UniProtKB - P12258 (HOBOT_DROME)
Protein
Transposable element Hobo transposase
Gene
T
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Essential for hobo transposase activity.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 73 – 131 | BED-typePROSITE-ProRule annotationAdd BLAST | 59 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- protein dimerization activity Source: InterPro
GO - Biological processi
- DNA integration Source: UniProtKB-KW
- DNA recombination Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Biological process | DNA integration, DNA recombination |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Transposable element Hobo transposase |
Gene namesi | Name:T |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Organism-specific databases
FlyBasei | FBgn0014191, hobo\T |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000084025 | 1 – 644 | Transposable element Hobo transposaseAdd BLAST | 644 |
Proteomic databases
PRIDEi | P12258 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 521 – 523 | 1 | 3 | |
Repeati | 524 – 526 | 2 | 3 | |
Repeati | 527 – 529 | 3 | 3 | |
Repeati | 530 – 532 | 4 | 3 | |
Repeati | 533 – 535 | 5 | 3 | |
Repeati | 536 – 538 | 6 | 3 | |
Repeati | 539 – 541 | 7 | 3 | |
Repeati | 542 – 544 | 8 | 3 | |
Repeati | 545 – 547 | 9 | 3 | |
Repeati | 548 – 550 | 10 | 3 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 521 – 550 | 10 X 3 AA tandem repeats of T-P-EAdd BLAST | 30 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 73 – 131 | BED-typePROSITE-ProRule annotationAdd BLAST | 59 |
Keywords - Domaini
Repeat, Zinc-fingerFamily and domain databases
InterProi | View protein in InterPro IPR008906, HATC_C_dom IPR018473, Hermes_transposase_DNA-db IPR012337, RNaseH-like_sf IPR003656, Znf_BED |
Pfami | View protein in Pfam PF10683, DBD_Tnp_Hermes, 1 hit PF05699, Dimer_Tnp_hAT, 1 hit |
SUPFAMi | SSF53098, SSF53098, 1 hit |
PROSITEi | View protein in PROSITE PS50808, ZF_BED, 1 hit |
i Sequence
Sequence statusi: Complete.
P12258-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPYIMIVEF LCLWSSVSAV NCPFFVFYDA ITSLLGFSII WKPKEKVTIM
60 70 80 90 100
AEAADFVKNK INNGTYSVAN KHKGKSVIWS ILCDILKEDE TVLDGWLFCR
110 120 130 140 150
QCQKVLKFLH KNTSNLSRHK CCLTLRRPTE LKIVSENDKK VAIEKCTQWV
160 170 180 190 200
VQDCRPFSAV TGAGFKNLVK FFLQIGAIYG EQVDVDDLLP DPTTLSRKAK
210 220 230 240 250
SDAEEKRSLI SSEIKKAVDS GRASATVDMW TDQYVQRNFL GITFHYEKEF
260 270 280 290 300
KLCDMILGLK SMNFQKSTAE NILMKIKGLF SEFNVENIDN VKFVTDRGAN
310 320 330 340 350
IKKALEGNTR LNCSSHLLSN VLEKSFNEAN ELKKIVKSCK KIVKYCKKSN
360 370 380 390 400
LQHTLETTLK SACPTRWNSN YKMMKSILDN WRSVDKILGE ADIHVDFNKS
410 420 430 440 450
SLKVVVDILG DFERIFKKLQ TSSSPSICFV LPSISKILEL CEPNILDLSA
460 470 480 490 500
AALLKERILE NIRKIWMANL SIWHKAAFFL YPPAAHLQEE DILEIKVFCI
510 520 530 540 550
SQIQVPISYT LSLESTETPR TPETPETPET PETPETPETP ETPETPETPE
560 570 580 590 600
SLESPNLFPK KNKTISSENE FFFPKPVTES NSNFNESPLD EIERYIRQRV
610 620 630 640
PLSQNFEVIE WWKNNANLYP QLSKLALKLL SIPASSAELK ECFP
Sequence cautioni
The sequence AAA51465 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 576 | P → L in AAA51465 (PubMed:1651170).Curated | 1 | |
Sequence conflicti | 638 – 644 | ELKECFP → AAERVFSLAGNIITEKRNRL CPKSVDSLLFLHSYYKNLNN SQ in AAA51465 (PubMed:1651170).Curated | 7 |
Polymorphismi
The number of repeats is highly polymorphic and varies among different strains.
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 521 – 541 | Missing 1 PublicationAdd BLAST | 21 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04705 Genomic DNA Translation: CAA28410.1 M69216 Genomic DNA Translation: AAA51465.1 Different initiation. |
PIRi | A25684 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04705 Genomic DNA Translation: CAA28410.1 M69216 Genomic DNA Translation: AAA51465.1 Different initiation. |
PIRi | A25684 |
3D structure databases
SMRi | P12258 |
ModBasei | Search... |
Proteomic databases
PRIDEi | P12258 |
Organism-specific databases
FlyBasei | FBgn0014191, hobo\T |
Miscellaneous databases
PROi | PR:P12258 |
Family and domain databases
InterProi | View protein in InterPro IPR008906, HATC_C_dom IPR018473, Hermes_transposase_DNA-db IPR012337, RNaseH-like_sf IPR003656, Znf_BED |
Pfami | View protein in Pfam PF10683, DBD_Tnp_Hermes, 1 hit PF05699, Dimer_Tnp_hAT, 1 hit |
SUPFAMi | SSF53098, SSF53098, 1 hit |
PROSITEi | View protein in PROSITE PS50808, ZF_BED, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HOBOT_DROME | |
Accessioni | P12258Primary (citable) accession number: P12258 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | October 1, 1989 | |
Last modified: | December 2, 2020 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Transposable elementDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase