UniProtKB - P12259 (FA5_HUMAN)
Coagulation factor V
F5
Functioni
Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 139 | CalciumBy similarity | 1 | |
Metal bindingi | 140 | CalciumBy similarity | 1 | |
Metal bindingi | 1843 | CopperBy similarity | 1 | |
Metal bindingi | 1845 | CopperBy similarity | 1 |
GO - Molecular functioni
- copper ion binding Source: InterPro
GO - Biological processi
- blood circulation Source: GO_Central
- blood coagulation Source: GO_Central
- blood coagulation, common pathway Source: ComplexPortal
- blood coagulation, extrinsic pathway Source: ComplexPortal
- proteolysis Source: ComplexPortal
- response to vitamin K Source: Ensembl
- zymogen activation Source: ComplexPortal
Keywordsi
Biological process | Blood coagulation, Hemostasis |
Ligand | Calcium, Copper, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | P12259 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-140875, Common Pathway of Fibrin Clot Formation R-HSA-204005, COPII-mediated vesicle transport R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-5694530, Cargo concentration in the ER R-HSA-8957275, Post-translational protein phosphorylation |
SignaLinki | P12259 |
SIGNORi | P12259 |
Names & Taxonomyi
Protein namesi | Recommended name: Coagulation factor VAlternative name(s): Activated protein C cofactor Proaccelerin, labile factor Cleaved into the following 2 chains: |
Gene namesi | Name:F5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3542, F5 |
MIMi | 612309, gene |
neXtProti | NX_P12259 |
VEuPathDBi | HostDB:ENSG00000198734 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: ComplexPortal
- extracellular vesicle Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: Ensembl
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- COPII-coated ER to Golgi transport vesicle Source: Reactome
- endoplasmic reticulum-Golgi intermediate compartment membrane Source: Reactome
- membrane Source: UniProtKB
- platelet alpha granule Source: GO_Central
- platelet alpha granule lumen Source: Reactome
- protein-containing complex Source: ComplexPortal
- serine-type endopeptidase complex Source: ComplexPortal
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Factor V deficiency (FA5D)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032700 | 1730 | Y → C in FA5D; Seoul 2. 2 PublicationsCorresponds to variant dbSNP:rs118203907EnsemblClinVar. | 1 | |
Natural variantiVAR_032701 | 2102 | R → C in FA5D; impairs both factor V secretion and activity. 1 PublicationCorresponds to variant dbSNP:rs118203910EnsemblClinVar. | 1 |
Thrombophilia due to activated protein C resistance (THPH2)9 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013621 | 334 | R → T in THPH2; Cambridge. 1 PublicationCorresponds to variant dbSNP:rs118203906EnsemblClinVar. | 1 | |
Natural variantiVAR_032698 | 387 | I → T in THPH2; Liverpool; mutant protein is expressed with an additional carbohydrate chain. 2 PublicationsCorresponds to variant dbSNP:rs118203911EnsemblClinVar. | 1 | |
Natural variantiVAR_001213 | 534 | R → Q in THPH2; factor V Leiden; associated with susceptibility to Budd-Chiari syndrome; associated with susceptibility to ischemic stroke. 5 PublicationsCorresponds to variant dbSNP:rs6025EnsemblClinVar. | 1 | |
Natural variantiVAR_032699 | 613 | C → R in THPH2; Nijkerk. 1 PublicationCorresponds to variant dbSNP:rs1453479152Ensembl. | 1 | |
Natural variantiVAR_017329 | 2102 | R → H in THPH2. 1 Publication | 1 |
Budd-Chiari syndrome (BDCHS)1 Publication
Ischemic stroke (ISCHSTR)1 Publication
Pregnancy loss, recurrent, 1 (RPRGL1)1 Publication
Keywords - Diseasei
Disease variant, ThrombophiliaOrganism-specific databases
DisGeNETi | 2153 |
GeneReviewsi | F5 |
MalaCardsi | F5 |
MIMi | 188055, phenotype 227400, phenotype 600880, phenotype 601367, phenotype 614389, phenotype |
OpenTargetsi | ENSG00000198734 |
Orphaneti | 131, Budd-Chiari syndrome 329217, Cerebral sinovenous thrombosis 326, Congenital factor V deficiency 391320, East Texas bleeding disorder 64738, NON RARE IN EUROPE: Non rare thrombophilia |
PharmGKBi | PA159 |
Miscellaneous databases
Pharosi | P12259, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3618 |
DrugBanki | DB13151, Anti-inhibitor coagulant complex DB09130, Copper DB00055, Drotrecogin alfa DB11571, Human thrombin DB11312, Protein C DB13149, Protein S human DB11300, Thrombin DB11572, Thrombin alfa DB05777, Thrombomodulin Alfa |
Genetic variation databases
BioMutai | F5 |
