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UniProtKB - P12259 (FA5_HUMAN)

Entry version 242 (25 May 2022)
Sequence version 4 (05 Oct 2010)
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Protein

Coagulation factor V

Gene

F5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by SERPINA5.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi139CalciumBy similarity1
Metal bindingi140CalciumBy similarity1
Metal bindingi1843CopperBy similarity1
Metal bindingi1845CopperBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBlood coagulation, Hemostasis
LigandCalcium, Copper, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P12259

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114608, Platelet degranulation
R-HSA-140875, Common Pathway of Fibrin Clot Formation
R-HSA-204005, COPII-mediated vesicle transport
R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-5694530, Cargo concentration in the ER
R-HSA-8957275, Post-translational protein phosphorylation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P12259

SIGNOR Signaling Network Open Resource

More...SIGNORi		P12259

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coagulation factor V
Alternative name(s):
Activated protein C cofactor
Proaccelerin, labile factor
Cleaved into the following 2 chains:
Coagulation factor V heavy chain
Coagulation factor V light chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:F5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3542, F5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612309, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P12259

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000198734

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Factor V deficiency (FA5D)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA blood coagulation disorder leading to a hemorrhagic diathesis known as parahemophilia.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0327001730Y → C in FA5D; Seoul 2. 2 PublicationsCorresponds to variant dbSNP:rs118203907EnsemblClinVar.1
Natural variantiVAR_0327012102R → C in FA5D; impairs both factor V secretion and activity. 1 PublicationCorresponds to variant dbSNP:rs118203910EnsemblClinVar.1
Thrombophilia due to activated protein C resistance (THPH2)9 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA hemostatic disorder due to defective degradation of factor V by activated protein C. It is characterized by a poor anticoagulant response to activated protein C resulting in tendency to thrombosis.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013621334R → T in THPH2; Cambridge. 1 PublicationCorresponds to variant dbSNP:rs118203906EnsemblClinVar.1
Natural variantiVAR_032698387I → T in THPH2; Liverpool; mutant protein is expressed with an additional carbohydrate chain. 2 PublicationsCorresponds to variant dbSNP:rs118203911EnsemblClinVar.1
Natural variantiVAR_001213534R → Q in THPH2; factor V Leiden; associated with susceptibility to Budd-Chiari syndrome; associated with susceptibility to ischemic stroke. 5 PublicationsCorresponds to variant dbSNP:rs6025EnsemblClinVar.1
Natural variantiVAR_032699613C → R in THPH2; Nijkerk. 1 PublicationCorresponds to variant dbSNP:rs1453479152Ensembl.1
Natural variantiVAR_0173292102R → H in THPH2. 1 Publication1
Budd-Chiari syndrome (BDCHS)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionA syndrome caused by obstruction of hepatic venous outflow involving either the hepatic veins or the terminal segment of the inferior vena cava. Obstructions are generally caused by thrombosis and lead to hepatic congestion and ischemic necrosis. Clinical manifestations observed in the majority of patients include hepatomegaly, right upper quadrant pain and abdominal ascites. Budd-Chiari syndrome is associated with a combination of disease states including primary myeloproliferative syndromes and thrombophilia due to factor V Leiden, protein C deficiency and antithrombin III deficiency. Budd-Chiari syndrome is a rare but typical complication in patients with polycythemia vera.
Related information in OMIM
Ischemic stroke (ISCHSTR)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionA stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
Related information in OMIM
Pregnancy loss, recurrent, 1 (RPRGL1)1 Publication
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Disease descriptionA common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions.
Related information in OMIM

Keywords - Diseasei

Disease variant, Thrombophilia

Organism-specific databases

DisGeNET

More...DisGeNETi		2153

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		F5

MalaCards human disease database

More...MalaCardsi		F5
MIMi188055, phenotype
227400, phenotype
600880, phenotype
601367, phenotype
614389, phenotype

