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Protein

Prolactin-inducible protein

Gene

PIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • aspartic-type endopeptidase activity Source: UniProtKB
  • IgG binding Source: UniProtKB
  • protein dimerization activity Source: UniProtKB

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProtKB
  • negative regulation of T cell apoptotic process Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • proteolysis Source: UniProtKB
  • retina homeostasis Source: UniProtKB
  • transmembrane transport Source: Reactome

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-HSA-5223345 Miscellaneous transport and binding events

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin-inducible protein
Alternative name(s):
Gross cystic disease fluid protein 15
Short name:
GCDFP-15
Prolactin-induced protein
Secretory actin-binding protein
Short name:
SABP
gp17
Gene namesi
Name:PIP
Synonyms:GCDFP15, GPIP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000159763.3
HGNCiHGNC:8993 PIP
MIMi176720 gene
neXtProtiNX_P12273

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5304
OpenTargetsiENSG00000159763
PharmGKBiPA33326

Polymorphism and mutation databases

BioMutaiPIP
DMDMi134170

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 282 PublicationsAdd BLAST28
ChainiPRO_000002428829 – 146Prolactin-inducible protein1 PublicationAdd BLAST118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29Pyrrolidone carboxylic acid2 Publications1
Disulfide bondi65 ↔ 911 Publication
Disulfide bondi89 ↔ 1231 Publication
Glycosylationi105N-linked (GlcNAc...) asparagine4 Publications1

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDiP12273
MaxQBiP12273
PaxDbiP12273
PeptideAtlasiP12273
PRIDEiP12273
ProteomicsDBi52845

PTM databases

iPTMnetiP12273
PhosphoSitePlusiP12273
SwissPalmiP12273

Expressioni

Tissue specificityi

Expressed in pathological conditions of the mammary gland and in several exocrine tissues, such as the lacrimal, salivary, and sweat glands.

Inductioni

By prolactin and androgen; inhibited by estrogen.

Gene expression databases

BgeeiENSG00000159763
CleanExiHS_PIP
GenevisibleiP12273 HS

Organism-specific databases

HPAiCAB002661
HPA009177

Interactioni

Subunit structurei

Monomer. Interacts with AZGP1.1 Publication

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • protein dimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi111321, 110 interactors
CORUMiP12273
IntActiP12273, 20 interactors
MINTiP12273
STRINGi9606.ENSP00000291009

Structurei

Secondary structure

1146
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi44 – 46Combined sources3
Beta strandi52 – 60Combined sources9
Beta strandi66 – 76Combined sources11
Helixi81 – 83Combined sources3
Beta strandi85 – 90Combined sources6
Beta strandi92 – 94Combined sources3
Beta strandi96 – 102Combined sources7
Beta strandi108 – 116Combined sources9
Beta strandi120 – 123Combined sources4
Helixi124 – 126Combined sources3
Beta strandi136 – 145Combined sources10

3D structure databases

ProteinModelPortaliP12273
SMRiP12273
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12273

Family & Domainsi

Sequence similaritiesi

Belongs to the PIP family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZUS Eukaryota
ENOG41116UQ LUCA
GeneTreeiENSGT00390000002099
HOGENOMiHOG000253013
HOVERGENiHBG065978
InParanoidiP12273
OMAiIRELGIC
OrthoDBiEOG091G0YJ1
PhylomeDBiP12273
TreeFamiTF336919