DMDMi | 308153653 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Add BLAST | 28 | |
ChainiPRO_0000002978 | 29 – 2224 | Coagulation factor VAdd BLAST | 2196 | |
ChainiPRO_0000002979 | 29 – 737 | Coagulation factor V heavy chainAdd BLAST | 709 | |
PropeptideiPRO_0000002980 | 738 – 1573 | Activation peptide (connecting region)Add BLAST | 836 | |
ChainiPRO_0000002981 | 1574 – 2224 | Coagulation factor V light chainAdd BLAST | 651 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 51 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 55 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 167 ↔ 193 | PROSITE-ProRule annotation | ||
Glycosylationi | 239 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 248 ↔ 329 | PROSITE-ProRule annotation | ||
Glycosylationi | 297 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 382 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 460 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 468 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 500 ↔ 526 | PROSITE-ProRule annotation | ||
Glycosylationi | 554 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 603 ↔ 684 | PROSITE-ProRule annotation | ||
Modified residuei | 640 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 693 | SulfotyrosineSequence analysis | 1 | |
Modified residuei | 724 | SulfotyrosineSequence analysis | 1 | |
Modified residuei | 726 | SulfotyrosineSequence analysis | 1 | |
Glycosylationi | 741 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 752 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 760 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 776 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 782 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 821 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Modified residuei | 859 | Phosphoserine; by FAM20C1 Publication | 1 | |
Glycosylationi | 938 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 977 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 1074 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1083 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1103 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1106 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1479 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1499 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 1522 | SulfotyrosineSequence analysis | 1 | |
Modified residuei | 1538 | SulfotyrosineSequence analysis | 1 | |
Modified residuei | 1543 | SulfotyrosineSequence analysis | 1 | |
Glycosylationi | 1559 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Modified residuei | 1593 | SulfotyrosineSequence analysis | 1 | |
Glycosylationi | 1703 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1725 ↔ 1751 | Curated | ||
Disulfide bondi | 1907 ↔ 2061 | PROSITE-ProRule annotation | ||
Glycosylationi | 2010 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 2066 ↔ 2221 | PROSITE-ProRule annotation | ||
Glycosylationi | 2209 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 334 – 335 | Cleavage; by activated protein C1 Publication | 2 | |
Sitei | 534 – 535 | Cleavage; by activated protein C1 Publication | 2 | |
Sitei | 707 – 708 | Cleavage; by activated protein C1 Publication | 2 | |
Sitei | 737 – 738 | Cleavage; by thrombin1 Publication | 2 | |
Sitei | 1022 – 1023 | Cleavage; by activated protein C1 Publication | 2 | |
Sitei | 1046 – 1047 | Cleavage; by thrombin1 Publication | 2 | |
Sitei | 1573 – 1574 | Cleavage; by thrombin1 Publication | 2 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation, ZymogenProteomic databases
CPTACi | non-CPTAC-2648 |
jPOSTi | P12259 |
MassIVEi | P12259 |
MaxQBi | P12259 |
PaxDbi | P12259 |
PeptideAtlasi | P12259 |
PRIDEi | P12259 |
ProteomicsDBi | 52838 |
PTM databases
CarbonylDBi | P12259 |
GlyConnecti | 1120, 16 N-Linked glycans (9 sites) |
GlyGeni | P12259, 59 sites, 19 N-linked glycans (10 sites), 6 O-linked glycans (31 sites) |
iPTMneti | P12259 |
PhosphoSitePlusi | P12259 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000198734, Expressed in liver and 181 other tissues |
ExpressionAtlasi | P12259, baseline and differential |
Genevisiblei | P12259, HS |
Organism-specific databases
HPAi | ENSG00000198734, Group enriched (choroid plexus, liver, placenta) |
Interactioni
Subunit structurei
Factor Va, the activated form of factor V, is composed of a heavy chain and a light chain, non-covalently bound. The interaction between the two chains is calcium-dependent. Forms heterodimer with SERPINA5.