Open Targets

More...OpenTargetsi		ENSG00000198734

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		131, Budd-Chiari syndrome
329217, Cerebral sinovenous thrombosis
326, Congenital factor V deficiency
391320, East Texas bleeding disorder
64738, NON RARE IN EUROPE: Non rare thrombophilia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA159

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P12259, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3618

Drug and drug target database

More...DrugBanki		DB13151, Anti-inhibitor coagulant complex
DB09130, Copper
DB00055, Drotrecogin alfa
DB11571, Human thrombin
DB11312, Protein C
DB13149, Protein S human
DB11300, Thrombin
DB11572, Thrombin alfa
DB05777, Thrombomodulin Alfa

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		F5

Domain mapping of disease mutations (DMDM)

More...DMDMi		308153653

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Add BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000297829 – 2224Coagulation factor VAdd BLAST2196
ChainiPRO_000000297929 – 737Coagulation factor V heavy chainAdd BLAST709
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000002980738 – 1573Activation peptide (connecting region)Add BLAST836
ChainiPRO_00000029811574 – 2224Coagulation factor V light chainAdd BLAST651

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi167 ↔ 193PROSITE-ProRule annotation
Glycosylationi239N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi248 ↔ 329PROSITE-ProRule annotation
Glycosylationi297N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi382N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi460N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi468N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi500 ↔ 526PROSITE-ProRule annotation
Glycosylationi554N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi603 ↔ 684PROSITE-ProRule annotation
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei640PhosphothreonineCombined sources1
Modified residuei693SulfotyrosineSequence analysis1
Modified residuei724SulfotyrosineSequence analysis1
Modified residuei726SulfotyrosineSequence analysis1
Glycosylationi741N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi752N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi760N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi776N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi782N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi821N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei859Phosphoserine; by FAM20C1 Publication1
Glycosylationi938N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi977N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1074N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1083N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1479N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1499N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1522SulfotyrosineSequence analysis1
Modified residuei1538SulfotyrosineSequence analysis1
Modified residuei1543SulfotyrosineSequence analysis1
Glycosylationi1559N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei1593SulfotyrosineSequence analysis1
Glycosylationi1703N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1725 ↔ 1751Curated
Disulfide bondi1907 ↔ 2061PROSITE-ProRule annotation
Glycosylationi2010N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2066 ↔ 2221PROSITE-ProRule annotation
Glycosylationi2209N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus).
Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity.3 Publications
Activated protein C inactivates factor V and factor Va by proteolytic degradation.1 Publication
Phosphorylated by FAM20C in the extracellular medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei334 – 335Cleavage; by activated protein C1 Publication2
Sitei534 – 535Cleavage; by activated protein C1 Publication2
Sitei707 – 708Cleavage; by activated protein C1 Publication2
Sitei737 – 738Cleavage; by thrombin1 Publication2
Sitei1022 – 1023Cleavage; by activated protein C1 Publication2
Sitei1046 – 1047Cleavage; by thrombin1 Publication2
Sitei1573 – 1574Cleavage; by thrombin1 Publication2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation, Zymogen

Proteomic databases

The CPTAC Assay portal

More...CPTACi		non-CPTAC-2648

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P12259

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P12259

MaxQB - The MaxQuant DataBase

More...MaxQBi		P12259

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P12259

PeptideAtlas

More...PeptideAtlasi		P12259

PRoteomics IDEntifications database

More...PRIDEi		P12259

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52838

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P12259

GlyConnect protein glycosylation platform

More...GlyConnecti		1120, 16 N-Linked glycans (9 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P12259, 59 sites, 19 N-linked glycans (10 sites), 6 O-linked glycans (31 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P12259

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P12259

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Plasma.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000198734, Expressed in liver and 181 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P12259, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P12259, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000198734, Group enriched (choroid plexus, liver, placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Factor Va, the activated form of factor V, is composed of a heavy chain and a light chain, non-covalently bound. The interaction between the two chains is calcium-dependent. Forms heterodimer with SERPINA5.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108452, 16 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6216, Coagulation factor Va complex

