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Protein

Serum amyloid P-component

Gene

Apcs

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi78Calcium 1PROSITE-ProRule annotation1
Metal bindingi79Calcium 1PROSITE-ProRule annotation1
Metal bindingi156Calcium 1PROSITE-ProRule annotation1
Metal bindingi156Calcium 2PROSITE-ProRule annotation1
Metal bindingi157Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi158Calcium 1PROSITE-ProRule annotation1
Metal bindingi158Calcium 2PROSITE-ProRule annotation1
Metal bindingi168Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serum amyloid P-component
Short name:
SAP
Gene namesi
Name:Apcs
Synonyms:Ptx2, Sap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:98229 Apcs

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, Secreted

Pathology & Biotechi

Involvement in diseasei

SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000002354221 – 224Serum amyloid P-componentAdd BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi56 ↔ 115PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP12246
PeptideAtlasiP12246
PRIDEiP12246

PTM databases

iPTMnetiP12246
PhosphoSitePlusiP12246

Expressioni

Gene expression databases

BgeeiENSMUSG00000026542 Expressed in 53 organ(s), highest expression level in liver
CleanExiMM_APCS
ExpressionAtlasiP12246 baseline and differential
GenevisibleiP12246 MM

Interactioni

Subunit structurei

Homopentamer. Pentraxin (or pentaxin) have a discoid arrangement of 5 non-covalently bound subunits.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203069, 1 interactor
STRINGi10090.ENSMUSP00000027824

Structurei

3D structure databases

ProteinModelPortaliP12246
SMRiP12246
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 224Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST200

Sequence similaritiesi

Belongs to the pentraxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1FD Eukaryota
ENOG410YN8S LUCA
GeneTreeiENSGT00760000119128
HOGENOMiHOG000247043
HOVERGENiHBG005405
InParanoidiP12246
OMAiMDKLLLW
OrthoDBiEOG091G0H6X
PhylomeDBiP12246
TreeFamiTF330208

Family and domain databases

CDDicd00152 PTX, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR030476 Pentaxin_CS
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00354 Pentaxin, 1 hit
PRINTSiPR00895 PENTAXIN
SMARTiView protein in SMART
SM00159 PTX, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00289 PTX_1, 1 hit
PS51828 PTX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12246-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKLLLWMFV FTSLLSEAFC QTDLKRKVFV FPRESETDHV KLIPHLEKPL
60 70 80 90 100
QNFTLCFRTY SDLSRSQSLF SYSVKGRDNE LLIYKEKVGE YSLYIGQSKV
110 120 130 140 150
TVRGMEEYLS PVHLCTTWES SSGIVEFWVN GKPWVKKSLQ REYTVKAPPS
160 170 180 190 200
IVLGQEQDNY GGGFQRSQSF VGEFSDLYMW DYVLTPQDIL FVYRDSPVNP
210 220
NILNWQALNY EINGYVVIRP RVWD
Length:224
Mass (Da):26,247
Last modified:January 1, 1990 - v2
Checksum:i1CDBC15F45E50DCA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151I → V in AAA40092 (PubMed:3183383).Curated1
Sequence conflicti151I → V in CAA32243 (PubMed:3183383).Curated1
Sequence conflicti154G → R in CAA68488 (PubMed:3658681).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23552 mRNA Translation: AAA40092.1
M29535 Genomic DNA Translation: AAA40093.1
X16899 Genomic DNA Translation: CAA34774.1
X14079 mRNA Translation: CAA32243.1
Y00426 mRNA Translation: CAA68488.1
BC061125 mRNA Translation: AAH61125.1
M23248 mRNA Translation: AAA40091.1
CCDSiCCDS15520.1
PIRiA30528
RefSeqiNP_035448.2, NM_011318.2
UniGeneiMm.330510

Genome annotation databases

EnsembliENSMUST00000027824; ENSMUSP00000027824; ENSMUSG00000026542
GeneIDi20219
KEGGimmu:20219
UCSCiuc007dqy.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23552 mRNA Translation: AAA40092.1
M29535 Genomic DNA Translation: AAA40093.1
X16899 Genomic DNA Translation: CAA34774.1
X14079 mRNA Translation: CAA32243.1
Y00426 mRNA Translation: CAA68488.1
BC061125 mRNA Translation: AAH61125.1
M23248 mRNA Translation: AAA40091.1
CCDSiCCDS15520.1
PIRiA30528
RefSeqiNP_035448.2, NM_011318.2
UniGeneiMm.330510

3D structure databases

ProteinModelPortaliP12246
SMRiP12246
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203069, 1 interactor
STRINGi10090.ENSMUSP00000027824

PTM databases

iPTMnetiP12246
PhosphoSitePlusiP12246

Proteomic databases

PaxDbiP12246
PeptideAtlasiP12246
PRIDEiP12246

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027824; ENSMUSP00000027824; ENSMUSG00000026542
GeneIDi20219
KEGGimmu:20219
UCSCiuc007dqy.2 mouse

Organism-specific databases

CTDi325
MGIiMGI:98229 Apcs

Phylogenomic databases

eggNOGiENOG410J1FD Eukaryota
ENOG410YN8S LUCA
GeneTreeiENSGT00760000119128
HOGENOMiHOG000247043
HOVERGENiHBG005405
InParanoidiP12246
OMAiMDKLLLW
OrthoDBiEOG091G0H6X
PhylomeDBiP12246
TreeFamiTF330208

Miscellaneous databases

PROiPR:P12246
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026542 Expressed in 53 organ(s), highest expression level in liver
CleanExiMM_APCS
ExpressionAtlasiP12246 baseline and differential
GenevisibleiP12246 MM

Family and domain databases

CDDicd00152 PTX, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR030476 Pentaxin_CS
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00354 Pentaxin, 1 hit
PRINTSiPR00895 PENTAXIN
SMARTiView protein in SMART
SM00159 PTX, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00289 PTX_1, 1 hit
PS51828 PTX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSAMP_MOUSE
AccessioniPrimary (citable) accession number: P12246
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 1, 1990
Last modified: November 7, 2018
This is version 176 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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