Protein-protein interaction databases
BioGRIDi | 108452, 16 interactors |
ComplexPortali | CPX-6216, Coagulation factor Va complex |
DIPi | DIP-47331N |
IntActi | P12259, 9 interactors |
MINTi | P12259 |
STRINGi | 9606.ENSP00000356771 |
Chemistry databases
BindingDBi | P12259 |
Miscellaneous databases
RNActi | P12259, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P12259 |
SMRi | P12259 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P12259 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 329 | F5/8 type A 1Add BLAST | 300 | |
Domaini | 30 – 193 | Plastocyanin-like 1Add BLAST | 164 | |
Domaini | 203 – 329 | Plastocyanin-like 2Add BLAST | 127 | |
Domaini | 348 – 684 | F5/8 type A 2Add BLAST | 337 | |
Domaini | 348 – 526 | Plastocyanin-like 3Add BLAST | 179 | |
Domaini | 536 – 684 | Plastocyanin-like 4Add BLAST | 149 | |
Repeati | 895 – 911 | 1-1Add BLAST | 17 | |
Repeati | 912 – 928 | 1-2Add BLAST | 17 | |
Repeati | 1185 – 1193 | 2-1 | 9 | |
Repeati | 1194 – 1202 | 2-2 | 9 | |
Repeati | 1203 – 1211 | 2-3 | 9 | |
Repeati | 1212 – 1220 | 2-4 | 9 | |
Repeati | 1221 – 1229 | 2-5 | 9 | |
Repeati | 1230 – 1238 | 2-6 | 9 | |
Repeati | 1239 – 1247 | 2-7 | 9 | |
Repeati | 1248 – 1256 | 2-8 | 9 | |
Repeati | 1257 – 1265 | 2-9 | 9 | |
Repeati | 1266 – 1274 | 2-10 | 9 | |
Repeati | 1275 – 1283 | 2-11 | 9 | |
Repeati | 1284 – 1292 | 2-12 | 9 | |
Repeati | 1293 – 1301 | 2-13 | 9 | |
Repeati | 1302 – 1310 | 2-14 | 9 | |
Repeati | 1311 – 1319 | 2-15 | 9 | |
Repeati | 1320 – 1328 | 2-16 | 9 | |
Repeati | 1329 – 1337 | 2-17 | 9 | |
Repeati | 1338 – 1346 | 2-18 | 9 | |
Repeati | 1347 – 1355 | 2-19 | 9 | |
Repeati | 1356 – 1364 | 2-20 | 9 | |
Repeati | 1365 – 1373 | 2-21 | 9 | |
Repeati | 1374 – 1382 | 2-22 | 9 | |
Repeati | 1383 – 1391 | 2-23 | 9 | |
Repeati | 1392 – 1400 | 2-24 | 9 | |
Repeati | 1401 – 1409 | 2-25 | 9 | |
Repeati | 1410 – 1418 | 2-26 | 9 | |
Repeati | 1419 – 1427 | 2-27 | 9 | |
Repeati | 1428 – 1436 | 2-28 | 9 | |
Repeati | 1437 – 1445 | 2-29 | 9 | |
Repeati | 1446 – 1454 | 2-30 | 9 | |
Repeati | 1455 – 1463 | 2-31 | 9 | |
Repeati | 1464 – 1472 | 2-32 | 9 | |
Repeati | 1473 – 1481 | 2-33 | 9 | |
Repeati | 1482 – 1490 | 2-34 | 9 | |
Repeati | 1493 – 1501 | 2-35 | 9 | |
Domaini | 1578 – 1907 | F5/8 type A 3Add BLAST | 330 | |
Domaini | 1578 – 1751 | Plastocyanin-like 5Add BLAST | 174 | |
Domaini | 1761 – 1907 | Plastocyanin-like 6Add BLAST | 147 | |
Domaini | 1907 – 2061 | F5/8 type C 1PROSITE-ProRule annotationAdd BLAST | 155 | |
Domaini | 2066 – 2221 | F5/8 type C 2PROSITE-ProRule annotationAdd BLAST | 156 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 692 – 1573 | BAdd BLAST | 882 | |
Regioni | 822 – 842 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 894 – 927 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 895 – 928 | 2 X 17 AA tandem repeatsAdd BLAST | 34 | |
Regioni | 982 – 1001 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1029 – 1048 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1097 – 1157 | DisorderedSequence analysisAdd BLAST | 61 | |
Regioni | 1185 – 1501 | 35 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-TAdd BLAST | 317 | |