Database of interacting proteins

More...DIPi		DIP-47331N

Protein interaction database and analysis system

More...IntActi		P12259, 9 interactors

Molecular INTeraction database

More...MINTi		P12259

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000356771

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P12259

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P12259, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12224
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P12259

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P12259

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P12259

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 329F5/8 type A 1Add BLAST300
Domaini30 – 193Plastocyanin-like 1Add BLAST164
Domaini203 – 329Plastocyanin-like 2Add BLAST127
Domaini348 – 684F5/8 type A 2Add BLAST337
Domaini348 – 526Plastocyanin-like 3Add BLAST179
Domaini536 – 684Plastocyanin-like 4Add BLAST149
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati895 – 9111-1Add BLAST17
Repeati912 – 9281-2Add BLAST17
Repeati1185 – 11932-19
Repeati1194 – 12022-29
Repeati1203 – 12112-39
Repeati1212 – 12202-49
Repeati1221 – 12292-59
Repeati1230 – 12382-69
Repeati1239 – 12472-79
Repeati1248 – 12562-89
Repeati1257 – 12652-99
Repeati1266 – 12742-109
Repeati1275 – 12832-119
Repeati1284 – 12922-129
Repeati1293 – 13012-139
Repeati1302 – 13102-149
Repeati1311 – 13192-159
Repeati1320 – 13282-169
Repeati1329 – 13372-179
Repeati1338 – 13462-189
Repeati1347 – 13552-199
Repeati1356 – 13642-209
Repeati1365 – 13732-219
Repeati1374 – 13822-229
Repeati1383 – 13912-239
Repeati1392 – 14002-249
Repeati1401 – 14092-259
Repeati1410 – 14182-269
Repeati1419 – 14272-279
Repeati1428 – 14362-289
Repeati1437 – 14452-299
Repeati1446 – 14542-309
Repeati1455 – 14632-319
Repeati1464 – 14722-329
Repeati1473 – 14812-339
Repeati1482 – 14902-349
Repeati1493 – 15012-359
Domaini1578 – 1907F5/8 type A 3Add BLAST330
Domaini1578 – 1751Plastocyanin-like 5Add BLAST174
Domaini1761 – 1907Plastocyanin-like 6Add BLAST147
Domaini1907 – 2061F5/8 type C 1PROSITE-ProRule annotationAdd BLAST155
Domaini2066 – 2221F5/8 type C 2PROSITE-ProRule annotationAdd BLAST156

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni692 – 1573BAdd BLAST882
Regioni822 – 842DisorderedSequence analysisAdd BLAST21
Regioni894 – 927DisorderedSequence analysisAdd BLAST34
Regioni895 – 9282 X 17 AA tandem repeatsAdd BLAST34
Regioni982 – 1001DisorderedSequence analysisAdd BLAST20
Regioni1029 – 1048DisorderedSequence analysisAdd BLAST20
Regioni1097 – 1157DisorderedSequence analysisAdd BLAST61
Regioni1185 – 150135 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-TAdd BLAST317
Regioni1341 – 1367DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1097 – 1115Polar residuesSequence analysisAdd BLAST19
Compositional biasi1133 – 1152Polar residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Domain B contains 35 x 9 AA tandem repeats, and 2 x 17 AA repeats.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QSUG, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158556

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000948_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P12259

Identification of Orthologs from Complete Genome Data

More...OMAi		GDYWEPS

Database of Orthologous Groups

More...OrthoDBi		454773at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P12259

