267136 Genomic DNA Translation: BAF35666.1
AB267137 Genomic DNA Translation: BAF35667.1
AB267138 Genomic DNA Translation: BAF35668.1
AB267139 Genomic DNA Translation: BAF35669.1
AB267140 Genomic DNA Translation: BAF35670.1
AB267141 Genomic DNA Translation: BAF35671.1
AB267142 Genomic DNA Translation: BAF35672.1
AB267143 Genomic DNA Translation: BAF35673.1
AB267144 Genomic DNA Translation: BAF35674.1
AB267145 Genomic DNA Translation: BAF35675.1
AB267146 Genomic DNA Translation: BAF35676.1
AB267147 Genomic DNA Translation: BAF35677.1
AB267148 Genomic DNA Translation: BAF35678.1
AB267149 Genomic DNA Translation: BAF35679.1
AB267150 Genomic DNA Translation: BAF35680.1
AB267151 Genomic DNA Translation: BAF35681.1
AB267152 Genomic DNA Translation: BAF35682.1
AB267153 Genomic DNA Translation: BAF35683.1
AB267154 Genomic DNA Translation: BAF35684.1
AB267155 Genomic DNA Translation: BAF35685.1
AB267156 Genomic DNA Translation: BAF35686.1
AB267157 Genomic DNA Translation: BAF35687.1
AB267158 Genomic DNA Translation: BAF35688.1
AB267159 Genomic DNA Translation: BAF35689.1
AB267160 Genomic DNA Translation: BAF35690.1
AB267161 Genomic DNA Translation: BAF35691.1
AB267162 Genomic DNA Translation: BAF35692.1
AB267163 Genomic DNA Translation: BAF35693.1
AB267164 Genomic DNA Translation: BAF35694.1
AB267165 Genomic DNA Translation: BAF35695.1
AB267166 Genomic DNA Translation: BAF35696.1
AB267167 Genomic DNA Translation: BAF35697.1
AB267168 Genomic DNA Translation: BAF35698.1
AB267169 Genomic DNA Translation: BAF35699.1
AB267170 Genomic DNA Translation: BAF35700.1
AB267171 Genomic DNA Translation: BAF35701.1
AB267172 Genomic DNA Translation: BAF35702.1
AB267173 Genomic DNA Translation: BAF35703.1
AB267174 Genomic DNA Translation: BAF35704.1
AB267175 Genomic DNA Translation: BAF35705.1
AB267176 Genomic DNA Translation: BAF35706.1
AB267177 Genomic DNA Translation: BAF35707.1
AB267178 Genomic DNA Translation: BAF35708.1
AB267179 Genomic DNA Translation: BAF35709.1
AB267180 Genomic DNA Translation: BAF35710.1
AB267181 Genomic DNA Translation: BAF35711.1
AB267182 Genomic DNA Translation: BAF35712.1
AB267183 Genomic DNA Translation: BAF35713.1
AB267184 Genomic DNA Translation: BAF35714.1
AB267185 Genomic DNA Translation: BAF35715.1
AB267186 Genomic DNA Translation: BAF35716.1
AB267187 Genomic DNA Translation: BAF35717.1
AB267188 Genomic DNA Translation: BAF35718.1
AB267189 Genomic DNA Translation: BAF35719.1
AB267190 Genomic DNA Translation: BAF35720.1
AB267191 Genomic DNA Translation: BAF35721.1
AB267192 Genomic DNA Translation: BAF35722.1
AB267193 Genomic DNA Translation: BAF35723.1
AB267194 Genomic DNA Translation: BAF35724.1
AB267195 Genomic DNA Translation: BAF35725.1
AB267196 Genomic DNA Translation: BAF35726.1
AB267197 Genomic DNA Translation: BAF35727.1
AB267198 Genomic DNA Translation: BAF35728.1
AB267199 Genomic DNA Translation: BAF35729.1
AB267200 Genomic DNA Translation: BAF35730.1
AB267201 Genomic DNA Translation: BAF35731.1
AB267202 Genomic DNA Translation: BAF35732.1
AB267203 Genomic DNA Translation: BAF35733.1
AB267204 Genomic DNA Translation: BAF35734.1
AB267205 Genomic DNA Translation: BAF35735.1
AB267206 Genomic DNA Translation: BAF35736.1
AB267207 Genomic DNA Translation: BAF35737.1
AB267208 Genomic DNA Translation: BAF35738.1
AB267209 Genomic DNA Translation: BAF35739.1
AB267210 Genomic DNA Translation: BAF35740.1
AB267211 Genomic DNA Translation: BAF35741.1
AB267212 Genomic DNA Translation: BAF35742.1
AB267213 Genomic DNA Translation: BAF35743.1
AB267214 Genomic DNA Translation: BAF35744.1
AB267215 Genomic DNA Translation: BAF35745.1
AB267216 Genomic DNA Translation: BAF35746.1
CCDSiCCDS34768.1
PIRiI37432 SQHUAC
RefSeqiNP_002643.1, NM_002652.2
UniGeneiHs.99949

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ES6X-ray3.23B29-146[»]
ProteinModelPortaliP12273
SMRiP12273
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111321, 114 interactors
CORUMiP12273
IntActiP12273, 18 interactors
MINTiP12273
STRINGi9606.ENSP00000291009

PTM databases

GlyConnecti1636
iPTMnetiP12273
PhosphoSitePlusiP12273
SwissPalmiP12273

Polymorphism and mutation databases

BioMutaiPIP
DMDMi134170

Proteomic databases

EPDiP12273
jPOSTiP12273
MaxQBiP12273
PaxDbiP12273
PeptideAtlasiP12273
PRIDEiP12273
ProteomicsDBi52845

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5304
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291009; ENSP00000291009; ENSG00000159763
GeneIDi5304
KEGGihsa:5304
UCSCiuc003wcf.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5304
DisGeNETi5304
EuPathDBiHostDB:ENSG00000159763.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PIP
HGNCiHGNC:8993 PIP
HPAiCAB002661
HPA009177
MIMi176720 gene
neXtProtiNX_P12273
OpenTargetsiENSG00000159763
PharmGKBiPA33326

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IZUS Eukaryota
ENOG41116UQ LUCA
GeneTreeiENSGT00390000002099
HOGENOMiHOG000253013
HOVERGENiHBG065978
InParanoidiP12273
OMAiIRELGIC
OrthoDBi1459895at2759
PhylomeDBiP12273
TreeFamiTF336919

Enzyme and pathway databases

ReactomeiR-HSA-5223345 Miscellaneous transport and binding events

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PIP human
EvolutionaryTraceiP12273

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Prolactin-induced_protein

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5304

Protein Ontology

More...
PROi
PR:P12273

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000159763 Expressed in 130 organ(s), highest expression level in seminal vesicle
CleanExiHS_PIP
GenevisibleiP12273 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR007990 PIP
PANTHERiPTHR15096 PTHR15096, 1 hit
PfamiView protein in Pfam
PF05326 SVA, 1 hit
PIRSFiPIRSF002572 PIP-GCDFP-15, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD021604 SV_autoAg, 1 hit
SUPFAMiSSF81296 SSF81296, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPIP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P12273
Secondary accession number(s): A0A963
, A0A9C3, A0A9F3, A4D2I1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: January 16, 2019
This is version 180 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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