Regioni | 1341 – 1367 | DisorderedSequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1097 – 1115 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 1133 – 1152 | Polar residuesSequence analysisAdd BLAST | 20 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502QSUG, Eukaryota |
GeneTreei | ENSGT00940000158556 |
HOGENOMi | CLU_000948_0_0_1 |
InParanoidi | P12259 |
OMAi | GDYWEPS |
OrthoDBi | 454773at2759 |
PhylomeDBi | P12259 |
TreeFami | TF329807 |
Family and domain databases
CDDi | cd00057, FA58C, 2 hits |
Gene3Di | 2.60.40.420, 5 hits |
InterProi | View protein in InterPro IPR011707, Cu-oxidase_N IPR033138, Cu_oxidase_CS IPR008972, Cupredoxin IPR000421, FA58C IPR024715, Factor_5/8-like IPR008979, Galactose-bd-like_sf |
Pfami | View protein in Pfam PF07732, Cu-oxidase_3, 2 hits PF00754, F5_F8_type_C, 2 hits |
PIRSFi | PIRSF000354, Factors_V_VIII, 1 hit |
SMARTi | View protein in SMART SM00231, FA58C, 2 hits |
SUPFAMi | SSF49503, SSF49503, 6 hits SSF49785, SSF49785, 2 hits |
PROSITEi | View protein in PROSITE PS01285, FA58C_1, 2 hits PS01286, FA58C_2, 2 hits PS50022, FA58C_3, 2 hits PS00079, MULTICOPPER_OXIDASE1, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MFPGCPRLWV LVVLGTSWVG WGSQGTEAAQ LRQFYVAAQG ISWSYRPEPT
60 70 80 90 100
NSSLNLSVTS FKKIVYREYE PYFKKEKPQS TISGLLGPTL YAEVGDIIKV
110 120 130 140 150
HFKNKADKPL SIHPQGIRYS KLSEGASYLD HTFPAEKMDD AVAPGREYTY
160 170 180 190 200
EWSISEDSGP THDDPPCLTH IYYSHENLIE DFNSGLIGPL LICKKGTLTE
210 220 230 240 250
GGTQKTFDKQ IVLLFAVFDE SKSWSQSSSL MYTVNGYVNG TMPDITVCAH
260 270 280 290 300
DHISWHLLGM SSGPELFSIH FNGQVLEQNH HKVSAITLVS ATSTTANMTV
310 320 330 340 350
GPEGKWIISS LTPKHLQAGM QAYIDIKNCP KKTRNLKKIT REQRRHMKRW
360 370 380 390 400
EYFIAAEEVI WDYAPVIPAN MDKKYRSQHL DNFSNQIGKH YKKVMYTQYE
410 420 430 440 450
DESFTKHTVN PNMKEDGILG PIIRAQVRDT LKIVFKNMAS RPYSIYPHGV
460 470 480 490 500
TFSPYEDEVN SSFTSGRNNT MIRAVQPGET YTYKWNILEF DEPTENDAQC
510 520 530 540 550
LTRPYYSDVD IMRDIASGLI GLLLICKSRS LDRRGIQRAA DIEQQAVFAV
560 570 580 590 600
FDENKSWYLE DNINKFCENP DEVKRDDPKF YESNIMSTIN GYVPESITTL
610 620 630 640 650
GFCFDDTVQW HFCSVGTQNE ILTIHFTGHS FIYGKRHEDT LTLFPMRGES
660 670 680 690 700
VTVTMDNVGT WMLTSMNSSP RSKKLRLKFR DVKCIPDDDE DSYEIFEPPE
710 720 730 740 750
STVMATRKMH DRLEPEDEES DADYDYQNRL AAALGIRSFR NSSLNQEEEE
760 770 780 790 800
FNLTALALEN GTEFVSSNTD IIVGSNYSSP SNISKFTVNN LAEPQKAPSH
810 820 830 840 850
QQATTAGSPL RHLIGKNSVL NSSTAEHSSP YSEDPIEDPL QPDVTGIRLL
860 870 880 890 900
SLGAGEFKSQ EHAKHKGPKV ERDQAAKHRF SWMKLLAHKV GRHLSQDTGS
910 920 930 940 950
PSGMRPWEDL PSQDTGSPSR MRPWKDPPSD LLLLKQSNSS KILVGRWHLA
960 970 980 990 1000
SEKGSYEIIQ DTDEDTAVNN WLISPQNASR AWGESTPLAN KPGKQSGHPK
1010 1020 1030 1040 1050
FPRVRHKSLQ VRQDGGKSRL KKSQFLIKTR KKKKEKHTHH APLSPRTFHP
1060 1070 1080 1090 1100
LRSEAYNTFS ERRLKHSLVL HKSNETSLPT DLNQTLPSMD FGWIASLPDH
1110 1120 1130 1140 1150
NQNSSNDTGQ ASCPPGLYQT VPPEEHYQTF PIQDPDQMHS TSDPSHRSSS
1160 1170 1180 1190 1200
PELSEMLEYD RSHKSFPTDI SQMSPSSEHE VWQTVISPDL SQVTLSPELS
1210 1220 1230 1240 1250
QTNLSPDLSH TTLSPELIQR NLSPALGQMP ISPDLSHTTL SPDLSHTTLS
1260 1270 1280 1290 1300
LDLSQTNLSP ELSQTNLSPA LGQMPLSPDL SHTTLSLDFS QTNLSPELSH
1310 1320 1330 1340 1350