TreeFam database of animal gene trees

More...TreeFami		TF329807

Family and domain databases

Conserved Domains Database

More...CDDi		cd00057, FA58C, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.420, 5 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011707, Cu-oxidase_N
IPR033138, Cu_oxidase_CS
IPR008972, Cupredoxin
IPR000421, FA58C
IPR024715, Factor_5/8-like
IPR008979, Galactose-bd-like_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07732, Cu-oxidase_3, 2 hits
PF00754, F5_F8_type_C, 2 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000354, Factors_V_VIII, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00231, FA58C, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49503, SSF49503, 6 hits
SSF49785, SSF49785, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01285, FA58C_1, 2 hits
PS01286, FA58C_2, 2 hits
PS50022, FA58C_3, 2 hits
PS00079, MULTICOPPER_OXIDASE1, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P12259-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFPGCPRLWV LVVLGTSWVG WGSQGTEAAQ LRQFYVAAQG ISWSYRPEPT 
        60         70         80         90        100
NSSLNLSVTS FKKIVYREYE PYFKKEKPQS TISGLLGPTL YAEVGDIIKV 
       110        120        130        140        150
HFKNKADKPL SIHPQGIRYS KLSEGASYLD HTFPAEKMDD AVAPGREYTY 
       160        170        180        190        200
EWSISEDSGP THDDPPCLTH IYYSHENLIE DFNSGLIGPL LICKKGTLTE 
       210        220        230        240        250
GGTQKTFDKQ IVLLFAVFDE SKSWSQSSSL MYTVNGYVNG TMPDITVCAH 
       260        270        280        290        300
DHISWHLLGM SSGPELFSIH FNGQVLEQNH HKVSAITLVS ATSTTANMTV 
       310        320        330        340        350
GPEGKWIISS LTPKHLQAGM QAYIDIKNCP KKTRNLKKIT REQRRHMKRW 
       360        370        380        390        400
EYFIAAEEVI WDYAPVIPAN MDKKYRSQHL DNFSNQIGKH YKKVMYTQYE 
       410        420        430        440        450
DESFTKHTVN PNMKEDGILG PIIRAQVRDT LKIVFKNMAS RPYSIYPHGV 
       460        470        480        490        500
TFSPYEDEVN SSFTSGRNNT MIRAVQPGET YTYKWNILEF DEPTENDAQC 
       510        520        530        540        550
LTRPYYSDVD IMRDIASGLI GLLLICKSRS LDRRGIQRAA DIEQQAVFAV 
       560        570        580        590        600
FDENKSWYLE DNINKFCENP DEVKRDDPKF YESNIMSTIN GYVPESITTL 
       610        620        630        640        650
GFCFDDTVQW HFCSVGTQNE ILTIHFTGHS FIYGKRHEDT LTLFPMRGES 
       660        670        680        690        700
VTVTMDNVGT WMLTSMNSSP RSKKLRLKFR DVKCIPDDDE DSYEIFEPPE 
       710        720        730        740        750
STVMATRKMH DRLEPEDEES DADYDYQNRL AAALGIRSFR NSSLNQEEEE 
       760        770        780        790        800
FNLTALALEN GTEFVSSNTD IIVGSNYSSP SNISKFTVNN LAEPQKAPSH 
       810        820        830        840        850
QQATTAGSPL RHLIGKNSVL NSSTAEHSSP YSEDPIEDPL QPDVTGIRLL 
       860        870        880        890        900
SLGAGEFKSQ EHAKHKGPKV ERDQAAKHRF SWMKLLAHKV GRHLSQDTGS 
       910        920        930        940        950
PSGMRPWEDL PSQDTGSPSR MRPWKDPPSD LLLLKQSNSS KILVGRWHLA 
       960        970        980        990       1000
SEKGSYEIIQ DTDEDTAVNN WLISPQNASR AWGESTPLAN KPGKQSGHPK 
      1010       1020       1030       1040       1050
FPRVRHKSLQ VRQDGGKSRL KKSQFLIKTR KKKKEKHTHH APLSPRTFHP 
      1060       1070       1080       1090       1100
LRSEAYNTFS ERRLKHSLVL HKSNETSLPT DLNQTLPSMD FGWIASLPDH 
      1110       1120       1130       1140       1150
NQNSSNDTGQ ASCPPGLYQT VPPEEHYQTF PIQDPDQMHS TSDPSHRSSS 
      1160       1170       1180       1190       1200
PELSEMLEYD RSHKSFPTDI SQMSPSSEHE VWQTVISPDL SQVTLSPELS 