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR007990 PIP
PANTHERiPTHR15096 PTHR15096, 1 hit
PfamiView protein in Pfam
PF05326 SVA, 1 hit
PIRSFiPIRSF002572 PIP-GCDFP-15, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD021604 SV_autoAg, 1 hit
SUPFAMiSSF81296 SSF81296, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLQLLFRA SPATLLLVLC LQLGANKAQD NTRKIIIKNF DIPKSVRPND
60 70 80 90 100
EVTAVLAVQT ELKECMVVKT YLISSIPLQG AFNYKYTACL CDDNPKTFYW
110 120 130 140
DFYTNRTVQI AAVVDVIREL GICPDDAAVI PIKNNRFYTI EILKVE
Length:146
Mass (Da):16,572
Last modified:October 1, 1989 - v1
Checksum:i93F3DA201133F03C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03460 mRNA Translation: AAA60091.1
X51501, X51502, X51504 Genomic DNA Translation: CAA35870.1
Y10179 mRNA Translation: CAA71252.1
AK312227 mRNA Translation: BAG35160.1
CH236959 Genomic DNA Translation: EAL23781.1
CH471198 Genomic DNA Translation: EAW51887.1
BC010950 mRNA Translation: AAH10950.1
BC010951 mRNA Translation: AAH10951.1
AB267097 Genomic DNA Translation: BAF35627.1
AB267098 Genomic DNA Translation: BAF35628.1
AB267099 Genomic DNA Translation: BAF35629.1
AB267100 Genomic DNA Translation: BAF35630.1
AB267101 Genomic DNA Translation: BAF35631.1
AB267102 Genomic DNA Translation: BAF35632.1
AB267103 Genomic DNA Translation: BAF35633.1
AB267104 Genomic DNA Translation: BAF35634.1
AB267105 Genomic DNA Translation: BAF35635.1
AB267106 Genomic DNA Translation: BAF35636.1
AB267107 Genomic DNA Translation: BAF35637.1
AB267108 Genomic DNA Translation: BAF35638.1
AB267109 Genomic DNA Translation: BAF35639.1
AB267110 Genomic DNA Translation: BAF35640.1
AB267111 Genomic DNA Translation: BAF35641.1
AB267112 Genomic DNA Translation: BAF35642.1
AB267113 Genomic DNA Translation: BAF35643.1
AB267114 Genomic DNA Translation: BAF35644.1
AB267115 Genomic DNA Translation: BAF35645.1
AB267116 Genomic DNA Translation: BAF35646.1
AB267117 Genomic DNA Translation: BAF35647.1
AB267118 Genomic DNA Translation: BAF35648.1
AB267119 Genomic DNA Translation: BAF35649.1
AB267120 Genomic DNA Translation: BAF35650.1
AB267121 Genomic DNA Translation: BAF35651.1
AB267122 Genomic DNA Translation: BAF35652.1
AB267123 Genomic DNA Translation: BAF35653.1
AB267124 Genomic DNA Translation: BAF35654.1
AB267125 Genomic DNA Translation: BAF35655.1
AB267126 Genomic DNA Translation: BAF35656.1
AB267127 Genomic DNA Translation: BAF35657.1
AB267128 Genomic DNA Translation: BAF35658.1
AB267129 Genomic DNA Translation: BAF35659.1
AB267130 Genomic DNA Translation: BAF35660.1
AB267131 Genomic DNA Translation: BAF35661.1
AB267132 Genomic DNA Translation: BAF35662.1
AB267133 Genomic DNA Translation: BAF35663.1
AB267134 Genomic DNA Translation: BAF35664.1
AB267135 Genomic DNA Translation: BAF35665.1
AB267136 Genomic DNA Translation: BAF35666.1
AB267137 Genomic DNA Translation: BAF35667.1
AB267138 Genomic DNA Translation: BAF35668.1
AB267139 Genomic DNA Translation: BAF35669.1
AB267140 Genomic DNA Translation: BAF35670.1
AB267141 Genomic DNA Translation: BAF35671.1
AB267142 Genomic DNA Translation: BAF35672.1
AB267143 Genomic DNA Translation: BAF35673.1
AB267144 Genomic DNA Translation: BAF35674.1
AB267145 Genomic DNA Translation: BAF35675.1
AB267146 Genomic DNA Translation: BAF35676.1
AB267147 Genomic DNA Translation: BAF35677.1
AB267148 Genomic DNA Translation: BAF35678.1
AB267149 Genomic DNA Translation: BAF35679.1
AB267150 Genomic DNA Translation: BAF35680.1
AB267151 Genomic DNA Translation: BAF35681.1