MTLSPELSQT NLSPALGQMP ISPDLSHTTL SLDFSQTNLS PELSQTNLSP
1360 1370 1380 1390 1400
ALGQMPLSPD PSHTTLSLDL SQTNLSPELS QTNLSPDLSE MPLFADLSQI
1410 1420 1430 1440 1450
PLTPDLDQMT LSPDLGETDL SPNFGQMSLS PDLSQVTLSP DISDTTLLPD
1460 1470 1480 1490 1500
LSQISPPPDL DQIFYPSESS QSLLLQEFNE SFPYPDLGQM PSPSSPTLND
1510 1520 1530 1540 1550
TFLSKEFNPL VIVGLSKDGT DYIEIIPKEE VQSSEDDYAE IDYVPYDDPY
1560 1570 1580 1590 1600
KTDVRTNINS SRDPDNIAAW YLRSNNGNRR NYYIAAEEIS WDYSEFVQRE
1610 1620 1630 1640 1650
TDIEDSDDIP EDTTYKKVVF RKYLDSTFTK RDPRGEYEEH LGILGPIIRA
1660 1670 1680 1690 1700
EVDDVIQVRF KNLASRPYSL HAHGLSYEKS SEGKTYEDDS PEWFKEDNAV
1710 1720 1730 1740 1750
QPNSSYTYVW HATERSGPES PGSACRAWAY YSAVNPEKDI HSGLIGPLLI
1760 1770 1780 1790 1800
CQKGILHKDS NMPMDMREFV LLFMTFDEKK SWYYEKKSRS SWRLTSSEMK
1810 1820 1830 1840 1850
KSHEFHAING MIYSLPGLKM YEQEWVRLHL LNIGGSQDIH VVHFHGQTLL
1860 1870 1880 1890 1900
ENGNKQHQLG VWPLLPGSFK TLEMKASKPG WWLLNTEVGE NQRAGMQTPF
1910 1920 1930 1940 1950
LIMDRDCRMP MGLSTGIISD SQIKASEFLG YWEPRLARLN NGGSYNAWSV
1960 1970 1980 1990 2000
EKLAAEFASK PWIQVDMQKE VIITGIQTQG AKHYLKSCYT TEFYVAYSSN
2010 2020 2030 2040 2050
QINWQIFKGN STRNVMYFNG NSDASTIKEN QFDPPIVARY IRISPTRAYN
2060 2070 2080 2090 2100
RPTLRLELQG CEVNGCSTPL GMENGKIENK QITASSFKKS WWGDYWEPFR
2110 2120 2130 2140 2150
ARLNAQGRVN AWQAKANNNK QWLEIDLLKI KKITAIITQG CKSLSSEMYV
2160 2170 2180 2190 2200
KSYTIHYSEQ GVEWKPYRLK SSMVDKIFEG NTNTKGHVKN FFNPPIISRF
2210 2220
IRVIPKTWNQ SIALRLELFG CDIY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MRJ7 | A0A0A0MRJ7_HUMAN | Coagulation factor V | F5 | 2,229 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 741 | N → S in ABD23003 (Ref. 7) Curated | 1 | |
Sequence conflicti | 908 | E → K in AAA52424 (PubMed:3110773).Curated | 1 | |
Sequence conflicti | 908 | E → K in CAC82573 (PubMed:11758222).Curated | 1 | |
Sequence conflicti | 991 | K → E in BAF84302 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 2213 | A → T in AAA52424 (PubMed:3110773).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021297 | 15 | G → S1 PublicationCorresponds to variant dbSNP:rs9332485EnsemblClinVar. | 1 | |
Natural variantiVAR_013886 | 107 | D → H2 PublicationsCorresponds to variant dbSNP:rs6019EnsemblClinVar. | 1 | |
Natural variantiVAR_013620 | 334 | R → G in Hong Kong; does not predispose to clinical thrombosis. 2 PublicationsCorresponds to variant dbSNP:rs118203905EnsemblClinVar. | 1 | |
Natural variantiVAR_013621 | 334 | R → T in THPH2; Cambridge. 1 PublicationCorresponds to variant dbSNP:rs118203906EnsemblClinVar. | 1 | |
Natural variantiVAR_032698 | 387 | I → T in THPH2; Liverpool; mutant protein is expressed with an additional carbohydrate chain. 2 PublicationsCorresponds to variant dbSNP:rs118203911EnsemblClinVar. | 1 | |
Natural variantiVAR_013887 | 413 | M → T2 PublicationsCorresponds to variant dbSNP:rs6033EnsemblClinVar. | 1 | |
Natural variantiVAR_013622 | 513 | R → K4 PublicationsCorresponds to variant dbSNP:rs6020EnsemblClinVar. | 1 | |
Natural variantiVAR_001213 | 534 | R → Q in THPH2; factor V Leiden; associated with susceptibility to Budd-Chiari syndrome; associated with susceptibility to ischemic stroke. 5 PublicationsCorresponds to variant dbSNP:rs6025EnsemblClinVar. | 1 | |