      1210       1220       1230       1240       1250
QTNLSPDLSH TTLSPELIQR NLSPALGQMP ISPDLSHTTL SPDLSHTTLS 
      1260       1270       1280       1290       1300
LDLSQTNLSP ELSQTNLSPA LGQMPLSPDL SHTTLSLDFS QTNLSPELSH 
      1310       1320       1330       1340       1350
MTLSPELSQT NLSPALGQMP ISPDLSHTTL SLDFSQTNLS PELSQTNLSP 
      1360       1370       1380       1390       1400
ALGQMPLSPD PSHTTLSLDL SQTNLSPELS QTNLSPDLSE MPLFADLSQI 
      1410       1420       1430       1440       1450
PLTPDLDQMT LSPDLGETDL SPNFGQMSLS PDLSQVTLSP DISDTTLLPD 
      1460       1470       1480       1490       1500
LSQISPPPDL DQIFYPSESS QSLLLQEFNE SFPYPDLGQM PSPSSPTLND 
      1510       1520       1530       1540       1550
TFLSKEFNPL VIVGLSKDGT DYIEIIPKEE VQSSEDDYAE IDYVPYDDPY 
      1560       1570       1580       1590       1600
KTDVRTNINS SRDPDNIAAW YLRSNNGNRR NYYIAAEEIS WDYSEFVQRE 
      1610       1620       1630       1640       1650
TDIEDSDDIP EDTTYKKVVF RKYLDSTFTK RDPRGEYEEH LGILGPIIRA 
      1660       1670       1680       1690       1700
EVDDVIQVRF KNLASRPYSL HAHGLSYEKS SEGKTYEDDS PEWFKEDNAV 
      1710       1720       1730       1740       1750
QPNSSYTYVW HATERSGPES PGSACRAWAY YSAVNPEKDI HSGLIGPLLI 
      1760       1770       1780       1790       1800
CQKGILHKDS NMPMDMREFV LLFMTFDEKK SWYYEKKSRS SWRLTSSEMK 
      1810       1820       1830       1840       1850
KSHEFHAING MIYSLPGLKM YEQEWVRLHL LNIGGSQDIH VVHFHGQTLL 
      1860       1870       1880       1890       1900
ENGNKQHQLG VWPLLPGSFK TLEMKASKPG WWLLNTEVGE NQRAGMQTPF 
      1910       1920       1930       1940       1950
LIMDRDCRMP MGLSTGIISD SQIKASEFLG YWEPRLARLN NGGSYNAWSV 
      1960       1970       1980       1990       2000
EKLAAEFASK PWIQVDMQKE VIITGIQTQG AKHYLKSCYT TEFYVAYSSN 
      2010       2020       2030       2040       2050
QINWQIFKGN STRNVMYFNG NSDASTIKEN QFDPPIVARY IRISPTRAYN 
      2060       2070       2080       2090       2100
RPTLRLELQG CEVNGCSTPL GMENGKIENK QITASSFKKS WWGDYWEPFR 
      2110       2120       2130       2140       2150
ARLNAQGRVN AWQAKANNNK QWLEIDLLKI KKITAIITQG CKSLSSEMYV 
      2160       2170       2180       2190       2200
KSYTIHYSEQ GVEWKPYRLK SSMVDKIFEG NTNTKGHVKN FFNPPIISRF 
      2210       2220 
IRVIPKTWNQ SIALRLELFG CDIY
Length:2,224
Mass (Da):251,703
Last modified:October 5, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i24AEF3FEA7332E37
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MRJ7A0A0A0MRJ7_HUMAN
Coagulation factor V
F5
2,229Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence ABD23003 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti741N → S in ABD23003 (Ref. 7) Curated1
Sequence conflicti908E → K in AAA52424 (PubMed:3110773).Curated1
Sequence conflicti908E → K in CAC82573 (PubMed:11758222).Curated1
Sequence conflicti991K → E in BAF84302 (PubMed:14702039).Curated1
Sequence conflicti2213A → T in AAA52424 (PubMed:3110773).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02129715G → S1 PublicationCorresponds to variant dbSNP:rs9332485EnsemblClinVar.1
Natural variantiVAR_013886107D → H2 PublicationsCorresponds to variant dbSNP:rs6019EnsemblClinVar.1
Natural variantiVAR_013620334R → G in Hong Kong; does not predispose to clinical thrombosis. 2 PublicationsCorresponds to variant dbSNP:rs118203905EnsemblClinVar.1
Natural variantiVAR_013621334R → T in THPH2; Cambridge. 1 PublicationCorresponds to variant dbSNP:rs118203906EnsemblClinVar.1
Natural variantiVAR_032698387I → T in THPH2; Liverpool; mutant protein is expressed with an additional carbohydrate chain. 2 PublicationsCorresponds to variant dbSNP:rs118203911EnsemblClinVar.1