AB267152 Genomic DNA Translation: BAF35682.1
AB267153 Genomic DNA Translation: BAF35683.1
AB267154 Genomic DNA Translation: BAF35684.1
AB267155 Genomic DNA Translation: BAF35685.1
AB267156 Genomic DNA Translation: BAF35686.1
AB267157 Genomic DNA Translation: BAF35687.1
AB267158 Genomic DNA Translation: BAF35688.1
AB267159 Genomic DNA Translation: BAF35689.1
AB267160 Genomic DNA Translation: BAF35690.1
AB267161 Genomic DNA Translation: BAF35691.1
AB267162 Genomic DNA Translation: BAF35692.1
AB267163 Genomic DNA Translation: BAF35693.1
AB267164 Genomic DNA Translation: BAF35694.1
AB267165 Genomic DNA Translation: BAF35695.1
AB267166 Genomic DNA Translation: BAF35696.1
AB267167 Genomic DNA Translation: BAF35697.1
AB267168 Genomic DNA Translation: BAF35698.1
AB267169 Genomic DNA Translation: BAF35699.1
AB267170 Genomic DNA Translation: BAF35700.1
AB267171 Genomic DNA Translation: BAF35701.1
AB267172 Genomic DNA Translation: BAF35702.1
AB267173 Genomic DNA Translation: BAF35703.1
AB267174 Genomic DNA Translation: BAF35704.1
AB267175 Genomic DNA Translation: BAF35705.1
AB267176 Genomic DNA Translation: BAF35706.1
AB267177 Genomic DNA Translation: BAF35707.1
AB267178 Genomic DNA Translation: BAF35708.1
AB267179 Genomic DNA Translation: BAF35709.1
AB267180 Genomic DNA Translation: BAF35710.1
AB267181 Genomic DNA Translation: BAF35711.1
AB267182 Genomic DNA Translation: BAF35712.1
AB267183 Genomic DNA Translation: BAF35713.1
AB267184 Genomic DNA Translation: BAF35714.1
AB267185 Genomic DNA Translation: BAF35715.1
AB267186 Genomic DNA Translation: BAF35716.1
AB267187 Genomic DNA Translation: BAF35717.1
AB267188 Genomic DNA Translation: BAF35718.1
AB267189 Genomic DNA Translation: BAF35719.1
AB267190 Genomic DNA Translation: BAF35720.1
AB267191 Genomic DNA Translation: BAF35721.1
AB267192 Genomic DNA Translation: BAF35722.1
AB267193 Genomic DNA Translation: BAF35723.1
AB267194 Genomic DNA Translation: BAF35724.1
AB267195 Genomic DNA Translation: BAF35725.1
AB267196 Genomic DNA Translation: BAF35726.1
AB267197 Genomic DNA Translation: BAF35727.1
AB267198 Genomic DNA Translation: BAF35728.1
AB267199 Genomic DNA Translation: BAF35729.1
AB267200 Genomic DNA Translation: BAF35730.1
AB267201 Genomic DNA Translation: BAF35731.1
AB267202 Genomic DNA Translation: BAF35732.1
AB267203 Genomic DNA Translation: BAF35733.1
AB267204 Genomic DNA Translation: BAF35734.1
AB267205 Genomic DNA Translation: BAF35735.1
AB267206 Genomic DNA Translation: BAF35736.1
AB267207 Genomic DNA Translation: BAF35737.1
AB267208 Genomic DNA Translation: BAF35738.1
AB267209 Genomic DNA Translation: BAF35739.1
AB267210 Genomic DNA Translation: BAF35740.1
AB267211 Genomic DNA Translation: BAF35741.1
AB267212 Genomic DNA Translation: BAF35742.1
AB267213 Genomic DNA Translation: BAF35743.1
AB267214 Genomic DNA Translation: BAF35744.1
AB267215 Genomic DNA Translation: BAF35745.1
AB267216 Genomic DNA Translation: BAF35746.1
CCDSiCCDS34768.1
PIRiI37432 SQHUAC
RefSeqiNP_002643.1, NM_002652.2
UniGeneiHs.99949

Genome annotation databases

EnsembliENST00000291009; ENSP00000291009; ENSG00000159763
GeneIDi5304
KEGGihsa:5304
UCSCiuc003wcf.2 human

Similar proteinsi

Entry informationi

Entry nameiPIP_HUMAN
AccessioniPrimary (citable) accession number: P12273
Secondary accession number(s): A0A963
, A0A9C3, A0A9F3, A4D2I1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: July 18, 2018
This is version 176 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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