Natural variantiVAR_032699 | 613 | C → R in THPH2; Nijkerk. 1 PublicationCorresponds to variant dbSNP:rs1453479152Ensembl. | 1 | |
Natural variantiVAR_035817 | 775 | S → A in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_047740 | 781 | S → R. Corresponds to variant dbSNP:rs13306350Ensembl. | 1 | |
Natural variantiVAR_013888 | 809 | P → S2 PublicationsCorresponds to variant dbSNP:rs6031EnsemblClinVar. | 1 | |
Natural variantiVAR_013889 | 817 | N → T2 PublicationsCorresponds to variant dbSNP:rs6018EnsemblClinVar. | 1 | |
Natural variantiVAR_001214 | 858 | K → R5 PublicationsCorresponds to variant dbSNP:rs4524EnsemblClinVar. | 1 | |
Natural variantiVAR_001215 | 865 | H → R5 PublicationsCorresponds to variant dbSNP:rs4525EnsemblClinVar. | 1 | |
Natural variantiVAR_021298 | 915 | T → S1 PublicationCorresponds to variant dbSNP:rs9332695EnsemblClinVar. | 1 | |
Natural variantiVAR_013890 | 925 | K → E5 PublicationsCorresponds to variant dbSNP:rs6032EnsemblClinVar. | 1 | |
Natural variantiVAR_021299 | 969 | N → S1 PublicationCorresponds to variant dbSNP:rs9332604EnsemblClinVar. | 1 | |
Natural variantiVAR_021300 | 980 | R → L1 PublicationCorresponds to variant dbSNP:rs9332605EnsemblClinVar. | 1 | |
Natural variantiVAR_013891 | 1146 | H → Q2 PublicationsCorresponds to variant dbSNP:rs6005EnsemblClinVar. | 1 | |
Natural variantiVAR_013892 | 1285 | L → I3 PublicationsCorresponds to variant dbSNP:rs1046712EnsemblClinVar. | 1 | |
Natural variantiVAR_013893 | 1327 | H → R2 PublicationsCorresponds to variant dbSNP:rs1800595EnsemblClinVar. | 1 | |
Natural variantiVAR_047741 | 1397 | L → F2 PublicationsCorresponds to variant dbSNP:rs13306334EnsemblClinVar. | 1 | |
Natural variantiVAR_021301 | 1404 | P → S1 PublicationCorresponds to variant dbSNP:rs9332608EnsemblClinVar. | 1 | |
Natural variantiVAR_013894 | 1530 | E → A2 PublicationsCorresponds to variant dbSNP:rs6007EnsemblClinVar. | 1 | |
Natural variantiVAR_013895 | 1685 | T → S1 PublicationCorresponds to variant dbSNP:rs6011EnsemblClinVar. | 1 | |
Natural variantiVAR_032700 | 1730 | Y → C in FA5D; Seoul 2. 2 PublicationsCorresponds to variant dbSNP:rs118203907EnsemblClinVar. | 1 | |
Natural variantiVAR_013896 | 1749 | L → V1 PublicationCorresponds to variant dbSNP:rs6034EnsemblClinVar. | 1 | |
Natural variantiVAR_013897 | 1764 | M → V3 PublicationsCorresponds to variant dbSNP:rs6030EnsemblClinVar. | 1 | |
Natural variantiVAR_013898 | 1820 | M → I1 PublicationCorresponds to variant dbSNP:rs6026EnsemblClinVar. | 1 | |
Natural variantiVAR_032701 | 2102 | R → C in FA5D; impairs both factor V secretion and activity. 1 PublicationCorresponds to variant dbSNP:rs118203910EnsemblClinVar. | 1 | |
Natural variantiVAR_017329 | 2102 | R → H in THPH2. 1 Publication | 1 | |
Natural variantiVAR_021302 | 2148 | M → T1 PublicationCorresponds to variant dbSNP:rs9332701EnsemblClinVar. | 1 | |
Natural variantiVAR_034603 | 2185 | K → R. Corresponds to variant dbSNP:rs6679078EnsemblClinVar. | 1 | |