Natural variantiVAR_013887413M → T2 PublicationsCorresponds to variant dbSNP:rs6033EnsemblClinVar.1
Natural variantiVAR_013622513R → K4 PublicationsCorresponds to variant dbSNP:rs6020EnsemblClinVar.1
Natural variantiVAR_001213534R → Q in THPH2; factor V Leiden; associated with susceptibility to Budd-Chiari syndrome; associated with susceptibility to ischemic stroke. 5 PublicationsCorresponds to variant dbSNP:rs6025EnsemblClinVar.1
Natural variantiVAR_032699613C → R in THPH2; Nijkerk. 1 PublicationCorresponds to variant dbSNP:rs1453479152Ensembl.1
Natural variantiVAR_035817775S → A in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_047740781S → R. Corresponds to variant dbSNP:rs13306350Ensembl.1
Natural variantiVAR_013888809P → S2 PublicationsCorresponds to variant dbSNP:rs6031EnsemblClinVar.1
Natural variantiVAR_013889817N → T2 PublicationsCorresponds to variant dbSNP:rs6018EnsemblClinVar.1
Natural variantiVAR_001214858K → R5 PublicationsCorresponds to variant dbSNP:rs4524EnsemblClinVar.1
Natural variantiVAR_001215865H → R5 PublicationsCorresponds to variant dbSNP:rs4525EnsemblClinVar.1
Natural variantiVAR_021298915T → S1 PublicationCorresponds to variant dbSNP:rs9332695EnsemblClinVar.1
Natural variantiVAR_013890925K → E5 PublicationsCorresponds to variant dbSNP:rs6032EnsemblClinVar.1
Natural variantiVAR_021299969N → S1 PublicationCorresponds to variant dbSNP:rs9332604EnsemblClinVar.1
Natural variantiVAR_021300980R → L1 PublicationCorresponds to variant dbSNP:rs9332605EnsemblClinVar.1
Natural variantiVAR_0138911146H → Q2 PublicationsCorresponds to variant dbSNP:rs6005EnsemblClinVar.1
Natural variantiVAR_0138921285L → I3 PublicationsCorresponds to variant dbSNP:rs1046712EnsemblClinVar.1
Natural variantiVAR_0138931327H → R2 PublicationsCorresponds to variant dbSNP:rs1800595EnsemblClinVar.1
Natural variantiVAR_0477411397L → F2 PublicationsCorresponds to variant dbSNP:rs13306334EnsemblClinVar.1
Natural variantiVAR_0213011404P → S1 PublicationCorresponds to variant dbSNP:rs9332608EnsemblClinVar.1
Natural variantiVAR_0138941530E → A2 PublicationsCorresponds to variant dbSNP:rs6007EnsemblClinVar.1
Natural variantiVAR_0138951685T → S1 PublicationCorresponds to variant dbSNP:rs6011EnsemblClinVar.1
Natural variantiVAR_0327001730Y → C in FA5D; Seoul 2. 2 PublicationsCorresponds to variant dbSNP:rs118203907EnsemblClinVar.1
Natural variantiVAR_0138961749L → V1 PublicationCorresponds to variant dbSNP:rs6034EnsemblClinVar.1
Natural variantiVAR_0138971764M → V3 PublicationsCorresponds to variant dbSNP:rs6030EnsemblClinVar.1
Natural variantiVAR_0138981820M → I1 PublicationCorresponds to variant dbSNP:rs6026EnsemblClinVar.1
Natural variantiVAR_0327012102R → C in FA5D; impairs both factor V secretion and activity. 1 PublicationCorresponds to variant dbSNP:rs118203910EnsemblClinVar.1
Natural variantiVAR_0173292102R → H in THPH2. 1 Publication1
Natural variantiVAR_0213022148M → T1 PublicationCorresponds to variant dbSNP:rs9332701EnsemblClinVar.1
Natural variantiVAR_0346032185K → R. Corresponds to variant dbSNP:rs6679078EnsemblClinVar.1
Natural variantiVAR_0138992222D → G1 PublicationCorresponds to variant dbSNP:rs6027EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M16967 mRNA Translation: AAA52424.1
L32779 L32778 Genomic DNA Translation: AAB59401.1
AY364535 Genomic DNA Translation: AAQ55063.1
Z99572 Genomic DNA No translation available.
AK291613 mRNA Translation: BAF84302.1
M14335 mRNA Translation: AAB59532.1
DQ377944 Genomic DNA Translation: ABD23003.1 Sequence problems.
AJ297255 mRNA Translation: CAC82573.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1281.1