Natural variantiVAR_013899 | 2222 | D → G1 PublicationCorresponds to variant dbSNP:rs6027EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M16967 mRNA Translation: AAA52424.1 L32779 , L32755, L32756, L32757, L32758, L32759, L32760, L32761, L32762, L32763, L32764, L32765, L32766, L32767, L32768, L32769, L32770, L32771, L32772, L32773, L32774, L32775, L32776, L32777, L32778 Genomic DNA Translation: AAB59401.1 AY364535 Genomic DNA Translation: AAQ55063.1 Z99572 Genomic DNA No translation available. AK291613 mRNA Translation: BAF84302.1 M14335 mRNA Translation: AAB59532.1 DQ377944 Genomic DNA Translation: ABD23003.1 Sequence problems. AJ297255 mRNA Translation: CAC82573.1 |
CCDSi | CCDS1281.1 |
PIRi | A56172, KFHU5 |
RefSeqi | NP_000121.2, NM_000130.4 |
Genome annotation databases
Ensembli | ENST00000367797.9; ENSP00000356771.3; ENSG00000198734.12 |
GeneIDi | 2153 |
KEGGi | hsa:2153 |
MANE-Selecti | ENST00000367797.9; ENSP00000356771.3; NM_000130.5; NP_000121.2 |
UCSCi | uc001ggg.2, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Factor V entry |
SeattleSNPs |
SHMPD The Singapore human mutation and polymorphism database |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M16967 mRNA Translation: AAA52424.1 L32779 , L32755, L32756, L32757, L32758, L32759, L32760, L32761, L32762, L32763, L32764, L32765, L32766, L32767, L32768, L32769, L32770, L32771, L32772, L32773, L32774, L32775, L32776, L32777, L32778 Genomic DNA Translation: AAB59401.1 AY364535 Genomic DNA Translation: AAQ55063.1 Z99572 Genomic DNA No translation available. AK291613 mRNA Translation: BAF84302.1 M14335 mRNA Translation: AAB59532.1 DQ377944 Genomic DNA Translation: ABD23003.1 Sequence problems. AJ297255 mRNA Translation: CAC82573.1 |
CCDSi | CCDS1281.1 |
PIRi | A56172, KFHU5 |
RefSeqi | NP_000121.2, NM_000130.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1CZS | X-ray | 1.90 | A | 2065-2224 | [»] | |
1CZT | X-ray | 1.87 | A | 2065-2224 | [»] | |
1CZV | X-ray | 2.40 | A/B | 2065-2224 | [»] | |
3P6Z | X-ray | 1.70 | C/I | 685-737 | [»] | |
3P70 | X-ray | 2.55 | M/N/O/P | 685-737 | [»] | |
3S9C | X-ray | 1.80 | B | 1561-1574 | [»] | |
7KVE | electron microscopy | 3.30 | B | 29-2224 | [»] | |
7KVF | electron microscopy | 3.60 | B | 29-2224 | [»] | |
7KXY | electron microscopy | 4.40 | A | 29-737 | [»] | |
B | 1574-2224 | [»] | ||||
AlphaFoldDBi | P12259 | |||||
SMRi | P12259 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108452, 16 interactors |
ComplexPortali | CPX-6216, Coagulation factor Va complex |
DIPi | DIP-47331N |
IntActi | P12259, 9 interactors |
MINTi | P12259 |
STRINGi | 9606.ENSP00000356771 |
Chemistry databases
BindingDBi | P12259 |
ChEMBLi | CHEMBL3618 |
DrugBanki | DB13151, Anti-inhibitor coagulant complex DB09130, Copper DB00055, Drotrecogin alfa DB11571, Human thrombin DB11312, Protein C DB13149, Protein S human DB11300, Thrombin DB11572, Thrombin alfa DB05777, Thrombomodulin Alfa |
PTM databases
CarbonylDBi | P12259 |
GlyConnecti | 1120, 16 N-Linked glycans (9 sites) |
GlyGeni | P12259, 59 sites, 19 N-linked glycans (10 sites), 6 O-linked glycans (31 sites) |
iPTMneti | P12259 |
PhosphoSitePlusi | P12259 |
Genetic variation databases
BioMutai | F5 |
DMDMi | 308153653 |
Proteomic databases
CPTACi | non-CPTAC-2648 |
jPOSTi | P12259 |
MassIVEi | P12259 |
MaxQBi | P12259 |
PaxDbi | P12259 |
PeptideAtlasi | P12259 |
PRIDEi | P12259 |
ProteomicsDBi | 52838 |
Protocols and materials databases
Antibodypediai | 863, 400 antibodies from 30 providers |
DNASUi | 2153 |
Genome annotation databases
Ensembli | ENST00000367797.9; ENSP00000356771.3; ENSG00000198734.12 |
GeneIDi | 2153 |
KEGGi | hsa:2153 |
MANE-Selecti | ENST00000367797.9; ENSP00000356771.3; NM_000130.5; NP_000121.2 |
UCSCi | uc001ggg.2, human |
Organism-specific databases
CTDi | 2153 |
DisGeNETi | 2153 |
GeneCardsi | F5 |
GeneReviewsi | F5 |
HGNCi | HGNC:3542, F5 |
HPAi | ENSG00000198734, Group enriched (choroid plexus, liver, placenta) |
MalaCardsi | F5 |
MIMi | 188055, phenotype 227400, phenotype 600880, phenotype 601367, phenotype 612309, gene 614389, phenotype |
neXtProti | NX_P12259 |
OpenTargetsi | ENSG00000198734 |
Orphaneti | 131, Budd-Chiari syndrome 329217, Cerebral sinovenous thrombosis 326, Congenital factor V deficiency 391320, East Texas bleeding disorder 64738, NON RARE IN EUROPE: Non rare thrombophilia |
PharmGKBi | PA159 |
VEuPathDBi | HostDB:ENSG00000198734 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QSUG, Eukaryota |
GeneTreei | ENSGT00940000158556 |
HOGENOMi | CLU_000948_0_0_1 |
InParanoidi | P12259 |
OMAi | GDYWEPS |
OrthoDBi | 454773at2759 |
PhylomeDBi | P12259 |
TreeFami | TF329807 |
Enzyme and pathway databases
PathwayCommonsi | P12259 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-140875, Common Pathway of Fibrin Clot Formation R-HSA-204005, COPII-mediated vesicle transport R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-5694530, Cargo concentration in the ER R-HSA-8957275, Post-translational protein phosphorylation |
SignaLinki | P12259 |
SIGNORi | P12259 |
Miscellaneous databases
BioGRID-ORCSi | 2153, 7 hits in 1070 CRISPR screens |
ChiTaRSi | F5, human |
EvolutionaryTracei | P12259 |
GeneWikii | Factor_V |
GenomeRNAii | 2153 |
Pharosi | P12259, Tbio |
PROi | PR:P12259 |
RNActi | P12259, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198734, Expressed in liver and 181 other tissues |
ExpressionAtlasi | P12259, baseline and differential |
Genevisiblei | P12259, HS |
Family and domain databases
CDDi | cd00057, FA58C, 2 hits |
Gene3Di | 2.60.40.420, 5 hits |
InterProi | View protein in InterPro IPR011707, Cu-oxidase_N IPR033138, Cu_oxidase_CS IPR008972, Cupredoxin IPR000421, FA58C IPR024715, Factor_5/8-like IPR008979, Galactose-bd-like_sf |
Pfami | View protein in Pfam PF07732, Cu-oxidase_3, 2 hits PF00754, F5_F8_type_C, 2 hits |
PIRSFi | PIRSF000354, Factors_V_VIII, 1 hit |
SMARTi | View protein in SMART SM00231, FA58C, 2 hits |
SUPFAMi | SSF49503, SSF49503, 6 hits SSF49785, SSF49785, 2 hits |
PROSITEi | View protein in PROSITE PS01285, FA58C_1, 2 hits PS01286, FA58C_2, 2 hits PS50022, FA58C_3, 2 hits PS00079, MULTICOPPER_OXIDASE1, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | FA5_HUMAN | |
Accessioni | P12259Primary (citable) accession number: P12259 Secondary accession number(s): A8K6E8 Q8WWQ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | October 5, 2010 | |
Last modified: | May 25, 2022 | |
This is version 242 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families