Protein sequence database of the Protein Information Resource

More...PIRi		A56172, KFHU5

NCBI Reference Sequences

More...RefSeqi		NP_000121.2, NM_000130.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000367797.9; ENSP00000356771.3; ENSG00000198734.12

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2153

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2153

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000367797.9; ENSP00000356771.3; NM_000130.5; NP_000121.2

UCSC genome browser

More...UCSCi		uc001ggg.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Factor V entry

SeattleSNPs
SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16967 mRNA Translation: AAA52424.1
L32779 L32778 Genomic DNA Translation: AAB59401.1
AY364535 Genomic DNA Translation: AAQ55063.1
Z99572 Genomic DNA No translation available.
AK291613 mRNA Translation: BAF84302.1
M14335 mRNA Translation: AAB59532.1
DQ377944 Genomic DNA Translation: ABD23003.1 Sequence problems.
AJ297255 mRNA Translation: CAC82573.1
CCDSiCCDS1281.1
PIRiA56172, KFHU5
RefSeqiNP_000121.2, NM_000130.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CZSX-ray1.90A2065-2224[»]
1CZTX-ray1.87A2065-2224[»]
1CZVX-ray2.40A/B2065-2224[»]
3P6ZX-ray1.70C/I685-737[»]
3P70X-ray2.55M/N/O/P685-737[»]
3S9CX-ray1.80B1561-1574[»]
7KVEelectron microscopy3.30B29-2224[»]
7KVFelectron microscopy3.60B29-2224[»]
7KXYelectron microscopy4.40A29-737[»]
B1574-2224[»]
AlphaFoldDBiP12259
SMRiP12259
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108452, 16 interactors
ComplexPortaliCPX-6216, Coagulation factor Va complex
DIPiDIP-47331N
IntActiP12259, 9 interactors
MINTiP12259
STRINGi9606.ENSP00000356771

Chemistry databases

BindingDBiP12259
ChEMBLiCHEMBL3618
DrugBankiDB13151, Anti-inhibitor coagulant complex
DB09130, Copper
DB00055, Drotrecogin alfa
DB11571, Human thrombin
DB11312, Protein C
DB13149, Protein S human
DB11300, Thrombin
DB11572, Thrombin alfa
DB05777, Thrombomodulin Alfa

PTM databases

CarbonylDBiP12259
GlyConnecti1120, 16 N-Linked glycans (9 sites)
GlyGeniP12259, 59 sites, 19 N-linked glycans (10 sites), 6 O-linked glycans (31 sites)
iPTMnetiP12259
PhosphoSitePlusiP12259

Genetic variation databases

BioMutaiF5
DMDMi308153653

Proteomic databases

CPTACinon-CPTAC-2648
jPOSTiP12259
MassIVEiP12259
MaxQBiP12259
PaxDbiP12259
PeptideAtlasiP12259
PRIDEiP12259
ProteomicsDBi52838

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		863, 400 antibodies from 30 providers

The DNASU plasmid repository

More...DNASUi		2153

Genome annotation databases

EnsembliENST00000367797.9; ENSP00000356771.3; ENSG00000198734.12
GeneIDi2153
KEGGihsa:2153
MANE-SelectiENST00000367797.9; ENSP00000356771.3; NM_000130.5; NP_000121.2
UCSCiuc001ggg.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2153
DisGeNETi2153

GeneCards: human genes, protein and diseases

More...GeneCardsi		F5
GeneReviewsiF5
HGNCiHGNC:3542, F5
HPAiENSG00000198734, Group enriched (choroid plexus, liver, placenta)
MalaCardsiF5
MIMi188055, phenotype
227400, phenotype
600880, phenotype
601367, phenotype
612309, gene
614389, phenotype
neXtProtiNX_P12259
OpenTargetsiENSG00000198734
Orphaneti131, Budd-Chiari syndrome
329217, Cerebral sinovenous thrombosis
326, Congenital factor V deficiency
391320, East Texas bleeding disorder
64738, NON RARE IN EUROPE: Non rare thrombophilia
PharmGKBiPA159
VEuPathDBiHostDB:ENSG00000198734

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QSUG, Eukaryota
GeneTreeiENSGT00940000158556
HOGENOMiCLU_000948_0_0_1
InParanoidiP12259
OMAiGDYWEPS
OrthoDBi454773at2759
PhylomeDBiP12259
TreeFamiTF329807

Enzyme and pathway databases

PathwayCommonsiP12259
ReactomeiR-HSA-114608, Platelet degranulation
R-HSA-140875, Common Pathway of Fibrin Clot Formation
R-HSA-204005, COPII-mediated vesicle transport
R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-5694530, Cargo concentration in the ER
R-HSA-8957275, Post-translational protein phosphorylation
SignaLinkiP12259
SIGNORiP12259

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2153, 7 hits in 1070 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		F5, human
EvolutionaryTraceiP12259

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Factor_V

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2153
PharosiP12259, Tbio

Protein Ontology

More...PROi		PR:P12259
RNActiP12259, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000198734, Expressed in liver and 181 other tissues
ExpressionAtlasiP12259, baseline and differential
GenevisibleiP12259, HS

Family and domain databases

CDDicd00057, FA58C, 2 hits
Gene3Di2.60.40.420, 5 hits
InterProiView protein in InterPro
IPR011707, Cu-oxidase_N
IPR033138, Cu_oxidase_CS
IPR008972, Cupredoxin
IPR000421, FA58C
IPR024715, Factor_5/8-like
IPR008979, Galactose-bd-like_sf
PfamiView protein in Pfam
PF07732, Cu-oxidase_3, 2 hits
PF00754, F5_F8_type_C, 2 hits
PIRSFiPIRSF000354, Factors_V_VIII, 1 hit
SMARTiView protein in SMART
SM00231, FA58C, 2 hits
SUPFAMiSSF49503, SSF49503, 6 hits
SSF49785, SSF49785, 2 hits
PROSITEiView protein in PROSITE
PS01285, FA58C_1, 2 hits
PS01286, FA58C_2, 2 hits
PS50022, FA58C_3, 2 hits
PS00079, MULTICOPPER_OXIDASE1, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFA5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P12259
Secondary accession number(s): A8K6E8
, Q14285, Q2EHR5, Q5R346, Q5R347, Q6UPU6, Q8WWQ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 5, 2010
Last modified: May 25, 2022
This is version 242 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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